POIS Paper Archive - a list of scientific articles about POIS

[Muon]

Thanks, Muon, didn’t know we could do that. You should give us an SMF tutorial!

You can do that for almost every software out there, it's almost a universal command, thus not bound to SMF. PDF readers, internet browsers, windows etcetera are making use of it.

[Muon]

New paper:

Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin

[demografx]

Thanks, Muon, sent to our POIS Research Team.

[Nas]

Good news I guess?
The problem is that my serum testosterone is actually normal high
So I don't know how to feel about testosterone treatment :/
Can we know exactly the guy's symptoms? The description doesn't sound sufficient for a POIS diagnoses.

[demografx]

Nas, I’ve had a theory, THAT I DON’T RECOMMEND TESTING WITHOUT CLOSE MEDICAL SUPERVISION, that TRT can also benefit some POISers with normal Free-T values. Not scientific. Call it a hunch. A POISer friend tried it and it didn’t help.

[Eliasjoelrivera]

New paper:

Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin

interesting article. I think I will be happy to seek treatment to put it into practice. At some point I thought about using testosterone patches. But this method seems more effective. I will start consulting an endocrinologist. thanks for the info.

[demografx]

Can we know exactly the guy's symptoms?

Email the author?

[demografx]

I will start consulting an endocrinologist.

An endocrinologist is the *only* physician/medical specialist I consulted who actually helped me.

Ten years ago, I was advised by a Harvard biophysicist friend who pioneered & then developed some successful AIDS treatment, to seek out a *university* based endocrinologist because they are more research-oriented and thus likely to be more open to POIS evaluation & treatment. So I did.

[Nas]

Can we know exactly the guy's symptoms?

Email the author?

Sorry I didn't read the full article, yes the patient seems to be suffering from POIS evident by his social withdrawal.

[demografx]

Thanks, Nas

[Nas]

So can we suppose that gonadotropin treatment is similar to TRT or should we consider it as a novel treatment with a different mechanism of action?

[demografx]

Keep in mind that Dr. Waldinger’s first co-author is an endocrinologist. Even 10 years ago, I was successful in persuading my endocrinologist to take me seriously by pointing this out.

As Quantum often suggests, I showed him the Waldinger+endocrinologist article from 2002.

[demografx]

So can we suppose that gonadotropin treatment is similar to TRT or should we consider it as a novel treatment with a different mechanism of action?

I would ask an endocrinologist.

[demografx]

I don’t know anything about them (NYU docs sound promising), but I considered a similar online chat with an endocrinologist:
Chat with an endocrinologist:
https://tinyurl.com/rq28vrt

[Muon]

My mother, her sister and my grandmother who got health problems all felt better during pregnancy. Take a look at this:
https://en.wikipedia.org/wiki/Human_chorionic_gonadotropin#Reference_levels_in_normal_pregnancy

Theoretically, both desensitization and TRT are able to stabilize mast cells:
https://poiscenter.com/forums/index.php?topic=2301.msg31643#msg31643

By applying hCG they could have expanded his Treg pool by stimulation of androgen receptors. See links about androgens and Tregs inside this thread: https://poiscenter.com/forums/index.php?topic=2891.0

It would be of interest to know what his FOXP3+Treg numbers were before and after hCG treatment. The outcome of this 'treatment' is very encouraging but don't forget that this is only a case report so far and his POIS has not been completely reversed from what I understand despite having a high T level after application.

Some other papers which might be of interest:

Serotonin secretion from rat Leydig cells

Human adrenal cortex hyperfunction due to LH/hCG