2025 POIS SCIENTIFIC RESEARCH STUDY

[Progecitor]

Will they examine the semen for pathogens or anything in it that could cause an immunological reaction?

From Dr. Tierney K. Lorenz, Principal Investigator, NORD’s POIS Research Study:

“Not pathogens per se, but we will be looking in ejaculate for a variety of immune markers including pro-inflammatory cytokines. Also we will be keeping the ejaculate samples in cryogenic storage so if we get the funding to extend the study, we might be able to look at additional markers (such as specific pathogens) if it looks like those would be helpful later on.”

This is great to hear! However I hope that they will also check for pro-inflammatory cytokines in other samples and at the proper time as well, otherwise the results may be misleading. The POIS associated burning pain is a clear sign of the pro-inflammatory activity. However the ejaculate only causes a burning feeling in a number of occasions and not every time. The occurrence may be less than 50% and probably depends on other circumstances like what I have eaten or how much physical activity I have done in the previous days. Of course POIS would emerge regardless. Most often the deterioration is the most apparent about half to an hour after O, when the eyes get very bloodshot in just a few minutes. I think this would be the best time to check for markers in blood samples. If they consider urine samples then it should be best taken about 6-12 hours after O as that is the time when muscle pain begins to emerge more apparently and there is a very clear association between the muscle pain and the burning intensity of the urine.

[freuemich]

Will they be evaluating the participants' DAO (Diamine Oxidase) activity and histamine levels? I believe it's also important to determine if there is any overgrowth of harmful bacteria in the digestive system, as this can influence DAO activity and histamine levels.

I believe it is also important to perform a Urinary Catecholamines and Metabolites Test. Are they planning to do it?

[MisterM]

What's the latest on this study?  Do they need participants?  I've tried to reach out to the two doctors on twitter but only one takes DMs and I haven't heard back.

Basically looking for info on how to join or follow what is going on.  I know the University of Nebraska is involved, but can't find anything about it on the web.

[demografx]

What's the latest on this study?  Do they need participants?  I've tried to reach out to the two doctors on twitter but only one takes DMs and I haven't heard back.

Basically looking for info on how to join or follow what is going on.  I know the University of Nebraska is involved, but can't find anything about it on the web.

MisterM, we’re close but not yet recruiting. (POIS initial study/measurement/analysis will be conducted at UCLA in Los Angeles, the other University involved in the Study).

Follow this thread for more Study details:
https://poiscenter.com/forums/index.php?topic=3006.0

and
https://poiscenter.com/forums/index.php?topic=4624.0

[demografx]

Dr. Nicole Prause, co-Investigator,
NORD’s 2025 POIS Research Study


Dr Prause discusses Orgasmic Science,
what POIS (post-orgasmic illness syndrome) is, and the physiology of orgasm. From 3 yrs ago.

https://youtu.be/-26bW8Q3wyw

[sartre02]

@Demo : do you know if Dr prause or the other Dr. Lorenz, do online consultations? if so how can I contact them ?

[demografx]

@Demo : do you know if Dr prause or the other Dr. Lorenz, do online consultations? if so how can I contact them ?

I’ll ask.

[Progecitor]

Considering urine samples they should also check for isoprostanes, as it could be highly informative. It is rather unfortunate that I could not find any lab that measures this.

SLE patients have an enhanced urinary excretion of isoprostanes, the well established biomarkers of lipid peroxidation.
https://www.jbc.org/article/S0021-9258(20)74652-1/fulltext

[demografx]

Mary Roach, shown here delivering a 2015 presentation at TedX. Dr. Nicole Prause, our co-Investigator of the 2025 NORD POIS Research Study - - actually gave a talk with Mary Roach at the San Francisco Science Museum!

A TEDx Talk is to an international audience, showcasing well-formed ideas that inspire and provoke thought.

https://youtu.be/aK-zBBSqFV4?si=XhXMfoGG66ZHAaKE

Major takeaway points:

1. You cannot control it. It is involuntary.

Orgasm is a reflex of the autonomic nervous system. Now, this is the part of the nervous system that deals with the things that we don’t consciously control, like digestion, heart rate, and sexual arousal.

