Author Topic: 2025 POIS SCIENTIFIC RESEARCH STUDY  (Read 156607 times)

Progecitor

  • Sr. Member
  • ****
  • Posts: 405
  • Aphrodisiacs are effective
Re: POIS NORD RESEARCH STUDY
« Reply #620 on: December 09, 2024, 01:18:03 AM »

Will they examine the semen for pathogens or anything in it that could cause an immunological reaction?


From Dr. Tierney K. Lorenz, Principal Investigator, NORD’s POIS Research Study:

“Not pathogens per se, but we will be looking in ejaculate for a variety of immune markers including pro-inflammatory cytokines. Also we will be keeping the ejaculate samples in cryogenic storage so if we get the funding to extend the study, we might be able to look at additional markers (such as specific pathogens) if it looks like those would be helpful later on.”

This is great to hear! However I hope that they will also check for pro-inflammatory cytokines in other samples and at the proper time as well, otherwise the results may be misleading. The POIS associated burning pain is a clear sign of the pro-inflammatory activity. However the ejaculate only causes a burning feeling in a number of occasions and not every time. The occurrence may be less than 50% and probably depends on other circumstances like what I have eaten or how much physical activity I have done in the previous days. Of course POIS would emerge regardless. Most often the deterioration is the most apparent about half to an hour after O, when the eyes get very bloodshot in just a few minutes. I think this would be the best time to check for markers in blood samples. If they consider urine samples then it should be best taken about 6-12 hours after O as that is the time when muscle pain begins to emerge more apparently and there is a very clear association between the muscle pain and the burning intensity of the urine.
The cause is probably a combination of autoimmunity and SASP leading to excessive oxidative stress and lipid peroxidation. Antioxidants, testosterone, NO and norepinephrine boosters, ERbeta, sigma-1, SIRT-1 and dopamine agonists, PDE4, PDE5 inhibitors and CD36 antagonists are effective.

freuemich

  • Newbie
  • *
  • Posts: 4
Re: POIS NORD RESEARCH STUDY
« Reply #621 on: December 09, 2024, 08:44:23 PM »
Will they be evaluating the participants' DAO (Diamine Oxidase) activity and histamine levels? I believe it's also important to determine if there is any overgrowth of harmful bacteria in the digestive system, as this can influence DAO activity and histamine levels.

I believe it is also important to perform a Urinary Catecholamines and Metabolites Test. Are they planning to do it?
« Last Edit: December 09, 2024, 09:09:51 PM by freuemich »

MisterM

  • Newbie
  • *
  • Posts: 2
Re: POIS NORD RESEARCH STUDY
« Reply #622 on: December 20, 2024, 11:37:15 AM »
What's the latest on this study?  Do they need participants?  I've tried to reach out to the two doctors on twitter but only one takes DMs and I haven't heard back.

Basically looking for info on how to join or follow what is going on.  I know the University of Nebraska is involved, but can't find anything about it on the web.

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: POIS NORD RESEARCH STUDY
« Reply #623 on: December 20, 2024, 12:22:36 PM »

What's the latest on this study?  Do they need participants?  I've tried to reach out to the two doctors on twitter but only one takes DMs and I haven't heard back.

Basically looking for info on how to join or follow what is going on.  I know the University of Nebraska is involved, but can't find anything about it on the web.


MisterM, we’re close but not yet recruiting. (POIS initial study/measurement/analysis will be conducted at UCLA in Los Angeles, the other University involved in the Study).

Follow this thread for more Study details:
https://poiscenter.com/forums/index.php?topic=3006.0

and
https://poiscenter.com/forums/index.php?topic=4624.0
« Last Edit: December 20, 2024, 12:28:36 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: POIS NORD RESEARCH STUDY
« Reply #624 on: December 22, 2024, 03:17:06 PM »



Dr. Nicole Prause, co-Investigator,
NORD’s 2025 POIS Research Study



Dr Prause discusses Orgasmic Science,
what POIS (post-orgasmic illness syndrome) is, and the physiology of orgasm. From 3 yrs ago.

https://youtu.be/-26bW8Q3wyw
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

sartre02

  • Newbie
  • *
  • Posts: 27
Re: POIS NORD RESEARCH STUDY
« Reply #625 on: December 25, 2024, 07:03:43 PM »
@Demo : do you know if Dr prause or the other Dr. Lorenz, do online consultations? if so how can I contact them ?

