another aproach

[david]

what do you think about it ?
https://www.youtube.com/watch?v=VlllUlBFPUY

i can understand about toxins removal procedures but i can't imagine how does he remove herpes-like viruses
where there is no cure up to date for epstein bar virus for example ...


anyway i got similar thoughts decades ago
just imagine how much energy a human body would get if there were no viruses and no bacteria inside the body
and so all that energy was spent years to fight them released

p.s. i'v found many articles about so many cancer that was connected to epstein-bar virus
i guess most of the cancer are because of latent viruses being not treated for years in the body

[certainlypois2]

Highly suspicious.  How does he find the virus in all those locations without some serious surgery.
He is from Florida watch out 

[demografx]

He is from Florida watch out 

certainlypois2:

[david]

found something very interesting
wonna get big balls and became alpha ?
now its easy
just get yourself some Lactobacillus reuteri !
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084877

[Vandemolen]

Some say Reuteri reduces histamine, but others say it raises histamine. So to be sure I avoid it. Lactobacillus Casei and Lactobacillus bulgaricus are bad for histamine (raising histamine). Well from what I read on duth diet sites.

[david]

pre scriptum: i will keep posting here my new findings to not spray them across all forum threads


so my new theory is:
severe brain fog and mental fatigue is because of histamine release in brain and consequent release of prolactine
as you may know brain has many H2 and H3 histamine receptors
and so it affects brain functionality in a grater way by activating those receptors


here is the two studies i'v found that back up my thoughts:
https://www.ncbi.nlm.nih.gov/pubmed/2904722
https://www.ncbi.nlm.nih.gov/pubmed/6308490


recently i'v experienced some profound satisfactory feeling along with very big sleepiness like narcolepsy 
it was right after big O and just one day before my regular planned cabergoline intake
honestly i didnt have such feeling for long since i started my trt
so i'v got very profound satisfaction along with very profound sleep desire - very unexpected cuz it was during the day not in the evening
it was so strong that i went to sleep and slept for several hours
just before sleeping i ate my regular cabergoline 0.125 mg dose
after sleep i woke up and felt way better
so since then i corrected my cabergoline plan to administer it every 5 days not every 7 days




also next time i will get same narcolepsy state i will take levocetirizine(3d generation antihistamine h2 receptor blocker) to see if it will help ..........
unfortunately in my country H3 receptors blockers are restricted medicines and its not so easy to get them although it would help better i guess cuz h3 receptors are responsible for for wakefullness(the opposite to narcolepsy)
https://www.ncbi.nlm.nih.gov/pubmed/19413575




another way to get rid of sleepeiness after big o is to get some more orexines
https://www.ncbi.nlm.nih.gov/pubmed/11250867

[Nas]

I tried all three types of anti-histamines without success. If you can't find an H3 antagonist in your country, see if Betahistine is available.

[david]

I tried all three types of anti-histamines without success. If you can't find an H3 antagonist in your country, see if Betahistine is available.

we have Betahistine but i guess it is to fight dizziness not for wakefullness
did you try modafinil ? (unfortunately it is restricted in my country)

[Nas]

we have Betahistine but i guess it is to fight dizziness not for wakefullness
did you try modafinil ? (unfortunately it is restricted in my country)

No but I tried betahistine and it didn't work. Betahistine is an H3 receptor antagonist.

[Wolf berry]

I tried all three types of anti-histamines without success. If you can't find an H3 antagonist in your country, see if Betahistine is available.

we have Betahistine but i guess it is to fight dizziness not for wakefullness
did you try modafinil ? (unfortunately it is restricted in my country)

Don't take modafinil during pois episode it doesn't help in pois ( for me anyway, made me mania, nervous, made all pois symotoms worse take it outside of pois you will become limitless lol

[Wolf berry]

I tried all three types of anti-histamines without success. If you can't find an H3 antagonist in your country, see if Betahistine is available.

we have Betahistine but i guess it is to fight dizziness not for wakefullness
did you try modafinil ? (unfortunately it is restricted in my country)

Ritalin
Adderal
Modafinil
L-tyrosine
Drugs that increase dopamine doesn't help in POIS episode

It will make you jittery and after the drugs wear off you will feel 10x of pois symotoms at least for me.

[david]

I tried all three types of anti-histamines without success. If you can't find an H3 antagonist in your country, see if Betahistine is available.

we have Betahistine but i guess it is to fight dizziness not for wakefullness
did you try modafinil ? (unfortunately it is restricted in my country)

Ritalin
Adderal
Modafinil
L-tyrosine
Drugs that increase dopamine doesn't help in POIS episode

It will make you jittery and after the drugs wear off you will feel 10x of pois symotoms at least for me.

