POIS NORD RESEARCH STUDY

[demografx]

I had a very pleasant meeting this morning with Dr. Nicole Prause,
POISCenter-funded 2022 NORD Study’s POIS researcher/co-Investigator
https://poiscenter.com/forums/index.php?topic=3006.0


As most of you know, our 2022 POIS Study lab work, directed by Dr Prause, has now been officially approved to be conducted by UCLA (University of California, Los Angeles).

*****With UCLA now as the POIS Study lab researcher, our study has much more prestige!

As Dr Prause indicates: “Two universities
[UCLA and UN-L (University of Nebraska - Lincoln)] make the NORD [POIS] study sound like a powerhouse. ” *****

I visited her POIS laboratory, which was very impressive, especially the computer systems. I even saw that the ejaculate-sample bottles had already arived for the POIS Study!
https://www.liberoscenter.com/



Dr. Tierney Lorenz,
our PI (Primary
POIS Investigator)

Wow, that must have been a really interesting visit! Thanks for keeping us all up to date on events, Demo.

Really interesting and…fascinating!

Thanks, hurray!

[demografx]

For those of you who are not aware that our original scope of study has expanded significantly
Demo

!

VERY EXCITING 2022 POIS RESEARCH NEWS!



“Hey Demo,

My name's Eric and I've been a member of the forum for a while now.  I only learned about the UNL [NORD] study recently and decided to investigate.  After learning of a few deficiencies as a result of limited funding (they weren't going to look into delayed onset symptoms and other autoimmune/inflammatory biomarkers) I decided to get in contact with them to see how much funding they would require to expand their study to cover the things I thought were important.

I asked them to give me numbers for how much they would need for the basic additions I requested along with any other ones they could think of for their "dream" study.  They came back to me with some ideas which I thought were good.

I and my family's foundation have decided to fully fund the "dream" study!  Before I gave them the go ahead, I had asked Quantum if he knew any medical researchers in the forum I could contact.  That's why I'd gotten in touch with him prior.  Thanks again Quantum! 

I also reached out to an autoimmune researcher friend of mine for suggested expansions to the study and she gave me a few that Tierney and Nicole hadn't thought of so those might be added too.

The study will be tracking more inflammatory biomarkers, including delayed onset people, adding research assistants, larger sample size, etc.  I've been asked not to share their hypotheses or the study proposal so I can't share those details.  Suffice it to say, the study should be more comprehensive than before and hopefully allow for some real progress.

I'm personally deeply motivated to increase visibility and research for POIS (since it's taken away a lot of joy from my life).  This study seems like a great start.

Thanks for all your hard work organizing this study!  The funding is almost the easy part, I think what you did was incredible.  Hope you keep up your good work!

Thanks,
Eric”

Thank you, Eric!
Best wishes!
Demo

[demografx]

==================================================
2022 POIS Research Study
======================================================

• funded by us at POISCenter:
https://poiscenter.com/forums/index.php?topic=3006.0


• For more recent POIS Study news:
https://poiscenter.com/forums/index.php?topic=3006.480

[demografx]

I really like Dr. Prause’s background and her focus on the changes orgasm has in our body. As I said before, I suspect the neurotransmitters released in the moments after the orgasm play a significant role in POIS, and probably something is not occurring as it should. The release of a "wrong" neurochemical cascade could result in POIS symptoms.

We should be encouraged for her previous studies and her knowledge about the brain response to orgasm.

Nice! I actually just gave a two hour interview about orgasm data yesterday (it does not release until September 2022).

Dr. Nicole Prause,
POISCenter-funded 2022 NORD Study’s POIS researcher/co-Investigator

[demografx]

I really like Dr. Prause’s background and her focus on the changes orgasm has in our body. As I said before, I suspect the neurotransmitters released in the moments after the orgasm play a significant role in POIS, and probably something is not occurring as it should. The release of a "wrong" neurochemical cascade could result in POIS symptoms.

We should be encouraged for her previous studies and her knowledge about the brain response to orgasm.

Nice! I actually just gave a two hour interview about orgasm data yesterday (it does not release until September 2022).

Dr. Nicole Prause,
POISCenter-funded 2022 NORD Study’s POIS researcher/co-Investigator

Well, looking forward to it in September!

[Disaster]

Hi guys, So when is this study finally starting? We lost so much valuable time on the 1st study and now many years because of the pandemic. But it seems like it?s been at least a year since the vaccines and things have opened up. Why did she only now just get the specimen holders? I feel like everything should have been prepared so that the second things opened up all the participant could get in there immediately. Also why are we doing only 1 study at a time? You know that no big organization has to pick or run these studies? I have been a part of many illness foundations and have seen how they pass out grants like it?s going out of style.