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: POIS NORD RESEARCH STUDY
« Reply #626 on: December 25, 2024, 07:12:40 PM »

@Demo : do you know if Dr prause or the other Dr. Lorenz, do online consultations? if so how can I contact them ?


I’ll ask.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Progecitor

  • Sr. Member
  • ****
  • Posts: 405
  • Aphrodisiacs are effective
Re: POIS NORD RESEARCH STUDY
« Reply #627 on: December 26, 2024, 03:59:18 AM »
Considering urine samples they should also check for isoprostanes, as it could be highly informative. It is rather unfortunate that I could not find any lab that measures this.

SLE patients have an enhanced urinary excretion of isoprostanes, the well established biomarkers of lipid peroxidation.
https://www.jbc.org/article/S0021-9258(20)74652-1/fulltext
The cause is probably a combination of autoimmunity and SASP leading to excessive oxidative stress and lipid peroxidation. Antioxidants, testosterone, NO and norepinephrine boosters, ERbeta, sigma-1, SIRT-1 and dopamine agonists, PDE4, PDE5 inhibitors and CD36 antagonists are effective.

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: POIS NORD RESEARCH STUDY
« Reply #628 on: January 13, 2025, 01:05:17 PM »


Mary Roach, shown here delivering a 2015 presentation at TedX. Dr. Nicole Prause, our co-Investigator of the 2025 NORD POIS Research Study - - actually gave a talk with Mary Roach at the San Francisco Science Museum!

A TEDx Talk is to an international audience, showcasing well-formed ideas that inspire and provoke thought.

https://youtu.be/aK-zBBSqFV4?si=XhXMfoGG66ZHAaKE

Major takeaway points:

1. You cannot control it. It is involuntary.

Orgasm is a reflex of the autonomic nervous system. Now, this is the part of the nervous system that deals with the things that we don’t consciously control, like digestion, heart rate, and sexual arousal.

2. You don’t need genitals. The orgasm reflex can be triggered by a surprisingly broad range of input. The most curious one that she came across was a case report of a woman who had an orgasm every time she brushed her teeth.

3. You can have an orgasm after you die, by oxygenating the sacral nerve.

4. Orgasms can cause bad breath. Theodoor van De Velde was something of a “semen connoisseur.” He could smell the semen of a man on the breath of a woman. He even went so far as to differentiate between a young man’s semen, and an older man’s.

5. Orgasms can cure hiccups.

6. Doctors once prescribed orgasm for fertility. The contractions that a woman experiences during orgasm, can actually serve to suck up the semen from the cervix. It doesn’t have much of a success rate in humans but…

7. The up-suck method works very well in pigs. It is used to propagate pig farming.

8. Studying human orgasm in a lab can get very complicated. Masters and Johnson who set out to do this, had to perform various experiments in their labs that were highly uncomfortable. (They had to make a sex machine.)

9. 8 feet is the longest distance traveled by semen during ejaculation.

10. Men have an evolutionary excuse for frequent masturbation. Sperm that sit around in the body for a week or more start to develop abnormalities that make them less effective at head-banging their way into the egg. British sexologist Roy Levin has speculated that this is perhaps why men evolved to be such enthusiastic and frequent masturbators. He said, “If I keep tossing myself off I get fresh sperm being made.”

Orgasm is just science.
« Last Edit: January 13, 2025, 04:32:30 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

carlo_francesco

  • Newbie
  • *
  • Posts: 4
Re: POIS NORD RESEARCH STUDY
« Reply #629 on: January 31, 2025, 03:28:32 AM »
This is pretty good news. Thank you very much.

