2025 POIS SCIENTIFIC RESEARCH STUDY

[demografx]

NORD/POIS 2025 SCIENTIFIC RESEARCH STUDY

“For the study of post-orgasmic illness syndrome, with funding from POISCenter.com:
Tierney Lorenz, Ph.D., University of Nebraska-Lincoln (Lincoln, NE)
Principal Investigator
Autonomic, endocrine, and immune mediators of post-orgasmic illness syndrome

Dr. Nicole Prause, co-Investigator of our upcoming
***2025*** POIS Scientific Research Study got a chance to talk a little POIS in this podcast!
https://youtu.be/ImsB_q-5IIM?feature=shared&t=2100

Please watch the above video to get a better idea of what’s coming soon with our upcoming
POIS Scientific Research Study!
Demo


interviews Dr. Nicole Prause!

Dr. Nicole Prause
**2025** POIS Science Investigator
https://youtu.be/cEqe5dHuQYE?feature=shared&t=5464

VERY EXCITING 2025 POIS SCIENTIFIC RESEARCH NEWS!

“Hey Demo,

My name's Eric and I've been a member of the forum for a while now.  I only learned about the UNL [NORD] study recently and decided to investigate.  After learning of a few deficiencies as a result of limited funding (they weren't going to look into delayed onset symptoms and other autoimmune/inflammatory biomarkers) I decided to get in contact with them to see how much funding they would require to expand their study to cover the things I thought were important.

I asked them to give me numbers for how much they would need for the basic additions I requested along with any other ones they could think of for their "dream" study.  They came back to me with some ideas which I thought were good.

I and my family's foundation have decided to fully fund the "dream" study!  Before I gave them the go ahead, I had asked Quantum if he knew any medical researchers in the forum I could contact.  That's why I'd gotten in touch with him prior.  Thanks again Quantum! 

I also reached out to an autoimmune researcher friend of mine for suggested expansions to the study and she gave me a few that Tierney and Nicole hadn't thought of so those might be added too.

The study will be tracking more inflammatory biomarkers, including delayed onset people, adding research assistants, larger sample size, etc.  I've been asked not to share their hypotheses or the study proposal so I can't share those details.  Suffice it to say, the study should be more comprehensive than before and hopefully allow for some real progress.

I'm personally deeply motivated to increase visibility and research for POIS (since it's taken away a lot of joy from my life).  This study seems like a great start.

Thanks for all your hard work organizing this study!  The funding is almost the easy part, I think what you did was incredible.  Hope you keep up your good work!

Thanks,
Eric”

Thank you, Eric!
Best wishes!
Demo

[demografx]

Some forum members have expressed difficulty in accessing the newspaper article link about our
POIS 2025 Scientific Research Study, so here is a text version of that article.



Crowdfunded grant will help UNL researcher
[in 2025] study sex-related condition
      By CHRIS DUNKER Lincoln Journal Star






Dr. Tierney Lorenz, our
POISCenter-funded
Scientific Research Study
Principal Investigator


Hundreds of millions of dollars slated for research flow into the University of Nebraska-Lincoln each year from federal agencies like the National Science Foundation and the U.S. Department of Agriculture.
Multimillion-dollar research projects that center on creating new materials that will make computers even faster or to study drug addiction in rural areas are a large part of UNL's $308 million in research expenditures this year.
But there are also research grants that fly under the radar while also advancing understanding of the human condition.

Take a recent grant awarded to UNL researcher and assistant professor of psychology Tierney Lorenz from the National Organization of Rare Disorders [NORD] to study a little-known condition affecting men following ejaculation.
Through a crowdfunded grant totaling $31,000 [now augmented $ignificantly by a forum member’s Family Foundation - Demo] Lorenz and California-based neuroscientist and sex researcher Nicole Prause will study post-orgasmic illness syndrome, or POIS, the rapid onset of flu-like symptoms in men at the conclusion of sex.
"It's a fairly rare condition, and it hasn't gotten much clinical attention," Lorenz said of the disease, which is commonly marked by coughing and sneezing, sore throats and stuffy noses as well as other physical symptoms.
Some men have reported cognitive difficulties such as a loss of attention span or memory loss. Symptoms can last for a few hours or as long as a week, Lorenz added.

“It's not life-threatening in any way, but these guys can get pretty sick, and the flu can take a big chunk out of their life," she said.
An online community for men who suffer from the disorder raised the funds and worked with the nonprofit National Organization for Rare Disorders in asking for research proposals. Lorenz and Prause's study of the "Autonomic, endocrine, and immune mediators of post-orgasmic illness syndrome" was accepted earlier this year.
The researchers believe a better understanding of the disorder could further larger insight into the physiology of the human orgasm, which could improve sexual health for all, even those without the condition.

