Ideas on Endothelial Dysfunction

[swell]

Thank you Dizzy.  Thank you Muon.  Muon would you know if HPV can be treated in the oral epithelium.  Since I dont have access to testing maybe I can try a supplement to see if my throat/vocal cord symptom improve

[Muon]

I have no idea, haven't looked into it though. Try to google it. But the first step should be to check if HPV plays a role. Someone should explore this option to rule out HPV involvement.

[swell]

Was just messing.  With medical docs there is no effective treatment for epithelial HPV etc.  There are vaccines that are still being 'researched' (pun intended) and they are not effective for over 21 anyway.   There are adjunct treatments laser that cuts through HPV affected tissue growths etc, but they are all localised treatments not useful unless cancerous, so nothing that can benefit a systemic problem acrossbody like POIS.  I dont think our POIS solution lies with docs its really chemistry, biomolecular practitioners that will if provide any breakthrough.

I have no idea, haven't looked into it though. Try to google it. But the first step should be to check if HPV plays a role. Someone should explore this option to rule out HPV involvement.

[Nas]

Hello guys,
Sorry for being absent from this forum, Iraq had been experiencing heavy protests and our "democratic government" decided to shut down internet access completely ( Thanks America! ) and not until lately have we had the chance of accessing internet through VPN.
So meanwhile I've been thinking about POIS and this theory, and one of the things that still baffle me is how are the brain and the reproductive system correlate to get us to have symptoms in both of those regions.
My theory comes down to that there are Epithelial leaks in the Urethra that causes the semen to leak into blood, then the immune system starts attacking the sperm component.
My only question remaining is: What's next? How do symptoms form? Does these sperm cells ( Or what ever is causing this auto-immune response ) inter the brain through the BBB? Do they enter other endotheliums and epitheliums causing the rest of the Physical symptoms?
So in order to confirm all of these suspicions, the following questions need to be answered:
1- Do you guys experience chronic Urethral inflammation? Pain or difficulty in peeing?
2- If semen or a semen components enters the blood stream, doesn't that mean that they are testable or observable in blood samples? Have you guys ever looked for semen or sperms in your blood right after ejaculation?
I think question 2 is very important when it comes to confirming this theory, if we do not find any traces then this theory is most likely incorrect, if anyone is able to make this test please let us know your results.
Thank you. 

[Nas]

Acetylcholine released by endothelial cells facilitates flow‐mediated dilatation:

"Circulating blood generates frictional forces (shear stress) on the walls of blood vessels. These frictional forces critically regulate vascular function. The endothelium senses these frictional forces and, in response, releases various vasodilators that relax smooth muscle cells in a process termed flow‐mediated dilatation."

"we show that the endothelium responds to flow by releasing ACh. Once liberated, ACh acts to trigger calcium release from the internal store in endothelial cells, nitric oxide production and artery relaxation."

Memeber ThisType Said that he did a genetic test and found mutations in these regions:
rs16969968 Nicotinic Acetylcholine Receptors
rs1051730 Nicotinic Acetylcholine Receptors
rs1824024 Muscarinic Acetylcholine Receptors. Ref

Hmmm, perhaps the Acetylcholine deficiency causes problems in Endothelial signaling?

[b_jim]

Brilliant. But why the delay ? I feel 50% muscular energy loss on day 2, not just after orgasm. Is choline loss with semen causing Ach defiency 24h later ?

[Nas]

Brilliant. But why the delay ? I feel 50% muscular energy loss on day 2, not just after orgasm. Is choline loss with semen causing Ach defiency 24h later ?

I don't know man, this illness is so confusing and nothing works for me and I just keep theorizing but reaching nothing, I so feel done with this crap.

[dizzy]

I don't know man, this illness is so confusing and nothing works for me and I just keep theorizing but reaching nothing, I so feel done with this crap.

I've been theorizing about my own situation, and perhaps there is a connection with (sex/porn) addiction, where the urge is delayed until day 2, because that's sort of when libido fully restores. The urge may cause the muscle problems. (?)

Not sure how that would be explained in terms of biochemistry though.

[Nas]

I don't know man, this illness is so confusing and nothing works for me and I just keep theorizing but reaching nothing, I so feel done with this crap.

I've been theorizing about my own situation, and perhaps there is a connection with (sex/porn) addiction, where the urge is delayed until day 2, because that's sort of when libido fully restores. The urge may cause the muscle problems. (?)

Not sure how that would be explained in terms of biochemistry though.

 Nah I don't think so, there are alot of people suffering from sex/porn addiction without having their genitals on flames after they done ejaculating. It's clearly and immune response to what ever is immunogenic. 

[swell]

My problems also show at right about the 24th hour.  Its creepy why the heck symptoms dont begin right away.  My 7th day will be tomorrow I am already celebrating for tomorrow to come.   So much relief is on the way.   

Brilliant. But why the delay ? I feel 50% muscular energy loss on day 2, not just after orgasm. Is choline loss with semen causing Ach defiency 24h later ?

[Nas]

My problems also show at right about the 24th hour.  Its creepy why the heck symptoms dont begin right away.  My 7th day will be tomorrow I am already celebrating for tomorrow to come.   So much relief is on the way.   

Brilliant. But why the delay ? I feel 50% muscular energy loss on day 2, not just after orgasm. Is choline loss with semen causing Ach defiency 24h later ?

