Author Topic: Milnacipran - completely stopping my brain fog  (Read 98373 times)

Prospero

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Re: Milnacipran - completely stopping my brain fog
« Reply #280 on: December 23, 2021, 02:00:39 PM »
My understanding is that SNRIs increase *extracellular* norepinephrine and decrease *intracellular* NOR. If your adrenergic receptors are upregulated as in nanna's original hypothesis, you have too much *intracellular* NOR in POIS. So Milnacipran may work by decreasing this.
« Last Edit: December 23, 2021, 02:04:03 PM by Prospero »

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #281 on: December 24, 2021, 04:56:09 PM »
My understanding is that SNRIs increase *extracellular* norepinephrine and decrease *intracellular* NOR. If your adrenergic receptors are upregulated as in nanna's original hypothesis, you have too much *intracellular* NOR in POIS. So Milnacipran may work by decreasing this.

That's an interesting hypothesis, Prospero. I am well aware of the respect that poiscenter.com members extend to nanna's theories.


« Last Edit: December 28, 2021, 09:53:20 AM by hurray »

Jan

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Milnacipran
« Reply #282 on: December 27, 2021, 01:19:11 PM »
Did anyone in the Netherlands bought "Milnacipran"? If so, did it work and how did you buy it?
Pois accepted, but wants to learn to live with pois and look for ways to reduce complaints.

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #283 on: December 28, 2021, 09:58:31 AM »
(edited previous post as the second part of what I said wasn't really related to Prospero's post)



hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #284 on: December 28, 2021, 10:00:09 AM »
I sometimes see people commenting that people who have found a "cure" for POIS often stop posting on the forum.

Well, I still have nothing but good news regarding my taking milnacipran to avoid POIS episodes. The last time I had POIS was about 3 months ago. I got drunk and forgot to take my usual precautions, resulting in 2-3 days of nasty brain fog. I'd forgotten how debilitating it was - I had to call in sick to work to avoid any social encounters. Driving my car would have been very challenging.

Fpr the 3 months before that and since then, I have been POIS-free  :)  I never thought I would be rid of this curse. Milnacipran has genuinely never stopped working for me.

So don't give up hope! It took me almost 20 years to find something that stopped my POIS symptoms. Hopefully you can find your own cure for POIS more quickly than I did :)

hurray,


Thank you Demo! We've both been fighting POIS for a long time  :)

demografx

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Re: Milnacipran - completely stopping my brain fog
« Reply #285 on: December 28, 2021, 09:51:02 PM »

hurray,




Thank you Demo! We've both been fighting POIS for a long time  :)


Feels like 5,000 years!

Yes, you and I have been with the POIS forums since 2007!!

It’ll be 15 years this coming February!!
« Last Edit: December 28, 2021, 09:55:51 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Jan

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Re: Milnacipran - completely stopping my brain fog
« Reply #286 on: January 31, 2022, 04:18:15 AM »
I ordered milnacipran in the Netherlands via the site arzneiprivat.de/
with a doctor's prescription. I have used it 2x for an o, and 0% brain fog, fatigue has remained. For me, brain fog is the worst. I am very happy with this. Milnacipran initially caused mood swings for me. I now only use it for o.

Thank you all!
Pois accepted, but wants to learn to live with pois and look for ways to reduce complaints.

Muon

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Re: Milnacipran - completely stopping my brain fog
« Reply #287 on: January 31, 2022, 10:53:29 AM »
I ordered milnacipran in the Netherlands via the site arzneiprivat.de/
with a doctor's prescription. I have used it 2x for an o, and 0% brain fog, fatigue has remained. For me, brain fog is the worst. I am very happy with this. Milnacipran initially caused mood swings for me. I now only use it for o.

Thank you all!

1 tablet prior to an O, what's the dose?

BoneBroth

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Re: Milnacipran - completely stopping my brain fog
« Reply #288 on: January 31, 2022, 11:08:41 AM »
Milnacipran "works by increasing the amount of serotonin and norepinephrine, natural substances that help stop the movement of pain signals in the brain." Just masking the pain? Well considering the long list of potential side effects of this prescription drug, I would, at best, take it only when its absolutely nessecary and not as a permanent POIS-sollution.

