Post Orgasmic Illness Syndrome (P.O.I.S.)
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+  Post Orgasmic Illness Syndrome (P.O.I.S.)
|-+  POIS Cause/Treatment Discussions
| |-+  Hormonal Causes and Treatments
| | |-+  Clomid instead of TRT
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: Clomid instead of TRT  ( 3404 )
Nas
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« #15 : October 26, 2018, 06:39:00 PM »

I don’t think so. Because by using corticosteroids like Prednisone your testosterone level will go down.

True but that's because of the abundance of steroid levels in the blood already, it's similar to when the body starts producing steroids less as you continue taking chorticosteroid medications. Right?
Nas
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« #16 : October 26, 2018, 06:44:35 PM »

I found nice link and here explanation on estrogen influce- neurotransmitesrs-
especially serotonin, dopamine, and norepinephrine

https://www.hotzehwc.com/2017/06/the-brain-and-estrogen-dominance/

Can induce hypothayroism, low gaba, panic atac seizures.


Because estrogen is womans dominance hormone.

Is it posible that in our brains estrogen make all this mees?
Vasodilation in pois and migrains?=estrogen couse? =low T

If this theory holds true then Clomid should help Vandermolen alot with his brain symptoms. Since it blocks estrogen.
Vandemolen
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« #17 : October 26, 2018, 08:11:51 PM »

I don’t know the answer of your question Nas.

Well, I will test it abouth a month. After 4 weeks the testosterone level must already go up. But the full effect is after 3 months.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
Hopeoneday
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« #18 : October 27, 2018, 08:05:51 AM »

Nas, i can tell you one thing for shoure , is  that low or lower range testasterone in man is not
normal, espesualy if it hawe hi estrogen.

Evan in womans who hawe elewated estrogen then normal, could hawe meny helt isues in long term.

Dr-pois.
Hopeoneday
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« #19 : October 27, 2018, 10:24:43 AM »

My POIS doctor gave me Clomid. He said it might help me a bit against POIS and prostatitis.
I have to take it for 3 to 6 months. And then my testosterone level will go up. Now it’s a bit low.

Link between low testosterone and prostatitis:

https://www.issm.info/news/sex-health-headlines/researchers-find-connection-between-low-testosterone-and-cp-cpps/

Thanks Hurray for the idea.

I started a new topic so everybody will see that Clomid is a potential help.


That's great news Vandemolen. I really hope that Clomid can help you with POIS and your prostatitis.

Your POIS doctor sounds like a very helpful and understanding person.

Hurray , thanks for sugestion.

Dr-pois.
Vandemolen
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« #20 : November 03, 2018, 08:27:32 AM »

i did
but before i tried cabergoline i did my bloodwork
so my prolactin was 275 mkME/ml  ref(86-324)
i consider it is high and so after one week of taking just 25mg of cabergoline i did my bloodwork again
and my prolactin became just 56 mkME/ml
so far i have no sideeffects except i can fuck right after 10 minutes past former ejaculation
i believe it helps my pois for about 35-45% the rest is that i eat natural ginger every day at least 5 grams
and two weeks ago i started taking clomid - after clomid i started to feel much more desire but not too much
i believe i steel need to rise my test which was 330 ng/dl ref(250-836) before starting clomid
in several days i will get by free testosterone bloodwork and i'm sure it is still less than 600
cus in about 5 days after starting to take each day 12.5mg of clomid(1/4 of standart tablete) i felt like a Real Man
jeesus it was awesome !
my mood was like a concretesteel hard my diq was as hard as it was never before
unfortunately that state was not for long= it was like a one day wave
so at that time i believe i had my "normal" testo level which i had not for years and developed pois

by the way i found the perfect forum for trt : it is peaktestosterone just google it highly recommended

p.s. english isnt my born language
So I am not the only member who started with Clomid. We almost started at te same day. In the first days my sex drive went up. But now it’s normal. Because I am ill because of Candida and that’s caused by antibiotics. I am curious about your side effects. I have hot flushes. Was it your idea to take Clomid or your doctor’s idea? And if Clomid helped you? I didn’t have sexual activity because being sick. I want to do a test about a month or maybe two months. After a month the testosterone should already be a bit higher. But the full effect is after 3 months. Some men take it for 6 months. But I think I will stop after 3 months. Because also Estriodol will rise.
« : November 03, 2018, 08:55:04 AM Vandemolen »

