Author Topic: POIS Paper Archive - a list of scientific articles about POIS  (Read 10233 times)

demografx

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Re: POIS Paper Archive
« Reply #105 on: April 14, 2020, 01:14:22 PM »
Totally agreed!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Hopeoneday

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Re: POIS Paper Archive
« Reply #106 on: April 14, 2020, 05:32:04 PM »
It is been dicovered what is discovered till this day, numerous studies are vriten about complex body pathways, ewrything in the body depend on something else in body. It would be greath  that exist a device in medicine today, that can measure every single proces in body in real time, like cytokines, molecular DNA levels, neurotransmiters , hormones, imune ractions, receptor regulation... buttt... unfortunatly we live in times that is only on begining to discovering such a devices.
Thats been said, that medicine  today is  wery limited, espheshuly in some parts of medicine.
Knowing this, me personaly hawe no big expe from medicine in this times...
Dr-pois.

demografx

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Re: POIS Paper Archive
« Reply #107 on: April 14, 2020, 09:56:02 PM »
hurray, very nice idea!

If we want the scientific community to take our ideas seriously, we need to speak their language. A scientific paper would be a great way for Muon to condense and formalize his research, and allow him to reach out to other scientists.

And Muon indeed speaks scientific-ese!
« Last Edit: April 15, 2020, 12:54:37 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: POIS Paper Archive
« Reply #108 on: May 17, 2020, 05:32:22 AM »
Got a new hit related to POIS, regarding a female case:

Clinical Conundrum: A 33-Year-Old With Pain Post-Orgasm and a History of Endometriosis

Sci-hub doesn't seem to unlock this one in contrary to the article in French:

Raisonnement clinique : Une femme de 33 ans avec ant?c?dents d'endom?triose ?prouvant des douleurs apr?s l'orgasme

Copying text from the article and putting them into a translator doesn't work well, punctuation marks aren't properly depicted when pasting.

Can someone get a hold on the full english version of the article or wanting to translate it to english?

demografx

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Re: POIS Paper Archive
« Reply #109 on: May 17, 2020, 03:24:32 PM »
Thanks, Muon, sent 1st link to POIS researchers.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Quantum

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Re: POIS Paper Archive
« Reply #110 on: May 17, 2020, 07:05:01 PM »
Got a new hit related to POIS, regarding a female case:

Clinical Conundrum: A 33-Year-Old With Pain Post-Orgasm and a History of Endometriosis

Sci-hub doesn't seem to unlock this one in contrary to the article in French:

Raisonnement clinique : Une femme de 33 ans avec ant?c?dents d'endom?triose ?prouvant des douleurs apr?s l'orgasme

Copying text from the article and putting them into a translator doesn't work well, punctuation marks aren't properly depicted when pasting.

Can someone get a hold on the full english version of the article or wanting to translate it to english?


Hi Muon, I suggest you use a newer online translator which is far better than any others:   DeepL   ( https://www.deepl.com/translator ).   Almost no punctuation problems with DeepL ( they are managed before translation, by erasing them automatically).  Here is the first 5000 characters with DeepL ( free online DeepL works with 5000 max at a time), with no correction :

