Gather and Post Here Your Medical Tests Results - Discussion Thread

[BoneBroth]

Guess what! My new doctor, who is a german gastroenterolog, knew all about SIBO and POIS and will take additional poop analysis and blood tests and put me on a 2 week antibiotic specifically for SIBO. I showed him my "alternative" bacterial analysis and lactulose test and he seriously looked at them and even ask the secretary to scan them and add to my medical journal! I'm still not sure if I'm dreaming or if this doctor is real...

[Journey]

Guess what! My new doctor, who is a german gastroenterolog, knew all about SIBO and POIS and will take additional poop analysis and blood tests and put me on a 2 week antibiotic specifically for SIBO. I showed him my "alternative" bacterial analysis and lactulose test and he seriously looked at them and even ask the secretary to scan them and add to my medical journal! I'm still not sure if I'm dreaming or if this doctor is its real...

Extremely happy to hear that :-)

[Quantum]

Guess what! My new doctor, who is a german gastroenterolog, knew all about SIBO and POIS and will take additional poop analysis and blood tests and put me on a 2 week antibiotic specifically for SIBO. I showed him my "alternative" bacterial analysis and lactulose test and he seriously looked at them and even ask the secretary to scan them and add to my medical journal! I'm still not sure if I'm dreaming or if this doctor is its real...

That's good to hear, there is more awareness about POIS among doctors than 10 years ago. 

BoneBroth, if you think your new doctor would be a good addition to our POIS Doctors list, let me know.  You can ask him if he is interested, or, if you prefer, just send me in PM his name and email address and I will ask him.

[BoneBroth]

I'll give it a try! Xifaxan (also known as Rifaximin) is what the doctor prescribed. It seems to be a popular antibiotic used for SIBO. There are some studies confirming its effectiviness and safety. I can find only two POIS users that has tryed Rifaximin on this forum. It didnt work for user lw, but user Bob morane reports good results. User Reve is currently taking it and sais he will update on this. Muon writes that "Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin." and has a compilation of users that tryed antibiotics here. My SIBO test showed only methane though...

[Charles_b]

I'll give it a try! Xifaxan (also known as Rifaximin) is what the doctor prescribed. It seems to be a popular antibiotic used for SIBO. There are some studies confirming its effectiviness and safety. I can find only two POIS users that has tryed Rifaximin on this forum. It didnt work for user lw, but user Bob morane reports good results. User Reve is currently taking it and sais he will update on this. Muon writes that "Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin." and has a compilation of users that tryed antibiotics here. My SIBO test showed only methane though...

I tried Xifaxan and Neomycin and it didn’t make a difference for me.  Still might help others, but wanted to throw my anecdote into the growing pool of data.

[BoneBroth]

Thanks Charles_b. What dose and for how long did you take it? Did you do a SIBO test and if so, was it positive on hydrogen, methane or both? Studies show improvements between 70-80% of patients with Rifaximin.

[berlin1984]

Tested positive for SIBO. Genova Diagnostics breath test. Let me know if anyone wants to see the full test results.

We want to :-)

Doesn't have to be detailed PNG/JPEG, i think it's enough if you say which kind of SIBO and what are the values(?)
I don't know if those numbers are comparable, but still interesting.

[BoneBroth]

User Clues SIBO test result is not very convincing for a SIBO diagnosis, the values is almost exactly on the start interval for SIBO. My lactulose tests was postivite only for methane, but quite hight.

[LookingForACure]

By popular request, here are the SIBO test results from Genova Diagnostics in full. Tested positive on both hydrogen and methane, but only just. Have started a cure of Berberine and Candibactin-AR, as recommended by my doctor. The latter is a prescription-only mix of herb extracts. The doc says this is scientifically proven to be at least as effective as antibiotics against SIBO.

Please consult a doctor before trying out any of these supplements. For example, Berberine can ostensibly interact unfavourably with some medicines.

Front page:



All pages:

Image 1
Image 2
Image 3

Clues, I'm looking forward to hearing about your results with candibactin AR and berberine. I went on candibactin AR and candibactin BR (which is primarily berberine) and experienced noticeable improvement in both my POIS and overall well-being. The effects unfortunately did not last forever in my case, but I probably experienced the closest thing to remission that I have ever had.

[demografx]

Not oficial, but i think it is worth to put this info here...
https://www.reddit.com/r/POIS/comments/rgr1xj/pois_research_in_china_before_20211215/

POIS research in China before 2021.12.15
My doctor, Guangpeng Xi, an allergist in Harbin, Heilong Jiang province, China, showed some interesting results of POISers. He collected the blood of six POISers and that of six healthy men, and test the semen-specific IgE antibody in their blood. The experiment shows the antibody exists in all of the 12 blood. BUT! Two POISers have higher concentration antibody than healthy men. Considering all of the POISers devote their blood during their healthy time(no-pois time), it is possible that POIS is caused by allergy, with higher semen-specific antibody than healthy men.

