Immunophenotypical Characterization of a Brazilian POIS Patient (15 oct 2019)

[demografx]

Ah ok, thanks Demo.

From our research friends:

“Sci-Hub is a great resource for this kind of thing:

https://sci-hub.se/10.1080/0092623x.2019.1677835

And for future reference: https://sci-hub.se/ “

[demografx]

I went to the article to request a free copy (academic), but I was stopped at username/password, I don’t have one

But it seems the right path.

Maybe you or Quantum can figure it out!

[demografx]

Muon, sorry if I accidentally hit lock topic. I hit unlock.

[Muon]

Muon, sorry if I accidentally hit lock topic. I hit unlock.

Hahah no problem. I have sent an email to the author just before you posted the link and received an email back from the author of that paper just after I got the paper from the link above.

[demografx]

Wonderful, Muon!

[Quantum]

Ah ok, thanks Demo.

From our research friends:

“Sci-Hub is a great resource for this kind of thing:

https://sci-hub.se/10.1080/0092623x.2019.1677835

And for future reference: https://sci-hub.se/ “

Thanks for this free access link !

So, I have just read the whole article, and in my book, it is a confirmation that desensitization with autologous semen does not work, or at least, does not work in all of POIS cases  ( in fact, is there anyone that had lasting, significant results, with desens , ever ?  I am not aware of any case )

Also, this case report, with two control patients, confirm that skin prick test with own semen can be positive for ANY man, even when he does not have POIS.  Let's hope every POIS researchers, at last, will forget about skin prick tests !!!   And, hopefully, about the allergy theory.  So we can carry on to something new, and find useful relief for a majority of POIS sufferers.

[demografx]

Quantum, I passed along your post above to Drs. L&P

[certainlypois2]

Ah ok, thanks Demo.

From our research friends:

“Sci-Hub is a great resource for this kind of thing:

https://sci-hub.se/10.1080/0092623x.2019.1677835

And for future reference: https://sci-hub.se/ “

Thanks for this free access link !

So, I have just read the whole article, and in my book, it is a confirmation that desensitization with autologous semen does not work, or at least, does not work in all of POIS cases  ( in fact, is there anyone that had lasting, significant results, with desens , ever ?  I am not aware of any case )

Also, this case report, with two control patients, confirm that skin prick test with own semen can be positive for ANY man, even when he does not have POIS.  Let's hope every POIS researchers, at last, will forget about skin prick tests !!!   And, hopefully, about the allergy theory.  So we can carry on to something new, and find useful relief for a majority of POIS sufferers.

What were they saying about  NK cell subsets and activation markers.
All I understood was the result in pois patient is seen in some psychiatric problems.

[nanna1]

What were they saying about  NK cell subsets and activation markers.
All I understood was the result in pois patient is seen in some psychiatric problems.

They measured deficient (low) NK cells and B cells in the patient. These immune deficiencies are see in some psychiatric disorders.

[fidalgo]

"Therefore, etiology of POIS remains unclear."


"The patient was submitted to specific immunotherapy with transient clinical response and was referred to a psychologist but did not demonstrate clinical improvement of symptoms."

And how are we supposed to trust that this psychologist did the right thing? He could've just bombarded the guy with depression medications and therapy and then write him off as not improved.

Hi people!! I didn't know this post. I just see it right now. I'm the patient of this brazilian study, but I didn't read yet...

Abou what you say, Nas, I didn't use any medicantion. I was indicate to a psychologist, not a psychiatrist. In my opinion, a psychologist is very useful for POIS patients improve and understand the best ways to coexist with POIS. But Pois is not a psychologist condition, so is not a cure. But I think all people should go to a psycologist for some time; it is a very good thing.

[fidalgo]

The reported failure of psychological test is positive too, in a sense.  This is a way to say that there is, really, a biological, neurological, hormonal or immune cause, and it has to be found.    It is not "all in our head" ( even if it can be to some extent, and more in some cases than others), and if we find the physical/physiological aspects of the illness, we will ba able to get some relief for POIS sufferers.

