Author Topic: POIS Theory Master List  (Read 425 times)

Muon

  • Hero Member
  • *****
  • Posts: 2263
    • MCAD Thread
POIS Theory Master List
« on: March 13, 2021, 04:07:11 PM »
Post theories regarding the Pathophysiology of POIS. This thread can function as a central hub. You may dump links to threads from other members in the comment section.

Rudimentary version

Adenylyl cyclase mediated mechanism: (1), (2)
Autoimmunity (G-protein coupled receptor autoantibodies, adrenergic receptor autoantibodies)
Autoinflammation (activation of inflammasome, Exosome-mediated inflammation)
Impaired Barrier function: (Epithelium/endothelium/BBB (VEGF, zonulin, occludin, claudins), leaky gut, ST2/IL-33 activation, leukocyte infiltration)   
(Central) sensitization
Cerebral blood flow: abnormal orgasm induced cerebral perfusion
Channelopathy
Cyclooxygenase/Arachidonic acid/PLA2/PLC mediated mechanism (Downstream effects)
Cytokines: Disordered profile, abnormal response
Damage-associated molecular pattern (AKA danger signals, alarmin): (ST2/IL-33 activation, Stress proteins)
Dysbiosis (Commensal): Gut microbiome, gut virome, loss of butyrate producing strains, Gut/Brain axis, Seminal proteome/microbiome
Dopaminergic hypofunction: low level, slow return to baseline, DA/DBH/NE metabolism. Loss of dopaminergic neurons.
Dysautonomia: Autonomic hyperreflexia, Sympathetic hyperactivity, abnormal output response to input
Endogenous opioid system disorder (Mu-opioid withdrawal)
Endothelial Dysfunction, (Regional) Vasomotor Dysfunction
Excitotoxin Syndrome
Hypersensitivity Type I, II, III, IV, V. (A48)
Hypogonadism
Limbic deregulation
Mast Cell Activation Syndrome (MCAS), Imbalanced Glia/Mast cell communication
(PI3K-Akt-)mTOR: Chronic activation
Mechanical, (1): Pinched (vagus) nerve, (cranio) cervical instability, Atlas Subluxation, nerve root irritation, brainstem compression
Metabolism: Catecholamines, Histamine (HNMT, DAO), NO/NOS/Arganine, Tryptophan.
Molecular mimicry
NAD+ or NAD+/NADH ratio: Low--> CD38/NAD+ axis signaling, IDO/TDO induced depletion of Tryptophan.
Neuroendocrine response: Different concentration vs time curves. Abnormal HPA response.
Neuroinflammatory disease (stress mediated + increased stress susceptibility)
Neurosensory disorder
Neurotransmitter profile (unique to POIS)
Neurotropic Virus Reactivation
Receptor over/under expression: CD38, CRH-R, alpha/betaAR, H1-4, mu-opioid, DAR.
ROS/antioxidant capacity ratio is off.
Small fiber neuropathy/dysfunction
Spinal Cord Injury
Synaptic Fatigue
Th1/Th2 imbalance
Transient Immune Deficiency
Tregs (self tolerance): Abnormal count, FOXP3+ expression or impaired IL-2/IL-10/TGF-b signaling.
Vagus nerve dysfunction/infection

What else?
« Last Edit: April 30, 2021, 05:02:29 PM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 2263
    • MCAD Thread
Re: POIS Theory Master List
« Reply #1 on: March 13, 2021, 04:07:56 PM »
Reminder: Some ideas might be left inside other threads like POIS paper treatment summary etc.
« Last Edit: April 22, 2021, 06:35:23 AM by Muon »

Muon

  • Hero Member
  • *****
  • Posts: 2263
    • MCAD Thread
Re: POIS Theory Master List
« Reply #2 on: March 13, 2021, 04:09:02 PM »
Reserved 2

Muon

  • Hero Member
  • *****
  • Posts: 2263
    • MCAD Thread
Re: POIS Theory Master List
« Reply #3 on: March 13, 2021, 04:10:24 PM »
Reserved final

Muon

  • Hero Member
  • *****
  • Posts: 2263
    • MCAD Thread
Re: POIS Theory Master List
« Reply #4 on: March 19, 2021, 07:42:34 AM »

Muon

  • Hero Member
  • *****
  • Posts: 2263
    • MCAD Thread
Re: POIS Theory Master List
« Reply #5 on: April 20, 2021, 07:23:55 AM »
Running nose and nasal congestion can be related to vasomotor dysfunction (ANS, endothelial dysfunction?) which is unrelated to allergy, people might not be aware of this:

Vasomotor rhinitis

https://en.wikipedia.org/wiki/Nonallergic_rhinitis

Muon

  • Hero Member
  • *****
  • Posts: 2263
    • MCAD Thread
Re: POIS Theory Master List
« Reply #6 on: April 22, 2021, 06:51:26 AM »
Fox:
Gluten sensitivity
Improves on Niacin rich food
Slight blood pooling upon standing (Sympathetic activation? Vasomotor function?)

I do remember that a certain subset of Tregs plays a role in gluten sensitivity, it was the CD39 subset if I'm not mistaken (paper needed for confirmation). Now throw Niacin into the mix and combine it with the following post, see pic: https://poiscenter.com/forums/index.php?topic=3765.msg40413#msg40413

Could Niacin intake affect Tryp/5HT pathway and improves vasomotor function, thus blood pooling?

What does Testosterone therapy have to do with this?---> T is able to increase Treg population directly. POISers who improved on antibiotics could have altered Treg populations. Treg increase can also be seen in some individuals who have done allergic desensitization therapy with succesful outcome (generally speaking that is, but could play a role in desensitized POISers). These points can be used to support MCAS theory as well. Tramadol--->Tregs?
« Last Edit: April 22, 2021, 09:43:32 AM by Muon »