2. You don’t need genitals. The orgasm reflex can be triggered by a surprisingly broad range of input. The most curious one that she came across was a case report of a woman who had an orgasm every time she brushed her teeth.

3. You can have an orgasm after you die, by oxygenating the sacral nerve.

4. Orgasms can cause bad breath. Theodoor van De Velde was something of a “semen connoisseur.” He could smell the semen of a man on the breath of a woman. He even went so far as to differentiate between a young man’s semen, and an older man’s.

5. Orgasms can cure hiccups.

6. Doctors once prescribed orgasm for fertility. The contractions that a woman experiences during orgasm, can actually serve to suck up the semen from the cervix. It doesn’t have much of a success rate in humans but…

7. The up-suck method works very well in pigs. It is used to propagate pig farming.

8. Studying human orgasm in a lab can get very complicated. Masters and Johnson who set out to do this, had to perform various experiments in their labs that were highly uncomfortable. (They had to make a sex machine.)

9. 8 feet is the longest distance traveled by semen during ejaculation.

10. Men have an evolutionary excuse for frequent masturbation. Sperm that sit around in the body for a week or more start to develop abnormalities that make them less effective at head-banging their way into the egg. British sexologist Roy Levin has speculated that this is perhaps why men evolved to be such enthusiastic and frequent masturbators. He said, “If I keep tossing myself off I get fresh sperm being made.”

Orgasm is just science.

[carlo_francesco]

This is pretty good news. Thank you very much.

[demografx]

This is pretty good news. Thank you very much.

Thank you, Carlo!

[Gino]

WOW! The 'dream' expanded study is amazing news. Thank you to everyone involved and also to Eric who I just read was behind the addition funding!! I can't wait for the updates and for any clues we get on how to treat (or even cure) this horrible condition! The photos in the POIS Lab thread make this so tangible. 2025 is filled with optimism       https://poiscenter.com/forums/index.php?topic=4624.0

[demografx]

WOW! The 'dream' expanded study is amazing news. Thank you to everyone involved and also to Eric who I just read was behind the addition funding!! I can't wait for the updates and for any clues we get on how to treat (or even cure) this horrible condition! The photos in the POIS Lab thread make this so tangible. 2025 is filled with optimism       https://poiscenter.com/forums/index.php?topic=4624.0

Thank you, Gino!

And I’ll passalong your nice comments to Eric!

[demografx]

…The photos in the POIS Lab thread make this so tangible…

And thank you to Quantum for converting the lab photos to the forum’s graphic format and then displaying them prominently!

[FireLordSL]

Posted previously


VERY EXCITING 2025 POIS RESEARCH STUDY NEWS!

“Hey Demo,

My name's Eric and I've been a member of the forum for a while now.  I only learned about the UNL[&UCLA]/[NORD] study recently and decided to investigate.  After learning of a few deficiencies as a result of limited funding (they weren't going to look into delayed onset symptoms and other autoimmune/inflammatory biomarkers) I decided to get in contact with them to see how much funding they would require to expand their study to cover the things I thought were important.

I asked them to give me numbers for how much they would need for the basic additions I requested along with any other ones they could think of for their "dream" study.  They came back to me with some ideas which I thought were good.

I and my family's foundation have decided to fully fund the "dream" study!  Before I gave them the go ahead, I had asked Quantum if he knew any medical researchers in the forum I could contact.  That's why I'd gotten in touch with him prior.  Thanks again Quantum! 

I also reached out to an autoimmune researcher friend of mine for suggested expansions to the study and she gave me a few that Tierney [Dr Lorenz] and Nicole [Dr Prause] hadn't thought of so those might be added too.

The study will be tracking more inflammatory biomarkers, including delayed onset people, adding research assistants, larger sample size, etc.  I've been asked not to share their hypotheses or the study proposal so I can't share those details.  Suffice it to say, the study should be more comprehensive than before and hopefully allow for some real progress.

