Gather and Post Here Your Medical Tests Results - Discussion Thread

[Muon]

Has anyone done an Omega-3 blood test? Many discussions about fatty acids but what are the levels in POISers?

[Andre2505]

Guys tomorrow I'll have to do some blood tests, Does it make sense to do them in a state of pois? for me yes, in fact I think I'll masturbate today, I have the analysis tomorrow morning

[Muon]

What could be the consequence of having a low secretory IgA?

https://www.perplexity.ai/search/what-could-be-the-consequence-fDqJZmnGTfOiQmPMG.CZYQ

Low secretory IgA (sIgA) levels can have several significant consequences for an individual's health, primarily affecting the immune system and mucosal surfaces. Here are the key implications:

## Increased Susceptibility to Infections

Low sIgA levels weaken the body's first line of defense against pathogens, particularly at mucosal surfaces like the respiratory tract, gastrointestinal system, and urogenital tract[1]. This can lead to:

- Frequent colds and sinus infections
- Recurrent respiratory infections
- Increased risk of gastrointestinal infections

## Digestive Issues

The gastrointestinal tract is particularly vulnerable when sIgA levels are low, potentially resulting in:

- Irritable Bowel Syndrome (IBS) symptoms
- Inflammatory Bowel Disease (IBD)
- Increased intestinal permeability ("leaky gut")
- Overgrowth of harmful bacteria, dysbiosis, and potential parasitic infections[2]

## Autoimmune and Inflammatory Conditions

Low sIgA can contribute to the development or exacerbation of autoimmune and inflammatory conditions:

- Higher risk of developing autoimmune diseases
- Skin problems such as acne or eczema
- Allergies and food sensitivities[3]

## Impaired Nutrient Absorption

The compromised gut barrier function associated with low sIgA can lead to:

- Malabsorption of nutrients
- Increased risk of nutrient deficiencies
- Potential for weight loss or malnutrition in severe cases

## Chronic Fatigue and Reduced Overall Health

The ongoing stress on the immune system can result in:

- Persistent fatigue and exhaustion
- Adrenal fatigue
- Generally lowered immune function[4]

## Increased Food Sensitivities

Low sIgA levels can make individuals more prone to developing food sensitivities, as the weakened mucosal barrier allows larger food particles to enter the bloodstream, potentially triggering immune responses[3].

To address low sIgA levels, it's crucial to identify and address the underlying causes, which may include chronic stress, poor diet, nutrient deficiencies, or chronic infections. Implementing stress management techniques, improving nutrition, and addressing any underlying health issues can help support and restore healthy sIgA levels[1][4].

Citations:
[1] https://www.rupahealth.com/post/secretory-iga-understanding-high-and-low-levels-causes-and-treatment-options
[2] https://sonyareynolds.com.au/secretory-iga/
[3] https://www.nutritionist-resource.org.uk/memberarticles/could-low-secretory-iga-be-the-driving-force-in-autoimmunity
[4] https://www.stevegranthealth.com/articles-posts/low-secretory-iga-siga-levels-causing-immune-digestive-issues/
[5] https://healthmatters.io/understand-blood-test-results/fecal-secretory-iga
[6] https://primaryimmune.org/understanding-primary-immunodeficiency/types-of-pi/selective-iga-deficiency
[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422646/
[8] https://vitawell.com.au/the-meaning-of-low-secretory-iga-levels/

[Sisyphus]

I just had some more general blood tests which I have done twice a year.
There are consistent patterns with my out of range blood tests, the ones of interest as follows:-

low neutrophils
high bilirubin (Gilbert's Syndrome diagnosis)
high transferrin saturation
low blood glucose
high testosterone
low PTH

Regarding low neutrophils, seems to be common amongst poisers. In my case I link it with all the recurrent infections I get.

Regarding high bilirubin, Gilbert's seems to be common amongst poisers.

Regarding high transferrin saturation, I've had a gene test for hemochromatosis which was negative.

Regarding low blood glucose, maybe this is just due to it being a fasting blood test.

Regarding high testosterone, haha, very deceptive. I'm built like a noodle and have the libido of a Panda. Low/normal testosterone levels seems more common in poisers.

Regarding PTH, I don't know much about it. My phosphate and calcium (adjusted) levels were normal. Does anyone else have low parathyroid hormone (PTH)? @Demografx - I read low PTH can cause tingling fingers and when I read this I thought of a symptom you mentioned in a post somewhere. I realise tingling fingers could probably be 100 other things but I wondered if you'd ever had your PTH tested?

[Warrior]

I just had some more general blood tests which I have done twice a year.
There are consistent patterns with my out of range blood tests, the ones of interest as follows:-

low neutrophils
high bilirubin (Gilbert's Syndrome diagnosis)
high transferrin saturation
low blood glucose
high testosterone
low PTH

Regarding low neutrophils, seems to be common amongst poisers. In my case I link it with all the recurrent infections I get.

Regarding high bilirubin, Gilbert's seems to be common amongst poisers.

Regarding high transferrin saturation, I've had a gene test for hemochromatosis which was negative.

Regarding low blood glucose, maybe this is just due to it being a fasting blood test.

Regarding high testosterone, haha, very deceptive. I'm built like a noodle and have the libido of a Panda. Low/normal testosterone levels seems more common in poisers.

