Author Topic: Women with Post Orgasmic Illness Syndrome  (Read 12112 times)

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #105 on: July 07, 2020, 06:16:56 AM »
Hi IronFeather,

Have they ever checked your testosterone and estrogen level?

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #106 on: July 08, 2020, 10:01:20 AM »
Estrogen ---> IFN-g:

"(1) estrogens upregulate IFN-γ secretion, a vital immunoregulatory cytokine"
Interferon-γ levels are upregulated by 17-β-estradiol and diethylstilbestrol

IronFeather had colitis (=IBD)
IFN-g ---> Tight junction modulation ---> IBD/(auto)-immune disease

"Cytokine mediated changes in paracellular permeability contribute to a multitude of pathologic conditions including inflammatory bowel disease (IBD), airway inflammation in asthma [1] and cystic fibrosis [2], and diseases that perturb the blood-brain barrier (BBB) "
Cytokine regulation of tight junctions

Estrogen can also affect NK cell activity and numbers.
« Last Edit: July 08, 2020, 10:36:27 AM by Muon »

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #107 on: July 09, 2020, 12:07:51 PM »
I believe these growth-factors are questionable for longevity.  We POIS'ers I think have a gifted DNA repair/archival process, and by un-necessarily keeping mTOR channels active long-enough is not conducive for longevity.  I actually appreciate Quantum's stack (its super healthy without all the growth on you everywhere) but I have not had any success with it. 

I have just exploring VEGF if that can improve our epithelial tissue ONLY without all that systemic all-across growth (that comes with other growth factors).  nanna1, Muon, and all you rest POIS'ers (or former POIS'ers), any thoughts?   

You may want to have a look at this swell: https://poiscenter.com/forums/index.php?topic=2695.msg35257#msg35257

IronFeather

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #108 on: July 13, 2020, 02:07:00 PM »
Hi IronFeather,

Have they ever checked your testosterone and estrogen level?

Hi Muon! Yes, they have. As far as I remember, both came back normal... Right now I'm really sick with a full-on pois attack, and I don't even know what caused it. Lymph nodes swollen everywhere, extreme fatigue (this is a new one for me), fever, nausea... I don't know what to do anymore.
25-year-old Spanish woman with POIS symptoms for the last 12 years.
Suffering from exercise intolerance since April 2020.

Heather1111

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #109 on: July 13, 2020, 09:49:49 PM »
Hi guys! I missed a post from earlier above with some questions. Sorry about that.  Before POIS yes I always had an extremely high libido. More than any boyfriend or husband I ever had. Although since it started making me feel so bad sex is the last thing I want to do.

I'm somewhat always stressed due to running my own business and taking care of my family.

I have done 3 hormone tests over the last year. All were when I was not symptomatic. All showed very high estrogen and non-existent testosterone. I will be happy to upload those here if that's possible.

I did show on one of the test my cholesterol was a little high which shocked me a lot.  My last test a few weeks ago showed low vitamin D which also shocked me considering I literally take a vitamin D pill every day and I'm outside a good bit.

I have been experiencing this for about 4 or 5 years now and the symptoms have gotten considerably progressive worse over time.

Anyway, I can round up all of my blood test and upload them if anybody wants.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #110 on: July 14, 2020, 04:56:20 PM »
I did show on one of the test my cholesterol was a little high which shocked me a lot.  My last test a few weeks ago showed low vitamin D which also shocked me considering I literally take a vitamin D pill every day and I'm outside a good bit.

I'm not surprised by these answers. My POIS doctor told me once he had a patient who expressed a vitamin D level close to zero and couldn't get it up by Vit D supplementation.

Anyway, I can round up all of my blood test and upload them if anybody wants.

Yes please, you may post them here: https://poiscenter.com/forums/index.php?topic=2684.0

And discuss about them here: https://poiscenter.com/forums/index.php?topic=2695.0

Journey

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #111 on: July 17, 2020, 01:52:32 AM »
I did show on one of the test my cholesterol was a little high which shocked me a lot.  My last test a few weeks ago showed low vitamin D which also shocked me considering I literally take a vitamin D pill every day and I'm outside a good bit.

I'm not surprised by these answers. My POIS doctor told me once he had a patient who expressed a vitamin D level close to zero and couldn't get it up by Vit D supplementation.

Anyway, I can round up all of my blood test and upload them if anybody wants.

Yes please, you may post them here: https://poiscenter.com/forums/index.php?topic=2684.0

And discuss about them here: https://poiscenter.com/forums/index.php?topic=2695.0
Isn't VitaminD used by immunity? Immunity or something else could be using up VitaminD in POIS or there's issue forming it so VitaminD deficiency causes/is related to POIS, not because of no sun/supplementation but as something prevents it from generating optimally.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #112 on: July 17, 2020, 08:02:22 AM »
Isn't VitaminD used by immunity? Immunity or something else could be using up VitaminD in POIS or there's issue forming it so VitaminD deficiency causes/is related to POIS, not because of no sun/supplementation but as something prevents it from generating optimally.

It is low in auto-immune diseases, inflammatory bowel disease, MCAD, malabsorption and can lead to osteoporosis. Low Vit D is probably the most frequent abnormality I've encountered so far on this forum and yet only one POIS paper has stated that the role of vit D could be investigated.