It also signals a new track of research at UNL. Lorenz, who just completed her first year on faculty, is the director of the Women, Immunity and Sexual Health lab, which studies how sexual behavior in women affects their immune and endocrine functions, while also providing help to survivors of sexual trauma through basic science and clinical research.
Lorenz, as well as Prause, previously conducted research at the Kinsey Institute at Indiana University Bloomington, where she studied the suppression of women's immune systems during ovulation -- an evolutionary change to prevent the immune system from attacking sperm cells or a zygote -- and whether sexual activity modulates that suppression.
She said the forthcoming POIS study, which will largely take place in Prause's lab in California, is a continuation of her work understanding the larger immune effects of the sexual response cycle.
"It's a really rare condition in which the whole system kind of goes haywire," Lorenz said, "but when we understand how something breaks down, it also helps us understand how it works.”






Dr. Nicole Prause
POISCenter-funded
NORD Study’s
co-Investigator



For those of you who haven’t seen the original announcement:


Our POIS 2025 Scientific Research Team

From NORD (National Organization for Rare Disorders):

Dear demografx,

We are very pleased to tell you that NORD's Medical Advisory Committee has selected the following POIS research project for funding:

Principal Investigator: Tierney Lorenz, PhD
Institution: University of Nebraska-Lincoln
Project Title:  Autonomic, endocrine, and immune mediators of Post-Orgasmic Illness Syndrome.

With funding from POISCenter.com

Congratulations!  We recognize that this has been a long journey for the POIS community and are so excited that this grant funding will be used to support Dr. Lorenz and her team in advancing the field of POIS research.

Research Administration
National Organization of Rare Disorders (NORD)






Dr. Tierney Lorenz, our Primary Investigator



Dr. Nicole Prause, our Co-Investigator




The POIS data will be collected at UCLA (University of California Los Angeles) in Los Angeles, but both Dr. Lorenz and Dr. Prause will be analyzing and reporting on it.









Dr. Tierney K. Lorenz
Principal Investigator
**2025** POIS
Scientific Research Study

To get an idea of her scientific-writing style, you can see it here! https://tinyurl.com/4vz755sh

Published in:

Published by:







It’s here! It all started here on February 18th, 2007, when forum member John21 posted at
our predecessor forum, the Naked Science Forum’s POIS thread.
https://tinyurl.com/3wpxsa6e

Soon to arrive in 2007 was forum member b_jim, with numerous contributions to aid the progress of POIS Research!

POIS forum “Oldtimers” include
(let me know if I missed YOU!!)
https://poiscenter.com/forums/index.php?topic=2892.0

• John21
• Animus
• demografx
• Daveman
• Observer
• certainlypois2
• b_jim
• Limejuice
• Defsync
• Vandemolen
• Gabin
• Bizzy
• hurray
• mellivora
• Starsky
• Habibou
• GoingLessCrazy
• Kurtosis
• B_Daniel


Then forum member Animus arrived, with the
most courageous journey ever in the history of POIS - - he concluded that surgically undergoing self-castration would cure his POIS.

And it did!

The Learning Channel's (TLC) feature TV presentation on Animus’ POIS:
https://m.youtube.com/watch?v=6sdaR18vw1s

You can also search “Animus” here at POISCenter or Naked Science Forum for more detailed information. Warning: this is a dangerous procedure, and scientifically unproven beyond the solitary experience of one member, Animus - - surgeons here wouldn’t do it, so he had to fly to India for the operation. At POISCenter, we have also looked at non-surgical ways to facilitate “dry orgasm”, which Animus attributes to his success.

We would all still be there at our old forum today, but the owner of the Naked Science Forum’s POIS thread would not allow us to conduct internal member fundrai$ing for what is now the
*2025* POIS Scientific Research Study:
https://poiscenter.com/forums/index.php?topic=3006.0

Million thanks, everyone - - old and new - - for making this the #1 forum on the internet for POIS!

I especially want to thank Quantum, my co-administrator, for being tremendously valuable and instrumental in raising greatly the level of scientific understanding & accomplishment - - including outreach to the medical community at large - in finding a solution to this misery we all call POIS!

And many, many thanks to our fellow administrators, Limejuice, and Berlin1984 for contributing their time - - and financial resources - - to this great commitment of ours: to stop POIS suffering!

Best wishes to everyone for a
Great Future in POIS-discovery through forum teamwork!

And a special thank you to Demo for organizing and leading our effort to cure POIS for the past 18 years! No easy feat especially when also battling POIS!

Thank you, Limejuice!

You’ve been teriffic!
Demo

[fernab]

Thank you Demo for updating us!

[demografx]

fernab, you’re quite welcome.

