Author Topic: Ideas on Endothelial Dysfunction  (Read 5614 times)

Nas

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Re: Ideas on Endothelial Dysfunction
« Reply #90 on: July 28, 2018, 06:41:23 PM »
My problems also show at right about the 24th hour.  Its creepy why the heck symptoms dont begin right away.  My 7th day will be tomorrow I am already celebrating for tomorrow to come.   So much relief is on the way.   

Brilliant. But why the delay ? I feel 50% muscular energy loss on day 2, not just after orgasm. Is choline loss with semen causing Ach defiency 24h later ?

In my case my cognitive symptoms start immediately and they build up for full hour. Then there are other symptoms that take time to appear, they are usually psychological and emotional; at about day 2 of POIS I start feeling down and I start getting attacked by pure OCD thoughts that either make me panic or more depressed. I think this has to do with how neurotransmitters are effected by brain inflammation.

Nas

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Re: Ideas on Endothelial Dysfunction
« Reply #91 on: August 30, 2018, 06:26:47 PM »
So one of the things we need to investigate is, what happens at the Urethra during ejaculation? Does the body attack semen that is stuck to the walls of the urethra and cause a sensitive reaction? Or is there a leak that causes semen to diffuse through the urethra and spread into blood and pass through multiple organs causing an either: 1) Allergic reaction 2) The body tries to get rid of this diffused semen but it faces difficulties and thus it gets stuck in a sarcoidosis like state 3) an auto-immune response ( I don't know because I can't tell from Muon's tests what he actually has, I wish his doctors would figure it out but apparently Muon seems to be meeting one of the worst doctors out there lol, ok that's not fair since non of them know about POIS but perhaps if they knew some stuff about POIS they would be able to tell? ).

What I also like to mention that it could be a case where every person who suffers from POIS can a have a totally different type of immune response to leaked out semen. This would explain why different treatment methods work specifically for some while it completely fails for others.

So any creative ideas to see if we can test for that? I would really appreciate your suggestions.

Thanks!

Vandemolen

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Re: Ideas on Endothelial Dysfunction
« Reply #92 on: August 30, 2018, 08:49:04 PM »
I have a small cyst near my testicles. My theory was that after ejaculation a small amount of semen stays there and that’s the cause of my UTI or/and my POIS. But my urologist doesn’t think so. He said the cyst is small.
POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.

Nas

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Re: Ideas on Endothelial Dysfunction
« Reply #93 on: August 30, 2018, 10:37:38 PM »
I have a small cyst near my testicles. My theory was that after ejaculation a small amount of semen stays there and that’s the cause of my UTI or/and my POIS. But my urologist doesn’t think so. He said the cyst is small.

Which is most likely correct. I don't speculate POIS occurs in the testicles region rather at the urethra.

Muon

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Re: Ideas on Endothelial Dysfunction
« Reply #94 on: January 11, 2019, 10:14:47 AM »
Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men

''In conclusion, a low plasma testosterone level was associated with endothelial dysfunction in men independent of other risk factors, suggesting a protective effect of endogenous testosterone on the endothelium.''

Since we have a bunch of members with low testosterone, there is a chance they could have an endothelial dysfunction as well.
People using TRT could be modulating their endothelial function. If this is the case and POIS symptoms improve then could POIS be related to an endothelial dysfunction? More food for thought.
« Last Edit: January 11, 2019, 10:26:26 AM by Muon »

Nas

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Re: Ideas on Endothelial Dysfunction
« Reply #95 on: January 11, 2019, 10:32:43 AM »
Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men

''In conclusion, a low plasma testosterone level was associated with endothelial dysfunction in men independent of other risk factors, suggesting a protective effect of endogenous testosterone on the endothelium.''

Since we have a bunch of members with low testosterone, there is a chance they could have an endothelial dysfunction as well.
People using TRT could be modulating their endothelial function. If this is the case and POIS symptoms improve then could POIS be related to an endothelial dysfunction? More food for thought.
Could NO dysfunction = weak pelvic muscles, thus = PE ?

Muon

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Re: Ideas on Endothelial Dysfunction
« Reply #96 on: January 11, 2019, 10:51:38 AM »
Could NO dysfunction = weak pelvic muscles, thus = PE ?
NO dysfunction could be responsible for hyperexcitatory disturbances of ejaculation (premature ejaculation). Here is a paper my POIS doctor gave me a long time ago: https://www.ncbi.nlm.nih.gov/pubmed/12597985 These kind of drugs may have an effect on PE.
Endothelial dysfunction could indicate problems relating to NO/acetylcholine cycles. We need FMD testing and if these are positive then this could be an indication to look further into NO and/or acetylcholine.
« Last Edit: January 11, 2019, 10:59:34 AM by Muon »

Nas

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Re: Ideas on Endothelial Dysfunction
« Reply #97 on: January 11, 2019, 11:35:24 AM »
Could NO dysfunction = weak pelvic muscles, thus = PE ?
NO dysfunction could be responsible for hyperexcitatory disturbances of ejaculation (premature ejaculation). Here is a paper my POIS doctor gave me a long time ago: https://www.ncbi.nlm.nih.gov/pubmed/12597985 These kind of drugs may have an effect on PE.
Endothelial dysfunction could indicate problems relating to NO/acetylcholine cycles. We need FMD testing and if these are positive then this could be an indication to look further into NO and/or acetylcholine.
Nitric-oxide donating drugs could be a good way of testing the role of NO on POIS. My deduction of its role, is probably related to our PE problems, the question is whether it is a fundamental issue in POIS, or just another symptom of the hyperactive immune-response in POIS.