One man in China benefit from desensitization, 90% relief of brain fog. But other poiser undergoing desenz have not seem good results.

Thanks, HOD, sent your China POIS summary above to our POIS Research team.

[Journey]

Thanks, HOD, sent your China POIS summary above to our POIS Research team.

When does the research start?

[demografx]

Thanks, HOD, sent your China POIS summary above to our POIS Research team.

When does the research start?

A message from our POIS research team

We appreciate the patience of the POIS community, particularly given the long wait everyone endured to even get the project funded in the first place. We are still working on the administrative and institutional approvals that are needed to restart after the pandemic. While we’d love to give a definitive answer on when those roadblocks will be cleared, unfortunately, the timeline is out of our hands as we work through multiple different offices and institutions. That said, our commitment to the research has not changed: the project will get done, even if it has been delayed much longer than any of us would have liked.

The commitment from the research team is encouraging and comforting. Thank you for sharing!

Thank you, Limejuice! As a long term forum member and Global Moderator, I’m sure you represent the views of many here!

[BoneBroth]

Now have passed two weeks after finnishing the 10 days with Xifaxan (3 tablets/day). So how am I feeling? The antibitotic was hardly noticably. The only sign that I was on it was perhaps that the poop got more yellowish each and every day on the tablet, but I'm not even sure thats a side effect of the antibiotic since I use to get that symptom with POIS anyway. So I had 1 O and two "near-O-experience" after the 10 days and I must say I got away with those pretty well. However that might as well be the cause of a restraining period before the Xifaxan. I've gained 4 kg though, which might be a good turn, but was that all the christmas food or improved intestines?

Anyway, in all my joy I ate quite a lot of chocholate and coockies every day (which I should avoid accoring to the gastroendolog) and that brought me back to the gas, head ache and rosacea issues again. And that's where I am today. Less affected with POIS (perhaps 50% improvement). Have the bacteria recovered so fast after the Xifaxan and is the small intestine in the same bad shape as before? Then it was expensive 10 days ($190). I will see the doctor this week and discuss further actions.

[lw]

I'm still on POIS. My gastroenterologist prescribed diarrhea inducing meds (for gas), during the week POIS was unbelievably unnoticeable, I was full of energy. After  1 week I started to feel worse. Gas came back, dysbacteriosis made worse. He added Rifaximin and some probiotics. I'll start the medications tomorrow and update you.
I feel very ill.

[BoneBroth]

I'm sorry to hear that lw. I wish you luck on the Rifaximin. My gastroenterologist didnt gave me anything with probiotics. He just agreed on that it might be a good idea to take a probiotic yoghurt after. My therapist dont think its a good idea to take milk products though. Lw, it seems that your symptoms are related to the production of gas. Do what you can to lower the gas. Find out what food is NOT causing gas. For me it helps to minimize gas after a meal when taking five drops of oregano oil in a table spoon of olive oil. I take it 2-5 times a day when I have much gas. Sugar and non resistent starch are causing gas here. Its for example better when I eat a cold potatoe cooked yesterday. Sweet potatoes always cause gas, so does bread, less with those without gluten. I'm sensitive to some of the FODMAP. Blueberries cause gas, but not rasperries.

On POIS we might be subjected to a lower production of bile or lack something that normally have a negative impact on the bacteria in the upper small intestine. There should not be so much bacteria there. Maybe the presence of gas and loads of bacteria are inhibiting the uptake of fat soluble vitamins in the small intestine and/or leaks substances to the blood that impacts the liver.

I've started to drink much more water during POIS day 1-3 and take antioxidants/vitamin C/omega 3 to ease the burden on the liver by diuting the blood and protect cells from free radical damage. Goats has a production of vitamin C of 40-100 grams a day and we dont produce any of it, we have to eat it. Perhaps a bile supplement would be a good additon to the oregano oil during the POIS state to reduce gas.

[Lihua]

I did a spit cortisol test (well, actually several, with sending in to a lab). This was out of POIS state as my belief is that POIS is just a manifestation of underlying other health issues. POIS as a symptom not a cause.

While the test results say I have normal values for all measurement points, for me the graph at least a bit confirms that I have energy issues related to low cortisol and maybe explains why I have good results with adaptogens/nootropics. (I have lows at ~11 and ~17 o'clock, but sometimes they are also related to bowel movements)

Picture attached.

Related threads:
https://poiscenter.com/forums/index.php?topic=3687
https://poiscenter.com/forums/index.php?topic=3011

hello, it seem that your cortisol is on the normbereich, so POIS is not caused by cortisol problem?

