Author Topic: Transiently Induced Immune Deficiency and Therapy  (Read 10590 times)

berlin1984

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #180 on: December 18, 2020, 02:45:42 PM »
He was also very skeptical about the benefits of IV Vitamin C generally speaking,

I liked it. I felt it killed off something in my body. But I stopped after 3 times because of money and logistics..

https://www.google.com/search?client=firefox-b-d&q=vitamin+c+as+antiviral
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Iwillbeatthis

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #181 on: December 18, 2020, 03:09:10 PM »
I saw improvements straight away with the immuno complex, I remember when I first tried I had some itchiness and rashes in groin but it didn't really make me feel ill. The copper gluconate on the other hand did make me feel bad like bad brain fog and nauseous however I did see improvements as time went on and I was less reactive to it. I remember on the immuno complex I did feel nauseous during POIS. I need to try the therapy again because I feel like all the progress made has been reset. I never did iv vitamin c also.

Nanna, trying your protocol and the immuno complex is hitting hard only after two days with symptoms of headache, brain fog, and insomnia. Should I layoff until symptoms subside and restart then?

Hey Nanna, just wanted to share that I’m beginning to feel really good - perhaps the best I’ve felt in 10 years. I also feel like this treatment is addressing the root cause and not just the symptoms. It’s been 2.5 months on your treatment. Thanks!

Similarly I went through 2 or 3 bottles before seeing significant improvements, along with the other supplements. As Nanna recommends I'll try to continue through 6 months and evaluate on the way.

Great to hear. May I ask how long you got bad feelings from taking it? When did headache etc stop?

Did you ever notice this kind of pattern from other supplements?

(I sometimes feel bad in morning from taking supplements, especially when taking them in late in evening and I'm now wondering if this is a similar effect that you get, something is killed off but can't get flushed out)

Same question (and congrats) to Iwillbeatthis :)

Mushnikk

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #182 on: December 25, 2020, 01:14:19 PM »

I believe this theory to be true for me also...during a cold my POIS is diminished and immune stimulating nutrients like vitamin C / copper / zinc make me fatigued. Plus I can link the start of my POIS to a time of immense psychological stress that probably manifested a viral infection.

I will try the protocol, thank you for all your input!

I got to be honest that I am somewhat skeptical about AHCC. It is a patented product and all studies seem to be financed by the company producing it. There seem to be other immunstimulating natural compounds out there - is there a specific reason to choose AHCC?

Other immunstimulating compounds I came across in my research:

Echinacea
L-Theanine
Astragalus
Cats's Claw
Neem Oil
Chitosan
« Last Edit: December 25, 2020, 01:27:20 PM by Mushnikk »

Prospero

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #183 on: December 27, 2020, 05:12:33 PM »
Hi nanna1,

I posted in this thread the results of my two experiences with the opioid Tramadol, which I took immediately after O. Short story: I had no POIS symptom the first time, and the second time I got a serotonin syndrome in the following hours but not the usual POIS symptoms.

I wonder if, in your opinion, there could be a link with Jiang, Yin & al.'s thesis regarding mu-opioid receptors, and with your own theory.

Of course there may be many possible explanations for the success of Tramadol.

https://poiscenter.com/forums/index.php?topic=3551.msg38184#msg38184

Codeine has the same positive effect as Tramadol for me. Two cheers for the Chinese Doctors Hypothesis... or for nanna1's, as far as I know.

Update : I tried to take Codeine (+Paracetamol) rather than Tramadol, immediately after O. I had many anxiety symptoms during the first hour, for some reason (psychological or else), then they vanished. And... absolutely no POIS symptoms. So, it seems quite sure now that my success with Tramadol was not caused by its SNRI properties.

berlin1984

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #184 on: January 08, 2021, 03:37:57 PM »
Hello guys, some feedback after getting 1st shot of Sputnik V vaccine yesterday in Moscow, Russia: I had chills and mild fever overnight which was alleviated with paracetamol, now some residual fatigue left, doctors warned that it may last a couple of days. They also told that the more acute the body reaction is - the more antibodies are subsequently produced. Second vaccine shot must be done in three weeks.

