Author Topic: Women with Post Orgasmic Illness Syndrome  (Read 97431 times)

swell

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #20 on: November 18, 2019, 07:00:51 PM »
I put my thoughts on another thread, Muon. (https://poiscenter.com/forums/index.php?topic=2512.0).  I really think, being concerned about a pathogen, while it could be true (and its our current way of finding diseases and research), in my opinion is a useless win-loose approach, where you win one battle and loose another later on.  Our body is itself a pathogen, there are infinite pathogens that live inside us (benefiting us and harming us), and our body deals with them (I believe much better than we would).  I think a "win-win" approach (from process engineering profession - that is mine) is to find the single significant and weakest link in the end-to-end value chain.  From this forum, and myself as case study, I gathered and now believe it is the impaired growth of our epithelial cells, such that our tissue has permeability which exposes us (un-necessarily) to these pathogens (that pathogen could be a lectin, shingles, candida or whatever hiding in semen).  How many pathogens are researchers going to go after, it could be a very counter-productive approach from a patient perspective.  I think, the best approach would be to increase resilience, thickness, the quality of our epithelial tissue, at least bring it to a reference/acceptable level where pathogens (good or bad) are no longer an issue.

I do believe now (as much as it would hurt some folks who are still suffering from POIS) that POIS inherently is good.  POIS is a protection mechanism where our body diverts essential resources away from brain (resulting in brain fog), essential resources away from tissue -> resulting in muscle weakness, skin symptoms, speech dysarthia, etc.  Our body wouldn't have to 'ration' resources this way for repair/replenishment if the weakest link - epithelial tissue was thicker and more resilient.  A curing of this weakest link, I think is big, much bigger than POIS, but I think its very rewarding (even though it would be threatening to some interest groups).  It would not only cure POIS, but give us a great overall health - longevity that we POIS'ers might be built for.

I think the various growth factors (too many by now :)) I have used, have essentially cured (or for better word 'managed') my POIS 100%, some better than the others, and some with effects that I dont like, but I am a perfectionist and I do believe the perfect solution is there, it just needs to be compiled and polished.  For e.g. Testosterone (a growth factor) while manages POIS not perfectly, maybe like 75%? (Dem would be more appropriate to comment on that) which is good as it aids our body in regenerating and growth during the 7 day POIS curfew, how?  by activating mTOR metabolic pathways and more.  While that is good for our brain fog and skin symptoms, but holistically, that is questionable (to me).  Same goes for Thyroid T3, which I have tried and tested, and I would say it works close to 100%.  nanna1's stack is also growth factors and actually works if you continue it for a longer period at higher dosages, but again I have reservations.  nanna1 stacks single compound TMG (like Creatine) taken for extended period is powerful, but it also sends your muscle cells in a fast-drive hypertophy mode.  I believe these growth-factors are questionable for longevity.  We POIS'ers I think have a gifted DNA repair/archival process, and by un-necessarily keeping mTOR channels active long-enough is not conducive for longevity.  I actually appreciate Quantum's stack (its super healthy without all the growth on you everywhere) but I have not had any success with it. 

I have just exploring VEGF if that can improve our epithelial tissue ONLY without all that systemic all-across growth (that comes with other growth factors).  nanna1, Muon, and all you rest POIS'ers (or former POIS'ers), any thoughts?   


My gf had orgasmic headaches (her doctor called it orgasm stress) in our teen years. Sometimes I wonder if I "caught" POIS from her.
So you are thinking about the transfer of a pathogen? Shaniliyl had the same thoughts, see link page 1.
« Last Edit: November 19, 2019, 12:24:59 AM by swell »
POIS Free, 2+ yrs (occasional/predictive lapses)
Pois symptoms: Peripheral (Skin: Urticaria, dryness, pale blotchy skin), Exasperation of: [Nerve weakness, Muscle weakness + Mental (CNS: Brain Fog, Irritation, Isolation, Speech lethargy, Anxiety)].
Other conditions: ASD, ADD, GA

IronFeather

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #21 on: November 26, 2019, 07:39:10 AM »
It's difficult to judge when nobody comes forward, that's my point. Women are aroused, have orgasms and can expel fluids during or as a result of sexual activity as well.