Regarding PTH, I don't know much about it. My phosphate and calcium (adjusted) levels were normal. Does anyone else have low parathyroid hormone (PTH)? @Demografx - I read low PTH can cause tingling fingers and when I read this I thought of a symptom you mentioned in a post somewhere. I realise tingling fingers could probably be 100 other things but I wondered if you'd ever had your PTH tested?

I have low neutrophils. Very common amongst POISers. These have improved substantially for me though as I've worked on my protocol.

Interesting that you have high transferrin. I'm the opposite.

[berlin1984]

high transferrin saturation
...
Regarding high transferrin saturation, I've had a gene test for hemochromatosis which was negative.

Did you also measure ferritin?
What was your transferrin saturation?
Which genes were tested for hemochromatosis, can you say the exact results? You might have symptoms even with heterozygous mutations.

[Sisyphus]

My neutrophils are typically only just below normal (1.89 10⁹/L in the most recent test) and when I've shown results like that to my doctor in the past, he tends to shrug his shoulders. I think they need to be much lower for him to take an interest.
I couldn't see a poll on neutrophil count in this forum so I've started one. I think it's potentially a biomarker for a subgroup of poisers and therefore of interest.

Transferrin saturation was 75% (normal is  20.1 to 50%)
Transferrin was 2.04 (normal is 2.01 to 3.8 g/l)
Ferritin was 150.66 (normal is 20 to 300μg/l)
Iron was 40.1 (normal is 5.9 to 34.5 μmol/l)
In previous tests my iron and ferritin levels have been normal, transferrin saturation is consistently high.

Re the haemochromatosis gene test, I don't know I'm afraid. My GP called me with the results at a bad moment and all I took in was that they were negative. I will try to find out and let you know Berlin.

[Sisyphus]

I'm becoming increasingly interested in PTH. Google tells me that amongst other things, hypoparathyroidism can make you vitamin D deficient and can be connected with fungal infections ex/ candida infections. It could be a red herring and I've had quite a few of those with POIS research but I'm going to delve into this a bit more.
It would be very interesting to hear if anyone else on this forum has a low PTH level.

[demografx]

Hi Sisyphus,
Not definitive. Just an “FYI”
PerplexityAI on PTH and POIS:
https://www.perplexity.ai/search/low-pth-and-pois-4tqd8u6iQnSdFIn5w4tK5A

“Low levels of parathyroid hormone (PTH) can lead to hypoparathyroidism, a condition characterized by low calcium and high phosphorus levels in the blood. Symptoms include muscle cramps, twitching, and fatigue. Causes of hypoparathyroidism include surgical removal or damage to the parathyroid glands, autoimmune disorders, and genetic conditions. Treatment typically involves lifelong calcium and vitamin D supplementation to maintain normal mineral levels.
POIS (Post-Orgasmic Illness Syndrome) is unrelated to PTH. It is a condition where men experience flu-like symptoms after ejaculation. The causes of POIS are not well understood, and it is a rare condition.”


Above emphasis mine,
Demo

[Sisyphus]

high transferrin saturation
...
Regarding high transferrin saturation, I've had a gene test for hemochromatosis which was negative.

Did you also measure ferritin?
What was your transferrin saturation?
Which genes were tested for hemochromatosis, can you say the exact results? You might have symptoms even with heterozygous mutations.

I got the details about my gene test from my doctor. Actually, the gene test seems to be semi positve in that I'm a carrier but there's only one copy. It says:-
Analysis has detected one copy of the heterozygous HFE variant c.187C>Gp.(his63Asp). The c.845G>A p.(Cys282Tyr) sequence variant was not detected.
The result confirms that this patient is a carrier of the c.187C>Gp.(his63Asp) variant in the HFE gene. The diagnosis of the most common HFE-related HH is excluded. Other causes of iron overload should be considered.
Hi Berlin, See above and if you need more info, please send me a PM.

[Sisyphus]

Hi Sisyphus,
Not definitive. Just an “FYI”
PerplexityAI on PTH and POIS:
https://www.perplexity.ai/search/low-pth-and-pois-4tqd8u6iQnSdFIn5w4tK5A

“Low levels of parathyroid hormone (PTH) can lead to hypoparathyroidism, a condition characterized by low calcium and high phosphorus levels in the blood. Symptoms include muscle cramps, twitching, and fatigue. Causes of hypoparathyroidism include surgical removal or damage to the parathyroid glands, autoimmune disorders, and genetic conditions. Treatment typically involves lifelong calcium and vitamin D supplementation to maintain normal mineral levels.
POIS (Post-Orgasmic Illness Syndrome) is unrelated to PTH. It is a condition where men experience flu-like symptoms after ejaculation. The causes of POIS are not well understood, and it is a rare condition.”


Above emphasis mine,
Demo

Hi Demo
Thanks for getting back to me. Thanks for the info on PTH. I'm not surprised that AI does not connect PTH with POIS. It will probably be proven one day that there is no connection between the two but until then, I prefer to keep a completely open mind about my POIS including all theories, causes, symptoms, everything, including PTH, until more research is done.

[demografx]

Sisyphus, thanks for your excellent perspective on waiting for POIS correlates to be proven/disproven. Scientifically!

[Sisyphus]

Sisyphus, thanks for your excellent perspective on waiting for POIS correlates to be proven/disproven. Scientifically!

You're welcome Demo. I'm fascinated by medical research (what I can understand of it!).