Post Orgasmic Illness Syndrome (P.O.I.S.)
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+  Post Orgasmic Illness Syndrome (P.O.I.S.)
|-+  POIS Cause/Treatment Discussions
| |-+  Hormonal Causes and Treatments
| | |-+  Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
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: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms  ( 1802 )
Nas
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« #15 : February 09, 2019, 09:34:06 PM »

I spent a while trying dopamine-related medications, hoping that they could alleviate my POIS:

piracetam
l-tyrosine
selegiline
wellbutrin
cabergoline
modafinil
Adderal
Caffeine

There's probably a bunch more that I can't remember right now, most were a number of years ago.

They didn't ultimately do much for me, although in some cases they gave my brain a boost when I was out of POIS.

I'm currently taking Ritalin, with the help of my psychiatrist (40mg/day). This has been the most useful medicine so far by some distance, but for me it doesn't prevent or cure POIS.

I'm not suggesting that there isn't a link between POIS and dopamine, but various dopaminergic drugs didn't feel like they were doing much to fight my POIS. I would be very interested to see somebody reporting long-term success with this class of drugs, I believed for years that dopamine was the key to the POIS mystery.

it can make you mania without cognitive improvement!

All the best, Wolf berry
Good to know, I haven't tried them yet and I feel pessimistic about their function. This is largely and indicator that it's not dopamine that is responsible, especially when it gives you mania without improving Cognitive symptoms. Any idea on what it could be otherwise? Something that could also potentially be involved in the HPA axis?
Nas
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« #16 : February 11, 2019, 02:01:39 PM »

Took L-Dopa yesterday. Surprisingly, I also had an orgasm that day. I took L-Dopa the first time and it was a good experience, I recommend it if you're suffering from anxiety and trouble focusing. However, its effect was not fundamental. When I had orgasm that day the symptoms arose with the same intensity. I took L-Dopa again after that and it also didn't do much. I later took B-comlex (B1-B6-B12) and it seems to work well with L-Dopa to increase relaxation. Yet I also recommend to have an anti-emetic with L-Dopa or any non-specific dopamine booster to avoid nausea. Overall it doesn't seem very promising for the catecholamines theory. 
Wolf berry
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Should try Chinese wolf berry it cured my POIS


« #17 : February 11, 2019, 06:11:18 PM »

Took L-Dopa yesterday. Surprisingly, I also had an orgasm that day. I took L-Dopa the first time and it was a good experience, I recommend it if you're suffering from anxiety and trouble focusing. However, its effect was not fundamental. When I had orgasm that day the symptoms arose with the same intensity. I took L-Dopa again after that and it also didn't do much. I later took B-comlex (B1-B6-B12) and it seems to work well with L-Dopa to increase relaxation. Yet I also recommend to have an anti-emetic with L-Dopa or any non-specific dopamine booster to avoid nausea. Overall it doesn't seem very promising for the catecholamines theory.

Vitamins B's play several role in the body including being important  to brain functions and energy.  It has been tried by several members with good results. Some of the theories behind the success of vitamin Bs are they help replenish brain neurotransmitters, they replace something lost after ejaculation and they help reduce excess histamine produced by the body.
 
quote by Edorgon
Yeah, I too have noticed that although B vitamins are really effective for getting my energy, blood flow and mental function up, after about a week they begin to cause an absolutely crushing fatigue. I don't know what to do about it. I'm thinking of just kind of scaling back how often i use them.

Has anyone else had this problem and, if so, how'd you fix it?

Quote by UnderstandingPois
he effects i get from taking a multivitamin is. Irritablness , feel crappy cant think at all or use personality trait thoughts. Severe depression. Everythings looks duller and is so bright and bothers me. No emotion . No energy . I noticed while taking it waayy harder to control urge of orgasm. Cause of all the awfullness and depression. Basically feel like hell. And i cannot believe one multivitamin does all that to me without adderall. And so much more horrible stuff like no socializing at all. Will stay away from people. Crushes personality completely. In every way it makes me sick and dead.  Cant proccess or understand things at all really very hard. Have to reread and reread to understand. My pois started when i hit puberty. And around the same time i started taking multivitamins and vitamins. So if that long i was taking them for and how i feel crappy just taking one multivitamin. Im so sure for me that thats what that chalky white stuff was , build up. First time my condition improved was when i was taking supplements and prozac n others and i had a orgasm and pop i felt in my head and all this chalky stuff came out for a long time in a big matter.  I cant ever imagine going thrue pois ever again. Its the definition of hell.  Im so glad those days are over. Yearsn years. Hope maybe this
 will benefit someone?

Qoute by Daveman
Hey UnderstandingPois,

Long time!

Glad you're feeling better. I agree about the multi-vitamins. At one point I started taking multi-vits and they made things WAY worse. Like maybe 5 times worse. I guess that's why I was surprised that just niacin, and/or the B vitamins worked so well. With niacin, I'm like you, no POIS!

Kurtosis said it not too long ago, POIS is a little different for each person, yet the "broken system" is the same for everybody. It's just what part of it is broken and how that makes the difference.

It seems to me for instance that Adderall doesn't work for many, nor does niacin work for all. So it's still vital to get to the bottom of all of this.

