Author Topic: Covid 19 Long Haulers  (Read 5424 times)

Charles_b

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Re: Covid 19 Long Haulers
« Reply #20 on: January 31, 2022, 02:59:44 PM »
Just came across the following study on long-covid correlated changes in microbiota.  This could potentially pertain to POIS as well if it is gut related, as many have postulated.  I know John21 had success with antimicrobials and probiotics, and others have had success with diet changes.

https://gut.bmj.com/content/early/2022/01/05/gutjnl-2021-325989


Interesting part on bacteria that was low or missing from the gut of long-haulers after 6 months: “ Butyrate-producing bacteria, including Bifidobacterium pseudocatenulatum and Faecalibacterium prausnitzii showed the largest inverse correlations with PACS at 6 months.”
« Last Edit: January 31, 2022, 03:03:25 PM by Charles_b »

certainlypois2

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longcovid drug combination
« Reply #21 on: December 25, 2022, 04:40:26 AM »
A Study is showing Guanfacine and the anti-oxidant NAC helps 8 out 10 longhaulers with brain fog. This might help us.
https://www.reddit.com/r/covidlonghaulers/comments/zuo9nl/13_exciting_brain_fog_drug_pacing_tips_and_a_xmas/

Quantum

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Re: Covid 19 Long Haulers
« Reply #22 on: January 11, 2023, 09:22:47 AM »
I stumbled upon an interesting article on Long Covid, and we can see similitude with POIS.  The article mentions similarities with Lyme, chronic fatigue syndrome, etc... if the authors knew about POIS, they may have included it in their list:
"How Long COVID Defies Simple SolutionsLong COVID is a “dynamic disability” that requires health professionals to go off script when a patient’s symptoms don’t respond in a predictable way to treatment, says David Putrino, PhD, a neuroscientist, physical therapist, and director of rehabilitation innovation for the Mount Sinai Health System in New York City. “We’re not so good at dealing with somebody who, for all intents and purposes, can appear healthy and non-disabled on one day and be completely debilitated the next day,” he says.
Putrino says more than half of his clinic’s long COVID patients told his team they had at least one of these persistent problems:
  • Fatigue (82%)
  • Brain fog (67%)
  • Headache (60%)
  • Sleep problems (59%)
  • Dizziness (54%)
And 86% said exercise worsened their symptoms.
The symptoms are similar to what doctors see with illnesses such as lupus, Lyme disease, and chronic fatigue syndrome – something many experts compare long COVID to. Researchers and medical professionals still don’t know exactly how COVID-19 causes those symptoms. But there are some theories.
Potential Causes Of Long COVID Symptoms
Putrino says it is possible the virus enters a patient’s cells and hijacks the mitochondria – a part of the cell that provides energy. It can linger there for weeks or months – something known as viral persistence. “All of a sudden, the body’s getting less energy for itself, even though it’s producing the same amount, or even a little more,” he says. And there is a consequence to this extra stress on the cells. “Creating energy isn’t free. You’re producing more waste products, which puts your body in a state of oxidative stress,” Putrino says. Oxidative stress damages cells as molecules interact with oxygen in harmful ways.
“The other big mechanism is autonomic dysfunction,” Putrino says. It’s marked by breathing problems, heart palpitations, and other glitches in areas most healthy people never have to think about. About 70% of long COVID patients at Mount Sinai’s clinic have some degree of autonomic dysfunction, he says.
For a person with autonomic dysfunction, something as basic as changing posture can trigger a storm of cytokines, a chemical messenger that tells the immune system where and how to respond to challenges like an injury or infection. “Suddenly, you have this on-off switch,” Putrino says. “You go straight to ‘fight or flight,’” with a surge of adrenaline and a spiking heart rate, “then plunge back to ‘rest or digest.’ You go from fired up to so sleepy, you can’t keep your eyes open.”
A patient with viral persistence and one with autonomic dysfunction may have the same negative reaction to exercise, even though the triggers are completely different."



Source:  https://www.webmd.com/covid/news/20220803/why-exercise-doesnt-help-people-with-long-covid ( probably not accessible to the public, I need to log in to have access)
What I also found interesting is their presentation of two different causes of long covid symptoms:  problems with energy production in mitochondria, or autonomic dysfunction causing cytokines imbalance. 