1.thanx to all for answers
2.I did try several times in different dosages(up to several grams) L-tyrosine and N-Acetyl-L-tyrosine(L-tyrosine version that can pass thru BBB) and felt absolutely Nothing, just nothing,
i guess it is strange so either i'm tolerant to this or i have enough dopamin

[david]

some news:

it is now 2 full months passed since i started real TRT (subQ testosterone injections)
i was trying different dosages every time to find my sweet spot and finally i did found
i feel great if i inject 24mg of testosterone cypionate every day
i checked it several times if i inject less them 21 i soon i start feeling not so energetic and mood became depressive
22mg and slight above gives me enough stamina and energy to do my workout
with less then 20 mg it is almost impossible to do workouts just absolutely no desire to even start it
also libido is great with 24mg

from the state where i am now i can say a year ago it was absolutely fantastic to have more then 4 orgasms a month(and even with having 4 it was a nightmare cuz of pois) and nowadays i'm having at least 15 and feel great

as you may already know i was struggling with low motivation since the very beginning of my pois battle in late 2018
and now it seems to me i finally won this battle too
recently i tried 2*300mg of NALT with 3*300mg of ALCAR along with 2*200mg Sulbutiamine
and i had quite decent motivation (btw libido is also stronger then usual )

will continue with testing it ... to get stable effect
motivation is very very important for me and for everybody i guess
although i have energy and stamina to do anything i need(after i started TRT) but ! i dont have enough motivation ... it is so stupid
i can do almost anything but i dont want to ! f..ck !

but i hope i found solution with increased dosages of NALT ALCAR and Sulbutiamine finally i felt decent motivation

also going to try Mucuna Pruriens cuz i found a lot of testimonials of it is more effective then NALT

wish me luck

[demografx]

Good luck, david! Many thanks for reporting!

[Nas]

Hey David, glad things are working out for you.
Did you take TRT based on low serum testosterone? It seems like POIS sufferers with low testosterone are having great success with TRT. Also how old are you?

[david]

Hey David, glad things are working out for you.
Did you take TRT based on low serum testosterone? It seems like POIS sufferers with low testosterone are having great success with TRT. Also how old are you?

here is my story:
https://poiscenter.com/forums/index.php?topic=2745.msg26043#msg26043
i did everything myself: research, test, bloodwork, test again, repeat...
i dont trust to any local docs- imho all of them just all are snobish  and ignorant persons who want your money only

15.11.2018 is my new birthday - it is the day i got my "testosterone honeymoon" started for a week - i felt myself like an almighty young god !!!
it was the best experience of my whole life. unfortunately it lasted for a week only
nowadays i experience it very rarely - only when i have big spike in my testosterone level and just for several hours ..
but any other day i feel like i'm for 80-90% from that godlike state and it is enough for a living good life

i still didnt do bloodwork since january to find out how much exactly my testosterone level is now but feeling much better i guess it is enough to just continue with my protocol

[Nas]

The problem is that my Testosterone is actually high since that I'm 21 and fairly young, so TRT would be bad for me. The involvement of testosterone is a weird one, because we really don't know how it works for us; we only know that it works.

[demografx]

True, Nas. The only thing that has “stuck” with me as to why TRT works for my POIS is the
anti-inflammatory aspect of TRT.

My theory (hypothesis) for a long time has been that the slow replenishment of semen causes my POIS and perhaps TRT speeds it up. I was much more enthusiastic about this years ago, not so much now at all.

[Vandemolen]

The problem is that my Testosterone is actually high since that I'm 21 and fairly young, so TRT would be bad for me. The involvement of testosterone is a weird one, because we really don't know how it works for us; we only know that it works.

On a Dutch website I read that a man has testosterone level 15 (should be at least 12) but because he had a lot low testosterone symptoms his doctor gave him Androgel. He was feeling better within a week and said it is like he has a whole new body. If someone is in the low normal range then a doctor can try it. But if is for example above 20 then I think no doctor will prescribe it. In relationship with POIS it is hard to say why it works for a few members here. A wild guess: maybe because testosterone brings down cortisol? But I am glad that it works for them. It would be interesting if more members with low testosterone would discuss it with their doctors. I am going to try it soon when I have an appointment with an internist. Otherwise I will go back to the urologist who treated me before I knew I had POIS. He was the one who sended me to dr. Waldinger. And this urologist has other POIS-patients.

[Nas]

On a Dutch website I read that a man has testosterone level 15 (should be at least 12) but because he had a lot low testosterone symptoms his doctor gave him Androgel. He was feeling better within a week and said it is like he has a whole new body. If someone is in the low normal range then a doctor can try it. But if is for example above 20 then I think no doctor will prescribe it. In relationship with POIS it is hard to say why it works for a few members here. A wild guess: maybe because testosterone brings down cortisol? But I am glad that it works for them. It would be interesting if more members with low testosterone would discuss it with their doctors. I am going to try it soon when I have an appointment with an internist. Otherwise I will go back to the urologist who treated me before I knew I had POIS. He was the one who sended me to dr. Waldinger. And this urologist has other POIS-patients.

Cortisol is not known for its inhibition of neurotransmitters that is seen in POIS and especially in me. Chronic cortisol could lead to brain damage but only in the long term and not as instant as in POIS. There are ways to inhibit cortisol by inhibiting androgen syntheses, however that'll also result in lower testosterone.

One other thing concerning cortisol that I've been thinking about is the involvement of fungal infection when it comes to ergosterol syntheses. Could there be an interference relationship between candida metabolism and human metabolism that causes some sort of endocrine dysfunction? Sounds unrelated to POIS though, so IDK.