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #289 on: February 09, 2022, 05:35:20 AM »
Milnacipran "works by increasing the amount of serotonin and norepinephrine, natural substances that help stop the movement of pain signals in the brain." Just masking the pain? Well considering the long list of potential side effects of this prescription drug, I would, at best, take it only when its absolutely nessecary and not as a permanent POIS-sollution.

I see that you've been a poster on this forum for just over 2 years, and you've already managed to make more posts than me. Well done  :)

But some people would argue that quality is more important than quantity. In your case, you've come on to the thread that I started and made some unsourced quote about "pain signals", which you've then tried to use to discredit the success that I've had taking milnacipran to stop my POIS.

I don't understand your motivations here. My experiences with milnacipran as I have related on this thread are completely genuine. Milnacipran doesn't "mask any pain" for me, it stops my brain fog, allowing me to live my life normally. Do you have a problem with that?

Jan

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Re: Milnacipran - completely stopping my brain fog
« Reply #290 on: February 09, 2022, 07:13:28 AM »
I got Milnacipran on a doctor's prescription. The doctor indicated he knew someone with Pois who also benefited from this. I don't think the doctor would have prescribed it if it was terrible for me. I only use one pill of 50 mg 1.5 hours before "the event." Not daily. It works well, no brain fog at all. Every time again! I've been using it for several weeks now. I suspect some mood swings, but brain fog is gone. I am very grateful to hurray.
Pois accepted, but wants to learn to live with pois and look for ways to reduce complaints.

demografx

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Re: Milnacipran - completely stopping my brain fog
« Reply #291 on: February 09, 2022, 08:36:19 AM »

…I am very grateful to hurray.


Ditto!
« Last Edit: February 10, 2022, 01:47:15 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business


Quantum

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Re: Milnacipran - completely stopping my brain fog
« Reply #293 on: February 09, 2022, 06:14:10 PM »
I got Milnacipran on a doctor's prescription. The doctor indicated he knew someone with Pois who also benefited from this. I don't think the doctor would have prescribed it if it was terrible for me. I only use one pill of 50 mg 1.5 hours before "the event." Not daily. It works well, no brain fog at all. Every time again! I've been using it for several weeks now. I suspect some mood swings, but brain fog is gone. I am very grateful to hurray.

Hi Jan,

I am glad that milnacipran works for you!  Keep me updated, so, after 2 to 3 months of use, I can add you as a reference member in the Milnacipran section of the POIS Types Chart along with Hurray, if it is still working for you.

Is this doctor from Waldinger's team ?   If he sees POIS patients, we could put his name on our POIS doctors list.  Coud you send me his name in a private message, so I can contact him?

I think Hurray takes 25mg in prevention.   Did you tried 25mg before going to 50mg ?
« Last Edit: February 09, 2022, 06:28:57 PM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #294 on: February 10, 2022, 04:36:27 AM »
I got Milnacipran on a doctor's prescription. The doctor indicated he knew someone with Pois who also benefited from this. I don't think the doctor would have prescribed it if it was terrible for me. I only use one pill of 50 mg 1.5 hours before "the event." Not daily. It works well, no brain fog at all. Every time again! I've been using it for several weeks now. I suspect some mood swings, but brain fog is gone. I am very grateful to hurray.

That's great news Jan :) It sounds like it works for you in the same way as it works for me, with the brain fog disappearing.

It's very interesting that your doctor had heard of milnacipran helping someone else with POIS, maybe awareness of POIS is increasing in the medical community. Congratulations  :)

hurray

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Re: Milnacipran - completely stopping my brain fog
« Reply #295 on: February 10, 2022, 04:56:38 AM »
I got Milnacipran on a doctor's prescription. The doctor indicated he knew someone with Pois who also benefited from this. I don't think the doctor would have prescribed it if it was terrible for me. I only use one pill of 50 mg 1.5 hours before "the event." Not daily. It works well, no brain fog at all. Every time again! I've been using it for several weeks now. I suspect some mood swings, but brain fog is gone. I am very grateful to hurray.

Hi Jan,

I am glad that milnacipran works for you!  Keep me updated, so, after 2 to 3 months of use, I can add you as a reference member in the Milnacipran section of the POIS Types Chart along with Hurray, if it is still working for you.