But what?s curious in relation to POIS and has already been pointed out before by other forum members: prior to vaccination I was still in the middle of POIS cycle (2-3 days after last O, normally lasts 7+ days for me) and after getting the vaccine and feeling first side effects I have simultaneously felt POIS symptoms to diminish (muscle pains and tension decreasing, brain fog subsiding except for the fever effect). So another case confirming that while being ill and having our immune systems boosted helps get rid of POIS. It goes contrary with Waldinger?s auto-immune theory as amplification of immune reaction obviously helps us battling POIS, rather than as it was assumed by Professor that immune system attacks our own body.

Assuming this being not just mere coincidence of our conditions improving following immune system boost it poses a question: is POIS a dormant infection or virus that gets activated following O that normally doesn?t trigger activation of our immune systems?
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Iwillbeatthis

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #185 on: January 10, 2021, 03:55:01 PM »
I started Sulforaphane (broccoli sprout powder) two days ago and I am seeing massive improvements from it in terms of inflammation and autistic symptoms, I got some pains and a few rashes as if its killing some infection/pathogen in my body. I feel really good in my head from it.

This supplement is incredibly unique and powerful, it turns on the nrf2 gene which combats oxidative stress and unlike most antioxidant supplements there is actually a lot of scientific studies to back up the benefits of Sulforaphane.

PS: If you know the doctor; Rhonda Patrick from the Joe Rogan podcasts this is the supplement she is always banging on about.
« Last Edit: January 10, 2021, 04:00:50 PM by Iwillbeatthis »

Muon

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #186 on: January 10, 2021, 04:19:11 PM »
PS: If you know the doctor; Rhonda Patrick from the Joe Rogan podcasts this is the supplement she is always banging on about.

You can find two of her papers about vit D in the paper thread.
« Last Edit: January 10, 2021, 04:26:32 PM by Muon »

berlin1984

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #187 on: January 14, 2021, 06:57:51 AM »
I started Sulforaphane (broccoli sprout powder) two days ago and I am seeing massive improvements from it in terms of inflammation and autistic symptoms, I got some pains and a few rashes as if its killing some infection/pathogen in my body. I feel really good in my head from it.

This supplement is incredibly unique and powerful, it turns on the nrf2 gene which combats oxidative stress and unlike most antioxidant supplements there is actually a lot of scientific studies to back up the benefits of Sulforaphane.

I'm homozygous for the sod2 rs4880 gene, (super oxide).

When I had this chronic infection from 2018-2019, I would wake up feeling like death in the mornings, the worst brain fog, autistic symptoms, feeling brain dead and l arginine cleared it so that indicates it was some type of nitric oxide/oxidative stress disorder. I still have this going on sometimes outside of POIS but much less severe.

I've tried lots of things to combat oxidative stress: NAC, liposomal glutathione, exercise, agmatine sulfate, l arginine and in the end most weren't very helpful.

However Sulforaphane doesn't compare to any of these things above and it is a game changer for me so far.

Congrats. I noted it on my list of stuff to try. Please update us in a few days/weeks if there is more good changes and also if there is some bad changes.
What's your dosage?

I see it is mentioned on this CFS forum too : https://forums.phoenixrising.me/search/?q=sulforaphane&o=date

EDIT: Haven't researched in detail, but this sounds like it's a herbal antibiotic: https://www.healthrising.org/forums/threads/histamine-intolerance-understanding-the-science.4019/#post-15924
« Last Edit: January 14, 2021, 07:10:45 AM by berlin1984 »
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Iwillbeatthis

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #188 on: January 14, 2021, 08:16:44 AM »

Congrats. I noted it on my list of stuff to try. Please update us in a few days/weeks if there is more good changes and also if there is some bad changes.
What's your dosage?

I see it is mentioned on this CFS forum too : https://forums.phoenixrising.me/search/?q=sulforaphane&o=date

EDIT: Haven't researched in detail, but this sounds like it's a herbal antibiotic: https://www.healthrising.org/forums/threads/histamine-intolerance-understanding-the-science.4019/#post-15924

I'm taking these cheap 1000mcg capsules twice to three times a day which are supposedly  0.4% sulforaphane
https://ebay.us/xXY6Ly

However Dr Rhonda Patrick said studies found that most supplements on the market contained no or very little sulforaphane as it's a very unstable substance. One of the ones which was found to have good amounts of sulforaphane and used in studies was Prostaphane - https://ebay.us/1tIRud, however this is much more expensive than the one I bought. I might try it to see if theres any difference.

I wasn't aware of any bad effects until I saw the link you posted, so maybe I should be more careful. It's strange Dr Rhonda Patrick didn't mention any of these...

