Author Topic: POIS Paper Archive - a list of scientific articles about POIS  (Read 13959 times)

Muon

  • Hero Member
  • *****
  • Posts: 1647
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #150 on: July 07, 2020, 06:10:39 AM »
New paper: Case of post‐orgasmic illness syndrome associated with hypogonadism

The Anti-Inflammatory Effects of Testosterone

Table 1, significantly elevated levels of the proinflammatory cytokines in hypogonadism:

TNF-α
MIP-1α (CCL3)
MIP-1β (CCL4)

Table 2, Therapy:

T enanthate: Adiponectin and leptin level decreased.

DHT + hCG: Significant changes in CRP, sVCAM-1, or sICAM-1.

Edit: Scroll down to the TRT & Tregs header.
https://poiscenter.com/forums/index.php?topic=2891.0
« Last Edit: July 08, 2020, 06:45:03 AM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1647
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #151 on: July 14, 2020, 03:38:16 PM »
Benign coital headache relieved by partner's pregnancies with implications for future treatment

Relieve of symptoms while partner was pregnant. My mother, aunt and grandma had relieve of symptoms in their pregnancies. I might respond to Norethisterone. Also progesterone inhibits mast cells. I suspect their activation is a family thing plus it may help with low 5-HT levels:

Progesterone Inhibits Mast Cell Secretion

Progesterone Triggers Selective Mast Cell Secretion of 5-Hydroxytryptamine

They mention Tamoxifen as well which may be helpful for Heather1111.

From first link: "Progesterone could also be absorbed per urethra during coitus, but this would not explain the beneficial affects of the compound after non-coital sexual activity."

This could explain POIS in sex vs masturbation. Some men don't have POIS during sex, those people could try norethisterone.
« Last Edit: July 15, 2020, 09:02:11 AM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1647
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #152 on: July 22, 2020, 01:14:40 PM »
Has anyone tried norethisterone for their POIS?

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 5244
  • All of us working together to defeat POIS!
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #153 on: July 22, 2020, 07:30:28 PM »
Has anyone tried norethisterone for their POIS?
Yes. Bad effect on me, stopped.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

  • Hero Member
  • *****
  • Posts: 1647
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #154 on: August 01, 2020, 08:48:22 AM »
Let me know in this comment section or via PM when you want me to add a paper to the non-POIS/worth a mention section that may be of relevance.

Muon

  • Hero Member
  • *****
  • Posts: 1647
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #155 on: August 06, 2020, 09:13:02 AM »
What's this, a reprint? That title is already on the list. Not sure what to do with this one, it's also locked without abstract:

https://www.auajournals.org/doi/abs/10.1097/JU.0000000000001212.02

Quantum

  • Administrator
  • Hero Member
  • *****
  • Posts: 1282
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #156 on: August 06, 2020, 09:46:30 PM »
What's this, a reprint? That title is already on the list. Not sure what to do with this one, it's also locked without abstract:

https://www.auajournals.org/doi/abs/10.1097/JU.0000000000001212.02
It looks like a published comment about the article of that name, because of the "RE:" at the beginning.

Usually, those open comments are short texts.
If you want to, you could ask the author of the comment if he wants to share it with us. He's an urologist from Chicago ( https://duckduckgo.com/?q=Craig+Niederberger&t=hk&ia=web ).  This would let him know about the existence of the poiscenter forum and community, and may be raise his interest for POIS research.
« Last Edit: August 07, 2020, 07:46:30 AM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Muon

  • Hero Member
  • *****
  • Posts: 1647
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #157 on: August 07, 2020, 08:29:45 AM »
If you want to, you could ask the author of the comment if he wants to share it with us.

I've sent him an email.

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 5244
  • All of us working together to defeat POIS!
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #158 on: August 07, 2020, 01:52:42 PM »
If you want to, you could ask the author of the comment if he wants to share it with us.

I've sent him an email.

Muon, very nice to see your proactive approach, not only here but throughout your postings and research activities.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Quantum

  • Administrator
  • Hero Member
  • *****
  • Posts: 1282
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #159 on: August 08, 2020, 11:17:50 AM »
If you want to, you could ask the author of the comment if he wants to share it with us.

