Small intestinal bacterial overgrowth (SIBO)

[Muon]

I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.     

https://en.wikipedia.org/wiki/D-lactate_dehydrogenase
This enzyme catalyses the following chemical reaction: (R)-lactate + NAD+ <----> pyruvate + NADH

[Mushnikk]

I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.     

https://en.wikipedia.org/wiki/D-lactate_dehydrogenase
This enzyme catalyses the following chemical reaction: (R)-lactate + NAD+ <----> pyruvate + NADH

Your point being?

[Muon]

Linking stuff:
https://poiscenter.com/forums/index.php?topic=3551.msg38867#msg38867

[Muon]

I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.     

What kind of test did you do for SIBO?

[Mushnikk]

I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.     

What kind of test did you do for SIBO?

Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg

[Muon]

Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg

Seems like methane producing species are dominant. Methane breathers are harder to threat than hydrogen breathers. Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin.

[Journey]

Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg

Seems like methane producing species are dominant. Methane breathers are harder to threat than hydrogen breathers. Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin.

How could  the SIBO be causing the POIS could SIBO be the root cause for the Mast Cell Activation Disorder which then gives the POIS?

[Mushnikk]

Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg

Seems like methane producing species are dominant. Methane breathers are harder to threat than hydrogen breathers. Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin.

That's also what I have read. Neomycin or Flagyl are often used for methane dominant SIBO, but I am not really sure if nuking/resetting my gut is a good or a bad thing. It is not something one simply tries, there could be irreversible changes the microbiome. Plus AB just have a lot of awful side effects. I will definitely follow a SIBO diet (and perhaps) herbal antibiotics and will report back.

There is definitely a dysbiosis in my gut...

What is worth noting is that carbs before and after O increase the severity of my POIS.

Also I currently looking for a lab to test D-lactate, I inquired a couple of labs: they all only measure L-lactate...

[Mushnikk]

Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg

Seems like methane producing species are dominant. Methane breathers are harder to threat than hydrogen breathers. Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin.

How could  the SIBO be causing the POIS could SIBO be the root cause for the Mast Cell Activation Disorder which then gives the POIS?

SIBO can cause malobsorption of nutrients and a compromised immune system as a possible cause of POIS. Or act on the gut-brain-axis, or could diminish a population of necessary gut bacteria which build neurotransmitters that are involved in regulating the autonomous nervous system, orgasms, ...

[Muon]

Also I currently looking for a lab to test D-lactate, I inquired a couple of labs: they all only measure L-lactate...

Redlabs Belgium provides that test: https://drive.google.com/file/d/1YBnZhO7yWYWHf17H23SimWHUOTzD_DA-/view

[berlin1984]

That's also what I have read. Neomycin or Flagyl are often used for methane dominant SIBO, but I am not really sure if nuking/resetting my gut is a good or a bad thing. It is not something one simply tries, there could be irreversible changes the microbiome.

Please google for: SIBO gut motility

From what I read, improving gut motility (many methods, e.g. more fasting between meals, motility supplements or medicine, more stomach acid, ...) and starving the critters a bit (low FODMAP diet) could already help?

I did some experiments in that direction, even though I don't think I have SIBO.

(Sidenote: However something diagnosed as SIBO might actually be unrelated to SmallIntestine(BO) but a general disbyosis which needs to be tackled...)

[Muon]

Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis

"D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome."

"We found that over 2/3rd of patients with brain fogginess demonstrated D-lactic acidosis,along with significantly higher prevalence of SIBO when compared to those without brain fogginess."

This number is quite large.

[Muon]

Childhood diet has lifelong impact

Eating too much fat and sugar as a child can alter your microbiome for life, even if you later learn to eat healthier, a new study in mice suggests.

[Muon]

Discussion:

Irritable Bowel Syndrome caused by MCAS? New report.

"A proportion of patients will experience SIBO after a severe bout of food poisoning either from Campylbacteor, E Coli, Shingella or Salmonella. These bacteria create a bacterial toxin called Cytolethal Distending Toxin (CdtB) with can lead to autoimmunity with anti-vincolin antibodies developing.

the anti-vincolin antibodies which cause a loss of function of the Migrating Motor Complex and also nerve damage which will result in bacterial overgrowth"

Edit:

Well, about 4 months ago I came down with a salmonella infection and got quite sick. I had a fever for a few days and felt very miserable. I had diarrhea and lots of it. Whatever was coming out of me was black and disgusting, perhaps blood in the diarrhea. After I recovered from the fever the diarrhea persisted and I had to go on antibiotics (azithromycin) to kill off most of the salmonella.