"THE CLINICAL PICTURE
Referred by a tertiary care centre in
sexual medicine, a 33 year old woman
presented with post-orgasm pain.
She had a history of dysmenorrhea and had
underwent laparoscopy about ten years ago plus t^ot for
treat probable endometriosis that was likely to be affected by
minimal to light. Thereafter, she remained under
continuous treatment with oral contraceptives and was
amenorrheic. She didn't present any history.
of dyspareunia. The patient was reaching orgasm,
which was pleasant and painless in itself, through the stimulation
of the clitoris and/or penetration with a partner
male. However, immediately after orgasm..,
she was suffering from cramps similar to dysmia.
enorrhea for approximately 30 minutes; these cramps
were also sometimes accompanied by vaginal bleeding.
Other symptoms included sweating,
occasional nausea and exhaustion. His
medical histories included a
resection at the diathermic loop to treat CIN1;
subsequent Pap test results were normal.
The patient reported a history of anxiety,
but she scored low on the questionnaire
on Generalized Anxiety Disorder GAD-7 (Generalized
Anxiety Disorder-7).
Clinician's comment: Pelvic pain after orgasm
are a little-studied phenomenon1. It would be important
to perform a speculum examination of the cervix, being
gives antecedents of post-coital bleeding and
treatment of CIN1 by diathermy loop resection.
Pelvic examination and imaging to detect the
the presence of endometriotic lesions, in particular of an endometriotic
deep endometriosis or ovarian endometriomas, would be
also instructive. It would also be useful to
imaging exams of the uterus itself to detect
the presence of adenomyosis, since the pain was similar to
is dysmenorrhea. The pelvic floor should also be examined, as pelvic floor dysfunction is a common cause of
pelvic floor would be a potential cause of pelvic floor pain.
moment of arousal, penetration or orgasm.
Finally, an examination of the vulva is recommended.
in all patients who experience pain during the course of
sexual intercourse.
THE DIAGNOSTIC PROCESS
On examination, the vulval skin and anatomy were
and palpation of the vulvar vestibule at the
with a cotton swab caused no pain.
Speculum examination revealed a cervix of the uterus.
appearance and the presence of a very good looking
small polyp on the external os. The results of
pelvic floor examination proved to be very helpful.
normal events and did not indicate any pain or
no sign of vaginismus. Pelvic exam, palpation...
of the uterus has allowed us to observe
a sensitivity, which was not the case with the bladder,
the pelvic floor, appendages or cul-de-sac, and
uterosacral ligaments. No nodularity was observed.
Detective. The endovaginal ultrasound revealed an
sensitivity to the cul-de-sac, both ligaments...
uterosacral and right ovary. On ultrasound, the uterus
showed a decrease in the demarcation
between the myometrium and endometrium, but otherwise, he's
was normal. The endometrial layer measured 5 mm.
and both ovaries were normal. A sign of the
positive slip between the uterus (cervix) and the c^olon a
e été observé, mais aucun signe echographique n'a pu
confirm the presence of nodules in the compartment
posterior.
Clinician's commentary: Given the sensitivity of the uterus
on bimanual palpation, it was issued as hypoth--
The uterus could be a factor in the origin of the
pain after orgasm. The elements that support this
are post-coital bleeding, which is diagnosed as post-coital bleeding.
could indicate a metrorrorror from the uterus,
and the ultrasound signs of adenomyosis (even though the
diagnosis cannot be confirmed due to the absence of
other echographic signs)2. However, the patient
was amenorrheic while she was using birth control.
oral, suggesting sufficient inhibition of
Uterine activity. The differential diagnosis includes the
recurrence of endometriosis; no sign of endometrioma
ovarian or deep endometriosis has been observed, but the
sensitivity to endovaginal ultrasound may be observed.
It is indicative of superficial peritoneal endometriosis3.
It is plausible that superficial endometriosis
may contribute to the post-orgasm pain, but it
would not be the direct cause of the bleeding, which indicates
a uterine cause. The differential diagnosis always holds
pelvic floor account, since the results of the
clinical examinations do not always correspond to the dysfunction.
of the pelvic floor in a sexual context.
We've considered increasing inhibition of the activity
uterine by administration of a progestin superimposed on the
oral contraceptive. A huddle... "


Sorry but due to the work overload linked to the pandemia  I do not have time to do the rest for now, or to edit this first part, but it is already very good as it is.

I am sure some dedicated member could do the rest !


( However - and there is a "spoiler" ahead - I have done a very rapid survey of the article, since I am French speaking, and the solution found in this case study is centered on controlling the endometriosis and the pain associated with it, so this will not apply to men, as I understand it after my very partial reading ).
« Last Edit: May 17, 2020, 07:16:32 PM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

Muon

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Re: POIS Paper Archive
« Reply #111 on: May 31, 2020, 06:04:20 PM »
hurray, very nice idea!

If we want the scientific community to take our ideas seriously, we need to speak their language. A scientific paper would be a great way for Muon to condense and formalize his research, and allow him to reach out to other scientists.

I have no experience in writing papers or how to publish one. I'm not affiliated to any institute and you will have to pay a fee for publishing open acces if I'm not mistaken. If someone could guide me through all the steps that are necessary to publish a paper I might consider to write one. Plus a mast cell disorder expert in the field should review the paper.

hurray

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Re: POIS Paper Archive
« Reply #112 on: June 01, 2020, 11:59:03 AM »
hurray, very nice idea!

If we want the scientific community to take our ideas seriously, we need to speak their language. A scientific paper would be a great way for Muon to condense and formalize his research, and allow him to reach out to other scientists.

I have no experience in writing papers or how to publish one. I'm not affiliated to any institute and you will have to pay a fee for publishing open acces if I'm not mistaken. If someone could guide me through all the steps that are necessary to publish a paper I might consider to write one. Plus a mast cell disorder expert in the field should review the paper.