Hello, everyone. This is my first post here, so... sorry if I'm breaking any rules, I hope not, but I'm not sure how this forum works yet. I came across this thread when looking for information about POIS research on women, as I'm a woman with very heavy POIS symptoms myself. I believe there must be many female POIS sufferers out there, but it's such an embarrassing topic to talk about that I can understand why many of us never speak about it.

In my case, no doctor has diagnosed me with POIS, as they mostly haven't even heard about it, and some of them tell me it must all be psychological when I describe my symptoms. But I believe it has to be POIS... Following O or even arousal, in less than 24 hours I get a fever, lose my appetite, my throat hurts so much I can barely swallow, I feel irritated and sometimes downright angry for no apparent reason, my skin gets very warm but I'm shivering and with a fast pulse... This is ruining my life, and the symptoms have been consistently getting worse and worse every time, to the point that I fear dying during one of these "POIS attacks". And lately my neck gets so stiff and hurts so much that I can't even takes notes properly in class. It's a nightmare.

I just wanted to put this out there... I'm going to read as many old posts here as I can, in hope of finding something that could help me, but there seems to be a lot of information, any suggestions on where to get started?
26-year-old Spanish woman with POIS symptoms for the last 13 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

Nas

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #22 on: November 26, 2019, 07:48:13 AM »
Hey IronFether,
Glad you came out forward.
What about your libido after orgasm do you feel that you shut down and can't perform anymore or can you continue with no problem?

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #23 on: November 26, 2019, 07:58:38 AM »
Welcome to the forum IronFeather.

How long do these symptoms last? Do they all fully disappear or is there still a low level of symptom intenstiy present after 'recovery'?

You can start by reading Waldinger's 2016 paper which you can find inside the POIS paper archive thread.

https://www.reddit.com/r/POIS/comments/dwblg5/helpful_links/

You can show this paper to your doctor especially this section about POIS in females: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001999/#__sec11title
« Last Edit: November 26, 2019, 08:06:47 AM by Muon »

IronFeather

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #24 on: November 26, 2019, 08:29:01 AM »
Thank you, Nas and Muon!

I'm not sure how to quote parts of two posts at the same time, so I'll reply without the quotes that you all are using and hope I'll get the hang of this editor soon. About what Nas asked me, my libido is always insanely high, as embarrassing as it is to admit it, and it doesn't decrease much after orgasm. In fact, even when I try to refrain from any type of sexual activity as much as I can, sometimes I miserably fail, and when that happens, sometimes I've thought "oh well, I know I'm going to get sick anyway already, so I might as well keep going a few more times". Very bad idea, that reasoning made me get horrible symptoms that left me postrated in bed for an entire month once, unable to even get up without throwing up, and I lost 20% of my body weight on top of being thin already. That's the only time in my life that I've missed class, and I've been really sick sometimes.

Muon, when I first developed POIS (as a teenager, around one year after getting my period for the first time), it only consisted of moderate fever during one day, exactly 24 hours. It's been getting consistently worse ever since, and that'w what scares me the most. During my teenage years it slowly graduated to fever during two days, three days, then a week... And once I started college I started getting other symptoms along with it, first swollen lymph nodes, then severe throat pain to the point that swallowing anything literally feels like I'm swallowing a knife, and now such bad neck pain that a few weeks ago I seriously thought I'd torn some ligament in my neck lifting weights the day before until I connected the dots and realized it wasn't that (it resolved in two days). Now my symptoms never last less that a week, and it's usually two.

After recovery, I usually still feel that my skin is warmer than usual, and I get mood swings that aren't typical of me at all. I've even snapped at people or screamed at friends before I realized what was happening, but apart from that it's pretty much all gone until the next time.

Thanks a lot for the info! I'll read those papers!
26-year-old Spanish woman with POIS symptoms for the last 13 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #25 on: November 26, 2019, 08:48:13 AM »
Sounds like POIS to me. Swollen lymph nodes could mean T-cell proliferation. Yes, doing it twice in a row makes it so much worse like for most people here on this forum.

How do you feel when you menstruate? Do you get symptoms from this?

And do your symptoms get worse when you expell more liquid down below?
« Last Edit: November 26, 2019, 09:05:20 AM by Muon »

IronFeather

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #26 on: November 26, 2019, 01:52:52 PM »
How do you feel when you menstruate? Do you get symptoms from this?

And do your symptoms get worse when you expell more liquid down below?