The only reason I haven?t started a foundation yet is because I am the sickest patient on here, I am bed bound going on 7 years. But I know there are many many old and new on here who are still working do living normal lives. All it takes is 1 of you to start the charity. Then we can have conferences where we get the sexual medicine doctors in the same room coming up idea to diagnose and treat us, like lorenzo?s oil, the movie. And we could have those same doctors collab on research and give presentation. Then when the doctor?s see the foundation they will take our illness more serious and realize there is potential funding if they do research. Instead I feel like we have all our eggs in 1 basket. And if you count that first study with the functional MRI, it?s a half a decade, hopefully not wasted if this results in anything,  but still if this is not started yet then how many more years are we looking at?

Last I want to point out that it is supposed to be a collab between the doctor in California and the Dr. in Texas. Could they have not just shifted the lab to Texas where Texas is much more lenient about COVID restrictions? I know you guys are trying to think positive about this but you have to admit it?s frustrating even more so for us then the current researchers because it?s the 2 research for us and the 1st on POIS for them. So it is twice as long for us for the same research funds.

I 2nd what Quantum says about you haters and complainers to start your own websites, reddit is not the same as your own website.  And about research then start a charity like I said and start doing it and less talk. I wish I could that?s why I push for it, but I?m not criticizing like you guys. Theses guys worked hard and did more than anyone so far! I appreciate their work and this forum. And without it we have next to nothing so thanks guys.

[Muon]

@Disaster
There are more MDs showing interest in doing a study. Do you have any suggestions/ideas for research?

[Quantum]

Hi guys, So when is this study finally starting? We lost so much valuable time on the 1st study and now many years because of the pandemic.

Hi Disaster,
We cannot say for sure, but my personal guess is that it should start this fall.  At any rate, if there is not a catastrophic worsening of the pandemic  ( and the war in Ukraine does not degenerate into World War III  ) , I think it should start before the end of 2022.  But as we have seen in the past, this is only a guestimate, so don't take this for granted.

[demografx]

I want to point out that it is supposed to be a collab between the doctor in California and the Dr. in Texas. Could they have not just shifted the lab to Texas where Texas is much more lenient about COVID restrictions?

There is no “Dr in Texas”.

[Disaster]

I want to point out that it is supposed to be a collab between the doctor in California and the Dr. in Texas. Could they have not just shifted the lab to Texas where Texas is much more lenient about COVID restrictions?

There is no “Dr in Texas”.

So Dr. Tierney Lorenz is not part of the study anymore? Wasn?t she in Texas when they first were chosen for the study? I see she is in Nebraska now, so then Nebraska and not Texas. Or am I confused and she was never part of the study? 

[demografx]

I want to point out that it is supposed to be a collab between the doctor in California and the Dr. in Texas. Could they have not just shifted the lab to Texas where Texas is much more lenient about COVID restrictions?

There is no “Dr in Texas”.

So Dr. Tierney Lorenz is not part of the study anymore? Wasn?t she in Texas when they first were chosen for the study? I see she is in Nebraska now, so then Nebraska and not Texas. Or am I confused and she was never part of the study? 

Nebraska.

Both Dr Lorenz (UN) & Dr Prause (UCLA) are originally from the famed sexual research organization at the
Kinsey Institute, Indiana


As a “refresher”, I have re-posted some 2022 POIS Research Study relevant info.
Demo

[Disaster]

The question still stands, not do the study in Nebraska where there are probably a lot less covid restrictions?

[demografx]

The question still stands, not do the study in Nebraska where there are probably a lot less covid restrictions?

It’s totally irrelevant.

There are no covid barriers to study POIS volunteers in Los Angeles. And it is totally impractical to
move 1,500 miles away (!) the POIS laboratory - - with all its equipment, employees, longstanding tenure, from Los Angeles to…Nebraska!!

And we have the added prestige (to Nebraska)  of lab work being initially conducted at UCLA! (University of California Los Angeles). And, as Dr. Prause indicates, 2 universities studying POIS makes the study sound like a powerhouse!

And Dr Lorenz’ co-investigator, Dr Prause, in Los Angeles, was selected because she is the best qualified teammate to have for the POIS Study.

[Disaster]

The question still stands, not do the study in Nebraska where there are probably a lot less covid restrictions?

It’s totally irrelevant.

There are no covid barriers to study POIS volunteers in Los Angeles. And it is totally impractical to
move 1,500 miles away (!) the POIS laboratory - - with all its equipment, employees, longstanding tenure, from Los Angeles to…Nebraska!!

And we have the added prestige (to Nebraska)  of lab work being initially conducted at UCLA! (University of California Los Angeles). And, as Dr. Prause indicates, 2 universities studying POIS makes the study sound like a powerhouse!

And Dr Lorenz’ co-investigator, Dr Prause, in Los Angeles, was selected because she is the best qualified teammate to have for the POIS Study.

