POIS Paper Archive - a list of scientific articles about POIS

[berlin1984]

I'm a bit sceptical that an NSAID would have such a major effect on POIS symptoms.

And IMHO that's only working around the cause, not curing it (whatever the cause might be).

From Wikipedia:
"It is believed to work by decreasing the production of prostaglandin.It blocks both cycloxygenase-1 (COX-1) and cycloxygenase-2 (COX-2)." https://en.wikipedia.org/wiki/Diclofenac


From Wikipedia about Sexual Headache:
"Case series have found indomethacin and beta blockers to be successful in treating these headaches. Propranolol, Bellergal, and triptans have also been used with success. Anecdotal and indirect evidence suggests a trial of magnesium supplementation may improve symptoms (in subjects with known or suspected low Mg levels)."
https://en.wikipedia.org/wiki/Sexual_headache

In our forum Indomethacin is proposed (see search function), which is has a more "pronounced selectivity towards COX-1"
https://www.emedexpert.com/compare/nsaids.shtml

But according to the POIS study Celecoxib (more COX-2) was also effective. So maybe it doesn't matter.


About the AD, nanna1 writes:

5. You wrote that you were hoping to resolve your neutropenia by following the immune competence therapy. Have you had any tests done afterwards? Has there been any change in your neutrophil count?

  The neutrophil count is a test that I should do. During the time I was boosting the immune system with supplements, I was monitoring my acne (face) and eczema (foot). Acne usually occurs when bacteria enters the skin. Then white blood cells (neutrophils) leave the blood vessels and invade the skin to attack the infection. The white blood cells are part of what give pimple their white color. I used to get acne/pimples in the days following orgasm as one of my POIS symptoms. As my acne cleared up, that gave me evidence that my neutrophil function had normalized. Certain foods (chocolate, dairy, high-sugar) that used to give me acne, no longer do.

  I also used to have eczema on the heel of my foot. This was not associated with orgasm or any related activity. Both the acne and eczema that I have dealt with since I was a teenager have cleared up. And I never get acne now, no matter what junk-food I eat . Side note: I did use tea tree oil on the eczema also.

  These are indirect (and free) measures of neutrophil activity. But I've mainly been avoiding spending money on more medical test.

[Clues]

I'm a bit sceptical that an NSAID would have such a major effect on POIS symptoms.

Same here, hurray. Be careful everyone! I personally believe that I and most likely many other POISers have some form of mast cell activation disorder, which is intimately tied to gut health. Long-term use of NSAIDs can mess with your gut, so you may be trading away your long-term gut health for some quick relief if you go heavy on the NSAIDs. Some research here and here.

[Nas]

Hey. Not sure if this has been posted. There is a study published on 15/06/20 by Japanese researchers. Conclusion is that NSAIDs are 'effective' in managing POIS.

https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123

Haha, I really like how Waldinger's (RIP) first paper set the criteria for testing, and when ever researchers try to build on it they instantly find that there is no detectable IgE for semen in patent's blood.
Also, since many of us don't really have physical symptoms, it's most likely the reason why NSAID's don't work for us. NSAID's only mask the inflammatory symptoms without addressing the underlying source.

[Muon]

I'm a bit sceptical that an NSAID would have such a major effect on POIS symptoms.

https://www.thenakedscientists.com/forum/index.php?topic=6576.8900

That's the only mention of Diclofenac I could find, and Green claimed it only reduced his POIS symptoms by 20% or so. It's great to see new POIS research, but we should bear in mind that this paper only deals with one patient.

I have seen more POISers over the years reacting positive to NSAIDs, also seen a few that got adverse reactions from it. I don't consider this paper research though, it's not that they investigate the underlying cause. It's more like a clinical report plus. NSAIDs are often used when one suspects inflammation. Conclusion states that it's effective, how effective (% of POISers)? The latter is impossible to know based on case reports.

I get the impression people are waiting for something that works for most POISers. If a mast cell disorder is at the root of POIS you probably won't find any since the cell behaves in diverse ways. Many of the 'treatments' which were succesful for people have in common that they are able to interact with mast cells directly and/or suppress downstream mediator effects.

Also, since many of us don't really have physical symptoms, it's most likely the reason why NSAID's don't work for us.