The problem I have with this, is clumsiness. I think most of us have a bad experience with psychologists since they always write us off as not ill, or it's "all in your head".
A good psychological assessment should compare psychological/neurological symptoms with potential neurological factors.
For example when you have depression a psychiatrist would prescribe you an SSRI; assuming that you have low serotonin.
If you have ADHD he will prescribe you a DRI or a NRI. Assuming that these are also low.
In fact psychologists sometimes take genetic and serum tests to treat rare cases of treatment resisting depression.
In short a psychiatrist is not a therapist. He should always have a more accurate etiological assessment that should definitely give a better insight of the situation.
That's why I have a hard time believing he was assessed by the psychiatrist properly.

I am not sure, Nas, that the patient was evaluated by a psychiatrist.  The abstract talks about a psychologist  ( so not a MD that has specialized in psychiatry, but a psychotherapist.)

My guess is that they have tried a short term, behavioral therapy, with 10 to 20 sessions, probably one to two session a week for a few months.   It is not possible that the patient went through a 3 to 5 years analytic therapy, considering the scope of the article.

In fact, my therapy was a few months, I think six, one day per week. It was a gerat therapy, with a psychoanalytic aproach. I like it a lot and I think the therapy helps me to accept POIS like it is; we don't have a choice, so we have to live with it.... But the therapy is not a Pois treatment, only a help...

[demografx]

Hi, fidalgo

[Quantum]

The reported failure of psychological test is positive too, in a sense.  This is a way to say that there is, really, a biological, neurological, hormonal or immune cause, and it has to be found.    It is not "all in our head" ( even if it can be to some extent, and more in some cases than others), and if we find the physical/physiological aspects of the illness, we will ba able to get some relief for POIS sufferers.

The problem I have with this, is clumsiness. I think most of us have a bad experience with psychologists since they always write us off as not ill, or it's "all in your head".
A good psychological assessment should compare psychological/neurological symptoms with potential neurological factors.
For example when you have depression a psychiatrist would prescribe you an SSRI; assuming that you have low serotonin.
If you have ADHD he will prescribe you a DRI or a NRI. Assuming that these are also low.
In fact psychologists sometimes take genetic and serum tests to treat rare cases of treatment resisting depression.
In short a psychiatrist is not a therapist. He should always have a more accurate etiological assessment that should definitely give a better insight of the situation.
That's why I have a hard time believing he was assessed by the psychiatrist properly.

I am not sure, Nas, that the patient was evaluated by a psychiatrist.  The abstract talks about a psychologist  ( so not a MD that has specialized in psychiatry, but a psychotherapist.)

My guess is that they have tried a short term, behavioral therapy, with 10 to 20 sessions, probably one to two session a week for a few months.   It is not possible that the patient went through a 3 to 5 years analytic therapy, considering the scope of the article.

In fact, my therapy was a few months, I think six, one day per week. It was a gerat therapy, with a psychoanalytic aproach. I like it a lot and I think the therapy helps me to accept POIS like it is; we don't have a choice, so we have to live with it.... But the therapy is not a Pois treatment, only a help...

Thanks for the information, Fidalgo !

[Nas]

Thanks for the insight Fidalgo.
Can you update us on your condition? Are you POIS free at the moment? What regiment are you still taking to alleviate POIS? 

[demografx]

fidalgo: he is a Great example of our *early*
homegrown POIS Research donor/contributors!

Hi, fidalgo

I just gave $100.00 for the POIS fund and I will still be donating this amount for each of the next 12 months. I expect that I could give more in the next months, but this amount I guarantee.

I´m giving for POIS because this disease screw up my life and I know that, even that we have chance to descover a cure for our own, our chances will be a lot more with especialist researchs and methods.

I know that a lot of people here don´t have a lot of money but the situation isn't easy for no one. For me, in particular, is more expensive because brasilian coin has a half the value of dolar. Let´s go people, let´s donate.

THANK YOU, FIDALGO!!

fidalgo, your generosity is sloooooooooowly paying off!!


NIH is spending $41.46 billion in 2020 on medical research. And once we’ve published the current POIS study, our hope is to get funded by NIH!

And our current POIS scientific researchers are totally committed to help us get as far along as possible on this path TO A CURE.