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: POIS NORD RESEARCH STUDY
« Reply #630 on: January 31, 2025, 01:04:48 PM »
This is pretty good news. Thank you very much.
Thank you, Carlo!
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Gino

  • Jr. Member
  • **
  • Posts: 60
Re: POIS NORD RESEARCH STUDY
« Reply #631 on: February 01, 2025, 02:15:16 AM »
WOW! The 'dream' expanded study is amazing news. Thank you to everyone involved and also to Eric who I just read was behind the addition funding!! I can't wait for the updates and for any clues we get on how to treat (or even cure) this horrible condition! The photos in the POIS Lab thread make this so tangible. 2025 is filled with optimism  ;D  :)   https://poiscenter.com/forums/index.php?topic=4624.0

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: POIS NORD RESEARCH STUDY
« Reply #632 on: February 01, 2025, 12:20:35 PM »

WOW! The 'dream' expanded study is amazing news. Thank you to everyone involved and also to Eric who I just read was behind the addition funding!! I can't wait for the updates and for any clues we get on how to treat (or even cure) this horrible condition! The photos in the POIS Lab thread make this so tangible. 2025 is filled with optimism  ;D  :)   https://poiscenter.com/forums/index.php?topic=4624.0


Thank you, Gino!

And I’ll passalong your nice comments to Eric! :)
« Last Edit: February 01, 2025, 12:46:11 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: POIS NORD RESEARCH STUDY
« Reply #633 on: February 01, 2025, 12:50:38 PM »

…The photos in the POIS Lab thread make this so tangible…


And thank you to Quantum for converting the lab photos to the forum’s graphic format and then displaying them prominently! :)
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: POIS NORD RESEARCH STUDY
« Reply #634 on: February 01, 2025, 01:14:32 PM »

Posted previously


VERY EXCITING 2025 POIS RESEARCH STUDY NEWS!

“Hey Demo,

My name's Eric and I've been a member of the forum for a while now.  I only learned about the UNL[&UCLA]/[NORD] study recently and decided to investigate.  After learning of a few deficiencies as a result of limited funding (they weren't going to look into delayed onset symptoms and other autoimmune/inflammatory biomarkers) I decided to get in contact with them to see how much funding they would require to expand their study to cover the things I thought were important.

I asked them to give me numbers for how much they would need for the basic additions I requested along with any other ones they could think of for their "dream" study.  They came back to me with some ideas which I thought were good.

I and my family's foundation have decided to fully fund the "dream" study!  Before I gave them the go ahead, I had asked Quantum if he knew any medical researchers in the forum I could contact.  That's why I'd gotten in touch with him prior.  Thanks again Quantum! 

I also reached out to an autoimmune researcher friend of mine for suggested expansions to the study and she gave me a few that Tierney [Dr Lorenz] and Nicole [Dr Prause] hadn't thought of so those might be added too.

The study will be tracking more inflammatory biomarkers, including delayed onset people, adding research assistants, larger sample size, etc.  I've been asked not to share their hypotheses or the study proposal so I can't share those details.  Suffice it to say, the study should be more comprehensive than before and hopefully allow for some real progress.

I'm personally deeply motivated to increase visibility and research for POIS (since it's taken away a lot of joy from my life).  This study seems like a great start.

Thanks for all your hard work organizing this study!  The funding is almost the easy part, I think what you did was incredible.  Hope you keep up your good work!

Thanks,
Eric”

Thank you, Eric!
Best wishes!
Demo
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

FireLordSL

  • Newbie
  • *
  • Posts: 8
Re: POIS NORD RESEARCH STUDY
« Reply #635 on: February 01, 2025, 02:15:40 PM »

Posted previously


VERY EXCITING 2025 POIS RESEARCH STUDY NEWS!

“Hey Demo,

My name's Eric and I've been a member of the forum for a while now.  I only learned about the UNL[&UCLA]/[NORD] study recently and decided to investigate.  After learning of a few deficiencies as a result of limited funding (they weren't going to look into delayed onset symptoms and other autoimmune/inflammatory biomarkers) I decided to get in contact with them to see how much funding they would require to expand their study to cover the things I thought were important.

I asked them to give me numbers for how much they would need for the basic additions I requested along with any other ones they could think of for their "dream" study.  They came back to me with some ideas which I thought were good.

I and my family's foundation have decided to fully fund the "dream" study!  Before I gave them the go ahead, I had asked Quantum if he knew any medical researchers in the forum I could contact.  That's why I'd gotten in touch with him prior.  Thanks again Quantum! 

I also reached out to an autoimmune researcher friend of mine for suggested expansions to the study and she gave me a few that Tierney [Dr Lorenz] and Nicole [Dr Prause] hadn't thought of so those might be added too.

The study will be tracking more inflammatory biomarkers, including delayed onset people, adding research assistants, larger sample size, etc.  I've been asked not to share their hypotheses or the study proposal so I can't share those details.  Suffice it to say, the study should be more comprehensive than before and hopefully allow for some real progress.

