POIS Paper Archive - a list of scientific articles about POIS

[Muon]

Article can be unlocked with sci-hub now. I will add it to the list (#32) because it's more than just pain although duration isn't typical. I can remove it if people disagree.

Clinical Conundrum: A 33-Year-Old With Pain Post-Orgasm and a History of Endometriosis

"Thus, it is possible that this patient has a form of post-orgasm illness syndrome in addition to endometriosis."

"Elagolix at a higher dosage yields more estradiol suppression"

"Reduced estrogen levels in the endometrium are responsible for the efficacy of elagolix in the treatment of endometriosis."
https://en.wikipedia.org/wiki/Elagolix

"Human MC express oestrogen receptors activation of which increase MC stimulation" https://onlinelibrary.wiley.com/doi/full/10.1111/exd.13288

Inhibition of MC induced neuroinflammation by suppression of estradiol?

Interesting article from Theoharides: Increased Numbers of Activated Mast Cells in Endometriosis Lesions Positive for Corticotropin-Releasing Hormone and Urocortin

CRH...

Overexpression of CRH receptors or increased CRH positive mast cells?: Stress Susceptibility Poll

"IL-8 may derive from endometrial epithelial cells, but is also the most abundant cytokine of human mast cells"

Oh really? I wasn't aware of this. Hmm if IL-8 is a major cytokine in inflammation of the male genital tract then mast cells may play a key role: Interleukin 8 and the male genital tract

More stuff:
https://scholar.google.com/scholar?start=0&q=endometriosis+mast+cell&hl=nl&as_sdt=0,5

Was there an update for poiscenter recently? Because symbols are messed up again when editing posts. Not in the mood to fix those.

[Muon]

Any interesting papers to share? I see people talking about infection or dopamin theories. Any paper worth sharing that might relate to the already existing POIS literature?

[Monte]

One of my theories is also dopamine. Orgasm = strong dopamine burst. We know that POIS is like narcotics withdrawal syndrome (most narcotics = strong dopamine burst). First day in POIS is yet not bad (like in narcotics withdrawal), second day is worse (like narcos withdrawal). Third day is hell. Seventh day testosteron goes up. Higher testosteron = higher dopamine. That`s why zinc and B6 makes many poisers better and that`s why hCG gives so positive results. In my case after 7 days I feel usely ok, but after 14 days I feel like little god (we know that dopamine is higher after 14 days). So if we could try ejaculate without big dopamine burst, we could check if theory is true. For example  many people say that when they have unconsciously wet dreams (ejaculating in wet dreams = dopamine burst with less intensity), they have not POIS or symptoms arent as strong as usely.

[Muon]

Higher testosteron = higher dopamine.

Can you find a scientific article that support this claim? I could add it.

[Monte]

I don`t remember where I found it but when I wrote now in google "higher testosteron higher dopamine" (but in my language) it showed me descripion here https://grananerwach.pl/jak-testosteron-dziala-na-dopamine/ (you can put this text into a translator, it`s interesting)

The blog is written by "Passionate about the scientific approach to health, an amateur of neuroscience, biohacking and fitness. Gifted but lazy. Supplementation specialist, the more and less advanced. Privately, an IT and programming enthusiast from a young age"

In his article he posted 2 sources:
1. Tertia D. Purves-Tyson et al. ?Testosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecules in the Adolescent Male Rat Nigrostriatal Pathway? PLoS One. 2014; 9(3): e91151.
2. Tertia D Purves-Tyson et al. ?Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra? BMC Neurosci. 2012; 13: 95.

[Muon]

Low serum vitamin D is associated with an increased likelihood of acquired premature ejaculation

Take a look under the vitamin D header on page 1 of this thread (serotonin).

[Muon]

A new hit on scholar:

https://books.google.nl/books?hl=nl&lr=&id=3PD6DwAAQBAJ&oi=fnd&pg=PA491&dq=post+orgasmic+illness+syndrome&ots=qBmOh_TADF&sig=awkvF8f-bOt-NJwLofYvU5tZKik&redir_esc=y#v=onepage&q=post%20orgasmic%20illness%20syndrome&f=false

Anyone got access to the full article? Some pages are blocked.

Symptoms escalated due to stress. I've seen this mentioned a few times on this forum over the years. Stress seem to be a trigger. Mast cell disorders are not mentioned in the suggested theories under key messages...

[hurray]

A new hit on scholar:

https://books.google.nl/books?hl=nl&lr=&id=3PD6DwAAQBAJ&oi=fnd&pg=PA491&dq=post+orgasmic+illness+syndrome&ots=qBmOh_TADF&sig=awkvF8f-bOt-NJwLofYvU5tZKik&redir_esc=y#v=onepage&q=post%20orgasmic%20illness%20syndrome&f=false

Anyone got access to the full article? Some pages are blocked.

Symptoms escalated due to stress. I've seen this mentioned a few times on this forum over the years. Stress seem to be a trigger. Mast cell disorders are not mentioned in the suggested theories under key messages...

The book is on sci-hub (chapter 33):

https://sci-hub.tw/10.1007/978-3-030-52298-8

[Muon]

Thanks hurray, tried sci-hub but for some reason didn't work. Your link however is working.