I'm personally deeply motivated to increase visibility and research for POIS (since it's taken away a lot of joy from my life).  This study seems like a great start.

Thanks for all your hard work organizing this study!  The funding is almost the easy part, I think what you did was incredible.  Hope you keep up your good work!

Thanks,
Eric”

Thank you, Eric!
Best wishes!
Demo

Demo, Is there a way to make a fund for the POIS members? Did anyone planned it before? If there is a transparent fund that everybody can donate, the money can be used to these type of studie and POIS promotions.
We have many members. Some are doing jobs and earning. Some are students. If everyone can donate 1$, there will be a significant amount of money that can be used for necessary tasks.

[demografx]

Demo, Is there a way to make a fund for the POIS members? Did anyone planned it before? If there is a transparent fund that everybody can donate, the money can be used to these type of studies and POIS promotions.
We have many members. Some are doing jobs and earning. Some are students. If everyone can donate 1$, there will be a significant amount of money that can be used for necessary tasks.

Yes, over many years, forum members have already contributed as much of their own - - and family - - money as possible to a POISCenter.com fund to pay for the 2025 POIS Research Study.

Please follow and support it any way you can.

[demografx]

Posted previously


VERY EXCITING 2025 POIS
SCIENTIFIC STUDY NEWS!

“Hey Demo,

My name's Eric and I've been a member of the forum for a while now.  I only learned about the UNL[&UCLA]/[NORD] study recently and decided to investigate.  After learning of a few deficiencies as a result of limited funding (they weren't going to look into delayed onset symptoms and other autoimmune/inflammatory biomarkers) I decided to get in contact with them to see how much funding they would require to expand their study to cover the things I thought were important.

I asked them to give me numbers for how much they would need for the basic additions I requested along with any other ones they could think of for their "dream" study.  They came back to me with some ideas which I thought were good.

I and my family's foundation have decided to fully fund the "dream" study!  Before I gave them the go ahead, I had asked Quantum if he knew any medical researchers in the forum I could contact.  That's why I'd gotten in touch with him prior.  Thanks again Quantum! 

I also reached out to an autoimmune researcher friend of mine for suggested expansions to the study and she gave me a few that Tierney [Dr Lorenz] and Nicole [Dr Prause] hadn't thought of so those might be added too.

The study will be tracking more inflammatory biomarkers, including delayed onset people, adding research assistants, larger sample size, etc.  I've been asked not to share their hypotheses or the study proposal so I can't share those details.  Suffice it to say, the study should be more comprehensive than before and hopefully allow for some real progress.

I'm personally deeply motivated to increase visibility and research for POIS (since it's taken away a lot of joy from my life).  This study seems like a great start.

Thanks for all your hard work organizing this study!  The funding is almost the easy part, I think what you did was incredible.  Hope you keep up your good work!

Thanks,
Eric”

Thank you, Eric!
Best wishes!
Demo

[demografx]

Some forum members have expressed difficulty in accessing the newspaper article link about our
POIS 2025 Scientific Research Study, so here is a text version of that article.



Crowdfunded grant will help UNL researcher study sex-related condition
      By CHRIS DUNKER Lincoln Journal Star






Dr. Tierney Lorenz, our
POISCenter-funded
Scientific Research Study
Principal Investigator


Hundreds of millions of dollars slated for research flow into the University of Nebraska-Lincoln each year from federal agencies like the National Science Foundation and the U.S. Department of Agriculture.
Multimillion-dollar research projects that center on creating new materials that will make computers even faster or to study drug addiction in rural areas are a large part of UNL's $308 million in research expenditures this year.
But there are also research grants that fly under the radar while also advancing understanding of the human condition.