I think I get no symptoms from menstruation at all. Sometimes I've had my period and POIS symptoms at the same time, but just because of a timing coincidence, and it doesn't make the symotoms better or worse as far as I can tell. Right now I've been in complete sexual abstinence for the past month, I'm on my period and I feel no symptoms at all. Sometimes my skin feels slightly warmer than usual, but that might be because even arousal causes mild symptoms in my case, and I can't control that as much as I'd like. I've read on this forum that this happens to some of you too.

Hmm, I don't think I expell any liquid, apart from normal natural lubrication (which I produce a lot of). Are you thinking of a possible allergy like the semen allergy hypothesis in the case of men?

I've had blood tests done multiple times during my worst fever episodes, and everything comes back normal except for very low levels of iron (I usually have normal or even high iron and hemoglobin levels), and through-the-roof amounts of C-reactive protein. This led doctors to think I could have mononucleosis or some kind of bacterial infection, but all specific tests came back negative. They put me on antibiotics anyway, and that solved most symptoms almost immediately and made me able to get out of bed and finally get better during the worst episode I've ever had. That's why I've always thought it must be some kind of infection by some pathogen, even when I used to believe an autoinmune reaction must be the cause. Now I don't even know what to believe or what to do.
26-year-old Spanish woman with POIS symptoms for the last 13 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #27 on: November 27, 2019, 10:07:17 AM »
Hi IronFeather,

1) You are talking about your teenage years, what's your age?

2) Symptoms started 1 year after your first period, was this the first time you masturbated?

3) Do you produce more natural lubricant when you orgasm?

4) How much time, roughly speaking, is there between the moment you start masturbating and reaching orgasm? There are people here with (lifelong) premature ejaculation.

5) Did you experience other symptoms before 'POIS' symptoms made their appearance?

6) What was the antibiotic you were using?

7) Did they measure your vitamin D, lactoferrin, interferons, NK, T and B cells?

8 ) If you feel like sharing your lab results you can do so here: https://poiscenter.com/forums/index.php?topic=2684.0

Iron is essential for bacterial growth. It sounds to me like arousal and orgasm alter immune parameter level(s) which are required to suppress bacterial growth. So orgasm might be a window of opportunity for the bacteria to grow. Once the rate of growth increases, they will take up more iron and you will see a drop in iron. Out of POIS the bacterial growth is decreased and bacterial iron uptake will be decreased and iron levels return to normal.

Since some of the bacterial suppressors are altered the body might switch to other mechanisms to reverse this behaviour like inducing fever. Once you are out of POIS the parameters return to a state in which they can suppress bacterial growth again. But everytime you orgasm the microbes gain more ground and the response gets worse over a longer period of time because their population becomes bigger. Lactoferrin might also play a role in this. I think your immune system might actually be in an abnormal state outside POIS and orgasm/arousal shifts this state, the shifting may not be preferable.

There is also something else that might induce fever: https://poiscenter.com/forums/index.php?topic=2695.msg31290#msg31290
The vagus nerve might activate mast cells leading to the release of mitochondrial DNA which the body misconstrues as innate pathogen and release antibodies against this DNA.

I personally had an iron defiency when I was a kid long before I became sexual active, including food sensitivities as well.
« Last Edit: November 27, 2019, 10:27:31 AM by Muon »

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #28 on: November 30, 2019, 07:30:33 AM »
@ IronFeather:

You may search literature which cytokines are capable of inducing fever and test these during fever mode. I've also sent you a private message regarding POIS researchers.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #29 on: December 01, 2019, 08:34:26 AM »
I have just exploring VEGF if that can improve our epithelial tissue ONLY without all that systemic all-across growth (that comes with other growth factors).  nanna1, Muon, and all you rest POIS'ers (or former POIS'ers), any thoughts?

I haven't looked into growth factors (other than VEGF) and the mTOR pathway. You can test VEGF at commercial labs, perhaps it's an idea to check that one out since no poiser has done this yet.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #30 on: December 02, 2019, 02:36:07 PM »
The fever could be caused by an abnormal response within the HPA-axis.

https://en.wikipedia.org/wiki/Fever#Pathophysiology

IronFeather

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #31 on: December 08, 2019, 04:43:31 PM »
Hi IronFeather,

1) You are talking about your teenage years, what's your age?