One place to start could be checking to see which journals have published POIS-related papers in the past. The list you have helpfully made at the start of this thread lists a few different journals.  :)

The Journal of Sexual Medicine seems like a good candidate - it is an Elsevier publication. They give a lot of information about what they expect from a submission here (under "Resources" at the bottom of the page):

https://mc.manuscriptcentral.com/jsm

They also have a very comprehensive guide for authors here:

https://www.elsevier.com/journals/the-journal-of-sexual-medicine/1743-6095/guide-for-authors#91001'_new'
« Last Edit: June 01, 2020, 12:01:38 PM by hurray »

Muon

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Re: POIS Paper Archive
« Reply #113 on: June 02, 2020, 09:25:09 AM »
The fee is just too much for the journal of sexual medicine.

I have added a new paper to the list. It's from Amstelveen the Netherlands, same residential area as Waldinger. Must be a colleague of his.

There is a reference in that paper I'm unfamiliar with, slipped under the radar I guess. Does anyone have full working link to this article:
https://www.researchgate.net/publication/297569313_A_clinical_case_of_suspected_postorgasmic_illness_syndrome
« Last Edit: June 02, 2020, 10:03:05 AM by Muon »

demografx

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Re: POIS Paper Archive
« Reply #114 on: June 02, 2020, 12:17:27 PM »
Thanks, Muon, sent to POIS Research Team.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Mushnikk

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Re: POIS Paper Archive
« Reply #115 on: June 02, 2020, 12:42:33 PM »
A new paper has been published: 29 May 2020 /
Clinical experience with post-orgasmic illness syndrome (POIS) patients?characteristics and possible treatment / https://www.nature.com/articles/s41443-020-0314-9

Abstract: Post-orgasmic illness syndrome (POIS) is a rare condition that includes a cluster of post-ejaculatory symptoms with debilitating physical and psychological consequences. The prevalence and incidence of POIS remain unknown as well as the pathophysiology of the syndrome, and there are no well-studied recognized treatment modalities. The current retrospective observational study describes a series of 14 highly selected patients who were actively looking for medical help as POIS has a significant effect on patients and their partners. The aim is to increase knowledge about this syndrome and possible treatment modality. According to a standard protocol, patients have been systematically interviewed, had a physical examination, laboratory blood tests, and treatments. Mean age was 34.07 ? 6.65 years. The majority of patients had only one symptom in common?extreme fatigue. The most prevalent complaints were head pressure/heaviness, nose congestion and muscle tension; all patients suffered from more than 1 symptom. POIS started on average within 30 min of ejaculation and lasted for 3.5 days. The patients reported emotional and psychosocial burden of their symptoms, which also influence their partner and relationships. Immunoglobulin-E measurements did not show elevated levels and/or significant increase within 24 h after ejaculation. Silodosin, a highly selective alpha1A-blocker, which actually causes anejaculation, was effective treatment in 57% of the patients.

demografx

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Re: POIS Paper Archive
« Reply #116 on: June 02, 2020, 01:07:22 PM »
Thanks, Mushnikk!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS Paper Archive
« Reply #117 on: June 02, 2020, 01:23:40 PM »
Sent to POIS Research Team.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: POIS Paper Archive
« Reply #118 on: June 02, 2020, 02:27:22 PM »
"Silodosin, which considered to cause anejaculation [15], was chosen as the first-line therapy. Eight patients (57%) were able to be effectively treated with this approach."

No ejaculation = no contact between UT mast cells and the ejaculate.

"Eleven (78.5%) patients had slightly elevated total IgE with a mean of 40.5 ? 24.7 kU/l (normal range <35)."

Cyokines can induce IgE in B-cells.

"Furthermore, the indicated level of IgE may not correlate with the extent or severity of symptoms when exposed to the allergen."

Eosinophil cationic protein correlates to allergic disease activity.

"There are no recognized treatment modalities. POIS patients have been treated with antihistamines, selective
serotonin reuptake inhibitors, nonsteroidal antiinflammatory medication, analgesics, benzodiazepines, and hyposensitization therapy.
"

In bold are the ones being used in MCAD. Steroids as well.


demografx

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Re: POIS Paper Archive
« Reply #119 on: June 02, 2020, 03:41:53 PM »

A new paper has been published: 29 May 2020 / ...


The POIS Research Team appreciated receiving!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business