"When tested between ejaculations, he was found not to have these conditions and to have an IQ of 150."

We have some polls in the poll category about intelligence and education. Dr. Bassett is located in Sheffield teaching hospitals NHS. That's where I have tested a couple of mast cell activation markers. I've sent her an email.

[Muon]

I've sent her an email.

Ok nevermind, automatic reply: "I am now on maternity leave until June 2021"

[Muon]

Immediate hypersensitivity to seminal fluid and atopic dermatitis

"Serum from the husband and nonrelated men also contained antigen that provoked histamine release from the patient's leukocytes in vitro. The antigen in serum was associated with the globulin fraction and had a temporal relationship to ejaculation, appearing within 12 hours of ejaculation and disappearing within four days."

It's an antigen for the woman's leukocytes but circulates in the serum of men up to 4 days? Just like the timing seen in POISers.

A new manifestation of seminal fluid hypersensitivity

[Muon]

Anatomy and Physiology of Erection, Ejaculation, and Orgasm

"Through activation of specific protein kinases, protein phosphorylation leads to opening of potassium channels, closing of calcium channels".

"Neurotransmitters play an important role in regulating ejaculation. Studies have shown that activation of serotonin 5HT1A receptors promotes ejaculation, while 5HT1B delays ejaculation [ 52 ]. Activation of dopamine receptors D2 and D3 promotes ejaculation"

"While these are similar between genders, in men there is additional activation in the periaqueductal gray matter."

https://en.wikipedia.org/wiki/Periaqueductal_gray

[Muon]

Table 1 Summary of the 3 clinical POIS cases.

Some of the symptoms above sound like neuromuscular transmissions problems. Here is another one regarding swallowing:
https://poiscenter.com/forums/index.php?topic=3416.msg36014#msg36014

[quikot]

Found another POIS article, this one was published yesterday. It's behind a pay wall though, so not sure what's exactly written there...

Re: Post-Orgasmic Illness Syndrome: History and Current Perspectives
https://www.auajournals.org/doi/full/10.1097/JU.0000000000001212.02

[demografx]

Found another POIS article, this one was published yesterday. It's behind a pay wall though, so not sure what's exactly written there...

Re: Post-Orgasmic Illness Syndrome: History and Current Perspectives
https://www.auajournals.org/doi/full/10.1097/JU.0000000000001212.02

quikot, thank you! (I sent to POIS Research Team)

This link enables your full viewing:

https://sci-hub.se/
Edit: sci-hub not working, trying to find out why

Post-edit: from POIS Research Team: “Sometimes it can take a day or two for papers to get uploaded to Sci-hub - they rely on folks uploading new papers as they become available so it's not automatic. Try again on Monday, perhaps?“

[Muon]

Found another POIS article, this one was published yesterday. It's behind a pay wall though, so not sure what's exactly written there...

https://poiscenter.com/forums/index.php?topic=3127.msg35738#msg35738

New:
Analysis of the Symptomatology, Disease Course, and Treatment of Postorgasmic Illness Syndrome in a Large Sample

"Common symptoms were difficulty concentrating (254, 84%), extreme fatigue (250, 83%), irritability (225, 74%), and muscle weakness (212, 70%)."

Fatigue shows exactly the same percentage as in table 1 of Afrin's MCAD study, namely 83%:
Often seen, rarely recognized: mast cell activation disease - a guide to diagnosis and therapeutic options

[Muon]

Paper from Natale et al. (Poiscenter survey) can now be unlocked with sci-hub: https://sci-hub.se/10.1016/j.jsxm.2020.08.020

"Conversely, the survey population included a high proportion of respondents complaining of muscle weakness, with 70% compared with just 18% of patients in the study by Waldinger et al12 and 14.3% of patients in the study by Reisman."

Waldinger (passed away) and Reisman are located in the same country, actually in the same city. Environmental and/or genetic factors could play a role here. Their numbers regarding muscle weakness are similar.

It seems Dr. Rubin had 2 success cases with antihistamines and tramadol:
https://twitter.com/jsexmed/status/1316952588718346241

[Quantum]

Paper from Natale et al. (Poiscenter survey) can now be unlocked with sci-hub: https://sci-hub.se/10.1016/j.jsxm.2020.08.020

"Conversely, the survey population included a high proportion of respondents complaining of muscle weakness, with 70% compared with just 18% of patients in the study by Waldinger et al12 and 14.3% of patients in the study by Reisman."

As a reminder, Caleb Natale is the member of the Tulane University team who lead the survey here on POISCenter in 2019, so this paper is the one that came out from our answers.

[demografx]

Quantum, thanks for your teriffic work in organizing this!

[Muon]

Article 1

"Both men were not particularly susceptible to viral infections, such as influenza"

Overactive immune system.

"Indeed, flulike syndromes have been described as side effects of the medical use of cytokines (Vial and Descotes, 1995a, 1995b). Involvement of an immediate-type immune response, clinically represented by urticaria, can be excluded by the unresponsiveness of symptoms to antihistamines."

Mast cells release foremost cytokines/chemokines, these are more frequently involved than histamine.

"However, oxytocine has been suggested to negatively interfere with cognition (Geenen et al., 1988)."