Author Topic: ANTI-INFLAMMATORIES THAT ITS BEEN SUGGESTED MIGHT HELP POIS  (Read 2156 times)

mellivora

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ANTI-INFLAMMATORIES THAT ITS BEEN SUGGESTED MIGHT HELP POIS
« on: January 06, 2012, 04:33:18 PM »
HERE IS THE PLACE TO POST RESEARCH INTO ANTI-INFLAMMATORIES THAT HAVE BEEN SUGGESTED MIGHT HELP POIS. SUCH SUGGESTIONS MAY BE FROM FORUM MEMBERS - EG. A MEMBER HAS BEEN EATING FOOD CONTAINING ANTI-INFLAMMATORIES OR TAKING THEM IN TABLETS AND THINKS IT MIGHT BE HELPING. (i.e. JUST BECAUSE IT HAS BEEN POSTED HERE DOESN'T MEAN IT DEFINITELY HELPS).

mellivora

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Re: ANTI-INFLAMMATORIES THAT ITS BEEN SUGGESTED MIGHT HELP POIS
« Reply #1 on: January 06, 2012, 04:36:21 PM »
Lee, S.J. et al (2003) Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation, Mol Cells 31;16(1):97-105

Abstract

Astaxanthin, a carotenoid without vitamin A activity, has shown anti-oxidant and anti-inflammatory activities; however, its molecular action and mechanism have not been elucidated. We examined in vitro and in vivo regulatory function of astaxanthin on production of nitric oxide (NO) and prostaglandin E2 (PGE2) as well as expression of inducible NO synthase (iNOS), cyclooxygenase-2, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta). Astaxanthin inhibited the expression or formation production of these proinflammatory mediators and cytokines in both lipopolysaccharide (LPS)-stimulated RAW264.7 cells and primary macrophages. Astaxanthin also suppressed the serum levels of NO, PGE2, TNF-alpha, and IL-1beta in LPS-administrated mice, and inhibited NF-kappaB activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS. This compound directly inhibited the intracellular accumulation of reactive oxygen species in LPS-stimulated RAW264.7 cells as well as H2O2-induced NF-kappaB activation and iNOS expression. Moreover, astaxanthin blocked nuclear translocation of NF-kappaB p65 subunit and I(kappa)B(alpha) degradation, which correlated with its inhibitory effect on I(kappa)B kinase (IKK) activity. These results suggest that astaxanthin, probably due to its antioxidant activity, inhibits the production of inflammatory mediators by blocking NF-kappaB activation and as a consequent suppression of IKK activity and I(kappa)B-alpha degradation.

http://www.ncbi.nlm.nih.gov/pubmed/14503852

mellivora

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Re: ANTI-INFLAMMATORIES THAT ITS BEEN SUGGESTED MIGHT HELP POIS
« Reply #2 on: January 20, 2012, 11:51:32 AM »