Author Topic: POIS Paper Archive - a list of scientific articles about POIS  (Read 14358 times)

Muon

  • Hero Member
  • *****
  • Posts: 1704
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #180 on: October 25, 2020, 06:40:19 AM »
Waldinger (2011, part 1) mentioned FOXP3. This has never been followed up.

"Another intriguing possibility is that PE in these men is causally associated to immunologic factors. However, currently, there are no data of immunologic factors relating to PE."

Yes I was thinking this as well and also haven't found anything in literature aside from one paper that treated PE with milnacipran which could indicate involvement of immunologic factors. Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress

Milnacipran for Postcoital Cephalgia and Premature Ejaculation

Could be an idea for a trial. Test Milnacipran in group of poisers with PE.

Edit: chromium chloride for PE?:
Chromium Deficiency: The Predicted Underlying Cause for Up-regulation of Calcium Signaling in Non-Excitable Cells.
« Last Edit: October 25, 2020, 06:59:42 AM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1704
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #181 on: November 05, 2020, 07:08:17 AM »
No POIS but potentially a very important paper. Adding this to the testosterone section on page 1:

RESOLUTION OF SEASONAL ALLERGIES BY TESTOSTERONE REPLACEMENT THERAPY IN A HYPOGONADAL MALE PATIENT: A CASE REPORT

Edit: Food for thought: There are Treg modulators in sperm. Could Hyposensitization actually be a modulation of Tregs?
« Last Edit: November 05, 2020, 02:10:47 PM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1704
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #182 on: November 16, 2020, 09:16:51 AM »
Someone could look into experimental low-dose IL-2 therapy for POIS. Perhaps a doctor seeing this message can look into it.

Targeting IL-2: an unexpected effect in treating immunological diseases

Androgen receptor modulates Foxp3 expression in CD4+CD25+Foxp3+ regulatory T-cells

RESOLUTION OF SEASONAL ALLERGIES BY TESTOSTERONE REPLACEMENT THERAPY IN A HYPOGONADAL MALE PATIENT: A CASE REPORT

Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin

Case of post-orgasmic illness syndrome associated with hypogonadism.

Neuroendocrinology of mast cells: Challenges and controversies.

Note: all female family members of mine with health issues felt better during pregnancy. T-reg numbers increase during pregnancy. Progesterone and hCG rise during pregnancy. Mast cells can stabilize as well via P4. One of them has seasonal allergies combine it with the above papers.

From the IL-2 paper:

"We also summarize proof-of-concept clinical trials which have shown that low-dose IL-2 can control autoimmune diseases safely and effectively...
« Last Edit: November 16, 2020, 09:37:19 AM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1704
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #183 on: November 20, 2020, 07:40:29 AM »
Low-dose IL-2 therapy compensates for metabolic shifts and reverses anxiety-like behavior in PD-1 deficiency-induced autoimmunity

PD-1 mice: "In PD-1-deficient (Pdcd1?/?) mice, a model for excessive immune activation, aberrant activation of T cells induces metabolic shifts by depleting amino acids, including tryptophan (Trp) and tyrosine (Tyr), which are essential precursors for monoamine neurotransmitter synthesis in the brain."

"In conclusion, our study provides the first evidence that low-dose IL-2 therapy could compensate for the deprivation of essential amino acids required for neurotransmitter syntheses, protect brain function and reverse anxiety-like behaviors in PD-1-deficient mice, a model used for systemic T-cell activation and associated autoimmunity"

My brother got decreased tryptophan levels.

Low dose IL-2 therapy mimicks desensitization?:
Interleukin-2 in seminal plasma of fertile and infertile men
« Last Edit: November 20, 2020, 07:49:26 AM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 1704
    • MCAD Thread
Re: POIS Paper Archive - a list of scientific articles about POIS
« Reply #184 on: November 20, 2020, 12:19:49 PM »
You won't find elevated IgE when IgG4 is elevated because the latter suppresses IgE. Also IgG4 doesn't activate complement.

"After the chronic antigen exposure, IgG1 and IgG4 become the predominantly produced subclasses of IgG isotype. In addition, IgG4 is unable to activate the classical complement pathway and is then known as an anti-inflammatory immunoglobulin and a blocking antibody towards IgE antibodies." Immunodominant Semen Proteins III: IgG1 and IgG4 Linkage in Female Immune Infertility

A potential antigen in seminal fluid can be located via IgG4. If characterized it can be checked if the same antigen is involved in hypersensitivity to semen in the case of my mother and brother plus potential crossreactivity with other types of antigens which have nothing in common with sexual fluids.

A comprehensive characterization of the peptide and protein constituents of human seminal fluid

IgG4 could have been induced by SCIT.

======================================================================
======================================================================

Allergen-specific intralymphatic immunotherapy in human and animal studies

"In the study of Witten et al. [13], both serum allergen-specific IgE and IgG4 were increased after ILIT. Moreover, IL-4 and IL-10 production, as well as the expression of FoxP3 increased, whereas interferon (IFN)-? production by stimulated PBMCs decreased after ILIT."

Androgen therapy also increases expression of FOXP3. It might be one mechanism. https://poiscenter.com/forums/index.php?topic=3127.msg37486#msg37486

"In our study, serum allergen-specific IgE and IgG4 increased 4 months after ILIT, but they had decreased by 1 year later"

Even the 'failure' in the brazilian patient (fidalgo) might be the same mechanism which reversed over time.
https://sci-hub.se/10.1080/0092623x.2019.1677835

"The patient was submitted to immunotherapy, and although he presented an improvement of symptoms in the first year of treatment, he quit immunotherapy after two years because the symptoms returned."

Intralymphatic Immunotherapy With Autologous Semen in a Korean Man With Post-Orgasmic Illness Syndrome

"The mechanism of ILIT is not sufficiently understood, but we propose that ILIT might be mediated by plasmablasts, plasma cells, and memory B cells that are activated by allergens injected into lymph nodes and produce allergen-specific IgE, IgG4, or other antibody isotypes with or without enhanced affinity."

===================================================================
===================================================================

Table 3: Immunotherapy. The rush protocol is more effective than the conventional method (also increased risk for anaphalaxis):
Human seminal plasma allergy: a review of a rare phenomenon

MethodAttempted inSuccessful in
Conventional149 (64%)
‘Rush’ protocol1111 (100%)
   Subcutaneous66 (100%)
   Intravaginal55 (100%)
« Last Edit: November 20, 2020, 12:45:41 PM by Muon »