Author Topic: Women with Post Orgasmic Illness Syndrome  (Read 12657 times)

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #165 on: March 23, 2021, 12:01:40 PM »
Posting this here, could be helpful to others.

I haven't been around much because I've been sick with POIS again, with crazy tachycardia and general weakness. I tried to start slowly exercising again and it was a disaster, I spent two weeks with a fever afterwards. I'm going to get a blood test done on Thursday, and I just realized that maybe you could recommend me something I could ask my doctor to test for. Is there anything specific that tends to come up wrong in the blood tests of people with POIS? I'm tired of doctors believing it's all in my head because all the parameters always come back perfect.

I've been reading old posts here and came across nanna1's theory about herpes and POIS. It fits what I think about POIS being some kind of infection in the nervous system.

Nanna made a small compilation: https://poiscenter.com/forums/index.php?topic=2695.msg24788#msg24788
Result thread: https://poiscenter.com/forums/index.php?topic=2684.0

If you think infection plays a role then you may want to investigate Th1/Th2 balance (IFN-g/IL-4): https://poiscenter.com/forums/index.php?topic=3717.0
(Cytokine panels could be checked for a disordered cytokine profile, see examples in thread above, fever is probably induced by cytokines)

POIS theories: https://poiscenter.com/forums/index.php?topic=3744.0
Ideas regarding parameters in the comment section: https://poiscenter.com/forums/index.php?topic=3207.0

SIBO test can be done if you suspect an overgrowth: https://poiscenter.com/forums/index.php?topic=3385.0

MCAS testing: https://poiscenter.com/forums/index.php?topic=3236.0

Options regarding the tachycardia:
-Alpha or beta adrenergic receptor autoantibodies (nobody has done these yet, seen in CFS and POTS patients):
https://poiscenter.com/forums/index.php?topic=2219.msg39210#msg39210
https://poiscenter.com/forums/index.php?topic=2219.msg39229#msg39229
-Increased plasma norepinephrine (measurement between laying down and standing position reveals increase)

VEGF if blood brain barrier permeability is increased and things are leaking through.

Your doctor probably don't got these tests. Btw if your Th1/Th2 balance shows a Th1 polarization it can mean you can have autoantibodies(virus can induce this, the Th1 response is due to viral infection) and probably of the adrenergic type since you got tachycardia see learner1 from CFS forum.

I would do a cytokine test including Th1/Th2 balance if you ask me.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #166 on: March 25, 2021, 08:45:43 AM »
Thanks a lot for all the info and for taking the time to put all of this together, the forum is a bit scattered sometimes and I hadn't found most of these things.

I had my blood test done today, I'll upload my results (and previous ones too) as soon as I have them. They couldn't test for some of the parameters I wanted, but I managed to convince my doctor to ask for all vitamins B, A, C and D, as well as IgG and IgM antibodies for all types of herpes, and the TH1/TH2 ratio you mentioned.

Forum is indeed scattered. Rule of thumb: Pinned threads contain the most relevant information including comment section. Th1/Th2 in combination with herpes...oke, let's wait and see.

Prospero

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #167 on: March 25, 2021, 09:43:26 AM »
Nice, thank you IronFeather. I wish more people could convince their doctors to do more specific blood tests of this kind. It's a shame that most of them keep asking only for the standard and irrelevant stuff which never shows anything interesting.
« Last Edit: March 25, 2021, 11:51:25 AM by Prospero »

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #168 on: March 25, 2021, 03:22:32 PM »
Ironfeather has quite some cases of cancer in her family. IDO is overexpressed in cancer. IDO inhibits natural killer cell function. It might be a problem in viral infection where you need intracellular clearing. Increased Interferon gamma in response to a viral infection could work against you if IDO is overexpressed (not in individuals with normal IDO numbers), in that it upregulates IDO so that inhibition of NK function dominates. Like a trap. Just wanted to throw this out there before i forget it. Tryptophan could be low as a consequence.

IronFeather

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #169 on: March 27, 2021, 10:43:35 AM »
I just created a thread with all the info about my case, I'll update it along the way, and soon I'll add the results of my previous blood tests.

https://poiscenter.com/forums/index.php?topic=3765.msg40013#msg40013


The lab did a disaster with this test though, they didn't take enough blood to analyze everything they needed, and for some reason they didn't even upload the TH1/TH2 to the results page, and only the HH1 and HH2 are showing (but not the HH3, 5 or 7, which my doctor also asked for). I'm trying to figure out what's happening, but maybe they don't have the equipment to test for these parameters...
25-year-old Spanish woman with POIS symptoms for the last 12 years.
Suffering from exercise intolerance since April 2020.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #170 on: April 19, 2021, 10:59:11 AM »
Among hormones, estrogens, glucorticoids and thyroxine are the best characterized modulators of the KP. Estrogens enhance TDO activity; enzyme activity is triplicated in women who are pregnant or are taking oral contraceptives Ref

https://www.thenakedscientists.com/forum/index.php?topic=14697.msg478002#msg478002

Giggly:
"I truly thought I was the only woman alive experiencing this.  For me, this all started AFTER menopause (I'm 53) and no longer had to take birth control pills (I was on those for 20+ years).  I thought maybe those two things combined were causing this.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #171 on: April 27, 2021, 07:14:07 AM »
Another female:

https://www.reddit.com/r/POIS/comments/mt1ehn/does_anyone_know_what_treatment_for_women_would_be/

"does anyone know what treatment for women would be?

I have all of the debilitating symptoms of POIS. i assume i have high testosterone and thats why this is happening but am not certain
"

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #172 on: April 27, 2021, 08:20:58 AM »
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=estrogen+intestinal+inflammation&btnG=

Estrogen seems to be protective against intestinal inflammation. Could this explain the male/female ratio in POIS? What about females that do have normal to high estrogen and still got POIS? Could they have reduced expression of estrogen beta receptors. Impaired estrogen signaling?

https://www.thenakedscientists.com/forum/index.php?topic=14697.msg478002#msg478002

Giggly:
"I truly thought I was the only woman alive experiencing this.  For me, this all started AFTER menopause (I'm 53) and no longer had to take birth control pills (I was on those for 20+ years).  I thought maybe those two things combined were causing this.

Estrogen and microglia:
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=estrogen+microglia&btnG=

Testosterone and microglia
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=testosterone+microglia&btnG=
« Last Edit: April 27, 2021, 08:56:01 AM by Muon »