Gather and Post Here Your Medical Tests Results - Discussion Thread

[Muon]

My CD57+ count was low. Did multiple tests for Lyme but all negative. 4 or 5 people did a test for IgM and only VandeMolen had low IgM. CD57+ NK cells are basically a subset of mature CD56 NK cells. CD56 NK cells express CD57 with age (CD57 = old CD56 NK cells).
https://ashpublications.org/blood/article/116/19/3865/28027/CD57-defines-a-functionally-distinct-population-of
https://link.springer.com/article/10.1007%2Fs00262-016-1803-z

Hmm to be more specific CD57 is a CD56^dimCD16⁺ NK-cell subset (30%-60%). Take a look at the brazilian POIS study, table 1:
"The subset analysis of NK cells showed that CD56^dimCD16⁺ NK cells that are the most common subtype of NK cells in the PBMC in healthy individuals were diminished in the POIS patient. The POIS patient presented fewer CD56^dimCD16⁺ NK cells in comparison to healthy individuals, but in contrast, presented more CD56^-CD16⁺ NK cells."

With other words: The CD57+ NK cells which was low in my case is actually a subset of a subtype of NK cells seen in the brazilian case study which was low as well. 

[Muon]

My CD57+ count was low. Did multiple tests for Lyme but all negative.

I stumbled over this, sounded interesting:

"Most commercial tests designed to detect chronic infections are based on measuring your immune reaction?the presence of antibodies?to the invading microbe. However, one of the primary cells that get infected with Lyme spirochetes are the white blood cells themselves, which is a bit of a game-changer? because if your white blood cells are infected, they lose the ability to produce antibodies.
Hence, it is relatively common to get a negative test result.  Dr. Klinghardt refers to this as ?the Lyme paradox,? because in order to diagnose Lyme disease properly with one of the accepted commercial tests, you have to first treat the Lyme disease, in order for your white blood cells to be able to mount an appropriate immune response. Only then can a lab test be used to detect the presence of Lyme disease."
"An indirect test is the CD57 test. ?CD-57? is a specific group of natural killer cells that are particularly damaged by the Lyme spirochetes. Therefore, if your numbers drop to a certain level, it is an indirect indicator that you may have Lyme disease, because the only known infection to suppress CD57 is that of Borrelia burgdorferi.
Normally, your CD57 value should be over 100. If it?s lower than that, you?re infected with Borrelia. If it?s below 60, you probably have both Borrelia and Mycoplasma, and, most likely, some other co-infections."

https://www.ppt-health.com/lyme-disease-basics/dr-klinghardt-interview/

I did not use commercial testing for Lyme. I have asked for a Mycoplasma pneumoniae test in the past for my Bell's Palsy, which is able to drive CD57+ count down as well, but this got rejected because I had no respiratory symptoms (which is not a prerequisite, you can even be asymptomatic). Could be reactivation of VZV as well.

Frequent detection of Mycoplasma pneumoniae in Bell's palsy

[Muon]

https://poiscenter.com/forums/index.php?topic=2684.msg35348#msg35348

What solution did you use BoneBroth?

I have some interesting new results from a physiospect frequence analyse yesterday.
- Beginning osteoporosis. Probably because of low pH. Maybe an affect of POIS as well.

Perhaps an idea to check this again with a DXA scan.

"Premature osteopenia/osteoporosis is frequently found in mast cell disease patients and is usually diffuse but may be focal."Ref

Small Intestinal Bacterial Overgrowth Is Common in Mast Cell Activation Syndrome (Solution: Lactulose, gases: Hydrogen+Methane)

[BoneBroth]

The solution I drank was lactulose. Hydrogen (H2) was normal 6 ppm (normal is  < 12 ppm).

[Muon]

The solution I drank was lactulose. Hydrogen (H2) was normal 6 ppm (normal is  < 12 ppm).

Ok thanks, good to know. Could you add this detail to your post in the results thread?

[BoneBroth]

Absolutely!