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
Vandemolen
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« #21 : November 14, 2018, 09:33:38 AM »

I asked my doctor if I can stop with Clomid. In my latetst blood test I saw that amalyse was too high: 111. It should be below 99. I read a paper were it’s described that people who are using Clomid can get acute pancreatitis. Also since a few weeks my pelvis and my flanks hurt. I think it’s because prostatitis. Because I have candida I stopped with antibiotics. But after a week I felt really bad. Fever and cold legs. So I started antobiotics again, but after a few days I only get more sick. So i don’t want to take any risks and asked my doctor if I can stop with Clomid. I still believe Clomid can help a bit against POIS and prostatitis. So about a few months when I feel better I want to test it again with my doctor’s permission.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
hurray
Lab1
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« #22 : November 18, 2018, 04:53:22 PM »

I asked my doctor if I can stop with Clomid. In my latetst blood test I saw that amalyse was too high: 111. It should be below 99. I read a paper were it’s described that people who are using Clomid can get acute pancreatitis. Also since a few weeks my pelvis and my flanks hurt. I think it’s because prostatitis. Because I have candida I stopped with antibiotics. But after a week I felt really bad. Fever and cold legs. So I started antobiotics again, but after a few days I only get more sick. So i don’t want to take any risks and asked my doctor if I can stop with Clomid. I still believe Clomid can help a bit against POIS and prostatitis. So about a few months when I feel better I want to test it again with my doctor’s permission.

Sorry to hear the Clomid didn't work out for you, Vandemolen. You are quite right not to want to take any risks.

If you do decide to try it again in a few months, it might be worth considering asking your doctor about lowering your initial dosage. I understand you were taking 25mg/day, which seems to be the most common dosage for men. However, some studies suggest a dose of 25mg once every 2 days:

http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=3;spage=357;epage=363;aulast=Ring

https://www.omicsonline.org/open-access/clomiphene-citrate-effectively-increases-testosterone-in-obese-young-hypogonadal-men-2161-038X-1000155.php?aid=63661

https://www.ncbi.nlm.nih.gov/pubmed/22044663
Vandemolen
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« #23 : November 18, 2018, 05:16:51 PM »

I asked my doctor if I can stop with Clomid. In my latetst blood test I saw that amalyse was too high: 111. It should be below 99. I read a paper were it’s described that people who are using Clomid can get acute pancreatitis. Also since a few weeks my pelvis and my flanks hurt. I think it’s because prostatitis. Because I have candida I stopped with antibiotics. But after a week I felt really bad. Fever and cold legs. So I started antobiotics again, but after a few days I only get more sick. So i don’t want to take any risks and asked my doctor if I can stop with Clomid. I still believe Clomid can help a bit against POIS and prostatitis. So about a few months when I feel better I want to test it again with my doctor’s permission.

Sorry to hear the Clomid didn't work out for you, Vandemolen. You are quite right not to want to take any risks.

If you do decide to try it again in a few months, it might be worth considering asking your doctor about lowering your initial dosage. I understand you were taking 25mg/day, which seems to be the most common dosage for men. However, some studies suggest a dose of 25mg once every 2 days:

http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=3;spage=357;epage=363;aulast=Ring

https://www.omicsonline.org/open-access/clomiphene-citrate-effectively-increases-testosterone-in-obese-young-hypogonadal-men-2161-038X-1000155.php?aid=63661

https://www.ncbi.nlm.nih.gov/pubmed/22044663
Yes if give Clomid another try I will take 25 mg 3 times a week for the first month. If the side effects are not too bad I will go to 25 mg everyday or 50 mg 3 times a week. And that for another 2 months. 3 months of Clomid must do the trick. I don’t want to use Androgel. I am afraid that even you use Clomid beside it that when you stop with Androgel the testosterone will drop even more. And it’s not good to mess up with your hormones.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
demografx
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« #24 : November 18, 2018, 05:38:22 PM »

All very interesting.