2) Symptoms started 1 year after your first period, was this the first time you masturbated?

3) Do you produce more natural lubricant when you orgasm?

4) How much time, roughly speaking, is there between the moment you start masturbating and reaching orgasm? There are people here with (lifelong) premature ejaculation.

5) Did you experience other symptoms before 'POIS' symptoms made their appearance?

6) What was the antibiotic you were using?

7) Did they measure your vitamin D, lactoferrin, interferons, NK, T and B cells?

8.) If you feel like sharing your lab results you can do so here: https://poiscenter.com/forums/index.php?topic=2684.0

Hi Muon, sorry that it took me so long to reply to this.

1) I'm 23 now, but I'll be 24 at the end of December. I've had POIS symptoms ever since I was around 12 or 13 years old, I can't remember exactly but I know it was around that age.

2) No, I was very young when I first masturbated, less than 3 years old. I used to do it very often as a kid, probably daily, unless I was sick. I used to be sick pretty often too, which I later found out was caused by a food intolerance (a very bad one, almost an allergy) to soy.

3) I can't be 100% sure, but I think I don't. Since arousal doesn't seem to cause POIS symptoms for me (yet, at least), I've been edging a lot lately but avoiding orgasm altogether, and I haven't noticed any decrease in the amount of lubricant that I produce.

4) If I were a man, I'd suffer from premature ejaculation for sure. I can orgasm in one minute easily, and it never takes me longer than two unless I'm playing/waiting on purpose.

5) Hmm, I don't think so. The only health problems I've had in my life are my soy allergy and an extreme sensitivity to cold (I never catch a cold or the flu from somebody else, but going outside in winter without four or five layers of clothes mean I'm going to get sick, 100% guaranteed). I also have very bad acne, I've had it since my first period, and I believe it's POIS-related because it gets noticeably worse during an episode.

6) I was prescribed cefixime. I took it for five days before it caused me to stop absorbing food adequately, I was going to the bathroom three-four times a day, so I had to stop taking it. But apparently it was enough, the symptoms had already lowered in intensity and I slowly improved by myself until the episode was over.

7) They did measure my vitamin D, which is always very low, below the critical levels. I'm taking vitamin D in drops daily but I don't seem to improve... I'm not sure about the other parameters, I'm going to see if I can find the results and check!

8.) Yes, of course, I'll post them as soon as I find them. They're in Spanish but medical terms tend to be very similar anyway, and if I can find the time I'll translate them too.

The vagus nerve idea seems interesting to me, because before I had even heard about POIS, I realized that one of my symptoms was a strange feeling of something being wrong around the center of my abdomen (the middle of the diaphragm, more or less), and if pressed that area my other symptoms got much worse. I told a doctor about this and, after some thinking, he told me that the only thing that occurred to him was something being wrong with my vagus nerve. And the only time that I got full POIS symptoms completely unrelated to masturbation, it happened after laying in bed face down reading a book, pressing that exact same spot against the bed. But what could possibly be wrong with the vagus nerve?


« Last Edit: December 08, 2019, 04:46:30 PM by IronFeather »
26-year-old Spanish woman with POIS symptoms for the last 13 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

demografx

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #32 on: December 08, 2019, 10:43:29 PM »

The vagus nerve idea seems interesting to me, because before I had even heard about POIS, I realized that one of my symptoms was a strange feeling of something being wrong around the center of my abdomen (the middle of the diaphragm, more or less), and if pressed that area my other symptoms got much worse. I told a doctor about this and, after some thinking, he told me that the only thing that occurred to him was something being wrong with my vagus nerve. And the only time that I got full POIS symptoms completely unrelated to masturbation, it happened after laying in bed face down reading a book, pressing that exact same spot against the bed. But what could possibly be wrong with the vagus nerve?


IronFeather, this forum committed heavily at one time to researching vagal dystonia as a possible POIS culprit. Some of us continue experimenting with tVNS devices as a possible POIS treatment:
https://poiscenter.com/forums/index.php?topic=2969.0
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Hopeoneday

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #33 on: December 09, 2019, 12:55:48 PM »


5) Hmm, I don't think so. The only health problems I've had in my life are my soy allergy and an extreme sensitivity to cold (I never catch a cold or the flu from somebody else, but going outside in winter without four or five layers of clothes mean I'm going to get sick, 100% guaranteed). I also have very bad acne, I've had it since my first period, and I believe it's POIS-related because it gets noticeably worse during an episode.