Take a recent grant awarded to UNL researcher and assistant professor of psychology Tierney Lorenz from the National Organization of Rare Disorders [NORD] to study a little-known condition affecting men following ejaculation.
Through a crowdfunded grant totaling $31,000 [now augmented $ignificantly by a forum member’s Family Foundation - Demo] Lorenz and California-based neuroscientist and sex researcher Nicole Prause will study post-orgasmic illness syndrome, or POIS, the rapid onset of flu-like symptoms in men at the conclusion of sex.
"It's a fairly rare condition, and it hasn't gotten much clinical attention," Lorenz said of the disease, which is commonly marked by coughing and sneezing, sore throats and stuffy noses as well as other physical symptoms.
Some men have reported cognitive difficulties such as a loss of attention span or memory loss. Symptoms can last for a few hours or as long as a week, Lorenz added.

“It's not life-threatening in any way, but these guys can get pretty sick, and the flu can take a big chunk out of their life," she said.
An online community for men who suffer from the disorder raised the funds and worked with the nonprofit National Organization for Rare Disorders in asking for research proposals. Lorenz and Prause's study of the "Autonomic, endocrine, and immune mediators of post-orgasmic illness syndrome" was accepted earlier this year.
The researchers believe a better understanding of the disorder could further larger insight into the physiology of the human orgasm, which could improve sexual health for all, even those without the condition.

It also signals a new track of research at UNL. Lorenz, who just completed her first year on faculty, is the director of the Women, Immunity and Sexual Health lab, which studies how sexual behavior in women affects their immune and endocrine functions, while also providing help to survivors of sexual trauma through basic science and clinical research.
Lorenz, as well as Prause, previously conducted research at the Kinsey Institute at Indiana University Bloomington, where she studied the suppression of women's immune systems during ovulation -- an evolutionary change to prevent the immune system from attacking sperm cells or a zygote -- and whether sexual activity modulates that suppression.
She said the forthcoming POIS study, which will largely take place in Prause's lab in California, is a continuation of her work understanding the larger immune effects of the sexual response cycle.
"It's a really rare condition in which the whole system kind of goes haywire," Lorenz said, "but when we understand how something breaks down, it also helps us understand how it works.”






Dr. Nicole Prause
POISCenter-funded
NORD Study’s
co-Investigator



For those of you who haven’t seen the original announcement:


Our POIS Scientific Research Team

From NORD (National Organization for Rare Disorders):

Dear demografx,

We are very pleased to tell you that NORD's Medical Advisory Committee has selected the following POIS research project for funding:

Principal Investigator: Tierney Lorenz, PhD
Institution: University of Nebraska-Lincoln
Project Title:  Autonomic, endocrine, and immune mediators of Post-Orgasmic Illness Syndrome.

With funding from POISCenter.com

Congratulations!  We recognize that this has been a long journey for the POIS community and are so excited that this grant funding will be used to support Dr. Lorenz and her team in advancing the field of POIS research.

Research Administration
National Organization of Rare Disorders (NORD)






Dr. Tierney Lorenz, our Primary Investigator



Dr. Nicole Prause, our Co-Investigator




The POIS data will be collected at UCLA (University of California Los Angeles) in Los Angeles, but both Dr. Lorenz and Dr. Prause will be analyzing and reporting on it.

[demografx]

================================



We now - - finally - - have the green light for the 2025 POIS Scientific Research Study to begin piloting!

The first pilot will be soon - then full recruitment starts!
https://poiscenter.com/forums/index.php?topic=3006.0



Dr. Tierney K. Lorenz
Principal Investigator
**2025** POIS Scientific
Research Study



Dr. Nicole Prause
co-Investigator
POIS Scientific
Research Study

================================


Dr. Nicole Prause, co-investigator of our upcoming
POIS Scientific Research Study got a chance to talk a little POIS in this podcast!
https://youtu.be/ImsB_q-5IIM?feature=shared&t=2100




Please watch the above video to get a better idea of what’s coming soon with our upcoming
POIS Scientific Research Study!

Demo

[Aladin]

Are the Trump budget cuts in medical research gonna affect this long awaited study?