Post Orgasmic Illness Syndrome (P.O.I.S.)
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+  Post Orgasmic Illness Syndrome (P.O.I.S.)
|-+  POIS Cause/Treatment Discussions
| |-+  Hormonal Causes and Treatments
| | |-+  Catecholamines Depletion as a Possible Cause for Cognitive Symptoms
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: Catecholamines Depletion as a Possible Cause for Cognitive Symptoms  ( 1803 )
Nas
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« : January 25, 2019, 03:27:40 PM »

Since Waldinger's paper was ever published, POIS was associated with immune activity, and the side effects were seen as caused by inflammation. How ever no has consistently treated his POIS symptoms by taking NSAID's. NSAID's are the first method of reducing inflammation all over the body since it inhibits the expression of COX 1-2 which are the major enzymes the body uses for the formation of Prostaglandins, this should've made, at least, some remedy to the symptoms, but at least in my case, it didn't. I also investigated the role of histamine without any success. One other point is that many of us who did MRI's in the brain, did not find any observable swelling. Thus any approach is proposed, in that instead of looking at the cognitive symptoms as a result/symptom of POIS. We could perhaps consider it as the main issue around POIS. Or perhaps to be more precise, it is a type of POIS where they immune activity is instigated by hormone depletion instead of the other way around. Which makes more sense, since the brain is quite far from the genital region to be directly affected by it if you ask me.

This thread could be potentially be a deeper investigation to Catecholamines deficiency theory. 

I'll start the first topic with this article:  Are you suffering from The Blahs?

This article is well written and articulates many observable phenomena that have been discovered in this forum.

"Dopamine, Epinephrine (adrenaline) and Norepinephrine (noradrenaline) are the primary catecholamines or ?cats?, as they are known. Catecholamines function both as hormones and neurotransmitters."

"If you have adequate cats, you feel energized, upbeat, alert and focused and you don?t crave caffeine or sugar for a pick-me-up.
If your cats are low, you may feel the kind of depression that lands you curled up in the bed all day with extremely low motivation."

If you ask me I have strong cravings for coffee and sugar when I'm in POIS which could be an indication of low dopamine, it can also explain what it actually helps with POIS.

"These are typical symptoms of people suffering from low cats:
- Trouble dragging yourself out of bed
- Inability to motivate yourself
- Feelings of worthlessness
- Feelings of hopelessness
- May lose temper for minor reasons
- Inability to handle stress
- Not enough focus or concentration
- Numb-feeling emotionally
- Lack of energy
- Craving carbs, alcohol, caffeine or drugs for energy
- Procrastination and indecisiveness
- Apathy
- Easily bored
- Attention Deficit Disorder diagnosis
- Reluctant to socialize, desire to be alone
- Lack of concern for family and friends"

I feel these are very accurate to what I feel right after orgasm, it does not mention difficulty speaking, trouble doing day to day jobs and bad short term memory. 

"What can Deplete Catecholamines?
- Chronic stress over time or acute stress during a crisis
- Genetic anomaly?some people have a genetic tendency toward low cats
- Chronic dieting with low calorie or high carb diets
- Low protein intake
- Sedentary lifestyle
- Low estrogen or testosterone
- Uncontrolled blood sugar
- Iron anemia"

Note Low estrogen or testosterone and Iron anemia these are two phenomena that have been discussed in this forum.

"These steps will allow your body and brain to receive the nutrients needed to make the neurotransmitters it needs to function optimally"
- Improve your stomach acid levels to properly digest and allow your body to use the nutrients you eat.
- Eat plenty of healthy fats and especially protein. Avoid these cooking oils and use plenty of these oils.
- Increase your Omega-3 essential fatty acid intake. A simple test can detect your current levels.
- Check your Vitamin D levels and supplement where needed. Vitamin D directs the conversion of tyrosine to cats.
- Ditch processed foods and enjoy lots of whole, organic food.
- Drink plenty of clean water.
- Eat fermented foods that are rich in probiotics.
- Good sources of catecholamine-rich foods are beef, fish and eggs. Americans who are not vegetarians/vegans typically consume plenty of these foods.
- Start slow with exercise. Try yoga, tai chi or meditation. Or simply take a walk.
- Consider amino acid and other supplements once your healthy nutrition is in place."