Going less Crazy

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #189 on: January 15, 2021, 08:49:23 PM »

Congrats. I noted it on my list of stuff to try. Please update us in a few days/weeks if there is more good changes and also if there is some bad changes.
What's your dosage?

I see it is mentioned on this CFS forum too : https://forums.phoenixrising.me/search/?q=sulforaphane&o=date

EDIT: Haven't researched in detail, but this sounds like it's a herbal antibiotic: https://www.healthrising.org/forums/threads/histamine-intolerance-understanding-the-science.4019/#post-15924

I'm taking these cheap 1000mcg capsules twice to three times a day which are supposedly  0.4% sulforaphane
https://ebay.us/xXY6Ly

However Dr Rhonda Patrick said studies found that most supplements on the market contained no or very little sulforaphane as it's a very unstable substance. One of the ones which was found to have good amounts of sulforaphane and used in studies was Prostaphane - https://ebay.us/1tIRud, however this is much more expensive than the one I bought. I might try it to see if theres any difference.

I wasn't aware of any bad effects until I saw the link you posted, so maybe I should be more careful. It's strange Dr Rhonda Patrick didn't mention any of these...

Any affects on sleep? Mood? Make you calm or give you energy?

I'm lately looking into antiinflammatories as an addition to diet. I noticed 400mg-600mg Ibuprofen helps extremely well if I eat something that I'm "allergic" to, and this helps me sleep, but as we know too much can mess up your stomach (although some strange research of it possibly extending life). Also heart attack/stroke risk.

So I came across sulforaphane lately and ordered some. Supposed to be good for body and brain inflammation with some good research into it helping inflammation related depression. I'll let y'all know how my trial turns out.

BTW ordered a bottle that has 10 mg or 10,000 mcg sulfurophane.
« Last Edit: January 16, 2021, 02:09:33 AM by Going less Crazy »
My POIS managed with modified Paleo Diet (@ diet that 100% manages my pois)Believe my POIS stems from inflammation in the gut. O and stimulation = neuro POIS from inflammation from the gut.

Current supps: microdose MSM, Reishi and glutamine in morning. 400mg-600mg Ibuprofen for insomnia if needed.

Iwillbeatthis

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #190 on: January 16, 2021, 08:30:33 AM »
Any affects on sleep? Mood? Make you calm or give you energy?
[

Haven't noticed any effects on sleep, but it clears brain fog and makes me feel good, yeah at first was mild euphoria and boost in energy but now it just makes me feel calm and good, improves autistic symptoms. I don't have chronic fatigue though. I started adding wasabi now to activate the sulfurophane as explained in the article bellow. What percentage of sulforaphane does your supplement say it has? That would be ten times more than the amount in my supplement if its around 0.4% sulforaphane.

"Do you need expensive broccoli supplements?

There are numerous cheap broccoli supplements and some moderately priced ones.

We know from the research that supplements generally are not reliable, because they often do not contain what is on the label.  This matters more with some products than others.  With broccoli products the big question is whether they really contain active myrosinase.  This is an enzyme that you need to make Sulforaphane when you eat broccoli.

Several years ago, when I started with Sulforaphane, I bought large tubs of Australian broccoli powder and one pack of Daikon radish powder.  Daikon radishes are rich in myrosinase and it is relative stable, so it can survive processing.  My idea was to start with just the broccoli powder and then, if not effective, add some Daikon radish powder for the extra myrosinase.  In the end I did not need to even open the Daikon radish powder.  A small scoop of this broccoli powder produced a profound effect, euphoria after minutes and then much more “speech”. Back then “speech” was more like babbling single words – but it was some kind of speech at least.

Many people report broccoli powder improved speech, even parents of young Aspies report it.

Some people found the effect on mood to be remarkable.

Long term users report that over time they have to increase the dose to maintain the effect.

It is important to note that for some people the benefit may not be from Sulforaphane, but rather from indole-3-carbinol (I3C).

 Spice up Broccoli with Wasabi?

In the original research from decades ago, the Johns Hopkins researchers combined Daikon radish sprouts with broccoli sprouts, the Daikon radish sprouts where there to provide myrosinase.  The product had to kept deep frozen.

Daikon radish is widely available and is a good source of myrosinase.

I was re-reading old research and noted one researcher advocating putting Wasabi on your broccoli – the spicier the better apparently. Wasabi is Japanese horseradish and is widely available.  If it comes on a large bottle is likely fake wasabi - yes like they fake saffron, they fake wasabi.

