I have some very interesting results to share.
I did a CBC after 11 days of abstinence. Right after the test was done, in the evening, I released twice. In the morning, I went to do another CBC. (Ordered both tests privately).
For many years I have had low neutrophils.
In the first CBC, my neutrophil count was 3.6. In the second CBC, taken the morning after 2 releases, my neutrophils were 2.1. This change literally happened in under 24 hours. I am currently not sick at all. This sudden and significant change in neutrophils are most likely caused by POIS.
Going to bring this experiment & result up with my functional med doc next time I see him.
Here are the results:
22/12/2022 2:50pm
https://gyazo.com/636415511d8fb29b7dac4104a63b3f48
Neutrophils 3.6
23/12/2022 8am
https://gyazo.com/abda0a1a284d88c8917f2d7d2fcc00ab
Neutrophils 2.1
I also have many blood tests dating back to 2020 with consistently low neutrophils, always around 1.8. I believe that my POIS solution has reduced the time my body is in the POIS state, and therefore gives my body a greater chance to get neutrophil ranges back to normal (hence 3.6 result after 11 days of abstience).
Also, the display of results between both days are different because I went to different pathologists (one I normally go to was closed).
Type IVd hypersensitvity is categorized as CD3+CD4+ and CD3+CD8+ T-cells which attract neutrophils mainly via GM-CSF and IL-8. The attraction works by gradients of these chemokines leading to sterile neutrophilic inflammation. Do neutrophil levels decrease due to extravasation? I've asked this to ChatGPT:
Question: What if neutrophils infiltrate tissue, is it possible it can lower neutrophils levels in blood?
Answer:
Yes, it is possible for neutrophil levels in the blood to decrease when they infiltrate tissues. Neutrophils are a type of white blood cell that plays a crucial role in the innate immune response. When an inflammatory process occurs, such as infection or tissue injury, neutrophils are recruited from the blood vessels to the site of inflammation or injury.
During inflammation, several factors guide neutrophils to migrate out of the blood vessels and into the affected tissues. This process is called extravasation. Once in the tissues, neutrophils can carry out their functions, including phagocytosis of pathogens and release of antimicrobial substances.
As neutrophils leave the bloodstream and migrate into tissues, their levels in the blood can decrease. This is because they are actively being recruited to the site of inflammation and are no longer circulating in the bloodstream. The movement of neutrophils from the blood vessels to the tissues is a tightly regulated process involving adhesion molecules, chemokines, and other signaling molecules.
It's worth noting that the decrease in neutrophil levels in the blood due to tissue infiltration is usually temporary. The bone marrow continuously produces new neutrophils to replenish the circulating pool. Once the inflammatory response subsides, the balance between neutrophil recruitment to tissues and their release from the bone marrow is restored, leading to a return to normal neutrophil levels in the blood.
