Author Topic: Gather and Post Here Your Medical Tests Results - Discussion Thread  (Read 68634 times)

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #525 on: July 28, 2020, 07:34:32 AM »
Vitamin b12 and D are low:
https://drive.google.com/file/d/1H-Gx4YaeMJTJiiQSertvGyHSLSmZx24f/view?usp=drivesdk

Nas should do a SIBO test IMHO. He also had low iron at one point if I'm not mistaken.

Muon's brother, BDNF, tryptophan: https://poiscenter.com/forums/index.php?topic=2545.0

"Altered tryptophan metabolism also was observed in the same animals, along with significantly reduced BDNF, oxytocin and vasopressin gene expression"

"Intriguingly, other CNS alterations in GF mice also are sex-dependent; e.g., altered expression of BDNF has been documented only in male GF mice"

Stress & the gut-brain axis: Regulation by the microbiome

"Our data support the view that measures of blood and plasma BDNF levels reflect brain-tissue BDNF levels."
Blood BDNF concentrations reflect brain-tissue BDNF levels across species
« Last Edit: July 28, 2020, 08:08:30 AM by Muon »

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #526 on: July 30, 2020, 08:36:14 AM »
"Given the duration of symptoms in this patient, a Type III reaction may also exist, which would be evaluated with complement levels (C4, CH50) to look for consumption by immune complexes". Page A48

In line with Stafie's measurements: https://poiscenter.com/forums/index.php?topic=2684.msg31172#msg31172

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #527 on: July 30, 2020, 11:29:48 AM »
Berlin1984: "symptoms 70% improved by diet (casein-free, wheat-free".

Have you done a SIBO test? Do or did you have any problems with bloating, white coatings on tounge or exzema/acne/rosacea?

"except for life-long atopic manifestations of bronchial asthma, allergic rhinitis and neurodermatitis". Ref

Supplementary Table 4. Allergic and non-allergic diseases for which pathogenetic involvement of mast cells has been demonstrated or suspected. https://www.tandfonline.com/doi/suppl/10.3109/07853890.2016.1161231?scroll=top&

?   allergy [ ]
?   anxiety/panic disorders [ , ]
?   asthma [1]
?   atherosclerosis [ ]
?   autism [ , ]
?   autoimmune diseases [5, ]
?   atopic dermatitis [ ]
?   cardiac arrhythmias [ , ]
?   chronic obstructive pulmonary disease [ ]
?   chronic fatigue syndrome [ ]
?   dysautonomia [ , ]
?   eosinophilic esophagitis [ ]
?   eosinophilic gastritis [ ]
?   eosinophilic enteritis and colitis [15]
?   fibromyalgia [ ]
?   heart failure [ ]
?   histamine intolerance [ ]
?   hypermobility-type Ehlers Danlos Syndrome [ , , ]
?   inflammatory bowel disease [ ]
?   interstitial cystitis [ ]
?   irritable bowel syndrome [ ]
?   systemic mast cell activation disease [ ]
?   migraines [ ]
?   multiple sclerosis [ ]
?   neurofibromatosis [ ]
?   neurogenic pain [ , ]
?   non-cardiac chest pain [27]
?   obesity [ ]
?   osteoporosis [ ]
?   peritoneal adhesions [ ]
?   postural orthostatic tachycardia syndrome [ ]
?   psoriasis [ ]
?   psychosomatism [ , , ]
?   rheumatoid arthritis [ ]
?   rosacea [ ]
?   sarcoidosis [ ]
?   vulvodynia [ ]
?   tumor growth [25]

You will find many POIS cases showing at least one of the above.
« Last Edit: August 01, 2020, 10:15:57 AM by Muon »

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #528 on: August 01, 2020, 10:37:58 AM »
Small Intestinal Bacterial Overgrowth Is Associated with NonAlcoholic Fatty Liver Disease

"In patients with NASH, SIBO has been associated with increased levels of LPS binding protein and up-regulation of the LPS ligand toll-like receptor 4 (TLR-4), which correlated with increased plasma levels of inflammatory markers such as interleukin (IL)-8 and hepatic expression of tumor necrosis factor (TNF)-α [16, 17]."