Many thanks again!!
Demo

[fidalgo]

Thanks for the insight Fidalgo.
Can you update us on your condition? Are you POIS free at the moment? What regiment are you still taking to alleviate POIS?

No, I'm not POIS free.  I had a great improve in my symptons in the first year of the threatment but,  I dont know why,  the symptons come back.
The imunothetapy is the best improve I ever had with Pois,  but was temporary. I think there is something in imunotherapy related with POIS and must be studied.

For aleviate my POIS I use Nasonex and I make gargle with Water and Salt. I only have cold showers,  dont drink coffee,  and I avoid things that makes my POIS worst.

One thing that is not writen in that study is that my imunotherapy was made years ago. I dont remind the exact year, but, in the study say that was 25, and Iam now with 33, s? it must be 8 years...

So,  I dont indicate for anybody,  but,  what I've done in this years was imunotherapy by my self. I have the same results of the research: it works for some time, and then the symptons come back.... what I do is immunotheapy for an year, more and less,  when symptons turn back I stop the threatment. When the symptons turn back equal in the beginning of the threatment,  in 2 years, more less, I start the imunotherapy again...

This, what I do, it's too risky and I dont indicate for anybody. I only do it because I already know how my body answer the first threatment and,  even so, is risky.

[berlin1984]

No, I'm not POIS free.  I had a great improve in my symptons in the first year of the threatment but,  I dont know why,  the symptons come back.
The imunothetapy is the best improve I ever had with Pois,  but was temporary. I think there is something in imunotherapy related with POIS and must be studied.

So it is you who is mentioned in this thread here?

If yes maybe you could read that thread and give your input there :-)

[Muon]

No, I'm not POIS free.  I had a great improve in my symptons in the first year of the threatment but,  I dont know why,  the symptons come back.

Reminds me of MCAD patients who lose their response to their previous successful therapy.

I think there is something in imunotherapy related with POIS and must be studied.

I agree. Very difficult to find out, there are tons of immunomodulators in seminal fluid.

For aleviate my POIS I use Nasonex and I make gargle with Water and Salt. I only have cold showers,  dont drink coffee,  and I avoid things that makes my POIS worst.

It contains mometasone https://en.m.wikipedia.org/wiki/Mometasone

Fidalgo, did you ever had moments where you felt great shortly after a subcutaneous injection for a short time window but the effect didn't persist?

[fidalgo]

fidalgo: he is a Great example of our *early*
homegrown POIS Research donor/contributors!

Hi, fidalgo

I just gave $100.00 for the POIS fund and I will still be donating this amount for each of the next 12 months. I expect that I could give more in the next months, but this amount I guarantee.

I´m giving for POIS because this disease screw up my life and I know that, even that we have chance to descover a cure for our own, our chances will be a lot more with especialist researchs and methods.

I know that a lot of people here don´t have a lot of money but the situation isn't easy for no one. For me, in particular, is more expensive because brasilian coin has a half the value of dolar. Let´s go people, let´s donate.

THANK YOU, FIDALGO!!

fidalgo, your generosity is sloooooooooowly paying off!!


NIH is spending $41.46 billion in 2020 on medical research. And once we’ve published the current POIS study, our hope is to get funded by NIH!

And our current POIS scientific researchers are totally committed to help us get as far along as possible on this path TO A CURE.

Many thanks again!!
Demo

8 years ago... A lot of time!!!
Yes, it's very good t? have more researchs t? find a cure. It's very unlikely that we find a cure by ourselves. We need more POIS researchs...

[fidalgo]

No, I'm not POIS free.  I had a great improve in my symptons in the first year of the threatment but,  I dont know why,  the symptons come back.
The imunothetapy is the best improve I ever had with Pois,  but was temporary. I think there is something in imunotherapy related with POIS and must be studied.

So it is you who is mentioned in this thread here?

If yes maybe you could read that thread and give your input there :-)

I going to read, but I don't think I can give inputs about... I don't have knowleage about the subjetct... And, in fact, ether the professor who made the research with me have clues about that exams... We need t? know if all Pois patients have the same distortion i have...