The POIS riddle can not only be solved by new research but also theoretically, based on existing knowledge, experiences and analyse results. I put far more hope in the latter then any new research. The outcome of mainstrem medical research will probably just be endless of years and after 20+ years, at best, a medicine that just hide symptoms and results in sideeffects like lower quality of life and shortened life time - just like 90% of all other pharmaceuticals. I strongly suggest that, parallell to this NORD research (that we obviously have zero influence over), we fundraise microprojects like booking appointments with, and presenting existing data for, hormonal experts. For example an evaluation at belgian doctor and world renomee hormonal expert Thierry Hertoge would cost around $600- $1000 including analyses. We must at least get experts like him to give their professional opinion on this disease and existing information.