Fatty liver POIS case report:
https://poiscenter.com/forums/index.php?topic=2684.msg27145#msg27145

Muon IL-8 (and ALT^), Bluesbrother TNF-alpha:
https://poiscenter.com/forums/index.php?topic=2301.msg35425#msg35425

Bonebroth SIBO:
https://poiscenter.com/forums/index.php?topic=2684.msg35348#msg35348

"Experimental and clinical data indicates that a depletion in NKT cells can lead to the chronic pro-inflammatory environment that can accompanies hepatic steatosis" https://www.frontiersin.org/articles/10.3389/fmicb.2018.00061/full

SIBO ---> Reduced Testosterone? (Bonebroth; low T + SIBO)
Small intestinal bacterial overgrowth (SIBO) as a potential cause of impaired spermatogenesis

Vitamin D deficiency in SIBO?

SIBO in MCAS:
Small Intestinal Bacterial Overgrowth Is Common in Mast Cell Activation Syndrome

Stress + SIBO ---> alterations in gut-brain axis --> reduced BDNF --> Premature ejaculation?
https://poiscenter.com/forums/index.php?topic=2695.msg35544#msg35544

"The patient subsequently self-started a probiotic containing Bacillus coagulans and fructooligosaccharide, which he reported improved his symptoms further" https://sci-hub.tw/10.1080/21681805.2019.1704861

https://en.wikipedia.org/wiki/Fructooligosaccharide
Garlic, banana's, apples contain prebiotics.

Prebiotics--->BDNF^ ? https://www.sciencedirect.com/science/article/pii/S2352289516300509
« Last Edit: August 02, 2020, 08:25:07 AM by Muon »

berlin1984

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #529 on: August 05, 2020, 05:14:23 AM »
Berlin1984: "symptoms 70% improved by diet (casein-free, wheat-free".

Have you done a SIBO test? Do or did you have any problems with bloating, white coatings on tounge or exzema/acne/rosacea?

Thank you for nudging me into this direction.
I think I might have SIBO. (?) I never did a test though.

I ordered some oregano oil capsules and started taking them yesterday. (I also started with D-Ribose for fatigue, so that's maybe confounding).
EDIT: I also ordered Pepto Bismol. Not so easy since it's not a licensed medicine in EU.

Bloating/Flatulence: Sure ;-)

Regarding eczema: Atopic dermatitis was corelated with POIS in the study papers. I don't have skin problems, but sometimes quite strong itching at the "Mons pubis" area of my body. (I'm male. I don't know the correct term for that area for males)

See also my poll about constipation.
« Last Edit: August 05, 2020, 06:40:16 AM by berlin1984 »
brain fog, motivation problems and body symptoms 70% improved by diet (casein-free, wheat-free, eating-not-much-egg, ginger, black coffee, vitamin/mineral/antioxidant/omega3/adaptogens/sperm supps), but I want to fix the rest (bone pain, muscle weakness, gut problems, social hostility the day after)


Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #531 on: August 10, 2020, 11:15:22 AM »
Nonsteroidal anti-inflammatory drugs are effective against postorgasmic illness syndrome: A case report

"These findings indicate that POIS could be caused by inflammatory mediators that are inhibited in the cyclooxygenase (COX) 2 pathway by the administration of these drugs."

Pro-inflammatory cytokines/chemokines are able to upregulate COX-2, they do not affect COX-1. There are indications that age-dependent decline in testosterone is mediated through COX-2 Ref. And since some men with low T show elevated cytokines Ref, these cytokines might be responsible for a faster decline of testosterone as a function of time. POISers with low T may respond to COX-2 inhibitors. POISers with low T could have overlap of cytokine/chemokine profiles, the overlap consists of the ones that affect COX-2. If true, what's the cellular source of these cytokines?

Case of post-orgasmic illness syndrome associated with hypogonadism

"Nonsteroidal anti-inflammatory drugs were initially administered and helped relieve headache and muscle pain. Thereafter, the patient was able to ejaculate three times a week. In addition, after administering testosterone enanthate once or twice a month, his general fatigue significantly improved, and he could ejaculate every day."

The NSAIDs don't affect cytokines. Cytokines are able to induce systemic effects like fatigue, NSAIDs didn't fix his fatigue. Some cytokines can be reduced by TRT, that would have fixed his fatigue like in the example above. Also those two can interact with mast cells as well.
« Last Edit: August 10, 2020, 11:45:53 AM by Muon »

Muon

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Re: Gather and Post Here Your Medical Tests Results - Discussion Thread
« Reply #532 on: August 10, 2020, 03:20:45 PM »
Directional Mast Cell Degranulation of TNF into Blood Vessels Primes Neutrophil Extravasation

Leakage of neutrophils

- Low Neutrophil Count: 1.47 10e9/L (1.56-6.52)
Results from blood tests in no-POIS state:

- TNF alpha 32.6 pg/ml above reference range (<12.0)