#1 that makes no sense. you say,?there is no covid barrier in LA? when the whole delay is due to a covid barrier in LA. Every state has different covid restriction. California arguably has had the most 10.7 million COVID cases, the most in all of America that is why they have had come of the strictest laws regarding indoor activities among other reason. Nebraska on the other hand has had 515,000 cases which is 38th out of 50 states.

#2 You what are we talking about for moving lab equipment, are they building cruise ships? It?s probably a mater of loading the trunk of 1 car lol. As far as Employees again what are we talking about it? This POIS study is not paying for those employees salaries. They have other things they are doing and can still do and how many employees are we talking about. Again 100 employees or are we talking about maybe 1 lol?

#3 If you flip that around the ?Prestige? is still exactly the same man! A study done at U. of Nebraska in conjunction with UCLA. It?s the same exact thing man. Same Powerhouse! Same Co-investigators!

The difference is the study would be started, and finished by now.  Instead let?s be reactive and wait 3 more years.

[Limejuice]

We are working with the top researchers in the world, and we are lucky that they want to work with us. It doesn't need to be said - they dedicate they're life to this work and know what is best for our case. It would behoove us to listen, take their adivce, and learn from the best - not pretend to know more than them, continuously challenge/annoy them, and push them away from us. 

I only speak for myself (and not the community), but as a POISer I am stubborn, hard to deal with, terrible at relationships, and communication. I feel blessed that these experts want to work with me/us, especially after the last failed research attempt due to POIS instability.

[Disaster]

We are working with the top researchers in the world, and we are lucky that they want to work with us. It doesn't need to be said - they dedicate they're life to this work and know what is best for our case. It would behoove us to listen, take their adivce, and learn from the best - not pretend to know more than them, continuously challenge/annoy them, and push them away from us. 

I only speak for myself (and not the community), but as a POISer I am stubborn, hard to deal with, terrible at relationships, and communication. I feel blessed that these experts want to work with me/us, especially after the last failed research attempt due to POIS instability.

Kind of a ridiculous statement. No one said anything bad about the researchers to warrant such a statement. And studies don?t work like that. Just because some study on a disease fails no one stops researching it.

The pandemic and working around it is not something anyone has experience with. This is just a practical matter of location and timeframe, not a knock on the type of research or how good it will be. Instead of being defensive for no reason, just look at the logic of my statement. It would be the same exact research, with the same exact researchers, the same exact patients, only done by now and not delayed 2.5 years. That is just common sense, nothing more is needed to think about. In any situation it makes sense.

[demografx]

Some forum members have expressed difficulty in accessing the newspaper article  link about our POIS Research Study, so here is a text version of that article.



Crowdfunded grant will help UNL researcher study sex-related condition
      By CHRIS DUNKER Lincoln Journal Star




Dr. Tierney Lorenz, our
POISCenter-funded
Research Study 2022
Principal Investigator


Hundreds of millions of dollars slated for research flow into the University of Nebraska-Lincoln each year from federal agencies like the National Science Foundation and the U.S. Department of Agriculture.
Multimillion-dollar research projects that center on creating new materials that will make computers even faster or to study drug addiction in rural areas are a large part of UNL's $308 million in research expenditures this year.
But there are also research grants that fly under the radar while also advancing understanding of the human condition.

Take a recent grant awarded to UNL researcher and assistant professor of psychology Tierney Lorenz from the National Organization of Rare Disorders [NORD] to study a little-known condition affecting men following ejaculation.
Through a crowdfunded grant totaling $31,000, Lorenz and California-based neuroscientist and sex researcher Nicole Prause will study post-orgasmic illness syndrome, or POIS, the rapid onset of flu-like symptoms in men at the conclusion of sex.
"It's a fairly rare condition, and it hasn't gotten much clinical attention," Lorenz said of the disease, which is commonly marked by coughing and sneezing, sore throats and stuffy noses as well as other physical symptoms.
Some men have reported cognitive difficulties such as a loss of attention span or memory loss. Symptoms can last for a few hours or as long as a week, Lorenz added.

“It's not life-threatening in any way, but these guys can get pretty sick, and the flu can take a big chunk out of their life," she said.
An online community for men who suffer from the disorder raised the funds and worked with the nonprofit National Organization for Rare Disorders in asking for research proposals. Lorenz and Prause's study of the "Autonomic, endocrine, and immune mediators of post-orgasmic illness syndrome" was accepted earlier this year.
The researchers believe a better understanding of the disorder could further larger insight into the physiology of the human orgasm, which could improve sexual health for all, even those without the condition.