[demografx]

May 13 article: interview with Dr Nicole Prause, our POIS Study co-investigator:

Mentions our POIS Grant:
“We (Tierney Lorenz, PhD and I) also just received a grant to study post-orgasmic illness syndrome (POIS) from the non-profit National Organisation of Rare Disorders.”

https://tinyurl.com/yx8v6lu9

[demografx]

NORD/POIS RESEARCH STUDY UPDATE
From Dr Nicole Prause
May 8, 2019:
Hi Demo,
Dr. Lorenz and I received the pre-review from
the IRB [defined in IRB explanatory post above - Demo] just yesterday. We read the comments, and they appear very reasonable. That is, we expect that we can fully satisfy all of the questions. We have a meeting scheduled between the two of us next week to generate our response.
The full review remains scheduled for May 30th. The pre-review is just a chance to catch anything that the reviewer feels would have been likely to create questions during the full review to speed up the process.
Feel free to share this information.
NP

Everyone, please keep your fingers crossed (a proven scientific methodology ). Today is the FULL IRB REVIEW of our self-funded POIS study at University of Nebraska - Lincoln (UNL) & University of California, Los Angeles (UCLA) laboratory - L.A.

[fernab]

Crossing fingers!

Thank you for updating us Demo!

[demografx]

You’re welcome, fernab.

[demografx]

Great news! The IRB [defined earlier in an above post] discussed our researchers’ protocol and reviewed it favorably. They are requesting some minor modifications, and some clarification of the overall protocol. Those should take about 4 to 6 weeks to complete and be approved. Then, the grant will need to be put into the financial system, and they will need to hire a technician on site in Los Angeles. So, we are looking at a start date approximately 2 - 3 months from now. Longer than we would like to wait, but not the six months delay that we had feared.

They are very excited to get started!

They thank you all for your patience throughout this whole process, and your faith in the research team - they will do their best to make solid progress in understanding POIS and help those who are suffering.

[Quantum]

Thanks for the update, Demo !

The process follows its normal course.

[fernab]

Thank you Demo!.... yes we have to be very patient....no choice!

[demografx]

Thanks, Quantum and fernab. Patience is the perfect word: some of us here have been waiting for this moment for 12 years!

[demografx]

TV interview with Dr Nicole Prause, NORD’s POIS Study co-Investigator:

https://m.youtube.com/watch?v=a9324O7usS4

Her interviews, articles and videos are not presenting her ideas about POIS. That work is yet to come. They are presented to give you a better idea of her and her research/style of thinking.

Also keep in mind that Dr Tierney Lorenz (you can refer to her as Dr L) is the PI (Principal Investigator). However, Dr Prause’s work appears more often in popular/mass/news media, e.g., TV, radio, conferences, podcasts, magazine articles.

[demografx]

One further note on this subject: this study is a basic science investigation into the mechanisms that lead to POIS symptoms, not an intervention study. So Dr. Lorenz & Dr. Prause won’t have multiple recruitment sites (like you might see in a treatment study, where there are multiple clinical centers tracking different cohorts of patients). Just the one in Los Angeles, where they can use the very specialized testing center at Liberos, LLC.

Above is being re-posted here for the benefit of those who asked about a possible European site for studying POIS.

[demografx]

Published on Oct 26, 2017
Following a series of accusations of sexual harassment, disgraced Hollywood producer Harvey Weinstein has reportedly checked himself into rehab for sex addiction -- a condition that some medical experts doubt.

Dr. Nicole Prause - our new POIS Study Co-Investigator joins CBSN to discuss the validity of these claims.



https://m.youtube.com/watch?v=5wihRWBiz5s

[demografx]

Dr. Tierney Lorenz and Dr Nicole Prause have just sent their responses for the requested revisions to the IRB (IRB is defined again several posts down). Once they received them, they could respond with additional questions.

The POIS researchers expect/hope that they will have approval to begin the study (i.e., order equipment, program tasks, etc.) in the next few weeks.

Progress!

[Nas]

Anyone recruited yet?
Keep the names classified obviously, just want to know numbers?

[demografx]

No, Nas, not yet. They have an ad campaign prepared (confidential, we can’t see it yet).

And with Quantum’s help, we will reach out by email to all 800 members.

They will also approach other groups, e.g., Facebook. Feel free to alert them, I am not in touch with them.

[demografx]

Nas, good question. I’ll send them our post exchange here (about recruiting). Thanks again.

[demografx]

The Institutional Review Board (IRB) is an administrative body established to protect the rights and welfare of human research subjects recruited to participate in research activities conducted under the auspices of the institution with which it is affiliated.

In our case, it’s the UNL (University of Nebraska - Lincoln) IRB

Re-posted. The term “IRB” is used frequently.