Author Topic: Colm's 28 Month Trial with Vagus Nerve Stimulation  (Read 10142 times)

demografx

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #15 on: March 29, 2019, 04:07:28 PM »
Sadly, we didn’t get far enough to find out or ask :(
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Nas

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #16 on: March 29, 2019, 04:30:19 PM »
Sadly, we didn’t get far enough to find out or ask :(
Can you contact him? Since the research was canceled we didn't at least get updated on what's progressing or any findings if there were any. Maybe if we can hear out his logic, POISers would pursue vagus nerve treatment for themselvs like what COLM did.

demografx

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #17 on: March 29, 2019, 04:31:00 PM »
Anyway, regardless of premise, I and several others will continue to explore tVNS. If it came from “the man in the street”, sure, I wouldn’t bother. But it came from someone I consider a world-class-knowledgeable orgasm researcher with whom I met. And we developed a relationship.


« Last Edit: March 29, 2019, 04:42:58 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #18 on: March 29, 2019, 04:34:05 PM »
Sadly, we didn’t get far enough to find out or ask :(
Can you contact him? Since the research was canceled we didn't at least get updated on what's progressing or any findings if there were any. Maybe if we can hear out his logic, POISers would pursue vagus nerve treatment for themselves like what COLM did.
Keep in mind that ours was an extremely turbulent environment. I just heard back from him, but extremely briefly. It will take time to get over the incident. Any more discussion let’s please keep it private.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Nas

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #19 on: March 29, 2019, 04:46:54 PM »
Keep in mind that ours was an extremely turbulent environment. I just heard back from him, but extremely briefly. It will take time to get over the incident. Any more discussion let’s please keep it private.
I don't see what's the harm in asking him about the involvement of the vagus nerve in POIS. Because honestly I don't even know how to tack the vagus nerve issue. I have no idea how it connects to POIS.   

demografx

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #20 on: March 29, 2019, 05:01:30 PM »
Nas, you asked a good question about his premise. I ran a research company, but I’m not a researcher myself, so I trusted these people to approve his logic:
https://poiscenter.com/forums/index.php?topic=2462.msg21005#msg21005
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #21 on: March 29, 2019, 05:37:10 PM »
Nas, I sent you a private message.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Nas

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #22 on: March 29, 2019, 05:50:06 PM »
Nas, you asked a good question about his premise. I ran a research company, but I’m not a researcher myself, so I trusted these people to approve his logic:
https://poiscenter.com/forums/index.php?topic=2462.msg21005#msg21005
Well, then I want to know the logic they trusted him for? We need to understand the premise before jumping straight into therapy!

demografx

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #23 on: March 29, 2019, 07:31:35 PM »
Nas, I explained that in my private message, which includes re-contacting our medical advisors, which we cannot do directly. I’m hoping that, in time, as the negativity subsides with time, we can get you some more answers! :)
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

COLM_2

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #24 on: March 30, 2019, 07:00:59 AM »
Nas, I explained that in my private message, which includes re-contacting our medical advisors, which we cannot do directly. I’m hoping that, in time, as the negativity subsides with time, we can get you some more answers! :)
Hello Gents,

Please allow me to post further here on this topic as soon as I get to do a short update here. There are too many variables at play In POIS syndrome to become over enthuastic about tVNS being a cure.

Please let me write more later on the topic in recent discussion here.

Regards,
Colm
« Last Edit: March 30, 2019, 07:05:44 AM by COLM_2 »
Formerly user COLM (previous username accidentally deleted). Few decades with POIS.

COLM_2

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #25 on: April 01, 2019, 02:43:46 PM »

Colm:    ...this [Nervana] is an expensive device...

Demo:   Dr. Komisaruk’s is $5,000!


Hi Demo,

I think the reason for a Dr. K $5K VNS price point would as you know, just like the Feinstein institute device for arthritis, be related to those devices actually targeting specific Immune bio markers.

A General VNS stimulating device possibly just influences the nervous system and the parasympathetic nerves, in so as far as I can gather and understand.

Am open to correction as I’m not an expert.

Regards,
Colm

Colm, do you think it could be eventually worthwhile for POISCenter to raise $5,000 to experiment with a more targeted device, perhaps in tandem with what the new research team might find in the way of autonomic, endocrine and immune mediators of POIS?
Hi Demo,

Sorry for taking time to get back to this.

I think that further VNS testing with a more targeted VNS device is worth experimenting with. If an extra $5K was being raised, there is potential benefits in seeing where that is best spent, be it building upon the new NORD funded study, or else as a separate sub study. Several studies need to be evaluated and this could be one of them.

It makes most sense IMHO to be patient and see what the focus of the new study is entitled and what proposition is being focused on.

If I recall correctly, the original study that did not run its course was entitled “Is POIS a case of Vagal Dystonia”. Based on his evaluation of the forums RFP and forum outline content back then he felt Vagus nerve could be implicated.

As Dr. K was an orgasm expert and had zeroed in on the Vagus Nerve influences in POIS, it certainly makes sense not to forget the possibilities.  Dystonia however can’t easily be seen as part of all the POIS types.

One of the suggested treatments for dystonia is electrical stimulation of the auricular branch of the vagus nerve, in studies seen as being potentially effective.

Using (in a committed manner), an appropriate VNS device as a minimally invasive treatment for dystonia, could obviously help a person with Dystonia. This download here speaks about the technical aspects in using an Auricular approach to Vagus Nerve stimulation, with the condition of dystonia.

https://www.degruyter.com/downloadpdf/j/bmte.2013.58.issue-s1-A/bmt-2013-4033/bmt-2013-4033.pdf

All the best,
Colm
« Last Edit: April 01, 2019, 10:50:01 PM by demografx »
Formerly user COLM (previous username accidentally deleted). Few decades with POIS.

demografx

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #26 on: April 01, 2019, 05:09:16 PM »
Hi Colm,

Teriffic reply! I never considered that the $5,000 might possibly be better spent elsewhere.

I hope you saw my recent note about our investigators’ willingness to take the next step in obtaining *outside* funding for the next study! If that happens, raising $5,000 amongst ourselves will be more justifiable.

We could even raise tVNS fund$ from the *outside* world - - once we’ve established ourselves credibly with a scientific article in a well-known peer reviewed journal. What we’re doing now is the painful first step of a
self-funded study for a rare, unknown disorder such as ours in order to attain that outside funding credibility.

Once again, Colm, thank you greatly for continuing with a theory formulated by one of the brightest minds in scientific orgasm research!

Best,
Demo


« Last Edit: April 01, 2019, 09:09:53 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #27 on: May 08, 2019, 11:58:17 AM »
Hi, Colm,

Are you continuing to work with VNS?

Best
Demo
« Last Edit: May 08, 2019, 12:10:55 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

COLM_2

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #28 on: May 09, 2019, 03:53:26 PM »
Hi, Colm,

Are you continuing to work with VNS?

Best
Demo
Hi Demo,

Sorry for delayed reply here. Yes, I am still continuing the use of VNS,
as a key part of my POIS preventive and recovery strategy.

I will update on the thread here if anything else meaningful is worth another short update over the coming 6 months.

Regards,
Colm
Formerly user COLM (previous username accidentally deleted). Few decades with POIS.

demografx

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Re: Colm's 28 Month Trial with Vagus Nerve Stimulation
« Reply #29 on: May 09, 2019, 03:55:50 PM »
Thank you, COLM, for everything you’ve done here to help the POIS-eradication effort!

You’re #1 in my book.

Best,
Demo
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business