The important is that you are POIS free, and "chalky stuff free" too!

it?s been only 1 day and you say it help your pois symptoms

All the Best, Wolf Berry
Nas
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« #18 : February 11, 2019, 07:40:32 PM »



The important is that you are POIS free, and "chalky stuff free" too!

it?s been only 1 day and you say it help your pois symptoms

All the Best, Wolf Berry
I don't think you understood what I said, it did not make me POIS free it only had minor relaxing effect, and taking Neurobine with it seems to make it better. But if we truly had catecholamines depletion I kind of expect a fundamental change, and it didn't bring me that change.
koko
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« #19 : February 14, 2019, 03:40:57 AM »

A month later I took a dopamine agonist with a name drug is "Requip 2 mg". Unfortunately, the drug did not have any effect on the symptoms. I asked my doctor to try to increase the dosage of the agonist for dopamine but thought it unnecessary and prescribed more psychiatric drugs instead of dopamine. The agony is still in my life
Nas
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« #20 : February 14, 2019, 01:32:56 PM »

A month later I took a dopamine agonist with a name drug is "Requip 2 mg". Unfortunately, the drug did not have any effect on the symptoms. I asked my doctor to try to increase the dosage of the agonist for dopamine but thought it unnecessary and prescribed more psychiatric drugs instead of dopamine. The agony is still in my life
I personally took an L-Dopa supplement plus vitamin B complex, this way you increase your base dopamine metabolism. If you're already depleted stimulating the receptors won't help. Plus always have an anti-emetic with you if you're messing with dopamine. Overall for me it does help, but it's not fundamental; it does not stop POIS.
hurray
Lab1
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« #21 : March 16, 2019, 05:50:39 PM »

I personally took an L-Dopa supplement plus vitamin B complex, this way you increase your base dopamine metabolism. If you're already depleted stimulating the receptors won't help. Plus always have an anti-emetic with you if you're messing with dopamine. Overall for me it does help, but it's not fundamental; it does not stop POIS.

An interesting article Nas. Some of the dopamine-related medication I have tried has had a useful stimulating effect outside of POIS. However, inside POIS they were ineffective at best, and they didn't do anything to prevent the onset of POIS.

I haven't tried L-DOPA, but it seems like an interesting supplement. The pharmaceutical L-DOPA that is prescribed to Parkinson's sufferers is usually combined with another drug such as carbidopa:

https://en.wikipedia.org/wiki/Carbidopa/levodopa

Quote
Levodopa is converted to dopamine via the action of a naturally occurring enzyme called DOPA decarboxylase. This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier. Activation of central dopamine receptors improves the symptoms of Parkinson's disease; however, activation of peripheral dopamine receptors causes nausea and vomiting. For this reason levodopa is usually administered in combination with a DOPA decarboxylase inhibitor (DDCI), in this case carbidopa, which is very polar (and charged at physiologic pH) and cannot cross the blood brain barrier, however prevents peripheral conversion of levodopa to dopamine and thereby reduces the unwanted peripheral side effects of levodopa. Use of carbidopa also increases the quantity of levodopa in the bloodstream that is available to enter the brain.

I wonder if this form of L-DOPA would be more effective for POIS sufferers than the supplements? Of course, carbidopa/levodopa could only be taken after a consultation with your doctor.

b_jim
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« #22 : March 17, 2019, 10:54:04 AM »

You should have a look of definition of :
serotonin syndrome
Symptoms match with my Pois symptoms.
I really wonder if a possible high level of serotonin/tryptophan could be the cause.

Anticholinergic symptom is another possible way to explore and it is linked itself to dopamine.

What science says ?
5gr of tryptophan can create "minor disorders" : drowness, headaches, acne, tachycardia, nausea. 5gr is huge much more what we found in a normal diet .

I will try again to take a source of tryptophan (pumpkin seeds) and sugar before orgasm.

 
« : March 17, 2019, 11:20:34 AM b_jim »

Taurine = Anti-Pois
Vandemolen
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« #23 : March 17, 2019, 11:12:17 AM »

You should have a look of definition of :
serotonin syndrome
Symptoms match with my Pois symptoms.
I really wonder if a possible high level of serotonin/tryptophan could be the cause.

Anticholinergic symptom is another possible way to explore and it is linked itself to dopamine.
A good way to check high serotonin is 5HIAA in 24 hours urine. High serotonine can be caused by a few things, including serotonin syndrom and carnoid tumors. Before this urine test you can not eat: bananas, tomatoes, avocado, nuts, kiwi, plums and old cheese.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
b_jim
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« #24 : March 17, 2019, 11:46:50 AM »

When I read this non-scientific article, it's a mirror of my personal situation...


Quote
According to Datis Kharrazian, PhD, DHSc, author of Why Isn’t My Brain Working?, mild symptoms of too much serotonin include:

    shyness
    feeling “not good enough”
    desiring, yet fearing, social interactions
    nervousness
    being easily upset by criticism
    lack of motivation (2)

More serious symptoms of too much serotonin include: (3, 4)

    feeling agitated or restless
    mental confusion or disorientation
    headache
    dizziness
    increased heart rate or blood pressure
    dilated pupils
    goose bumps, sweating, or shivering
    diarrhea, nausea, or vomiting
    tremors or twitchy muscles

The mild symptoms match with my symptoms out of Pois (anxiety)
And more serious symptom, in Pois...

Taurine = Anti-Pois
b_jim
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« #25 : March 18, 2019, 12:54:44 PM »

For 2019, my new strategy is to add 2 amino-acid 30 min before orgasm : Glycine + Taurine.
I hope to get an effect on serotonin/tryptophan and NMDA/glutamate receptor.

Taurine = Anti-Pois
Nas
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« #26 : March 18, 2019, 12:58:51 PM »

For 2019, my new strategy is to add 2 amino-acid 30 min before orgasm : Glycine + Taurine.
I hope to get an effect on serotonin/tryptophan and NMDA/glutamate receptor.
I'm also expecting Glycine soon, we'll see how that'll work out.
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