Just after that, it is said that both types have the same negative effects from exercise, but with totally different triggers.  This is much in line with my hypothesis of different types of POIS leading to the same symptoms.
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Quantum

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Re: Covid 19 Long Haulers
« Reply #23 on: February 17, 2023, 07:52:13 PM »
If you have spare time, it is definitively worth reading this article about the evolution of the research on long Covid:
https://www.scientificamerican.com/article/long-covid-now-looks-like-a-neurological-disease-helping-doctors-to-focus-treatments/
They discuss brain inflammation caused by cytokine release, the possibility that viral particles remain in the body and cause inflammation, POTS and other neurological problems, ME/CFS similarities with Long Covid, Long Covid as an umbrella term for different specific presentations, and so on...   As you can see, most of this could apply to POIS as well.


You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Unluckiest_Lady_Alive

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Re: Covid 19 Long Haulers
« Reply #24 on: June 04, 2023, 08:55:14 PM »
Was just Googling "Long COVID symptoms" last night and a lot of them overlap with POIS (per CDC website):


General symptoms (Not a Comprehensive List):

Tiredness or fatigue that interferes with daily life
Symptoms that get worse after physical or mental effort (also known as “post-exertional malaise”)
Fever

Respiratory and heart symptoms:

Difficulty breathing or shortness of breath
Cough
Chest pain
Fast-beating or pounding heart (also known as heart palpitations)

Neurological symptoms:

Difficulty thinking or concentrating (sometimes referred to as “brain fog”)
Headache
Sleep problems
Dizziness when you stand up (lightheadedness)
Pins-and-needles feelings
Change in smell or taste
Depression or anxiety

Digestive symptoms:

Diarrhea
Stomach pain

Other symptoms:

Joint or muscle pain
Rash
Changes in menstrual cycles

Notice it's 'not a comprehensive list' and they go on to say that "Some people with Long COVID have symptoms that are not explained by tests or easy to manage."  Clearly everyone with Long COVID won't have ALL these symptoms and some will have symptoms not listed here. 

ACE-2 receptors are located throughout the body, not just the heart & lungs, so for doctors to dismiss anything not lung/heart related is very shortsighted.  COVID is the new Great Imitator as far as I'm concerned.  It can reactivate 8 herpesviruses that reside in our bodies (chickenpox/shingles, Epstein-Barr, CMV, etc), cause serious neurological complications including triggering Parkinson's disease* in at least 6 people & create all kinds of autoimmune havoc in survivors.  Why symptoms would worsen after masturbation/sex is beyond me (post-exertional malaise maybe?), but I've often thought that's what's going on with me. 



* CDC Long COVID page: 
https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html

* PubMed COVID/Parkinson's study:   
https://pubmed.ncbi.nlm.nih.gov/36807419/
« Last Edit: June 04, 2023, 08:57:36 PM by Unluckiest_Lady_Alive »
Current Meds:  Prozac, Topamax, Adderall, Omeprazole, clobenzorex, OTC sleep aids (Benadryl, Unisom, Valerian, melatonin), codeine, griseofulvin, topical antifungals (azoles, allylamines, benzylamines, others).

certainlypois2

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Re: Covid 19 Long Haulers
« Reply #25 on: July 30, 2023, 01:42:27 AM »
https://time.com/6238147/microclots-long-covid/
https://www.npr.org/2023/05/10/1175217130/long-covid-scientists-try-to-unravel-blood-clot-mystery

Micro clots could be the cause long covid, including the cognitive symptoms. Inflammation damage blood vessels which attracts plaques that cause clots. When there are clots, the mitochondria do not get the nutrients they need to function properly which leads to other cells not function at 100%

Progecitor

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Re: Covid 19 Long Haulers
« Reply #26 on: July 31, 2023, 07:34:57 AM »
https://time.com/6238147/microclots-long-covid/
https://www.npr.org/2023/05/10/1175217130/long-covid-scientists-try-to-unravel-blood-clot-mystery

Micro clots could be the cause long covid, including the cognitive symptoms. Inflammation damage blood vessels which attracts plaques that cause clots. When there are clots, the mitochondria do not get the nutrients they need to function properly which leads to other cells not function at 100%

Phosphatidylserine probably has a key role in this process. There is also a post about it, if you are interested.
https://poiscenter.com/forums/index.php?topic=4321.msg46330#msg46330
The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.

certainlypois2

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« Last Edit: September 07, 2023, 06:51:45 PM by certainlypois2 »