Again, these which are in bold, are all discussed in this forum in detail.

Now to the supplements part, the Article proposes the following supplements:
- Tyrosine
- Phenylalanine
- Beta-Phenylethylamine (PEA)
- SAMe
- mucuna pruriens
- Blueberry Extract
- Alpha Lipoic Acid, Selenium and N-acetyl-cysteine

Notable comments on these supplements:

Talking about Tyrosine: "These important nutrients are cofactors used in the conversion of tyrosine:  Folate, Niacin, Vitamin C, Copper and SAMe. In other words, you need these to make tyrosine convert into the catecholamines."
See Folate, Niacin and SAMe are the most successful remedies that have been tested in this forum.

Talking about Phenylalanine: "Phenylalanine metabolism requires the following cofactors: Vitamin B6 (P5P), Niacin, Vitamin C, Copper, SAMe, Iron and Folate."
Again these in bold were all discussed in this forum.
b_jim
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« #1 : January 25, 2019, 03:37:15 PM »

Absolutely agree. The fact tyrosine is pumped by cathecolamines production and by thyroid is something i didn't think before.

Taurine = Anti-Pois
Vandemolen
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« #2 : January 25, 2019, 04:05:30 PM »

Sleep also plays an important role in catecholamines. Better sleep means a better gut. And in the gut is where a few hormones are produced. A healthy gut also means that you will sleep better. A bad sleep means high cortisol. Cortisol controls adrenaline and noradrenaline.
« : January 25, 2019, 06:15:11 PM Vandemolen »

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
Nas
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« #3 : January 25, 2019, 06:20:41 PM »

Sleep also plays an important role in catecholamines. Better sleep means a better gut. And in the gut is where a few hormones are produced. A healthy gut also means that you will sleep better. A bad sleep means high cortisol. Cortisol controls adrenaline and noradrenaline.
That's weird since the use of corticosteroids in my case is quite benefitial. I've read in an article somewhere that corticosteroids can potentially damage the brain and reduce Norepinephrine and dopamine production, quite paradoxical...
Hopeoneday
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« #4 : January 31, 2019, 08:41:56 AM »

Guys... Nas , as i observing my self lately i can fell that my body cant metabolise
some chemicals normaly. Those test results (genetic) i posted recently from one poiser,
mean exsces cemicals not less,
so in certein situations like arosaul sex, "He hawe exsces cemicals" and cant degrade
naturaly in proper whey.
Check this out: My conection with trauma and hiperstress..

http://www.healing-arts.org/tir/n-r-diehl.htm


    Increased levels of catecholamines (chronic hyperstress)
    Decreased levels of glucocorticoids (poor immune functioning)
    Decreased alpha-2 Adrenergetic receptors (less regulation of catecholamines)
    Increased endogenous opioid levels during traumatic memory triggers (equivalent to the consumption of 8mg of morphine!)
    Acoustic startle response: (ACR) Survivors of trauma are easily trigger by loud noises or surprises sounds. While other's may "jump" only the first couple of times they hear a loud noise, trauma survivors often startle with each and every repeat of the noise.
   


« : January 31, 2019, 09:38:35 AM Hopeoneday »

Dr-pois.
Nas
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« #5 : January 31, 2019, 10:31:01 AM »

HOP, maybe try adrenocepter antagonists and see if they work.
FernandoPOIS
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37 year old. POIS Since I was 28. Vagus Nerve Heal


« #6 : February 05, 2019, 12:34:35 PM »

I agree with you NAS.

