I received Hordenine yesterday (epinephrine norepinephrine precursor), its clearing all my brain fog from a shower and wet dream today. I need to test further in the coming weeks to see if it stays consistent so I will update.
I had a metabolic organic acids test done a few months ago which said I had low production or decreased metabolism of norepinephrine and epinephrine.
It also said I also have a :
High HVA/VMA ratio (35) the HVA/VMA ratio reflects the balance between dopamine and norepinephrine/epinephrine
production by catecholamine producing neurons in the central nervous system, sympathetic nervous system, and adrenal
gland. The most common reason for an elevation of the HVA/VMA ratio is a decreased conversion of dopamine to
norepinephrine.
This makes sense why it makes me feel so good as when I try dopaminergic things such a tyrosine or bupropion I feel awful, down bellow the test results suggest the use of Droxidopa if DBH enzyme activity is low but I am unable to get this drug in UK. Hordenine seems similar to droxidopa hence why I ordered it but I was not expecting it to work. Unfortunately also I am unsure if its safe or not because there hasn't been any studies on it. Also makes sense as Milnacapran works for Hurray and people who have tried levodopa(precursor) also have much better results than neurotransmitter agonists or antagonists .
I've tried co factors for norepinephrine like copper and liposomal vitamin c but they seem to have little effect
https://selfhacked.com/blog/hordenine-benefits/ - "Hordenine increased response to noradrenaline in rats by 65%."
"Monoamine oxidase-B (MAO-B) inactivates hordenine. MAO-B is responsible for inactivating other neurotransmitters such as dopamine and phenylethylamine. When MAO-B is busy breaking down hordenine, it may cause other neurotransmitters to build up"
"It is a cholinesterase inhibitor, meaning it keeps the enzyme cholinesterase from breaking down acetylcholine"
https://medium.com/@liftmode/hordenine-benefits-top-3-effects-of-the-supplement-derived-from-bitter-orange-37b1f26c0fcb#_ftn6 -
"Suppresses neuroinflammation "
Test results in full:
Vanillylmandelic acid (VMA) levels (34) below the mean indicate low production and/or decreased metabolism of the
neurotransmitters norepinephrine and epinephrine. Vanillylmandelic acid is a metabolite of the neurotransmitters
norepinephrine and epinephrine. Low production of VMA can be due to decreased intake or absorption of norepinephrine ’s
and epinephrine’s precursor amino acids such as phenylalanine and/or tyrosine, decreased quantities of cofactors needed
for biosynthesis of norepinephrine and epinephrine such as tetrahydrobiopterin and vitamin B6 coenzyme or decreased
amounts of cofactors such as S-adenosylmethionine (Sam-e) needed to convert norepinephrine and epinephrine to VMA.
In addition, a number of genetic variations such as single nucleotide polymorphisms (SNPs) or mutations in MAO or
COMT genes can cause reduced production of VMA. Such SNPs are available on The Great Plains DNA methylation
pathway test which can be performed on a cheek swab. VMA values below the mean but which are much lower than HVA
values are usually due to impairment of dopamine beta hydroxylase due to Clostridia metabolites, the mold metabolite
fusaric acid, pharmaceuticals such as disulfiram, or food additives like aspartame or deficiencies of cofactors such as
vitamin C or copper. Values may be decreased in patients on monoamine oxidase (MAO) inhibitors. Another cause for a
low VMA value is a genetic variation (single nucleotide polymorphism or SNP) of the DBH enzyme. This DBH test is now
available at The Great Plains Laboratory on blood serum. Patients with low VMA due to Clostridia metabolites or genetic
DBH deficiency should not be supplemented with phenylalanine, tyrosine, or L- DOPA.
High HVA/VMA ratio (35) the HVA/VMA ratio reflects the balance between dopamine and norepinephrine/epinephrine
production by catecholamine producing neurons in the central nervous system, sympathetic nervous system, and adrenal
gland. The most common reason for an elevation of the HVA/VMA ratio is a decreased conversion of dopamine to
norepinephrine. The enzyme responsible for this conversion, dopamine beta-hydroxylase (DBH), is copper and vitamin C
dependent so an elevated ratio could be due to deficiencies of these cofactors . The most common reason for this
elevated ratio is inhibition of this enzyme by Clostridia byproducts including HPHPA, 4-cresol, or 4-hydroxyphenylacetic
acid. Other causes of an increased ratio include inhibition of DBH by the mold metabolite fusaric acid, pharmaceuticals
such as disulfiram, or food additives like aspartame. Another cause for an elevated ratio is a genetic variation (single
nucleotide polymorphism or SNP) of the DBH enzyme. Alternatively, the activity of the DBH enzyme can be measured on
blood serum. Individuals with low DBH activity can be treated with the drug DroxidopaTM, which provides adequate
norepinephrine by an alternate biochemical pathway. This DBH test on blood serum is now available at The Great Plains
Laboratory. High ratios are common in a large number of neuropsychiatric diseases regardless of the reason for DBH
deficiency.
If you have any thoughts or advice on this then please leave a reply.