[BoneBroth]

I belive its the other way around - chronic high level if cortisol (not necessarily extremely hight, but long term in the upper normal) is caused by POIS. Cortisol is always excreted by the adrenals when there is an inflammation in the body. Cortisol by itself does not cause inflammation, but lowers inflammation. The inflammation comes first, then cortisol. Without enough cortisol, the consequences of POIS would probably be much worse. Without cortisol you would probably be dead in 24 hours. Long term cortisol not only put stress on the body and put the body in a degenerative state, but also takes resources from other hormones that are very important for the inflammatory system to work.

[Lihua]

I'm still on POIS. My gastroenterologist prescribed diarrhea inducing meds (for gas), during the week POIS was unbelievably unnoticeable, I was full of energy. After  1 week I started to feel worse. Gas came back, dysbacteriosis made worse. He added Rifaximin and some probiotics. I'll start the medications tomorrow and update you.
I feel very ill.

hey lw, how about you recently? What is the situation of your POIS after a month of antibiotic and probiotics

[Quantum]

Comment from Lihua moved here, was in the "no-comment" results thread:

Just got my 43 pages microbiom report from smartDNAglobal in Australia. They have tested 10 000 bacteria. Just showing values of interest that is off the normal intervals. Here's a short summary. Red color is over reference, blue is under. I might add some values later. My therapist has a very good hope that fixing theese issues (that might take six months) will improve POIS.

Classification rate by phylum (bacteria main class) level:

Firmicutes: 66,8%
Bacteriodetes: 16,62%
Proteobacteria: 5,61%
Actinobacteria: 5,03%
Synergistetes: 0,00%
Tenericutes: 0,32%
Cyanobacteria: 0,65%
Lentisphaerae: 0,23%
Verrycomicrobia: 0,01%
Fusobacteria: 0,03%
TM7: 0,00%
Other bacteria: 2,69%

Details:

Firmicutum phylum
Clostridiumbolteae: not detected
Faecalibacterium prausnitzi: 0,883%
Roseburiaintestinalis: 0,472%

Bacteroides phylum
Bacteroides vulgatus: not detected
Odoribacter spp: not detected

Actinobacteria phylum
Bifodobacterium animalis: not detected
Bifodobacterium bifidum: not detected
Bifodobacterium breve: not detected
Bifodobacterium infantis: not detected
Bifodobacterium longum: not detected
Collinsella aerofaciens: not detected

Fusobacterium Phylum
(all seven strains not detected)

Advanced microbial insight

Butyrate producers (butyric acid, good for intestines): 10,15% (>13,41%)
Succinate metabolism: 17,6,3% (>24,934%)
Beta-clucuronidase producing (important for phase II liver detoxification): 1,67% (6,46%)
Oxelate degrading (shoul de hight, beneficial for kidney health): 0,002% (>0,004%)
Faecallibacterium prausnitzii (has an anti-inflammatory effect of the gastro-intestinal tract): 0,883% (>4,198%)
Akkermansia mucinophila (maintaining a healthy balance between mucus lining utilisation and breakdown): 0,005% (>0,006%)
Ruminococcus bromii (breaking down resistant starch so other bacteria can utilise butyrate which is important for health gut function): 0,075% (>0,082%)
Cobalamin B12 (small intestine sis the sole site of absorption): not detected
Biotin B7: not detected
GABA consumers: 0,8% (<0,7%)
Indolipropionic acid (antioxidant, important for protecting nerve cells): not detected
BCAA (important for building muscles and regulation of fat and sugar metabolism): not detected
LPS inflammation (inflammation promoting molecule that can cross the blood barrier of the intestine causing heart disease, autoimmune diseas non alcoholic fatty liver and type 2 diabetes: 1,395% (<0,721%)

Other

Caffeine metabolism (I should cut down coffeine coffee): <0,001 (0,00001-0,0113)
Stereoid biosynthetis: <0,001 (0,0006-0,0343)

Hi bro, did you do something for your abnormal intestinal flora? what is the result and what have you done?

[BoneBroth]

Hi bro, did you do something for your abnormal intestinal flora? what is the result and what have you done?

I'm directing my protocols to the flora now. First I took a 10 day antibiotic Rifaximin (sold under the brand name Xifaxan) to kill off the bad bactteria. I didnt notice any diffrence righth after, but later I had a better period. Then it got worse again, but I think its because had too much sugar in the diet. Now I'm about to start a anti-SIBO plan with many supplenments and dietary changes. I will report how that will turn out! One thing seems to be clear. When I have much gas the symptoms becomes much worse for a longer period. Just by avoiding gas producing foods symptoms might be very good.