Author Topic: Developed POIS after antibiotic use  (Read 35656 times)

Simon66

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Re: Developed POIS after antibiotic use
« Reply #345 on: February 24, 2021, 07:20:43 PM »

Try sulforaphane it gets rid of oxidative stress very well for me, I have many problematic genes for super oxide so I also believe I have high levels as well. Sulforaphane turns on the NFR2 gene that combats oxidative stress. It's the only antioxidant that has strong evidence behind it in clinical studies for being beneficial to health. Make sure you have wasabi with it as it activates the sulforaphane.

When I wake up sometimes feeling brain dead with a very painful feeling in the sides of my head with brainfog and extreme autistic symptoms, sulforaphane is the only thing that gets rid of it, so it must be bad oxidative stess. And this kind of brain fog is very different to the  usual POIS neurological burning type of brainfog, the POIS one feels less severe in comparison.

Alpha Lipoic Acid didn't help me either.

Thanks very much for the response, which product are you taking?

Coincidentally, I first read about sulforaphane only a couple of days ago because I was looking at investing in a company called Evgen Pharma who claim to have the patent for the only pure, synthetic form. It seems to have some anti-cancer properties.
Disclaimer: Please research all supplements thoroughly and take them at your own risk. I am not responsible for any adverse reaction you may suffer.

Avoid all Fluoroquinolone antibiotics including Ciprofloxacin, Levaquin and Avelox.

Iwillbeatthis

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Re: Developed POIS after antibiotic use
« Reply #346 on: February 24, 2021, 08:09:02 PM »

Thanks very much for the response, which product are you taking?


Well I tried two brands first I used https://ebay.us/ve9HK5 this is really cheap brand and it worked well. Then I read that most sulforaphane supplements contain little or no sulforaphane so I bought this expensive one called Prostaphane which has been used in clinical studies and has been confirmed to have sulforaphane inside. And I saw no difference with the expensive one infact I felt it was weaker than the cheap one. So I've ordered more of the cheap one 360 capsules for £20

A safe way to make sure sulforaphane is activated is to add wasabi. This is what I read in an article:

"I was re-reading old research and noted one researcher advocating putting Wasabi on your broccoli – the spicier the better apparently. Wasabi is Japanese horseradish and is widely available.  If it comes on a large bottle is likely fake wasabi - yes like they fake saffron, they fake wasabi.

Is it crazy to add wasabi to your broccoli capsules?

Look at what is in the expensive Avmacol supplement that they only sell in North America.

In the research they found that adding just 0.25% Daikon to frozen broccoli “brought it back to life” and sulforaphane was found in the person eating it.

If you are using gelatine capsules with broccoli powder you can open them and, using a pointed knife, add a small amount of wasabi, re-seal and then swallow.  There is no taste or smell of wasabi."

Simon66

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Re: Developed POIS after antibiotic use
« Reply #347 on: February 24, 2021, 09:38:57 PM »
Thanks, really helpful.

I was looking at supplements and surprised that one capsule only seems to have 1000mcg (1 milligram) of the sulforaphane ingredient. I wonder if eating the vegetables would be better.

Unfortunately, I seem to react very badly to eating Broccoli and Cauliflower since the Cipro, maybe it is the sulforaphane. As a first step, I'm going to eat brussel sprouts over the next few days and see what happens, I've been avoiding green vegetables due to the uptick in symptoms I experienced previously.

Will keep the wasabi and the supplements in mind, definitely a new avenue for me to investigate.

With regards to the Alpha Lipoic Acid, I get a very severe headache/fatigue syndrome if I take 600-1200mg per day. I possibly get some very good days after stopping but the discomfort while dosing is unbearable so I am reluctant to retry high dosages. My kidneys also ache while taking supplements, they are perhaps damaged from the Cipro.

I've found some posts on another forum that may point towards the need to decrease the dosage and detox slowly over several years:
https://forums.phoenixrising.me/threads/my-journey-to-heal-from-cfs-diary.57813/page-4#post-994059
https://forums.phoenixrising.me/threads/my-experiences-with-alpha-lipoic-acid-benefits-and-side-effects.5533/#post-118794

Would be interesting if my problems are from ineffective detoxification due to low Alpha Lipoic Acid production.
Disclaimer: Please research all supplements thoroughly and take them at your own risk. I am not responsible for any adverse reaction you may suffer.

Avoid all Fluoroquinolone antibiotics including Ciprofloxacin, Levaquin and Avelox.