The vagus nerve idea seems interesting to me, because before I had even heard about POIS, I realized that one of my symptoms was a strange feeling of something being wrong around the center of my abdomen (the middle of the diaphragm, more or less), and if pressed that area my other symptoms got much worse. I told a doctor about this and, after some thinking, he told me that the only thing that occurred to him was something being wrong with my vagus nerve. And the only time that I got full POIS symptoms completely unrelated to masturbation, it happened after laying in bed face down reading a book, pressing that exact same spot against the bed. But what could possibly be wrong with the vagus nerve?
Hi IronFeather- 5)-match with me complitly the same(severe acne in that age, cold intoleraces,colds after that...
Vagus nerve could be infected (by "my theory"), or toxic , again by "my theory" and linked to gut and imunity.
I will write about this soon.

Sometimes only air small of bloat on that erea, induce me to hawe heart palpilations, in pois badly.
« Last Edit: December 09, 2019, 04:12:48 PM by Hopeoneday »
Dr-pois.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #34 on: December 13, 2019, 06:46:05 PM »
9) Did you do a test for soy allergy to determine it's a true allergy? And was this soy 'allergy' present before your first POIS symptoms emerged?

10) Do you have any intravaginal sensitivities?

11) Have you ever tried NSAIDs? https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug

12) Do the sickness symptoms from cold exposure have any overlap with POIS symptoms?

13) Do you have any problems with heat, like hot weather?

14) Do you experience any autonomic related symptoms/dysfunction (see picture below)?

15) Do you have any relatives with health problems? If so what kind of health problems?

16) Are you susceptible to stress? And once you are stressed is it difficult to reverse this?



https://en.wikipedia.org/wiki/Dysautonomia
« Last Edit: December 13, 2019, 07:06:42 PM by Muon »

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #35 on: December 25, 2019, 11:51:22 AM »
About what Nas asked me, my libido is always insanely high, as embarrassing as it is to admit it, and it doesn't decrease much after orgasm.

''Finally, there is the mystery of the presence of mast cells in neuroendocrine organs, such as the pineal, hypothalamus, pituitary, thyroid and the uterus [3], where the pathophysiologic function of the mast cells remains unknown. These findings may possibly explain our observation that many females with MCMD report increased libido and orgasms.''

Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?

I wonder if her fever could be explained by mast cell activation in the hypothalamus.
« Last Edit: February 16, 2020, 07:36:00 PM by Muon »

IronFeather

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #36 on: January 03, 2020, 01:23:59 PM »
9) Did you do a test for soy allergy to determine it's a true allergy? And was this soy 'allergy' present before your first POIS symptoms emerged?

10) Do you have any intravaginal sensitivities?

11) Have you ever tried NSAIDs? https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug

12) Do the sickness symptoms from cold exposure have any overlap with POIS symptoms?

13) Do you have any problems with heat, like hot weather?

14) Do you experience any autonomic related symptoms/dysfunction (see picture below)?

15) Do you have any relatives with health problems? If so what kind of health problems?

16) Are you susceptible to stress? And once you are stressed is it difficult to reverse this?

I'm sorry that I'm taking so long to reply, I'm about to start college final exams and it's taking a toll on my free time, that was almost non-existent anyway. I'll try to come back here more often from now on.

9) I haven't done a soy allergy test, so I can't be sure if it's a true allergy or not, but I believe it isn't. I have been eating soy consistently since I was a kid, because a lot of foods that I love have soy as an ingredient or even the main ingredient (tamari sauce, miso, sushi), and never had any intense reactions except for stomach problems, and it took me years to realize that soy was the cause. It got worse when (around 10 years old) I incorporated new foods with soy into my diet and my digestive system couldn't take it anymore: I spent 4 months with colitis and lost half of my weight until thankfully my mother deduced that soy was the culprit. So I believe that, if it was a true allergy, I'd have had a more intense reaction. And yes, I've never tolerated soy well, and I've had that problem for as long as I can remember.

10) Not at all, at least not that I know.

11) No, I haven't, I try to avoid taking medications as much as possible. The only medications I've taken in my life are paracetamol and a couple of antibiotics, always because of the flu or very bad POIS episodes when I needed to manage the symptoms.

