not really sure if niacin works ?

[Bulls eye]

Hey and welcome to the group , great things are happening right now in pois treatments

what kind of pois symptoms do you suffer from ?

no there is no need to take it daily ,

for niacin to work do as follows

1) it works better on an  a somehow empty stomach so when you take niacin , for best results its better to be fasting for about 3-4 hours
2) you take 100mg for rapid acting niacin and make sure its nicotinic acid and not that flush free crap
3) wait for the flush it should kick in about 5-15 minutes , you'll feel warmth in your face like a mild sunburn
4) if no flush have another half a tablet
5) wait about 20 minutes after incidence of flush before having an orgasm


  

[Bulls eye]

Day 1 after O , no POIS symptoms , usually on the 2nd day my joints tend to become more sore and cognitive symptoms hits hard, i tend to find difficulty recalling and usually i fail , but i'm actually doing very good now and today i'm studying for my board exam.

[Observer]

Oh boy that's  very exciting indeed , going through life with out the usual  set back of pois , i've tried several methods over the years none of them worked , i cant believe that i had an O 8 hours ago without the usual symptoms kicking in and i still have energy to do several things

Congratulations Bulls eye!

I know how do you feel.  I could not believe that i was not feeling miserable after the O. This is a life changing event and you will realize the difference in an amazing way. Keep us informed.

[b_jim]

Congratulations Bulls eye

I like to hear good news like this and especially an improvement with flu-like symptoms (like joint sore) with B3. Hard to explain but that's very nice.

[b_jim]

First test with 300mg od B3 (inotisol hexanicotinate).
It didn't improve my chillness symptoms just after ejaculation.
But I didn't have flu-like symptoms and my concentration is good.

[Daveman]

First test with 300mg od B3 (inotisol hexanicotinate).
It didn't improve my chillness symptoms just after ejaculation.
But I didn't have flu-like symptoms and my concentration is good.

B_Jim,

Inotisol hexanicotinate is the least effective type of niacin for POIS that there is. That is the no flush type. So if you are getting at least a little help with it, then you should get much better results with the pure niacin. Nicotinic acid.

Please find the right kind and follow the instructions in the posts above to the letter. I'm sure you will find that this will help you  immensely.

I hate to see someone suffering when the solution is at their fingertips.

[b_jim]

Ok, I keep in mind this. If it's really the case it means the efficiency is not really the vitamin B3 itself but the flush caused. It's even more difficult for me to understand.

Starsky said :

POIS is some kind of enviromental sensitivity. Niacin is causing histamine to fill the mast cells, not a release. When they are full then you flush.

[Daveman]

Ok, I keep in mind this. If it's really the case it means the efficiency is not really the vitamin B3 itself but the flush caused. It's even more difficult for me to understand.

Starsky said :

POIS is some kind of enviromental sensitivity. Niacin is causing histamine to fill the mast cells, not a release. When they are full then you flush.

No, it's the reverse. It's ALL about the niacin. The Inotisol hexanicotinate that you take is a chemically modified version of niacin. I guess it was an attempt at reducing the flushing aspect while maintaining the niacin effect, but most doctors agree that the attempt failed. One of the most widely sought benefits of niacin is to reduce harmful colesterol, but this modified version of niacin doesn't even work well for that.

The flush is generally considered a side-effect of niacin. In the common usage, to reduce cholesterol, the flush is not required, in fact is is avoided, although not at all dangerous. Some say unpleasant, but many of us actually like it. It does come with a "mild sunburn" feeling, but also comes with other pleasant feelings, a sort of healthy invigorating feeling. Besides, once you have experienced the niacin relief of POIS, the flush is a VERY anticipated feeling, one that tells you you are protected again!

As Starsky indicates in his quote, the flush indicates "when you have reached the saturation point", when you have taken just the right amount. With the slow release or niacinimide, you don't get that indication. But it's only an indication. It is NOT the flush that gives you the POIS relief, it is the niacin, but the flush tells you that you have taken enough!

But don't try to understand it. It makes it all too complicated. You are losing precious time, suffering POIS when you don't have to, just because you want to understand.

But if the no flush kind is giving you even just a little relief, even just a very little, then I'm sure that if you follow the strict rules as noted above in this thread with REAL niacin, that you will find great relief. (And it's not necessary to understand why). Try it, find your relief, and THEN, with a clear and very relieved mind you can get to understand why.