I'm personally deeply motivated to increase visibility and research for POIS (since it's taken away a lot of joy from my life).  This study seems like a great start.

Thanks for all your hard work organizing this study!  The funding is almost the easy part, I think what you did was incredible.  Hope you keep up your good work!

Thanks,
Eric”

Thank you, Eric!
Best wishes!
Demo

Demo, Is there a way to make a fund for the POIS members? Did anyone planned it before? If there is a transparent fund that everybody can donate, the money can be used to these type of studie and POIS promotions.
We have many members. Some are doing jobs and earning. Some are students. If everyone can donate 1$, there will be a significant amount of money that can be used for necessary tasks.

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: POIS NORD RESEARCH STUDY
« Reply #636 on: February 02, 2025, 12:52:59 PM »

Demo, Is there a way to make a fund for the POIS members? Did anyone planned it before? If there is a transparent fund that everybody can donate, the money can be used to these type of studies and POIS promotions.
We have many members. Some are doing jobs and earning. Some are students. If everyone can donate 1$, there will be a significant amount of money that can be used for necessary tasks.


Yes, over many years, forum members have already contributed as much of their own - - and family - - money as possible to a POISCenter.com fund to pay for the 2025 POIS Research Study.

Please follow and support it any way you can.
« Last Edit: February 03, 2025, 02:34:19 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
2025 POIS SCIENTIFIC RESEARCH STUDY
« Reply #637 on: Today at 03:05:19 PM »
Posted previously


VERY EXCITING 2025 POIS RESEARCH STUDY NEWS!

“Hey Demo,

My name's Eric and I've been a member of the forum for a while now.  I only learned about the UNL[&UCLA]/[NORD] study recently and decided to investigate.  After learning of a few deficiencies as a result of limited funding (they weren't going to look into delayed onset symptoms and other autoimmune/inflammatory biomarkers) I decided to get in contact with them to see how much funding they would require to expand their study to cover the things I thought were important.

I asked them to give me numbers for how much they would need for the basic additions I requested along with any other ones they could think of for their "dream" study.  They came back to me with some ideas which I thought were good.

I and my family's foundation have decided to fully fund the "dream" study!  Before I gave them the go ahead, I had asked Quantum if he knew any medical researchers in the forum I could contact.  That's why I'd gotten in touch with him prior.  Thanks again Quantum! 

I also reached out to an autoimmune researcher friend of mine for suggested expansions to the study and she gave me a few that Tierney [Dr Lorenz] and Nicole [Dr Prause] hadn't thought of so those might be added too.

The study will be tracking more inflammatory biomarkers, including delayed onset people, adding research assistants, larger sample size, etc.  I've been asked not to share their hypotheses or the study proposal so I can't share those details.  Suffice it to say, the study should be more comprehensive than before and hopefully allow for some real progress.

I'm personally deeply motivated to increase visibility and research for POIS (since it's taken away a lot of joy from my life).  This study seems like a great start.

Thanks for all your hard work organizing this study!  The funding is almost the easy part, I think what you did was incredible.  Hope you keep up your good work!

Thanks,
Eric”

Thank you, Eric!
Best wishes!
Demo
« Last Edit: Today at 03:50:05 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

  • Administrator
  • Hero Member
  • *****
  • Posts: 6454
  • All of us working together to defeat POIS!
Re: 2025 POIS SCIENTIFIC RESEARCH STUDY
« Reply #638 on: Today at 03:05:49 PM »
================================



We now - - finally - - have the green light for the 2025 POIS Research Study to begin piloting!

The first pilot will be soon - then full recruitment starts!

https://poiscenter.com/forums/index.php?topic=3006.0



Dr. Tierney K. Lorenz
Principal Investigator
POIS Research Study



Dr. Nicole Prause
co-Investigator
POIS Research Study

================================


Dr. Nicole Prause, co-investigator of our upcoming
POIS Research Study got a chance to talk a little POIS in this podcast!
https://youtu.be/ImsB_q-5IIM?feature=shared&t=2100




Please watch the above video to get a better idea of what’s coming soon with our upcoming
POIS Research Study!


Demo
« Last Edit: Today at 03:49:06 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business