[Muon]

The structural homology (molecular mimicry) between pathogen and host proteins can result in "collateral damage" to surrounding human tissue.

Host proteins as in seminal fluid proteins?

[Muon]

A Zero Carbohydrate, Carnivore Diet can Normalize Hydrogen Positive Small Intestinal Bacterial Overgrowth Lactulose Breath Tests: A Case Report (2021)

[BoneBroth]

A carnivore diet (eat only meat) is what my SIBO-terapeut say I should try if the FODMAP doesnt work. I have eat a lot of steamed broccoli for some time but now I suspect that it is partly responsible for the gas-production since my faher experience the same thing (all vegetables). After periods of bad smelly gas POIS symptoms always comes after. I think the inflammatory substances of orgasm also weakens the intestines.

[Muon]

Intriguing Gastrointestinal Properties of Bismuth: A Folk Remedy Brought into the Realm of Clinical and Investigative Medicine

"BSS is almost completely hydrolyzed in the stomach to form bismuth oxychloride and salicylic acid. The bismuth released exerts its cytoprotective action not only by coating the gastric lining but also by stimulating prostoglandin synthesis. Very little bismuth (less than 1%) is absorbed by the small intestine. In the colon, bismuth salts react with hydrogen sulphide produced by anaerobic bacteria to produce bismuth sulphide, a highly insoluble black salt responsible for the often noted darkening of the stool. This reaction does not interfere with standard tests to detect occult blood. Salicylate derived from BSS is almost completely absorbed from the GI tract."

"The downside of bismuth relates to the sequestration of this heavy metal in multiple tissue sites"

Bismuth Table 1:
Review article: microscopic colitis - lymphocytic, collagenous and 'mast cell' colitis

Loperamide used for lymphocytic colitis:
https://www.sciencedirect.com/science/article/abs/pii/S0002927002054473

One POISer in literature uses Loperamide for IBS. IBS caused by infiltration of the GI tract with leukocytes?

Infiltration:
https://poiscenter.com/forums/index.php?topic=2695.msg39394#msg39394

never had any intense reactions except for stomach problems, and it took me years to realize that soy was the cause. It got worse when (around 10 years old) I incorporated new foods with soy into my diet and my digestive system couldn't take it anymore: I spent 4 months with colitis and lost half of my weight until thankfully my mother deduced that soy was the culprit. So I believe that, if it was a true allergy, I'd have had a more intense reaction. And yes, I've never tolerated soy well, and I've had that problem for as long as I can remember.

All lymphocytes or are mast cells hiding as well? Quote from a book in this post:
https://poiscenter.com/forums/index.php?topic=2695.msg39141#msg39141

Pepto Bismol thread: https://poiscenter.com/forums/index.php?topic=3316.0
John reacts to pepto bismol as well as antibiotics:

It seems my POIS is gone, hopefully forever.  I can explain how I believe it happened although I don't really understand what happened.  In my previous posts I explained how Pepto Bismol prevented POIS when taken before O. This made me wonder if maybe there was something in the gut that was happening  to cause the POIS symptoms. Well, about 4 months ago I came down with a salmonella infection and got quite sick. I had a fever for a few days and felt very miserable. I had diarrhea and lots of it. Whatever was coming out of me was black and disgusting, perhaps blood in the diarrhea. After I recovered from the fever the diarrhea persisted and I had to go on antibiotics (azithromycin) to kill off most of the salmonella. I started eating yogurt, kefir, and sauerkraut to try to re-establish a healthy gut microbiome. The diarrhea went away and my system normalized. But even now, almost 4 months afterward, it seems that my digestive system is different than it was before the food poisoning.

Black stool but without pepto bismol? Check first quote of this post about peptobismol: "a highly insoluble black salt responsible for the often noted darkening of the stool."

Discussion:

Irritable Bowel Syndrome caused by MCAS? New report.

"A proportion of patients will experience SIBO after a severe bout of food poisoning either from Campylbacteor, E Coli, Shingella or Salmonella. These bacteria create a bacterial toxin called Cytolethal Distending Toxin (CdtB) with can lead to autoimmunity with anti-vincolin antibodies developing.

the anti-vincolin antibodies which cause a loss of function of the Migrating Motor Complex and also nerve damage which will result in bacterial overgrowth"

[Muon]

ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth

8. Methanobrevibacter smithii appears to be the key methanogen responsible for breath methane production.

[Muon]

GPR109a: The Missing Link between Microbiome and Good Health?