Milnacipran - completely stopping my brain fog

[Laotzu1980]

This is great news Hurray. Thanks for sharing it, and for reappearing to answer questions. Very grateful.
I checked every hospital in Thailand, unfortunately they recently stopped importing Milnacipran into the country. Such a pity, because brain fog is a nightmare for me too. Complete inability to socialise. Has plagued me for years. Total state of confusion for several days after O. I was desperate to find it, and now with COVID countries are closed, nothing is easy.

I may fly to another country as soon as it opens just to try it.
If there is any hope at all, I have to go for it.

One question, have you ever tried it after orgasm? E.g. after a wet dream? And do you take it on an empty stomach or with food or it doesn't matter?

Thanks a lot,
Jeff

[hurray]

This is great news Hurray. Thanks for sharing it, and for reappearing to answer questions. Very grateful.
I checked every hospital in Thailand, unfortunately they recently stopped importing Milnacipran into the country. Such a pity, because brain fog is a nightmare for me too. Complete inability to socialise. Has plagued me for years. Total state of confusion for several days after O. I was desperate to find it, and now with COVID countries are closed, nothing is easy.

I may fly to another country as soon as it opens just to try it.
If there is any hope at all, I have to go for it.

One question, have you ever tried it after orgasm? E.g. after a wet dream? And do you take it on an empty stomach or with food or it doesn't matter?

Thanks a lot,
Jeff

Hi Laotzu, welcome to the forum 

Your brain fog sounds a lot like mine - even basic conversations are a challenge in POIS for me, and I just try to avoid all human contact.

All my orgasms have been POIS-free (I never thought I'd be able to say that!), so I haven't had the chance to test it after orgasm. I've tried it with and without food, it doesn't seem to make much difference.

I live in the UK, and it's not available here either. I purchased my supply from an online pharmacy - 25ml Milza capsules. Interesting that Thailand recently stopped importing milnacipran, I hope it doesn't become more difficult to buy in other countries too.

Let me know if you have any more questions 

[Mushnikk]

This is great news Hurray. Thanks for sharing it, and for reappearing to answer questions. Very grateful.
I checked every hospital in Thailand, unfortunately they recently stopped importing Milnacipran into the country. Such a pity, because brain fog is a nightmare for me too. Complete inability to socialise. Has plagued me for years. Total state of confusion for several days after O. I was desperate to find it, and now with COVID countries are closed, nothing is easy.

I may fly to another country as soon as it opens just to try it.
If there is any hope at all, I have to go for it.

One question, have you ever tried it after orgasm? E.g. after a wet dream? And do you take it on an empty stomach or with food or it doesn't matter?

Thanks a lot,
Jeff

Hi Laotzu, welcome to the forum 

Your brain fog sounds a lot like mine - even basic conversations are a challenge in POIS for me, and I just try to avoid all human contact.

All my orgasms have been POIS-free (I never thought I'd be able to say that!), so I haven't had the chance to test it after orgasm. I've tried it with and without food, it doesn't seem to make much difference.

I live in the UK, and it's not available here either. I purchased my supply from an online pharmacy - 25ml Milza capsules. Interesting that Thailand recently stopped importing milnacipran, I hope it doesn't become more difficult to buy in other countries too.

Let me know if you have any more questions 

Where did you order it if I may ask? Send me a pm with the info, thanks!

[Laotzu1980]

Hi Hurray. If you can, it would also be great to know where I can get this online. If not, I'll be forced to fly overseas to get it which I really cannot afford to do, but I cannot continue to live like this.

Did you need a prescription to buy it online? I can get one here, but have no idea how that works when buying overseas.

Appreciate the information you provided regarding taking the pills and food. Glad you've had success with it for 3+ months too, amazing news. You must be living a whole new life. I can't even imagine it.

[hurray]

PMs sent. Prescriptions are usually only involved when buying from a pharmacy in your own country - processing prescriptions from overseas would be a nightmare.

[Laotzu1980]

Thank you Hurray. Much appreciated... 🙏
I am very cautious - if you take a moment to research these online pharmacies they all look like complete scams. I have checked the reviews for the place you ordered from and the reviews are very fishy. Many people say fraud happened on their credit card shortly after ordering. Their Facebook page has a few comments saying they paid but didn't receive their order, and the company never replies. That was 3 years ago... Very fishy to me.
I also read about the legitimacy of online pharmacies and they say that you know it's fraudulent if they don't request a prescription for a drug that normally requires one from a doctor. To me this also seems very strange and illegal. Drug addicts could exploit them if this was the case. The worry is that the medication you will receive is not genuine. May even be harmful.
I am encouraged by your post still, and am amazed by your results. It is possible you got lucky with your prescription. But you'll notice if you call the place you bought it from, they will not answer the phone. And when you try to pay by credit card it says 'technical error' and then asks you to pay by wireless transfer. Very, very fishy to me. Who knows. Sometimes the competitors write these negative reviews, but they never seem to try and reply to the complaints or answer calls, so I am highly sceptical.
Still, I am willing to give it a try from a legitimate pharmacy - the worst that can happen is it doesn't work. It seems it worked on your first use of it, so there is no big risk relative to the benefit.

Thanks again for your info... Really appreciate it.

[hurray]

Hi Laotzu,

I would like to emphasise that I do NOT recommend people purchase prescription drugs via unofficial channels. If, following a consultation with a doctor, they decide to prescribe you some medicine, you should then get that prescription filled at a local pharmacy that you trust.

