POIS Cause/Treatment Discussions > Investigation Areas

CNS inflammation and NSAID


Why don't NSAID relieve brain inflammation, in our case? Shouldn't that be an indicator that we don't have inflammation, rather something else?

Tylenol or paracetamol is reported to be the only possible Cox-3 which allows to cross brain barrier while others are only Cox-1 or 2.


Alleve should reduce inflammation, epsecially if taken beforehand to prevent the initial inflammatory response.

All NSAIDS can cross the blood brain barrier. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900635/

I'm not sure if COX-3 is relevant

My personal physician said "alleve is best", so I'll go with his word, but really any NSAID in sufficient dose should do, assuming inflammation is the underlying cause.


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