10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
Vandemolen
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« #25 : December 25, 2018, 07:17:43 PM »

I used Clomid for 3 weeks. I am researching what the cause of my hives is. Back then I did not read all the side effects. But now I see that Clomid can cause hives. I was also on antibiotics and that can cause hives too. I am also on Amitryptyline in the side effects is also hives written. Maybe it is a combination of those 3 medicines.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
Vandemolen
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« #26 : December 31, 2018, 11:44:59 AM »

I used Clomid for 3 weeks. I am researching what the cause of my hives is. Back then I did not read all the side effects. But now I see that Clomid can cause hives. I was also on antibiotics and that can cause hives too. I am also on Amitryptyline in the side effects is also hives written. Maybe it is a combination of those 3 medicines.
I am sick for two months now. Maybe it is the Clomid. I can not fall in sleep. And when I do sleep I wake up a few times during the night. Even if I am more than 8 hours in bed when I get out I am tired and feeling cold all day. I read that women get sleep problems by Clomid. I am off Clomid now for more than 6 weeks. I wonder when this side effect will go away. Because it makes me sick. I do not think that I will give Clomid another try.

I am in POIS state but I have not had any sexual activity in 10 weeks. Because of the Clomid maybe my hormones are messed up. After sex a lot of POIS patients can not sleep. The next day we wake up tired and feeling cold. Maybe because of POIS our hormones are also messed up. But the hormone level recovers after a few days. Until you have sex and then the whole starts again. Insomia after sex, wake up tired and feeling cold.
« : December 31, 2018, 12:10:35 PM Vandemolen »

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
david
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« #27 : January 17, 2019, 08:13:10 AM »

I used Clomid for 3 weeks. I am researching what the cause of my hives is. Back then I did not read all the side effects. But now I see that Clomid can cause hives. I was also on antibiotics and that can cause hives too. I am also on Amitryptyline in the side effects is also hives written. Maybe it is a combination of those 3 medicines.
I am sick for two months now. Maybe it is the Clomid. I can not fall in sleep. And when I do sleep I wake up a few times during the night. Even if I am more than 8 hours in bed when I get out I am tired and feeling cold all day. I read that women get sleep problems by Clomid. I am off Clomid now for more than 6 weeks. I wonder when this side effect will go away. Because it makes me sick. I do not think that I will give Clomid another try.

I am in POIS state but I have not had any sexual activity in 10 weeks. Because of the Clomid maybe my hormones are messed up. After sex a lot of POIS patients can not sleep. The next day we wake up tired and feeling cold. Maybe because of POIS our hormones are also messed up. But the hormone level recovers after a few days. Until you have sex and then the whole starts again. Insomia after sex, wake up tired and feeling cold.


very much probably clomid had its adverse effect:
https://www.peaktestosterone.com/Clomid_Risk.aspx
 yesterday i' made a new blood tests
i esspecially didnt apply androgel 35 hours before test but i was on clomid constantly since october 20
so my tests showed no improvement ! i have the same level of T !
and at the same time i got  collateral adverse effects:
1.floaters !!
2.less libido and shorter orgasms

but nethertheless i got  rid of pois

i guess when i started androgel with clomid since 19 november my body was not accustomed to this two substances and i got real boost for my T  level
and the very first in my life i got proper T level
but it was lasting only for one week
 but that was really awesome experience so as i had read at reddit that some guys use clomid for years  and read some clinical trials at pubmed that effect of clomid go stronger with time so i proceed to use clomid and androgel until yesterday

clomid consist of two substances: Enclomiphene and Zuclomiphene
https://www.peaktestosterone.com/Clomid_Half_Life.aspx

what we need is the Enclomiphene but not the Zuclomiphene with is really an estrogen receptors agonist = it will work just like the estrogen !!!
also Zu has dramatically long half life  = 14 days ! while En t/2=3 days

so i stopped clomid but i'm still on androgel and hope i will get rid of those nasty sideeffects in about a week or two

also i'm moving to real TRT i just ordered Testosteron cypionat 10ml ....

i can say during my whole life i was truly alive for just one that week when i got my proper T level - that was awesome and there is no way back for me since then
i need that again and i want live like that for as long as i can
so i'm on trt for life :)
« : January 17, 2019, 08:16:08 AM david »

current protocol: 24mg test. cypionate subQ every day, Cabergoline 0.125mg every 5 days, Alcar 2 grams per day, NALT 0.6 gram per day sulbutiamine 2*200 every day highly potent vitamins each day = no pois at all and in addition now have quite decent motivation
Vandemolen
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« #28 : January 17, 2019, 10:18:56 AM »

David, I am happy for you that androgel works for you. But you should know that when you take androgel and other TRT for a few weeks you probably have to take it your whole life. Your body propably can not make testosterone anymore. Maybe ask your doctor to be sure.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
demografx
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« #29 : January 17, 2019, 12:07:53 PM »

David, will you be injecting? (That didn’t work for me).

10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
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