Is this doctor from Waldinger's team ?   If he sees POIS patients, we could put his name on our POIS doctors list.  Coud you send me his name in a private message, so I can contact him?

I think Hurray takes 25mg in prevention.   Did you tried 25mg before going to 50mg ?

I took 25mg for a long time, for 2 reasons:

1) I experienced nausea if I took more than 25mg for the first 1-2 months of use
2) I have high blood pressure, and one of the specified side-effects of milnacipran is that it can raise your blood pressure

The nausea stopped happening after a while, and I've been monitoring my blood pressure closely and milnacipran doesn't seem to have a significant effect on my blood pressure, thankfully, although I would urge anyone else taking milnacipran to be aware of this potential issue.

I've gone up to 50mg now - it seems to increase the duration of milnacipran's protection - but I'd agree that 25mg is a good place to start to minimize any potential side-effects.

IronFeather

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Re: Milnacipran - completely stopping my brain fog
« Reply #296 on: February 10, 2022, 11:08:39 AM »
But some people would argue that quality is more important than quantity. In your case, you've come on to the thread that I started and made some unsourced quote about "pain signals", which you've then tried to use to discredit the success that I've had taking milnacipran to stop my POIS.

I don't understand your motivations here. My experiences with milnacipran as I have related on this thread are completely genuine. Milnacipran doesn't "mask any pain" for me, it stops my brain fog, allowing me to live my life normally. Do you have a problem with that?

Well, I'm not the person you were replying to, I was just browsing the forum and came across this, but I just wanted to say that I also think you should be very cautious when taking a psychiatric medication like Milnacipran. It's great that it helps you, but many things have helped people with POIS, which means they are probably just masking different symptoms and not attacking the cause, since said cause is still unknown. I suppose many medications that affect brain function and mood could make people with POIS feel better, that's what they're supposed to do in general, but they could have serious effects in the long run. Just saying you should maybe be cautious. I hope you won't be offended by this, it's your choice after all, but I personally think sex isn't that important as to take random psychiatric medications so we can have it, no matter what doctors think or say (we all know how effortlessly some of them prescribe meds, and none of them knows the slightest thing for sure about POIS yet). Best of luck to you, take care!
26-year-old Spanish woman with POIS symptoms for the last 13 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

Quantum

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Re: Milnacipran - completely stopping my brain fog
« Reply #297 on: February 10, 2022, 12:04:42 PM »
But some people would argue that quality is more important than quantity. In your case, you've come on to the thread that I started and made some unsourced quote about "pain signals", which you've then tried to use to discredit the success that I've had taking milnacipran to stop my POIS.

I don't understand your motivations here. My experiences with milnacipran as I have related on this thread are completely genuine. Milnacipran doesn't "mask any pain" for me, it stops my brain fog, allowing me to live my life normally. Do you have a problem with that?

Well, I'm not the person you were replying to, I was just browsing the forum and came across this, but I just wanted to say that I also think you should be very cautious when taking a psychiatric medication like Milnacipran. It's great that it helps you, but many things have helped people with POIS, which means they are probably just masking different symptoms and not attacking the cause, since said cause is still unknown. I suppose many medications that affect brain function and mood could make people with POIS feel better, that's what they're supposed to do in general, but they could have serious effects in the long run. Just saying you should maybe be cautious. I hope you won't be offended by this, it's your choice after all, but I personally think sex isn't that important as to take random psychiatric medications so we can have it, no matter what doctors think or say (we all know how effortlessly some of them prescribe meds, and none of them knows the slightest thing for sure about POIS yet). Best of luck to you, take care!

I would like to reflect on some points related to this discussion. 

Hurray, and Jan use milnacipran not on a daily basis, but only as pre-medication before O.  This has to be considered because this has less potential for long-term effects on the brain's neurotransmitters en receptors architecture.   Taking an antidepressant daily for years will create a downregulation of receptors and alteration of neurotransmitters equilibrium that occasional use will not ( this will cause withdrawal if abruptly stopped).  with occasional use, you can still have side effects, but between doses, your brain has time to, completely or in part, to go back to its natural physiology. From there, it is up to the patient and the doctor to evaluate the risks and side effects vs the benefits.  That is why each member is responsible for what decisions he or she makes for managing his/her POIS symptoms.  It is ok for BoneBroth and you to not be interested in this treatment for yourselves, and it is ok to express your concerns about this treatment. And, it is also ok if Hurray and Jan choose to go on with this method of relief because they consider that, for themselves, the benefits outweigh the risks and drawbacks.  Their doctors are also there for supervision, so this can add a level of safety, even if not total protection, of course.