Iwillbeatthis

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Re: Developed POIS after antibiotic use
« Reply #348 on: February 25, 2021, 03:48:00 AM »
Thanks, really helpful.

I was looking at supplements and surprised that one capsule only seems to have 1000mcg (1 milligram) of the sulforaphane ingredient. I wonder if eating the vegetables would be better.

Unfortunately, I seem to react very badly to eating Broccoli and Cauliflower since the Cipro, maybe it is the sulforaphane. As a first step, I'm going to eat brussel sprouts over the next few days and see what happens, I've been avoiding green vegetables due to the uptick in symptoms I experienced previously.

Will keep the wasabi and the supplements in mind, definitely a new avenue for me to investigate.

With regards to the Alpha Lipoic Acid, I get a very severe headache/fatigue syndrome if I take 600-1200mg per day. I possibly get some very good days after stopping but the discomfort while dosing is unbearable so I am reluctant to retry high dosages. My kidneys also ache while taking supplements, they are perhaps damaged from the Cipro.

I've found some posts on another forum that may point towards the need to decrease the dosage and detox slowly over several years:
https://forums.phoenixrising.me/threads/my-journey-to-heal-from-cfs-diary.57813/page-4#post-994059
https://forums.phoenixrising.me/threads/my-experiences-with-alpha-lipoic-acid-benefits-and-side-effects.5533/#post-118794

Would be interesting if my problems are from ineffective detoxification due to low Alpha Lipoic Acid production.

Yeah I also react very bad to broccoli if I eat for dinner they I wake up with oxidative stress brain dead feeling in the morning so I haven't eaten it for a year or two. The sulforaphane doesn't give me this reaction though I'm not sure why maybe there's something else in the broccoli I was reacting to.

BoneBroth

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Re: Developed POIS after antibiotic use
« Reply #349 on: February 25, 2021, 08:20:50 AM »
Both me and my dad experience gas when eating broccoli.

Huser

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Re: Developed POIS after antibiotic use
« Reply #350 on: February 27, 2021, 04:39:28 PM »
Hi Simon,

cycling is very bad excercise. It makes my symptomes even worse as sex. When cycling you are squizing body and all the nerves. Its worse as sitting.

Walking is the best excercise. Hiking in nature. Body is active and brain is resting!

BoneBroth

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Re: Developed POIS after antibiotic use
« Reply #351 on: February 28, 2021, 04:03:09 AM »
Cycling might also expose your testicles to pressure which might reduce testosterone production.
« Last Edit: March 17, 2021, 02:46:48 PM by BoneBroth »

Simon66

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Re: Developed POIS after antibiotic use
« Reply #352 on: March 23, 2021, 04:56:51 PM »
Been taking two different probiotics called L. Plantarum 299V (Jarrow IBS or Sanprobi IBS) and BioGaia Protectis drops. Also been taking some Allicin Max (called Allimax/Allimed in the US) which is a special garlic anti-microbial/anti-fungal.

Yesterday, I had pain in my left testicle, the motor nerve in my left arm and today I have pain in my brain and right knee. My mood today has been extremely good with low anxiety, this is very rare.

Every time an episode like this happens, my immediate feeling is that I've temporarily dislodged a very nasty pathogen from the tissues where it resides. The episode only lasts a few days and then I'll usually see some kind of rash appear on my skin.

I'm going to make it my life's work to figure out a regimen to fight this thing, the three supplements above are a good starting point. If anyone's done any research on the microbiome, you'll know that gut bacteria control the immune system. Pharma companies are now trialling gut bacteria to fight cancer and neurodegenerative disorders. I wonder if the lack of diversity in my microbiome is the cause of these lingering infections.

Drinking milk and orange juice daily may also play some part in overall health.
« Last Edit: March 23, 2021, 05:03:47 PM by Simon66 »
Disclaimer: Please research all supplements thoroughly and take them at your own risk. I am not responsible for any adverse reaction you may suffer.

Avoid all Fluoroquinolone antibiotics including Ciprofloxacin, Levaquin and Avelox.

Muon

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Re: Developed POIS after antibiotic use
« Reply #353 on: April 21, 2021, 07:54:52 AM »
I wonder if the lack of diversity in my microbiome is the cause of these lingering infections inflammation.

Smoldering Inflammation in Cardio-Immune-Metabolic Disorders


Simon66

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Re: Developed POIS after antibiotic use
« Reply #354 on: April 22, 2021, 09:05:00 PM »
I have a feeling that a lot of inflammation comes from a damaged mucosal lining of the gut.

