Author Topic: POIS Paper Archive - a list of scientific articles about POIS  (Read 73928 times)

Muon

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #220 on: November 01, 2022, 06:11:21 PM »
This one slipped under the radar: https://apccm.in/wp-content/uploads/2022/05/Pulmon-2022-Jan-Apr-Final-Pdf.pdf#page=44

Histamine gives a larger flare than semen in the skin prick test. What does this mean?

demografx

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #221 on: November 01, 2022, 09:08:31 PM »
This one slipped under the radar: https://apccm.in/wp-content/uploads/2022/05/Pulmon-2022-Jan-Apr-Final-Pdf.pdf#page=44

Histamine gives a larger flare than semen in the skin prick test. What does this mean?

Thanks. Sent to POIS Research Team.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Marius

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #222 on: March 03, 2023, 02:40:53 PM »
Hey! I see that are some Atopic Dermatitis links, i read them but my english is not my first language, can somebody link a corellation from one or more of this studies with POIS?

Muon

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #223 on: March 06, 2023, 08:33:02 AM »
Hey! I see that are some Atopic Dermatitis links, i read them but my english is not my first language, can somebody link a corellation from one or more of this studies with POIS?

I have posted a few articles that may shed some light on potential mechanisms in atopic dermatitis. There is no correlation with any of these (yet) because there is a lack of POIS research data. Atopic dermatitis shows up in a couple of POIS papers.

demografx

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #224 on: March 06, 2023, 12:16:10 PM »
Hey! I see that are some Atopic Dermatitis links, i read them but my english is not my first language, can somebody link a corellation from one or more of this studies with POIS?

I have posted a few articles that may shed some light on potential mechanisms in atopic dermatitis. There is no correlation with any of these (yet) because there is a lack of POIS research data. Atopic dermatitis shows up in a couple of POIS papers.

Muon, could this possibly explain my bizarre dermatitis POIS reaction? All 10 fingertips go “nuts” on me. My dermatologist said there are hundreds of thousands of nerve endings there!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #225 on: March 06, 2023, 02:14:05 PM »
Muon, could this possibly explain my bizarre dermatitis POIS reaction? All 10 fingertips go “nuts” on me. My dermatologist said there are hundreds of thousands of nerve endings there!

It's possible that nerve endings communicate improperly with mast cells, the latter can be involved in dermatitis.

demografx

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #226 on: March 06, 2023, 04:36:25 PM »
Muon, could this possibly explain my bizarre dermatitis POIS reaction? All 10 fingertips go “nuts” on me. My dermatologist said there are hundreds of thousands of nerve endings there!


It's possible that nerve endings communicate improperly with mast cells, the latter can be involved in dermatitis.


Thank you.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Progecitor

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #227 on: March 07, 2023, 09:12:12 AM »
Muon, could this possibly explain my bizarre dermatitis POIS reaction? All 10 fingertips go “nuts” on me. My dermatologist said there are hundreds of thousands of nerve endings there!

It's possible that nerve endings communicate improperly with mast cells, the latter can be involved in dermatitis.

Some info that may be relevant in this interpretation.

As one of the principle mediators of innate immunity, mast cell (MC) functionality and population are affected by aging. The MC population was found to increase by 27% in mesenteric lymphatic vessels (MLVs) and with a 400% increase in activated MCs in the mesentery of the aged rats (24 months) compared to the younger control (9 months). It was concluded that this increase in MC population and activation in MLVs are essential for the degradation of the lymphatic vessels that occurs with age. Further, in healthy aged individuals (above 75 years), the MC population increased in the skin (papillary dermis) by 40% compared to the biopsies from younger individuals (less than 30 years), and dermal MCs associated more with macrophages and nerve fibers in aged skin compared to the younger samples. Interestingly, despite their increased presence in the papillary dermis, MC degranulation was significantly lower in aged skin, which might be explained by the reduced expression of the tachykinin precursor 1 (TAC1) gene encoding substance P, a neuropeptide that is also an MC activator in skin. Immunohistochemical staining of the eyelid and eyeball of the murine model of atopic dermatitis, Derm1NC/Nga mice, revealed that MCs increased significantly in the aged, diseased mice (10 and 16 weeks) compared to the younger (4 weeks) mice afflicted with atopic keratoconjunctivitis. Dexamethasone, an anti-inflammatory drug, reduced MC density in the eyeballs of these mice, demonstrating that manipulation of MCs may influence outcomes in age-related disease.
It was reported that although prostaglandin E2 (PGE2) is not a MC activator in younger mice, in older mice, PGE2 acts as a potent MC degranulation mediator for dermal MCs.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650013/
The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.

mike_sweden

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #228 on: March 08, 2023, 03:34:20 PM »
i had eczema as a child
having very dry and sensitive skin after orgasm

Hopeoneday

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #229 on: March 17, 2023, 04:50:54 PM »
https://www.tandfonline.com/doi/full/10.1080/13685538.2023.2174511
Complementary role of Benson’s relaxation technique in post orgasmic illness syndrome.
Dr-pois.

Muon

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Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #230 on: November 29, 2023, 07:35:53 AM »
Email from Dr. Waldinger to Muon April 9, 2018, 9:27 AM

Beste heer *****,

Ik heb de laatste tijd een pilot study gedaan met het middel Diclofenac 25 mg, in te nemen ca. 2 uur voor seksuele activiteit (masturbatie of geslachtsgemeenschap). Sommige mannen reageerden hier redelijk op met afname van de POIS klachten, anderen reageerden helemaal niet. Diclofenac kan maagklachten geven. Vanwege onvoldoende resultaat, zie ik echter af van een officiele studie die ik aanvankelijk hiermee wilde doen. Echter indien u hierin geinteresseerd bent, dan kan ik u een recept geven en dan kunt u dit proberen.

Laat maar weten wat u wilt doen,

Met vr groet,

Prof. dr. M.D. Waldinger

Translation:

Dear mr. *****,

I have recently done a pilot study with the drug Diclofenac 25 mg, to be taken approximately 2 hours before sexual activity (masturbation or sexual intercourse). Some men responded reasonably well to this with a decrease in POIS complaints, others did not respond at all. Diclofenac can cause stomach problems. However, due to insufficient results, I am abandoning an official study that I initially wanted to do with this. However, if you are interested, I can give you a recipe and you can try this.

Just let me know what you want to do,

Yours sincerely,

Prof. dr. M.D. Waldinger

Edit:
Commentary on the pilot study by Nanna1
« Last Edit: December 01, 2023, 03:13:31 PM by Muon »