1) 3 hrs. min fasting (food AND alcohol)
2) 100mg regular niacin
3) Wait about 15 minutes for flush
4) Wait another 15 or so to let the flush pass its peak
5) HAVE SEX
6) BE HAPPY

(if the flush doesn't come take another 75mg and wait 10 minutes more.)

[b_jim]

I'll try to make a good post and i will edit it several time.
It's difficult for me to understand all what you said and the point of view of Starsky.

No, it's the reverse. It's ALL about the niacin.

Ok, so the flush don't help with Pois. It's only the "sign" that mast cells are RELOADED as Starsky said. So vitamin B3 is the possible helper for Pois improvement. Why ? Nobody knows but B3 can be linked to :
- teststosterone and other sexual hormones synthesis
- histamines synthesis
- other neurotransmitters (Dopamine and serotonin with tryptophan pathway)
- insulin (important for me)

But first point, I don't know if the fact that mast cells are full of histamines is the improvement itself.
I forget the auto-immune or auto-allergy for the moment because I think it's not the good explanantion for my Pois.

Starsky said Niacin may help to reload mass cells. But maybe the important histamine for Pois symptoms is not histamine in mast cells but maybe the circulating histamine ( espcecially the histamine role in nervous system. ) About this, there is a disease called narcolepsy and the role of histamine in this disease is supposed. (french study : narcolepsy might be linked to a histamine deficiency).

On the Naked Scientist Forum GoingCrazy wrote me this :

How can you say that without ever taken any antihistamines?
It's very surprising how I have felt while taking claritin.  I don't know if it's the anti-histamine/vitamin C combination, but it seems to be working and I am still POIS free.

I didn't answer him because I didn't know what I can add. My mood was bad last week and sometimes I prefer to shut up. But I have thought it all these days.
So What I imagine about his :
Orgasm => Allergy to semen => Histamine release=> deficiency*
Orgasm===============> Histamine release=>deficiency*

*deficiency of what ? Niacine, histamines... ?

Allergy to semen is no needed to involve histamine release or what Starsky called "kind of enviromental sensitivity". Orgasm ITSELF may cause the release.

Look this page :
http://www.straightdope.com/columns/read/460/why-do-i-sneeze-after-every-orgasm
This woman is not necesserly allergic to semen. But orgasm disrupt something.
In these conditions, maybe GoingCrazy is right and it will be nice to test Claritin even if its improvement is not clear and dispite I don't believe allergy to sperm is the cause for me.

but most doctors agree that the attempt failed. One of the most widely sought benefits of niacin is to reduce harmful colesterol, but this modified version of niacin doesn't even work well for that.

Ok, I have understood you reasoning. If Inotisol hexanicotinate can't improve cholesterol like other forms, it proves this form is not well assimalated.  Have we found some studies about this ? (I didn't search on the forum, maybe I missed something).

I will read again the topcis about niacin.
Anyway before Inotisol hexanicotinate, the form I took was NICOTINAMIDE. I took 100-150 mg without flush and without real success, maybe cognitive improvement.





 

[Daveman]

Perhaps the most relevant in what you say in your post is the following:

[B_Jim]
Ok, so the flush don't help with Pois. It's only the "sign" that mast cells are RELOADED as Starsky said. So vitamin B3 is the possible helper for Pois improvement. Why ? Nobody knows but B3 can be linked to :
- teststosterone and other sexual hormones synthesis
- histamines synthesis
- other neurotransmitters (Dopamine and serotonin with tryptophan pathway)
- insulin (important for me)


It seems like there's a limited supply of base materials to produce the histamines and neurotransmitters. If heavier histamine production is required, like after ejaculation, these base materials are used up and there's not enough left over to produce the other neurotransmitters or even testosterone, and so we feel like "crap" for a week until we can make up the shortfall. B3 bolsters the shortfall, and therefore allows our system to work like it's supposed to.

Niacinimide has shown to be effective as well, but doses of 500mg to 1000 mg are required. The problem with niacinimide, is that there is no "indicator" like the flush to say, "OK, you've taken the right amount". But, so far I haven't heard of anyone hear complain of "overdose". I don't know how much you would have to take to overdose.

If it's the flush that you are afraid of, don't worry about it, it really isn't all that bad. As I said, some of us have even gotten to like it. With 100mg of niacin, you can't really have a BAD flush. I've had one or two a little stronger, depending on conditions, but nothing to make you feel excessively uncomfortable.

The flush starts (after about 15 minutes) with a light prickly feeling then rapidly increases (within another 5 minutes) to this light sunburn feeling, and just when it is at it's peak, it starts dropping off and the more pleasant feelings start to enter. In about 10 more minutes, the most of it have passed.

