Since Waldinger's paper was ever published, POIS was associated with immune activity, and the side effects were seen as caused by inflammation. How ever no has consistently treated his POIS symptoms by taking NSAID's. NSAID's are the first method of reducing inflammation all over the body since it inhibits the expression of COX 1-2 which are the major enzymes the body uses for the formation of Prostaglandins, this should've made, at least, some remedy to the symptoms, but at least in my case, it didn't. I also investigated the role of histamine without any success. One other point is that many of us who did MRI's in the brain, did not find any observable swelling. Thus any approach is proposed, in that instead of looking at the cognitive symptoms as a result/symptom of POIS. We could perhaps consider it as the main issue around POIS. Or perhaps to be more precise, it is a type of POIS where they immune activity is instigated by hormone depletion instead of the other way around. Which makes more sense, since the brain is quite far from the genital region to be directly affected by it if you ask me.
This thread could be potentially be a deeper investigation to Catecholamines deficiency theory.
I'll start the first topic with this article:
Are you suffering from The Blahs? This article is well written and articulates many observable phenomena that have been discovered in this forum.
"Dopamine, Epinephrine (adrenaline) and Norepinephrine (noradrenaline) are the primary catecholamines or ?cats?, as they are known. Catecholamines function both as hormones and neurotransmitters.""If you have adequate cats, you feel energized, upbeat, alert and focused and you don?t crave caffeine or sugar for a pick-me-up.
If your cats are low, you may feel the kind of depression that lands you curled up in the bed all day with extremely low motivation."If you ask me I have strong cravings for coffee and sugar when I'm in POIS which could be an indication of low dopamine, it can also explain what it actually helps with POIS.
"These are typical symptoms of people suffering from low cats:
- Trouble dragging yourself out of bed
- Inability to motivate yourself
- Feelings of worthlessness
- Feelings of hopelessness
- May lose temper for minor reasons
- Inability to handle stress
- Not enough focus or concentration
- Numb-feeling emotionally
- Lack of energy
- Craving carbs, alcohol, caffeine or drugs for energy
- Procrastination and indecisiveness
- Apathy
- Easily bored
- Attention Deficit Disorder diagnosis
- Reluctant to socialize, desire to be alone
- Lack of concern for family and friends"I feel these are very accurate to what I feel right after orgasm, it does not mention difficulty speaking, trouble doing day to day jobs and bad short term memory.
"What can Deplete Catecholamines?
- Chronic stress over time or acute stress during a crisis
- Genetic anomaly?some people have a genetic tendency toward low cats
- Chronic dieting with low calorie or high carb diets
- Low protein intake
- Sedentary lifestyle
- Low estrogen or testosterone
- Uncontrolled blood sugar
- Iron anemia"Note
Low estrogen or testosterone and
Iron anemia these are two phenomena that have been discussed in this forum.
"These steps will allow your body and brain to receive the nutrients needed to make the neurotransmitters it needs to function optimally"
- Improve your stomach acid levels to properly digest and allow your body to use the nutrients you eat.
- Eat plenty of healthy fats and especially protein. Avoid these cooking oils and use plenty of these oils.
- Increase your Omega-3 essential fatty acid intake. A simple test can detect your current levels.
- Check your Vitamin D levels and supplement where needed. Vitamin D directs the conversion of tyrosine to cats.
- Ditch processed foods and enjoy lots of whole, organic food.
- Drink plenty of clean water.
- Eat fermented foods that are rich in probiotics.
- Good sources of catecholamine-rich foods are beef, fish and eggs. Americans who are not vegetarians/vegans typically consume plenty of these foods.
- Start slow with exercise. Try yoga, tai chi or meditation. Or simply take a walk.
- Consider amino acid and other supplements once your healthy nutrition is in place."Again, these which are in
bold, are all discussed in this forum in detail.
Now to the supplements part, the Article proposes the following supplements:
- Tyrosine
- Phenylalanine
- Beta-Phenylethylamine (PEA)
- SAMe
- mucuna pruriens
- Blueberry Extract
- Alpha Lipoic Acid, Selenium and N-acetyl-cysteine
Notable comments on these supplements:
Talking about Tyrosine:
"These important nutrients are cofactors used in the conversion of tyrosine: Folate, Niacin, Vitamin C, Copper and SAMe. In other words, you need these to make tyrosine convert into the catecholamines."See
Folate,
Niacin and
SAMe are the most successful remedies that have been tested in this forum.
Talking about Phenylalanine:
"Phenylalanine metabolism requires the following cofactors: Vitamin B6 (P5P), Niacin, Vitamin C, Copper, SAMe, Iron and Folate."Again these in bold were all discussed in this forum.