Is it crazy to add wasabi to your broccoli capsules?

Look at what is in the expensive Avmacol supplement that they only sell in North America.

In the research they found that adding just 0.25% Daikon to frozen broccoli “brought it back to life” and sulforaphane was found in the person eating it.

If you are using gelatine capsules with broccoli powder you can open them and, using a pointed knife, add a small amount of wasabi, re-seal and then swallow.  There is no taste or smell of wasabi.

It is bit fiddly to do this, but you soon master doing it."

Going less Crazy

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #191 on: Today at 06:23:46 AM »
It seems I may have been duped into thinking it was 10000 mcg sulforaphane. This is what I ordered arriving soon:

https://www.amazon.com/Sulforaphane-Supplement-000mcg-Antioxidant-Optimization/dp/B08B5LFVJW/ref=mp_s_a_1_6?dchild=1&keywords=sulforaphane&qid=1610882233&sr=8-6

Broccoli sprout powder -1000mg and broccoli sprout extract - 10000mcg standardized to 12% sulforaphane. So it may just be 1.2 mg per serving, or only 600 mcg per pill. But than I look at recently answered questions and they answer some like there is 10000 mcg sulfurophane, seems misleading...Hope I'm wrong but this looks like the case.

I'm wondering how sulforaphane will affect my insomnia since antiinflammatories like ibuprofen seem to really help in times of need. Do you have any sleep issues or no?
My POIS managed with modified Paleo Diet (@ diet that 100% manages my pois)Believe my POIS stems from inflammation in the gut. O and stimulation = neuro POIS from inflammation from the gut.

Current supps: microdose MSM, Reishi and glutamine in morning. 400mg-600mg Ibuprofen for insomnia if needed.

Iwillbeatthis

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #192 on: Today at 10:49:54 AM »


I'm wondering how sulforaphane will affect my insomnia since antiinflammatories like ibuprofen seem to really help in times of need. Do you have any sleep issues or no?

It hasn't really affected my sleep I don't think. The last few months I have been oversleeping and at times I have had some difficulty getting to sleep before 2-3.

Yesterday I needed **two capsules in the morning to see a good effect, you can add wasabi to make sure sulforophane is produced - this did make me a little nauseous but it wasn't bothering
« Last Edit: Today at 03:16:59 PM by Iwillbeatthis »

berlin1984

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #193 on: Today at 02:51:10 PM »
Is it crazy to add wasabi to your broccoli capsules?

No.
A popular plant based medicine in Germany for respiratory and urinary tract infections is "Angocin Anti-Infekt N".


The ingredients are Tropaeolum and Horseradish(= western wasabi). They both contain Sulforaphane and probably a lot of other stuff.

It's prescription free and marketed in Germany as having antiviral and antibacterial function. Apparantely the combination of the two ingredients makes sure that it's absorbed early in the gut and therefore does not affect gut bacteria (much) but propagates to lung and urinary tract.

I actually take it everytime I feel a sore throat is coming up (and so far I did not catch covid, note this is not medicine advice  ;) ) .. I didn't think so far about using it to influence POIS... (my symptoms are managed ok with adaptogens and neurotransmiter precursors)... but I'll think on how I could use it.

EDIT: There are some english language studies too: https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=angocin&btnG=
« Last Edit: Today at 02:55:35 PM by berlin1984 »
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Iwillbeatthis

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Re: Transiently Induced Immune Deficiency and Therapy
« Reply #194 on: Today at 03:19:05 PM »
No.
A popular plant based medicine in Germany for respiratory and urinary tract infections is "Angocin Anti-Infekt N".


The ingredients are Tropaeolum and Horseradish(= western wasabi). They both contain Sulforaphane and probably a lot of other stuff.

It's prescription free and marketed in Germany as having antiviral and antibacterial function. Apparantely the combination of the two ingredients makes sure that it's absorbed early in the gut and therefore does not affect gut bacteria (much) but propagates to lung and urinary tract.

I actually take it everytime I feel a sore throat is coming up (and so far I did not catch covid, note this is not medicine advice  ;) ) .. I didn't think so far about using it to influence POIS... (my symptoms are managed ok with adaptogens and neurotransmiter precursors)... but I'll think on how I could use it.

EDIT: There are some english language studies too: https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=angocin&btnG=

Haha that wasn't me asking, it was part of an article about wasabi I copied and pasted but thanks for your input.