"It is also important to establish any influence on males with POIS, of the 25-OH D vitamin deficiency, if we consider the epidemic character and the implications of this vitamin(7)." Ref

The enzymes that play a role in vit D metabolism are Cytochrome P450 enzymes (indicated with CYP):
https://www.wikipathways.org/index.php/Pathway:WP1531

I haven't put time into this yet but noticed this today. The potential processes behind abnormalities seen in POISers, at least in this thread, might be driven by Cytochrome P450 enzymes (or their genes), https://en.wikipedia.org/wiki/Cytochrome_P450:
"Cytochrome P450 enzymes are present in most tissues of the body, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism."

Also these enzymes seem to need iron, low iron is also seen in POISers:
https://en.wikipedia.org/wiki/Cytochrome_P450#Structure

They also play a role in AA metabolism and could lead to inflammation by the molecules depicted in red, some POISers may actually suffer from an active inflammatory pathway via P450 instead of COX:


This family of enzymes can be affected by many things including diet. These enzymes are wide spread and I wonder if they can induce multi-system symptoms aside from conditions like MCAS.
« Last Edit: July 17, 2020, 10:14:42 AM by Muon »

drop247

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #113 on: July 17, 2020, 03:29:53 PM »
We need to check the "control" group to before we can say low Vitamin D is especially prevelant in this disorder POISers. What I'm saying is I suspect it's low in huge amount of the population.

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #114 on: August 30, 2020, 03:21:26 PM »
How is it going with the TRT treatment?

I'm actually a little confused. I was doing really great. Actually even had an orgasm last week and had absolutely zero symptoms afterwards. Thought I was cured!! This was the first time I have had an orgasm in a looooong time. Had sex (no orgasm) Friday night. I did end up with a headache by Saturday morning. I still have a slight headache now. It's definitely not as bad as before by any means. It's actually just more of the headache too instead of all of the brainfog and confusion and irritability that I used to get. I go back to the hormone doctor Tuesday. I'm still on a super ridiculously low dose of testosterone. I'm going to ask for my dose to be increased. I absolutely am doing much better than before though. There is drasticimprovement over how I used to get. I think I've had sex 4 times since starting the testosterone and one orgasm  and this is the first headache I have gotten. That's amazing for me.

My Test prescription is a cream that is compounded. It is 2 mgs, but I only apply .25 mgs of that daily.

Got my blood test back. My testosterone level went from basically zero to a 4. Even with getting a headache the last time that was still a huge improvement over what it used to be. So still keeping my fingers crossed.
« Last Edit: September 05, 2020, 12:15:57 PM by Muon »

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #115 on: September 05, 2020, 12:31:30 PM »
Heather's headache:

Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer's Disease

"Migraine is also known to induce BBB permeability"

"Increased BBB permeability causes edema, increased S100B expression, and neuroinflammation (Koh and Lee, 2014). Activated mast cells cause both neuronal response and vascular response, as they are close to BBB structure and neurons. Stress-induced mast cell activation in dural vasculature plays an important role in the acute and chronic headaches"

"Because of the presence of vicious positive-feedback mechanism of mast cells and glial cells activation with inflammatory mediators’ release, even a small number of mast cells can induce significant neuroinflammation in the brain. In fact, about 50% of histamine and 25% of tumor necrosis factor-alpha (TNF-alpha) are from the mast cells in the rat brain that can cause nociception and pain signals in the brain"

Things to test during headache: TNF-alpha (+IL-1beta and IL-6)

If headache affects BBB: VEGF, S100B

More parameters under the header: Mast Cells, Pain, and Neuroinflammation

Milnacipran worked for Hurray's brainfog + testosterone patches worked for his symptoms similar to TRT helping Heather: Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress

Additionally IL-1beta and IL-6 could be tested.
« Last Edit: September 05, 2020, 12:41:12 PM by Muon »

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #116 on: September 08, 2020, 11:37:11 AM »
I see you believe that mast cell activation syndrome could be the main cause of POIS, do you think it can cause acne too?

Maybe:

https://www.reddit.com/r/POIS/comments/ioi1lm/antihistamines_definitely_reduced_acne/

New Aspects in Acne Inflammation

Neuroendocrine regulation of sebocytes - a pathogenetic link between stress and acne

"These findings suggest that SP may stimulate lipogenesis of the sebaceous glands which may be followed by proliferation of Propionibacterium acnes, and may yield a potent influence on the sebaceous glands by provocation of inflammatory reactions via mast cells."
« Last Edit: September 08, 2020, 11:39:20 AM by Muon »

Muon

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #117 on: September 11, 2020, 01:14:13 PM »
How does the strength/intensity of orgasm affect POIS symptoms in female POISers? Any female that want to answer this?

Muon

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abdul

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Re: Women with Post Orgasmic Illness Syndrome
« Reply #119 on: September 26, 2020, 02:22:02 PM »
Hi everyone. I am a female poiser.
I am 27 and I had the symptoms since I was 10 or something.
I used to overmasturbate. And I think my pois is because of excessive masturbation
 I started masturbating at the age of 10 or so I guess, however this habit was not an ongoing one. I mean it was on and off. at the age of 19 I stopped masturbating and having sex and I did not have NE and that age. After 1 year of not having orgasm my symptoms have been reduced, but did not disappear. My face used to get very ugly and my stress level was super high. Now I still get ugly after orgasm but not as much as it used to get, and I still have all symptoms but in a lighter level compared to the past. But it is still VERY annoying. I decided to stop having orgasm for a couple of years but that seems impossible because of NEs. Every 6 day one NE!
I am sure my pois is because of over masturbation
My question is if any of you has the same problem? Did you over masturbate?
Do you think excessive masturbation or masturbating at early age (before puberty) caused your pois, too?

I believe that our nervous systems have been overstimulated by excessive orgasms and we need to find out to restore its normal functionalities