AND IT'S TIME TO GO PLAY!!

If all goes well, it should be one of the most memorable moments you've had in a long time. THE FIRST TIME  YOU'VE HAD SEX WITHOUT MAJOR POIS IN A LONG TIME.

The good thing is that it is repeatable. Your POIS should be greatly reduced and very much shorter.

On day 1 I have parts of the day (usually later in the day) that are sort of POISy. On day 2 I might feel just a bit of POIS (very light) and that's it!

I am finding myself realizing, even on day 1 that I forgot that I had sex the day before. I forget that I should be having POIS.

Don't lose precious time. Be POIS free NOW.

[tirasoft]

Hello all users.
I have POIS for a long time.
I followed ocasionally the POIS info on internet.

Today I finnaly order some Niacimide 500 mg tablets because I am want to do something on it.

I am very ancious about using this drug, I will report online the effects.

I am from Romania, here nobody heard about POIS.
 I found the site after long searches on the net without knowing the term "POIS" . I was very happy to find that these strange feelings I am living with have a name and I am not alone , and also it have a (unknown yet) medical explanation. I couldnt find yet Relora to try it just someting named "Super Cortisol Support" wich contain 200mg of Relora. But it think Niacin (Niacimide) helps more (after I red some of topics)

See you.

[Daveman]

I'm glad that you found us, and am sure we should be able to help in some way, if not only as company among others who know how you feel!

[Daveman]

I would like to reiterate how important it is to take niacin "in just the right way".

Yesterday I took niacin in the morning (as a prelude to orgasm of course) which I don't normally do because I prefer my orgasms at night to sleep off any undesirable effects in the first hours.

Normally as well I have noticed that niacin is "stronger" in the morning, most likely because one has not eaten for 8 hours at least before. So I took 100mg to start off. In the morning, or after a long fast, this is usually enough. But nothing. This may have been because I took 200 mg the night before and aborted "activity" because I didn't get a flush.

So I took another 100. Waited about 20 minutes, and still not much, maybe a light sense that niacin was in my system, but no flush. So another 75mg. Usually that's a lot for the morning after fasting, but I figured it was because of the 200 I had taken the night before.

So given I had a "slight tingle", and figuring that I had taken enough, "we started in". With the activity, the flush started to intensify. and during "the best part", I was "glowing like a virgin on her wedding night"! The flush lasted over an hour, but was principally AFTER the orgasm.

I was OK for about 4 hours, but then the POIS started to set in, took me quite a bit to get to sleep at night, feeling like crap and then bad dreams at night!!

But not too bad this morning. we'll have to see how it goes.

But, it's so important to wait till after the flush passes to get best effect. Even in this case, where the flush had begun before we started.

The last three sessions, I barely had a flush, maybe even less than what I had when I started last night, but the fact that "the flush had passed" in these previous session made a big difference.

It's hard to interrelate all the details. IF today I go most of the day and only feel a light passing of POIS in the evening, it will be like the last three sessions, ignoring the bad stuff yesterday which I would have otherwise "slept off". If my POIS is heavier today, it's because I should have waited for the flush to pass completely. I think anyways, that if I had let the flush pass, I wouldn't have felt as bad last night.

[Nightingale]

Normally as well I have noticed that niacin is "stronger" in the morning, most likely because one has not eaten for 8 hours at least before. So I took 100mg to start off. In the morning, or after a long fast, this is usually enough. But nothing. This may have been because I took 200 mg the night before and aborted "activity" because I didn't get a flush.

So I took another 100. Waited about 20 minutes, and still not much, maybe a light sense that niacin was in my system, but no flush. So another 75mg. Usually that's a lot for the morning after fasting, but I figured it was because of the 200 I had taken the night before.

So given I had a "slight tingle", and figuring that I had taken enough, "we started in". With the activity, the flush started to intensify. and during "the best part", I was "glowing like a virgin on her wedding night"! The flush lasted over an hour, but was principally AFTER the orgasm.

I was OK for about 4 hours, but then the POIS started to set in, took me quite a bit to get to sleep at night, feeling like crap and then bad dreams at night!!

These are my EXACT experiences with trying what you were trying.  Relief to know it's not an exclusive phenomenon.  I hate having to "abort" as it means not only will I not get relief that moment, I will have to be extra resilient to abstain longer for the niacin to work efficiently later.