In my case my cognitive symptoms start immediately and they build up for full hour. Then there are other symptoms that take time to appear, they are usually psychological and emotional; at about day 2 of POIS I start feeling down and I start getting attacked by pure OCD thoughts that either make me panic or more depressed. I think this has to do with how neurotransmitters are effected by brain inflammation.

[Nas]

So one of the things we need to investigate is, what happens at the Urethra during ejaculation? Does the body attack semen that is stuck to the walls of the urethra and cause a sensitive reaction? Or is there a leak that causes semen to diffuse through the urethra and spread into blood and pass through multiple organs causing an either: 1) Allergic reaction 2) The body tries to get rid of this diffused semen but it faces difficulties and thus it gets stuck in a sarcoidosis like state 3) an auto-immune response ( I don't know because I can't tell from Muon's tests what he actually has, I wish his doctors would figure it out but apparently Muon seems to be meeting one of the worst doctors out there lol, ok that's not fair since non of them know about POIS but perhaps if they knew some stuff about POIS they would be able to tell? ).

What I also like to mention that it could be a case where every person who suffers from POIS can a have a totally different type of immune response to leaked out semen. This would explain why different treatment methods work specifically for some while it completely fails for others.

So any creative ideas to see if we can test for that? I would really appreciate your suggestions.

Thanks!

[Vandemolen]

I have a small cyst near my testicles. My theory was that after ejaculation a small amount of semen stays there and that’s the cause of my UTI or/and my POIS. But my urologist doesn’t think so. He said the cyst is small.

[Nas]

I have a small cyst near my testicles. My theory was that after ejaculation a small amount of semen stays there and that’s the cause of my UTI or/and my POIS. But my urologist doesn’t think so. He said the cyst is small.

Which is most likely correct. I don't speculate POIS occurs in the testicles region rather at the urethra.

[Muon]

Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men

''In conclusion, a low plasma testosterone level was associated with endothelial dysfunction in men independent of other risk factors, suggesting a protective effect of endogenous testosterone on the endothelium.''

Since we have a bunch of members with low testosterone, there is a chance they could have an endothelial dysfunction as well.
People using TRT could be modulating their endothelial function. If this is the case and POIS symptoms improve then could POIS be related to an endothelial dysfunction? More food for thought.

[Nas]

Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men

''In conclusion, a low plasma testosterone level was associated with endothelial dysfunction in men independent of other risk factors, suggesting a protective effect of endogenous testosterone on the endothelium.''

Since we have a bunch of members with low testosterone, there is a chance they could have an endothelial dysfunction as well.
People using TRT could be modulating their endothelial function. If this is the case and POIS symptoms improve then could POIS be related to an endothelial dysfunction? More food for thought.

Could NO dysfunction = weak pelvic muscles, thus = PE ?

[Muon]

Could NO dysfunction = weak pelvic muscles, thus = PE ?

NO dysfunction could be responsible for hyperexcitatory disturbances of ejaculation (premature ejaculation). Here is a paper my POIS doctor gave me a long time ago: https://www.ncbi.nlm.nih.gov/pubmed/12597985 These kind of drugs may have an effect on PE.
Endothelial dysfunction could indicate problems relating to NO/acetylcholine cycles. We need FMD testing and if these are positive then this could be an indication to look further into NO and/or acetylcholine.

[Nas]

Could NO dysfunction = weak pelvic muscles, thus = PE ?

NO dysfunction could be responsible for hyperexcitatory disturbances of ejaculation (premature ejaculation). Here is a paper my POIS doctor gave me a long time ago: https://www.ncbi.nlm.nih.gov/pubmed/12597985 These kind of drugs may have an effect on PE.
Endothelial dysfunction could indicate problems relating to NO/acetylcholine cycles. We need FMD testing and if these are positive then this could be an indication to look further into NO and/or acetylcholine.

Nitric-oxide donating drugs could be a good way of testing the role of NO on POIS. My deduction of its role, is probably related to our PE problems, the question is whether it is a fundamental issue in POIS, or just another symptom of the hyperactive immune-response in POIS.

[Vandemolen]

Could NO dysfunction = weak pelvic muscles, thus = PE ?

NO dysfunction could be responsible for hyperexcitatory disturbances of ejaculation (premature ejaculation). Here is a paper my POIS doctor gave me a long time ago: https://www.ncbi.nlm.nih.gov/pubmed/12597985 These kind of drugs may have an effect on PE.
Endothelial dysfunction could indicate problems relating to NO/acetylcholine cycles. We need FMD testing and if these are positive then this could be an indication to look further into NO and/or acetylcholine.

Nitric-oxide donating drugs could be a good way of testing the role of NO on POIS. My deduction of its role, is probably related to our PE problems, the question is whether it is a fundamental issue in POIS, or just another symptom of the hyperactive immune-response in POIS.

The question is why some POIS-patients have PE and others do not. I can last for hours. One time more than 4 hours. And is PE connected to POIS? We think so because the majority of the POIS-patients in the first Waldinger-paper have PE. When I came to this forum and before on the Naked Scientist Forum I discovered there are a lot of other men who do not have PE. The same for prostate/bladder problems. I have that problem. So I thought it was connected with POIS. But a lot of members here do not have those problems.

[Muon]

Guys, the bottom line is; We will need testing/research, these will give us answers. Without research, we will continue to speculate in circles for years here on this forum.