Most of the immune system is in the lining of the gut where it needs to kill pathogens from our food. Without a strong mucosal lining, I imagine the immune system goes haywire.

I've had a flare of my issues recently and did not improve from taking probiotics, colostrum or Allicin. I'm currently focusing on rebuilding my gut mucosa, I think Lecithin could be the supplement needed so I've ordered some soy lecithin softgels which I tolerate well. For those allergic to soy, there is also sunflower lecithin.
Disclaimer: Please research all supplements thoroughly and take them at your own risk. I am not responsible for any adverse reaction you may suffer.

Avoid all Fluoroquinolone antibiotics including Ciprofloxacin, Levaquin and Avelox.

BoneBroth

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Re: Developed POIS after antibiotic use
« Reply #355 on: April 23, 2021, 02:34:05 AM »
Yes, all therapists I have visited has independantly concluded that my intestines are inflamed, has bacteria overgrowth and slow movements. I belive this is caused by the inflammation caused by POIS worsened by a comprimised liver function. When the liver is weak it does not produce enough bile which is essential for keeping bad bacterias and fungus away from the gut. Lecitin is one of the main ingredient in bile. I will now look into if there is a hepatitis involved, which I got indications of.

Simon66

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Re: Developed POIS after antibiotic use
« Reply #356 on: April 23, 2021, 08:48:24 PM »
Yes, all therapists I have visited has independantly concluded that my intestines are inflamed, has bacteria overgrowth and slow movements. I belive this is caused by the inflammation caused by POIS worsened by a comprimised liver function. When the liver is weak it does not produce enough bile which is essential for keeping bad bacterias and fungus away from the gut. Lecitin is one of the main ingredient in bile. I will now look into if there is a hepatitis involved, which I got indications of.

Thanks, very useful information.

I once took Milk Thistle powder for liver health so I will go back and retest it along with the lecithin.

I'm also going to be exploring some other leaky gut supplements like Marshmallow Root and Slippery Elm.
Disclaimer: Please research all supplements thoroughly and take them at your own risk. I am not responsible for any adverse reaction you may suffer.

Avoid all Fluoroquinolone antibiotics including Ciprofloxacin, Levaquin and Avelox.

BoneBroth

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Re: Developed POIS after antibiotic use
« Reply #357 on: April 24, 2021, 03:54:06 AM »
After I did a liver detox with milk tistle and two other herbs that I dont recall, my acne suddenly disapeared from my face. That made me think that the liver is involved. Probably many organs are involved but that helped the liver.

Muon

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Re: Developed POIS after antibiotic use
« Reply #358 on: May 04, 2021, 02:54:20 PM »
I'm no longer going to reply on this thread as it's really long but yeah it's possibly some kind of pathogen that gets triggered by the fluoroquinolone class of antibiotics.

I'm still not recovered 3 years after the Ciprofloxacin, I've learnt to change my diet and that minimises my symptoms. I'm now very intolerant to strange things like sea salt and coffee so I have to be careful what I eat.

My Cipro issues are located in very specific areas of my body, like only one leg has some burning sensation, one ear has tinnitus, one hand has lost some of the fat padding. My working theory is maybe it's a systemic candida infection, I'm still looking for a cure.

Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2)

Fluoroquinolone Antibiotics
"Fluoroquinolone antibiotics, such as ciprofloxacin, moxifloxacin, and norfloxacin, are commonly used broad-spectrum antibiotics [143,145]. In a recent case report, the authors reported an MRGPRX2-linked hypersensitivity reaction from a topical fluoroquinolone ophthalmic preparation [110]. Evidence has been reported on fluoroquinolone-induced MC activation via MRGPRX2 [72,111]. Ciprofloxacin increased MC degranulation and MRGPRX2-dependent Ca2+ release in a concentration-dependent manner [72]. Moreover, ex vivo stimulation of wild-type and MRGPRB2 mutant mice has demonstrated an MRGPRB2-dependent MC activation [72]. Contrary to this finding, one researcher found no activity of ciprofloxacin in an MRGPRX2-expressing stable cell line Ca2+ release assay up to a 100 ?M concentration [87]. Possible reasons may be the differences in the ciprofloxacin concentration used, application type, or study design. In another study, several fluoroquinolone antibiotics were tested for MRGPRX2 activation potential via in vitro and in vivo mouse models [111]. Fluoroquinolone antibiotics have shown a concentration-dependent MC degranulation, Ca2+ release and increased vascular permeability through an MRGPRX2-dependent mechanism [111]."