[Daveman]

Normally as well I have noticed that niacin is "stronger" in the morning, most likely because one has not eaten for 8 hours at least before. So I took 100mg to start off. In the morning, or after a long fast, this is usually enough. But nothing. This may have been because I took 200 mg the night before and aborted "activity" because I didn't get a flush.

So I took another 100. Waited about 20 minutes, and still not much, maybe a light sense that niacin was in my system, but no flush. So another 75mg. Usually that's a lot for the morning after fasting, but I figured it was because of the 200 I had taken the night before.

So given I had a "slight tingle", and figuring that I had taken enough, "we started in". With the activity, the flush started to intensify. and during "the best part", I was "glowing like a virgin on her wedding night"! The flush lasted over an hour, but was principally AFTER the orgasm.

I was OK for about 4 hours, but then the POIS started to set in, took me quite a bit to get to sleep at night, feeling like crap and then bad dreams at night!!

These are my EXACT experiences with trying what you were trying.  Relief to know it's not an exclusive phenomenon.  I hate having to "abort" as it means not only will I not get relief that moment, I will have to be extra resilient to abstain longer for the niacin to work efficiently later.

Yesterday and today have been pretty "clean" as far as POIS goes, so here's how I interpret all of this.

In my first months with niacin, I seemed to need only near 100mg (with a good fast prior). Now that has gone up to about 250mg. In part I think it's because the niacin is getting old. I'm fairly sure it "gets stale easily".

I have to get a new batch to know for sure.

Secondly, I am noticing, that even though I don't get a full flush, as long as I take a reasonable amount (for me 250mg or so), it still works fairly well, perhaps 80% as efficient as a good flush. Even if I have a good flush, if I don't wait for the flush to pass the peak, it is also not as strong an effect. In my case, that meant the first day was heavier, but the POIS passed quickly, only had about 1 day of POIS.

So when I reported in my last post, I was in the first day and it was not all that great!!

It is a bummer to have to abort, and to do the fast! It's the worst part about niacin, but I wouldn't stop taking it for the world. It's still a LOT better than it used to be. I'm in day 2 and I can think, have drive and don't feel like crap!!

It really hasn't worked well for me taking it under the tongue, maybe a little faster, but I haven't been able to reduce the quantity or have better effects after eating.

[Ccconfucius]

If its getting old it the pill loose its white color and start looking yellowish. That is what happend to mine and when i bought new one it looked white

Customs in chile dont stop pills do they, we can always hook you up from the US.

[Nightingale]

I have my doubts about niacin degraded that fast.  I just looked at my GNC bottle of niacin, and saw an 01/2015 "best by" date.  GNC always has the highest quality stuff.

I've also used niacin I left in bottles that I thought were empty and thus sat around a good while with their caps off.  I couldnt tell a difference.  I'm interested in hearing your results Daveman

[Daveman]

If its getting old it the pill loose its white color and start looking yellowish. That is what happend to mine and when i bought new one it looked white

Customs in chile dont stop pills do they, we can always hook you up from the US.

Yeah, they are a little yellower. It's been several months now that I've had the same bottle.

I tried to import from a reputable supplier, but they wouldn't let it in. Bummer!

[Daveman]

I have my doubts about niacin degraded that fast.  I just looked at my GNC bottle of niacin, and saw an 01/2015 "best by" date.  GNC always has the highest quality stuff.

I've also used niacin I left in bottles that I thought were empty and thus sat around a good while with their caps off.  I couldnt tell a difference.  I'm interested in hearing your results Daveman

I should check the expiry date, although it may not apply to POIS. We may need ultimate potency!

Basically it's still working, and even after this last one, where I didn't wait out the peak of the flush, I only had one day of medium POIS. It's just that I have to take 250 to 300mg now.

[Observer]

I have my doubts about niacin degraded that fast.  I just looked at my GNC bottle of niacin, and saw an 01/2015 "best by" date.  GNC always has the highest quality stuff.

I've also used niacin I left in bottles that I thought were empty and thus sat around a good while with their caps off.  I couldnt tell a difference.  I'm interested in hearing your results Daveman

I should check the expiry date, although it may not apply to POIS. We may need ultimate potency!

Basically it's still working, and even after this last one, where I didn't wait out the peak of the flush, I only had one day of medium POIS. It's just that I have to take 250 to 300mg now.

Hey Guys, don´t worry about that. It has happened to me before. I left open one bottle and the air entered; i used the niacin and the effect was not the same. Then, next week i used another new bottle, and ... excellent results!! It seems that they degraded so fast if you don´t close the bottle.