12) No, not at all. The only effect that cold has on me is that, well, I get a cold or the flu pretty easily, especially if my feet get cold. Now that my POIS symptoms are getting worse, I also get a very sore throat with it, but it's a completely different kind of sore compared to when I'm sick from a cold. It doesn't feel like an infection, it just hurts, if that makes sense.

13) Not at all, I love hot weather.

14) That's an interesting question. I've definitely had stomach problems related to POIS, stomachaches and gas that can't be explained by any change in my diet and that disappear when POIS symptoms go away. And also an elevated heart rate, but maybe that's because of the fever?

15) My two grandmothers died from breast cancer, and one of my grandfathers died of prostate cancer, but apart from that, the only health problems I can think of in my family are the endless digestive problems of my mother. She's been diagnosed with irritable bowel syndrome and lactose intolerance, but her troubles only appeared after the emotional turmoil of her relationship with my physically abusive father, so that might explain her issues.

16) No, not at all. I live a very stressful life as a student, always trying to get perfect grades and studying two degrees at the same time (I'm an extreme perfectionist), and it hasn't given me any problems so far, I'm used to stress and have always worked well under pressure.

If you have any other questions, Muon, feel free to ask whatever, I'll try to reply as soon as possible! :)
26-year-old Spanish woman with POIS symptoms for the last 13 years.
Suffering from exercise intolerance since April 2020.
My case thread, with medical tests results.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #37 on: January 13, 2020, 12:41:50 PM »
16) No, not at all. I live a very stressful life as a student, always trying to get perfect grades and studying two degrees at the same time (I'm an extreme perfectionist), and it hasn't given me any problems so far, I'm used to stress and have always worked well under pressure.

You may be completely wrong about your statement highlighted in bold.

Fever is also a symptom of colitis. It may be possible that you are triggering colitis by sexual activity. Mucosa is dense in mast cells. If you are triggering mast cells it could lead to inflamed mucosa, in your case colitis. I'm not sure what part of the GI tract absorbs vit D, I wonder whether the colonic inflammation inhibits Vit D absorption. Iron deficiency could have made your Vit D low: https://vitamindwiki.com/Iron+deficiency+is+a+cause+of+Vitamin+D+deficiency

My two cents: There is probably some interaction between: Mast cells, mucosa, colitis, sexual activity, iron, vitamin D, stress. I bet the sore throat is probably mucosal mast cell activation as well. Your first intestinal mucosal mast cell trigger was soy, the second trigger later in life might be sexual related, which could synergize with stress.

Often seen, rarely recognized: mast cell activation disease - a guide to diagnosis and therapeutic options

Table 1:  Cold intolerance,  Mood disturbances (e.g., anger, depression (13%)), inflammatory/irritable bowel syndrome (colitis=IBD), selective vitamin and/or other micronutrient deficiencies, weight change, increased susceptibility to infection, Soy: Types I, II, III, and IV hypersensitivity reactions (e.g., allergy, delayed-type hypersensitivity, etc.).
« Last Edit: January 17, 2020, 05:42:27 PM by Muon »

Timtim

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #38 on: January 21, 2020, 05:52:54 AM »
Hi everyone. I am a female poiser.
I am 27 and I had the symptoms since I was 10 or something.
I used to overmasturbate. And I think my pois is because of excessive masturbation
 I started masturbating at the age of 10 or so I guess, however this habit was not an ongoing one. I mean it was on and off. at the age of 19 I stopped masturbating and having sex and I did not have NE and that age. After 1 year of not having orgasm my symptoms have been reduced, but did not disappear. My face used to get very ugly and my stress level was super high. Now I still get ugly after orgasm but not as much as it used to get, and I still have all symptoms but in a lighter level compared to the past. But it is still VERY annoying. I decided to stop having orgasm for a couple of years but that seems impossible because of NEs. Every 6 day one NE!
I am sure my pois is because of over masturbation
My question is if any of you has the same problem? Did you over masturbate?
Do you think excessive masturbation or masturbating at early age (before puberty) caused your pois, too?
My English is not very good, sorry about it.

demografx

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #39 on: January 21, 2020, 07:52:12 AM »
Timtim, I do think that over-engagement is a possible cause, but I also know that many people here disagree.
« Last Edit: January 21, 2020, 07:53:46 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business