I've sent him an email.
Thanks, Muon !
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Muon

  • Hero Member
  • *****
  • Posts: 1647
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #160 on: August 29, 2020, 10:01:49 AM »
Article can be unlocked with sci-hub now. I will add it to the list (#32) because it's more than just pain although duration isn't typical. I can remove it if people disagree.

Clinical Conundrum: A 33-Year-Old With Pain Post-Orgasm and a History of Endometriosis

"Thus, it is possible that this patient has a form of post-orgasm illness syndrome in addition to endometriosis."

"Elagolix at a higher dosage yields more estradiol suppression"

"Reduced estrogen levels in the endometrium are responsible for the efficacy of elagolix in the treatment of endometriosis."
https://en.wikipedia.org/wiki/Elagolix

"Human MC express oestrogen receptors activation of which increase MC stimulation" https://onlinelibrary.wiley.com/doi/full/10.1111/exd.13288

Inhibition of MC induced neuroinflammation by suppression of estradiol?

Interesting article from Theoharides: Increased Numbers of Activated Mast Cells in Endometriosis Lesions Positive for Corticotropin-Releasing Hormone and Urocortin

CRH...

Overexpression of CRH receptors or increased CRH positive mast cells?: Stress Susceptibility Poll

"IL-8 may derive from endometrial epithelial cells, but is also the most abundant cytokine of human mast cells"

Oh really? I wasn't aware of this. Hmm if IL-8 is a major cytokine in inflammation of the male genital tract then mast cells may play a key role: Interleukin 8 and the male genital tract

More stuff:
https://scholar.google.com/scholar?start=0&q=endometriosis+mast+cell&hl=nl&as_sdt=0,5

Was there an update for poiscenter recently? Because symbols are messed up again when editing posts. Not in the mood to fix those.
« Last Edit: August 29, 2020, 02:59:29 PM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1647
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #161 on: August 31, 2020, 01:39:47 PM »
Any interesting papers to share? I see people talking about infection or dopamin theories. Any paper worth sharing that might relate to the already existing POIS literature?

Monte

  • Newbie
  • *
  • Posts: 17
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #162 on: September 01, 2020, 04:33:33 AM »
One of my theories is also dopamine. Orgasm = strong dopamine burst. We know that POIS is like narcotics withdrawal syndrome (most narcotics = strong dopamine burst). First day in POIS is yet not bad (like in narcotics withdrawal), second day is worse (like narcos withdrawal). Third day is hell. Seventh day testosteron goes up. Higher testosteron = higher dopamine. That`s why zinc and B6 makes many poisers better and that`s why hCG gives so positive results. In my case after 7 days I feel usely ok, but after 14 days I feel like little god (we know that dopamine is higher after 14 days). So if we could try ejaculate without big dopamine burst, we could check if theory is true. For example  many people say that when they have unconsciously wet dreams (ejaculating in wet dreams = dopamine burst with less intensity), they have not POIS or symptoms arent as strong as usely.

Muon

  • Hero Member
  • *****
  • Posts: 1647
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #163 on: September 01, 2020, 07:50:30 AM »
Higher testosteron = higher dopamine.

Can you find a scientific article that support this claim? I could add it.

Monte

  • Newbie
  • *
  • Posts: 17
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #164 on: September 01, 2020, 05:00:13 PM »
I don`t remember where I found it but when I wrote now in google "higher testosteron higher dopamine" (but in my language) it showed me descripion here https://grananerwach.pl/jak-testosteron-dziala-na-dopamine/ (you can put this text into a translator, it`s interesting)

The blog is written by "Passionate about the scientific approach to health, an amateur of neuroscience, biohacking and fitness. Gifted but lazy. Supplementation specialist, the more and less advanced. Privately, an IT and programming enthusiast from a young age"

In his article he posted 2 sources:
1. Tertia D. Purves-Tyson et al. ?Testosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecules in the Adolescent Male Rat Nigrostriatal Pathway? PLoS One. 2014; 9(3): e91151.
2. Tertia D Purves-Tyson et al. ?Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra? BMC Neurosci. 2012; 13: 95.

« Last Edit: September 01, 2020, 05:07:30 PM by Monte »