I suspect NSAIDs don't work for most, because of the variety of pro-inflammatory profiles in POISers. But this argumentation could be applied to other medication as well. Multiple inflammatory mediators might be involved in people that react partially to meds.

https://scholar.google.com/scholar?hl=nl&as_sdt=0%2C5&q=atopic+dermatitis+mast+cell+&btnG=

[Quantum]

Hey. Not sure if this has been posted. There is a study published on 15/06/20 by Japanese researchers. Conclusion is that NSAIDs are 'effective' in managing POIS.

https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123

What is AD? Autoimmune disorder?

AD, in the article referred to, =  Atopic dermatitis    see https://en.wikipedia.org/wiki/Atopic_dermatitis

[Muon]

Where are the patients with GI tract complaints in Reisman's paper? It doesn't appear in table 2, why?

[demografx]

Hey. Not sure if this has been posted. There is a study published on 15/06/20 by Japanese researchers. Conclusion is that NSAIDs are 'effective' in managing POIS.

https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12123

Thanks, quikot, sent to POIS Research Team.

quikot, I sent your post above to the POIS Research Team. They appreciated it: “ Interesting – and good to keep on track of the newest work. Thanks Demo!”

And thanks to everyone else (Quantum, Muon et al) who posted about it!

[drop247]

Thanks Quantum.

[quikot]

quikot, I sent your post above to the POIS Research Team. They appreciated it: “ Interesting – and good to keep on track of the newest work.

Glad to be of help!

[demografx]

quikot, I sent your post above to the POIS Research Team. They appreciated it: “ Interesting – and good to keep on track of the newest work.

Glad to be of help!

quikot, really appreciated!
Demo

[Muon]

New paper: Case of post‐orgasmic illness syndrome associated with hypogonadism

The Anti-Inflammatory Effects of Testosterone

Table 1, significantly elevated levels of the proinflammatory cytokines in hypogonadism:

TNF-α
MIP-1α (CCL3)
MIP-1β (CCL4)

Table 2, Therapy:

T enanthate: Adiponectin and leptin level decreased.

DHT + hCG: Significant changes in CRP, sVCAM-1, or sICAM-1.

Edit: Scroll down to the TRT & Tregs header.
https://poiscenter.com/forums/index.php?topic=2891.0

[Muon]

Benign coital headache relieved by partner's pregnancies with implications for future treatment

Relieve of symptoms while partner was pregnant. My mother, aunt and grandma had relieve of symptoms in their pregnancies. I might respond to Norethisterone. Also progesterone inhibits mast cells. I suspect their activation is a family thing plus it may help with low 5-HT levels:

Progesterone Inhibits Mast Cell Secretion

Progesterone Triggers Selective Mast Cell Secretion of 5-Hydroxytryptamine

They mention Tamoxifen as well which may be helpful for Heather1111.

From first link: "Progesterone could also be absorbed per urethra during coitus, but this would not explain the beneficial affects of the compound after non-coital sexual activity."

This could explain POIS in sex vs masturbation. Some men don't have POIS during sex, those people could try norethisterone.

[Muon]

Has anyone tried norethisterone for their POIS?

[demografx]

Has anyone tried norethisterone for their POIS?

Yes. Bad effect on me, stopped.

[Muon]

Let me know in this comment section or via PM when you want me to add a paper to the non-POIS/worth a mention section that may be of relevance.

[Muon]

What's this, a reprint? That title is already on the list. Not sure what to do with this one, it's also locked without abstract:

https://www.auajournals.org/doi/abs/10.1097/JU.0000000000001212.02

[Quantum]

What's this, a reprint? That title is already on the list. Not sure what to do with this one, it's also locked without abstract:

https://www.auajournals.org/doi/abs/10.1097/JU.0000000000001212.02

It looks like a published comment about the article of that name, because of the "RE:" at the beginning.

Usually, those open comments are short texts.
If you want to, you could ask the author of the comment if he wants to share it with us. He's an urologist from Chicago ( https://duckduckgo.com/?q=Craig+Niederberger&t=hk&ia=web ).  This would let him know about the existence of the poiscenter forum and community, and may be raise his interest for POIS research.

[Muon]

If you want to, you could ask the author of the comment if he wants to share it with us.

I've sent him an email.

[demografx]

If you want to, you could ask the author of the comment if he wants to share it with us.

I've sent him an email.

Muon, very nice to see your proactive approach, not only here but throughout your postings and research activities.

[Quantum]

If you want to, you could ask the author of the comment if he wants to share it with us.

I've sent him an email.

Thanks, Muon !