Vandemolen

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Re: Ideas on Endothelial Dysfunction
« Reply #98 on: January 11, 2019, 11:42:10 AM »
Could NO dysfunction = weak pelvic muscles, thus = PE ?
NO dysfunction could be responsible for hyperexcitatory disturbances of ejaculation (premature ejaculation). Here is a paper my POIS doctor gave me a long time ago: https://www.ncbi.nlm.nih.gov/pubmed/12597985 These kind of drugs may have an effect on PE.
Endothelial dysfunction could indicate problems relating to NO/acetylcholine cycles. We need FMD testing and if these are positive then this could be an indication to look further into NO and/or acetylcholine.
Nitric-oxide donating drugs could be a good way of testing the role of NO on POIS. My deduction of its role, is probably related to our PE problems, the question is whether it is a fundamental issue in POIS, or just another symptom of the hyperactive immune-response in POIS.
The question is why some POIS-patients have PE and others do not. I can last for hours. One time more than 4 hours. And is PE connected to POIS? We think so because the majority of the POIS-patients in the first Waldinger-paper have PE. When I came to this forum and before on the Naked Scientist Forum I discovered there are a lot of other men who do not have PE. The same for prostate/bladder problems. I have that problem. So I thought it was connected with POIS. But a lot of members here do not have those problems.
POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.

Muon

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Re: Ideas on Endothelial Dysfunction
« Reply #99 on: January 11, 2019, 11:55:58 AM »
Guys, the bottom line is; We will need testing/research, these will give us answers. Without research, we will continue to speculate in circles for years here on this forum.

Nas

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Re: Ideas on Endothelial Dysfunction
« Reply #100 on: January 11, 2019, 11:58:26 AM »
Guys, the bottom line is; We will need testing/research, these will give us answers. Without research, we will continue to speculate in circles for years here on this forum.
I'm getting NO supplements soon, that'll be my part.

Muon

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Re: Ideas on Endothelial Dysfunction
« Reply #101 on: January 11, 2019, 12:08:13 PM »
Guys, the bottom line is; We will need testing/research, these will give us answers. Without research, we will continue to speculate in circles for years here on this forum.
I'm getting NO supplements soon, that'll be my part.
I have read something about it that it's not known whether taking them in supplement form can also have an impact on NO synthesis. The drugs stated in the paper are different than the 'NO' supplements which you can buy in store.

Nas

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Re: Ideas on Endothelial Dysfunction
« Reply #102 on: January 11, 2019, 12:51:07 PM »
So one of the biggest mysteries about POIS that I just simply cannot decipher, is the type of immune response that is suggested to cause the symptoms. On one hand, Waldinger tested positive for semen prick tests, but is this an indication of auto-immune disease? In that I question, whether normal people also can test positive for semen prick test without having POIS? Then I ask about the type of immune response in POIS, if it is MCAS related, then why does usual MCAS treatment which comprises of anti-histamine treatment not work for me? When I try to think about possible reasons I can not find any other explanation to MCAS. Yet when I ask MCAS sufferers who suffer from Neuropsychiatric symptoms about what they take as remedy they say that usual MCAS treatment gave them back their brain, yet it clearly fails in my case. In fact I question if there was an immune response at all?
I know that Muon always suggests doing tests but where have tests lead us so far? We need a better theoretical frame to base our tests on. Currently I find the Mast Cell theory to be the most testable of the other theories. But I find that the lack of effect the MCAS treatment regiment had on me is starting to give me doubts. This illness is nothing less than a curse, one that is more seen in the world of the metaphysical. Sigh.

Muon

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Nas

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Re: Ideas on Endothelial Dysfunction
« Reply #104 on: January 22, 2019, 10:34:39 AM »
Nebivolol: The Somewhat-Different β-Adrenergic Receptor Blocker

Comparison of Beta blockers on endothelial function

''In conclusion, nebivolol has beneficial effects on endothelial function mainly by increasing NO bioavailability.''
Nebivolol and Endothelial Dysfunction in Patients With Essential Hypertension: A Reputation Saver of β‐Blockers?
Again, I'm not really sure about this, wouldn't lowering the blood pressure be bad for POTS? If not it would also be bad for inflammation? Since more vasodilation means more penetration?