It is clear that this use is an off-label use ( any use of any medication for POIS is off-label - POIS does not exist in pharmacological treatments yet), but considering the current state of medical knowledge about POIS, this method is one among others, just like using niacin, propranolol, Mytelase, or other drugs or supplements.  You mention avoiding sex totally, but in the case of men, total abstinence may be just partly possible, because of nocturnal emissions occurring after some time, depending on your age and your usual time interval. Do women with POIS have POIS symptoms from erotic dreams?  I have no idea.  But it is easier for men to have a planned, voluntary ejaculation at a known time after a known interval of time, with a preventive relief method to control symptoms, than ending up with a NE at a totally inappropriate time. What a nightmare to have a NE the night before a busy day or an important meeting or else !
« Last Edit: February 10, 2022, 12:11:40 PM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Quantum

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Re: Milnacipran - completely stopping my brain fog
« Reply #298 on: February 10, 2022, 12:14:02 PM »
I got Milnacipran on a doctor's prescription. The doctor indicated he knew someone with Pois who also benefited from this. I don't think the doctor would have prescribed it if it was terrible for me. I only use one pill of 50 mg 1.5 hours before "the event." Not daily. It works well, no brain fog at all. Every time again! I've been using it for several weeks now. I suspect some mood swings, but brain fog is gone. I am very grateful to hurray.

Hi Jan,

I am glad that milnacipran works for you!  Keep me updated, so, after 2 to 3 months of use, I can add you as a reference member in the Milnacipran section of the POIS Types Chart along with Hurray, if it is still working for you.

Is this doctor from Waldinger's team ?   If he sees POIS patients, we could put his name on our POIS doctors list.  Coud you send me his name in a private message, so I can contact him?

I think Hurray takes 25mg in prevention.   Did you tried 25mg before going to 50mg ?

I took 25mg for a long time, for 2 reasons:

1) I experienced nausea if I took more than 25mg for the first 1-2 months of use
2) I have high blood pressure, and one of the specified side-effects of milnacipran is that it can raise your blood pressure

The nausea stopped happening after a while, and I've been monitoring my blood pressure closely and milnacipran doesn't seem to have a significant effect on my blood pressure, thankfully, although I would urge anyone else taking milnacipran to be aware of this potential issue.

I've gone up to 50mg now - it seems to increase the duration of milnacipran's protection - but I'd agree that 25mg is a good place to start to minimize any potential side-effects.
Thanks for these precisions, I will link to them in the Milanacipran section of the POIS types Chart, for the benefit of other members and their health professionals.
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Progecitor

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Re: Milnacipran - completely stopping my brain fog
« Reply #299 on: February 11, 2022, 12:04:20 PM »

Milnacipran (MIL) is a representative of a new class of antidepressants (SNRIs) which inhibit selectively the reuptake of serotonin and noradrenaline but, in contrast to tricyclics, show no affinity for neurotransmitter receptors. MIL was administered at a dose of 10 or 30 mg/kg p.o. once or repeatedly (twice daily for 14 days). MIL did not change the number or affinity (Bmax and KD) of a1-adrenergic receptors in the cerebral cortex for [3H]prazonsin, however, the ability of the a1-adrenoceptor agonist phenylephrine to compete for these sites was significantly enhanced. MIL given repeatedly (but not acutely) inhibited both the head twitch reaction induced by L-5-HTP or (+-)DOI, the effects mediated by serotonergic 5-HT2A receptors. The above results indicate that repeated MIL administration increases the responsiveness of a1-adrenergic system (behavioural and biochemical changes) and decreases the responsiveness of the serotonergic 5-HT2A receptors (especially behavioural changes) as tricyclics do. It may be concluded that the lack of MIL affinity for neurotransmitter receptors is of no importance to the development of adaptive changes in the studied systems, observed after repeated treatment with antidepressants.
https://link.springer.com/article/10.1007/s007020070022

The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.