My POIS only happens with masturbation. Normal sex does not generate POIS symptoms. When I have no back pain and I masturbate the POIS symptoms are weaker and last for at most 2 days. My POIS is related to the health of my thoracic and cervical spine. Postural and Aerobic Exercise heal the vagus.
Nas
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« #7 : February 05, 2019, 06:21:29 PM »

So yesterday I tried a medication called Bromocriptine. It is supposed to lower prolactin levels and raise dopamine. I tried that right after orgasm ( I also did another round right after that cause I'm horny like that ). I also took all of this in a day where I worked my ass off for a house we're moving in to, and didn't get enough time to eat a lot, so my blood pressure and sugar levels were probably low.  So all of that culminated in my getting super dizzy and nauseous, and I threw up a lot. I had to take two bags of nutrients to re-up my blood pressure. Bromocriptine stimulates Dopamine receptor non-specifically so it can stimulate D2 receptors which induced my vomiting + low blood sugar dizziness. Suffice to say I don't recommend this. The medication had no immediate effect, however now I'm on my second day and I don't feel quite bad, maybe it was the vomiting or maybe it was the medication. I suspect that perhaps supplementing L-Dopa is a much better and safer way than to stimulate dopamine receptors, after all you can't stimulate what's already depleted. I'm obviously not taking the medication nor do I recommend it. The experiment was, interesting though, I guess...
FernandoPOIS
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37 year old. POIS Since I was 28. Vagus Nerve Heal


« #8 : February 06, 2019, 06:24:40 AM »

I'm laughing a lot here. Very cool these experiences. Cheers, my friend.

My POIS only happens with masturbation. Normal sex does not generate POIS symptoms. When I have no back pain and I masturbate the POIS symptoms are weaker and last for at most 2 days. My POIS is related to the health of my thoracic and cervical spine. Postural and Aerobic Exercise heal the vagus.
Nas
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« #9 : February 06, 2019, 08:42:55 AM »

I'm laughing a lot here. Very cool these experiences. Cheers, my friend.
Why are you laughing at my misery ;D
demografx
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« #10 : February 06, 2019, 02:14:32 PM »

Nas, can I laugh, too?




10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
Nas
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« #11 : February 06, 2019, 02:41:47 PM »

Nas, can I laugh, too?




Help your self :P
FernandoPOIS
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37 year old. POIS Since I was 28. Vagus Nerve Heal


« #12 : February 07, 2019, 12:11:18 PM »

I'm sorry, but I keep remembering my experiences with various products that unfortunately did not result in anything and some days I thought I would die due to side effects. Today I think funny but at the time it was haunting hahahaha

My POIS only happens with masturbation. Normal sex does not generate POIS symptoms. When I have no back pain and I masturbate the POIS symptoms are weaker and last for at most 2 days. My POIS is related to the health of my thoracic and cervical spine. Postural and Aerobic Exercise heal the vagus.
koko
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« #13 : February 09, 2019, 07:42:02 PM »

I think the pois is due to depletion of dopamine in the brain after the orgasm. I convinced my doctor to prescribe a dopamine receptor drug, a drug given to Parkinson's disease and to restless leg syndrome.

I hope this medicine will improve my life.
Wolf berry
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Should try Chinese wolf berry it cured my POIS


« #14 : February 09, 2019, 08:49:22 PM »

I think the pois is due to depletion of dopamine in the brain after the orgasm. I convinced my doctor to prescribe a dopamine receptor drug, a drug given to Parkinson's disease and to restless leg syndrome.
Qoute from hurray

I hope this medicine will improve my life.
I spent a while trying dopamine-related medications, hoping that they could alleviate my POIS:

piracetam
l-tyrosine
selegiline
wellbutrin
cabergoline
modafinil
Adderal
Caffeine

There's probably a bunch more that I can't remember right now, most were a number of years ago.

They didn't ultimately do much for me, although in some cases they gave my brain a boost when I was out of POIS.

I'm currently taking Ritalin, with the help of my psychiatrist (40mg/day). This has been the most useful medicine so far by some distance, but for me it doesn't prevent or cure POIS.

I'm not suggesting that there isn't a link between POIS and dopamine, but various dopaminergic drugs didn't feel like they were doing much to fight my POIS. I would be very interested to see somebody reporting long-term success with this class of drugs, I believed for years that dopamine was the key to the POIS mystery.

it can make you mania without cognitive improvement!

All the best, Wolf berry
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