I am not here to promote or defend online pharmacies, so I can't really address the points that you make here. I have made multiple milnacipran purchases from the pharmacy you refer to, and each of them were successfully delivered without any issues, but I am NOT recommending that anybody else does the same.

Thailand is a beautiful country, would love to visit again one day

[cn7]

Weird. Wonder why it cures your dry hair too. Its just an antidepressant

[hurray]

Weird. Wonder why it cures your dry hair too. Its just an antidepressant

Milnacipran was developed as a cure for fibromyalgia, but it has a secondary use as an antidepressant. Most common antidepressants are SSRIs that increase levels of serotonin, milnacipran is an SNRI that increases both serotonin and norepinephrine.

Apparently, norepinephrine regulates keratinocyte proliferation to promote the growth of hair follicles:

https://www.karger.com/Article/FullText/446020

It's possible that without milnacipran, my norepinephrine levels drop much lower than normal after O, which might interfere with the process described above, causing my hair to feel very dry.

[Journey]

Weird. Wonder why it cures your dry hair too. Its just an antidepressant

Milnacipran was developed as a cure for fibromyalgia, but it has a secondary use as an antidepressant. Most common antidepressants are SSRIs that increase levels of serotonin, milnacipran is an SNRI that increases both serotonin and norepinephrine.

Apparently, norepinephrine regulates keratinocyte proliferation to promote the growth of hair follicles:

https://www.karger.com/Article/FullText/446020

It's possible that without milnacipran, my norepinephrine levels drop much lower than normal after O, which might interfere with the process described above, causing my hair to feel very dry.

U feel same u did before getting POIS? Mind works same as b4 getting it?

[hurray]

Weird. Wonder why it cures your dry hair too. Its just an antidepressant

Milnacipran was developed as a cure for fibromyalgia, but it has a secondary use as an antidepressant. Most common antidepressants are SSRIs that increase levels of serotonin, milnacipran is an SNRI that increases both serotonin and norepinephrine.

Apparently, norepinephrine regulates keratinocyte proliferation to promote the growth of hair follicles:

https://www.karger.com/Article/FullText/446020

It's possible that without milnacipran, my norepinephrine levels drop much lower than normal after O, which might interfere with the process described above, causing my hair to feel very dry.

U feel same u did before getting POIS? Mind works same as b4 getting it?

That's a good question, Journey. I've had POIS for over 20 years, so it's not easy to be sure exactly how my mind worked back then compared with now.

In terms of being able to be sociable straight after O, yes my mind is working in the same way.

[Journey]

Weird. Wonder why it cures your dry hair too. Its just an antidepressant

Milnacipran was developed as a cure for fibromyalgia, but it has a secondary use as an antidepressant. Most common antidepressants are SSRIs that increase levels of serotonin, milnacipran is an SNRI that increases both serotonin and norepinephrine.

Apparently, norepinephrine regulates keratinocyte proliferation to promote the growth of hair follicles:

https://www.karger.com/Article/FullText/446020

It's possible that without milnacipran, my norepinephrine levels drop much lower than normal after O, which might interfere with the process described above, causing my hair to feel very dry.

U feel same u did before getting POIS? Mind works same as b4 getting it?

That's a good question, Journey. I've had POIS for over 20 years, so it's not easy to be sure exactly how my mind worked back then compared with now.

In terms of being able to be sociable straight after O, yes my mind is working in the same way.

Do you recall more stuff now? Has time perception speed changed?

[hurray]

Yes, my time perception speed has increased as I've aged, maybe 20%-30%. Although if I am doing something particularly interesting or challenging, it slows right down. Not sure of any link to POIS, but interesting to think about 

[demografx]

hurray, do you (or any other forum member) know anything about dietary supplement Prevagen?

My pharmacist recommended it to counter aging-related memory loss.

[berlin1984]

I'd be worried about the "false advertising" claims https://www.webmd.com/vitamins/ai/ingredientmono-1486/apoaequorin

Since you're anyway on TRT, I'd try Bacopa Monnierei (which causes temporary male infertility). It's "time proven" by the Indians :-)
https://www.google.com/search?client=firefox-b-d&q=bacopa+monnieri+memory+loss

I have a bunch at home, but stopped taking it because I'm still interested in having a second child.

(That said.. given the side effects... maybe this herb is an interesting approach to try to treat POIS!??)

EDIT: let's discuss Bacopa on https://poiscenter.com/forums/index.php?topic=2403.msg35698

[Quantum]

hurray, do you (or any other forum member) know anything about dietary supplement Prevagen?

My pharmacist recommended it to counter aging-related memory loss.

Not available here in Canada, but it does look like the company had exaggerated its supposed benefits:  https://en.wikipedia.org/wiki/Aequorin#Marketing

[demografx]

hurray, do you (or any other forum member) know anything about dietary supplement Prevagen? My pharmacist recommended it to counter aging-related memory loss.

Not available here in Canada, but it does look like the company had exaggerated its supposed benefits:  https://en.wikipedia.org/wiki/Aequorin#Marketing

Thanks, Quantum!!

[Muon]

Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia

"The monoamine norepinephrine reduces the production of cytokines by activated microglia in vitro."

[hurray]

Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia

"The monoamine norepinephrine reduces the production of cytokines by activated microglia in vitro."

Thanks Muon, good find. Perhaps having an O without milnacipran lowers my norepinephrine levels to the extent that the production of cytokines is greatly increased, triggering POIS. It certainly fits the MCAS theory of POIS.

With milnacipran, maybe cytokine production remains low, and POIS is averted.

[Muon]

Have you tried NSAIDs hurray?