It also signals a new track of research at UNL. Lorenz, who just completed her first year on faculty, is the director of the Women, Immunity and Sexual Health lab, which studies how sexual behavior in women affects their immune and endocrine functions, while also providing help to survivors of sexual trauma through basic science and clinical research.
Lorenz, as well as Prause, previously conducted research at the Kinsey Institute at Indiana University Bloomington, where she studied the suppression of women's immune systems during ovulation -- an evolutionary change to prevent the immune system from attacking sperm cells or a zygote -- and whether sexual activity modulates that suppression.
She said the forthcoming POIS study, which will largely take place in Prause's lab in California, is a continuation of her work understanding the larger immune effects of the sexual response cycle.
"It's a really rare condition in which the whole system kind of goes haywire," Lorenz said, "but when we understand how something breaks down, it also helps us understand how it works.”






Dr. Nicole Prause
POISCenter-funded NORD Study’s researcher/co-Investigator



For those of you who haven’t seen the original announcement.


Our POIS Research Team


https://rarediseases.org/for-clinicians-and-researchers/research-opportunities/research-grant-recipients/
(See Research Grant Recipients)

From NORD:

Dear Demo,

We are very pleased to tell you that NORD's Medical Advisory Committee has selected the following POIS research project for funding:

Principal Investigator: Tierney Lorenz, PhD
Institution: University of Nebraska-Lincoln
Project Title:  Autonomic, endocrine, and immune mediators of Post-Orgasmic Illness Syndrome.

With funding from POISCenter.com

Congratulations!  We recognize that this has been a long journey for the POIS community and are so excited that this grant funding will be used to support Dr. Lorenz and her team in advancing the field of POIS research.

Research Administration
National Organization of Rare Disorders (NORD)





Dr. Tierney Lorenz, our Primary Investigator



Dr. Nicole Prause, our Co-Investigator




The POIS data will be collected at Dr. Prause’s lab (Liberos LLC) in Los Angeles, but both Dr. Lorenz and Dr. Prause will be analyzing it.
www.liberoscenter.com
In conjunction with UCLA

[demografx]

For those of you who are not aware that our original ($31,000) scope of study has ***expanded ($$$)*** significantly
Demo

!

VERY EXCITING 2022 POIS RESEARCH NEWS!



“Hey Demo,

My name's Eric and I've been a member of the forum for a while now.  I only learned about the UNL [NORD] study recently and decided to investigate.  After learning of a few deficiencies as a result of limited funding (they weren't going to look into delayed onset symptoms and other autoimmune/inflammatory biomarkers) I decided to get in contact with them to see how much funding they would require to expand their study to cover the things I thought were important.

I asked them to give me numbers for how much they would need for the basic additions I requested along with any other ones they could think of for their "dream" study.  They came back to me with some ideas which I thought were good.

I and my family's foundation have decided to fully fund the "dream" study!  Before I gave them the go ahead, I had asked Quantum if he knew any medical researchers in the forum I could contact.  That's why I'd gotten in touch with him prior.  Thanks again Quantum! 

I also reached out to an autoimmune researcher friend of mine for suggested expansions to the study and she gave me a few that Tierney and Nicole hadn't thought of so those might be added too.

The study will be tracking more inflammatory biomarkers, including delayed onset people, adding research assistants, larger sample size, etc.  I've been asked not to share their hypotheses or the study proposal so I can't share those details.  Suffice it to say, the study should be more comprehensive than before and hopefully allow for some real progress.

I'm personally deeply motivated to increase visibility and research for POIS (since it's taken away a lot of joy from my life).  This study seems like a great start.

Thanks for all your hard work organizing this study!  The funding is almost the easy part, I think what you did was incredible.  Hope you keep up your good work!

Thanks,
Eric”

Thank you, Eric!
Best wishes!
Demo

[demografx]

We are working with the top researchers in the world, and we are lucky that they want to work with us. It doesn't need to be said - they dedicate they're life to this work and know what is best for our case. It would behoove us to listen, take their adivce, and learn from the best - not pretend to know more than them, continuously challenge/annoy them, and push them away from us. 

I only speak for myself (and not the community), but as a POISer I am stubborn, hard to deal with, terrible at relationships, and communication. I feel blessed that these experts want to work with us, especially after the last failed research attempt due to POIS instability, which they are well aware of.

[Emphasis mine,
Demo]

Beautifully expressed sentiments!

[Kit]

I tried to participate in this study over 2 years ago and when I met one of the researchers, it seemed very off to me so I never pursued it. I have been malpracticed by Dr. I Goldstein, a doctor that this forum recommended (guy is highly irresponsible and is still being recommended by the forum, so who really wants to help who?). I really hope that members are being safe when participating in these studies, and I will fully support them if they feel that they have been harmed as a result of negligence or irresponsibility from the doctors or researchers that this forum is mentioning. I would also like admins to do the same. Mistakes happen, but irresponsibility, negligence, and intentional lies are different and should be held accountable. I just hope that members are able to find their relief method on time from people they can truly trust and the information they create so that they can pursue happier lives.