[BoneBroth]

I seem to be sensitive to sugars. When I get better in POIS and fall for the temptation to eat bakery/wheat/cakes I always seem to get ballon stommach and then skin rashes (rosacea like) on my forehead and headaches + bad smelling urine, warm inflammation feeling in the body, bulging blood vessels and even some red eczema at the top of my willy. The symptoms doubles when having orgasm in the same period. When I do waterfast for some days those symptoms go away. This is a typhical SIBO-symptoms, but do you mean that malfunctional mastcells is the underlaying cause in the upper small intestine? Does anyone else share my symptoms?

[Muon]

but do you mean that malfunctional mastcells is the underlaying cause in the upper small intestine?

I'm just throwing that idea around as a potential cause yes.

Do you have constipation or diarrhea?

[BoneBroth]

During the last six months I had at least two severe constipations that lasted for over a week. Had diarreha too but that was probably caused by the constipation-medicine/herbs. I've also had yellowish-grey and claylike stool (like mustard) during the same time. Tryed some bitter herbs for the liver/bile and drank 2-4 table spoons of apple cider vinaegar before breakfast and after 1-2 months the stool got dark brown again. But the rosacea-like exzema on my forehead and foggy headache is really bad now. Talked to the SIBO therapis today. We're starting a whole year SIBO plan now.  She recommended a only-meat or a meat based diet (with some vegetables that are ok with SIBO), but I dont know how compatible that is with the nanna-protocol, where it is recommended vegetarian diet.

[Muon]

"In conclusion, a methane positive breath test is associated with constipation as a symptom."
Methane Production During Lactulose Breath Test Is Associated with Gastrointestinal Disease Presentation

There are more people on this board with constipation. I bet they are CH₄ breathers as well.

In case of a Diarrheic Type of IBS:
"Symptoms related to the irritable bowel syndrome improved in 60% of patients treated with elimination diet and in 67% of those treated with oral cromolyn sodium (1500 mg/day) for 1 month."
Oral Cromolyn Sodium in Comparison with Elimination Diet in the Irritable Bowel Syndrome, Diarrheic Type Multicenter Study of 428 Patients

I'm also interested in a study repeating this SIBO test for a group of POISers.

[certainlypois2]

During the last six months I had at least two severe constipations that lasted for over a week. Had diarreha too but that was probably caused by the constipation-medicine/herbs. I've also had yellowish-grey and claylike stool (like mustard) during the same time. Tryed some bitter herbs for the liver/bile and drank 2-4 table spoons of apple cider vinaegar before breakfast and after 1-2 months the stool got dark brown again. But the rosacea-like exzema on my forehead and foggy headache is really bad now. Talked to the SIBO therapis today. We're starting a whole year SIBO plan now.  She recommended a only-meat or a meat based diet (with some vegetables that are ok with SIBO), but I dont know how compatible that is with the nanna-protocol, where it is recommended vegetarian diet.

His old protocol involved eating vegetarian. His new protocol does not require that.

[BoneBroth]

Good to hear certainlypois2! Muon: The last constipation happened two months before the SIBO test thought and since then I had no constipations. It's hard to find information on the syncronicity of the constipation and the methane release with the IBS-patients from that study. Nevertheless intreresting!
   

[Muon]

Demografx has low Testosterone levels, POIS symptoms decrease by TRT (and benadryl+forced sleep for more improvement).

Has anyone tried norethisterone for their POIS?

Yes. Bad effect on me, stopped.

Heather has low Testosterone, low progesterone, high estrogen and responding to TRT (although results may be premature at the time of posting this, needs update).

Heather1111:
"They did try me on progesterone a few months back as my levels are low and it was so horrible I couldn't be on it for more than a few weeks. It made me so incredibly sleepy and made me gain some weight in that short time."

[berlin1984]

Postorgasmic illness syndrome: випадок із практики
The patient is consulted by a psychoneurologist. Conclusion: asthenic syndrome.

When Googling for this word, I only find a movie as result.
However post viral asthenic syndrome is a Google recommended query for this, which plays into the POIS<->CFS direction...

[Muon]

Use keywords 'asthenic syndrome medical':

"Asthenic syndrome (syndrome of chronic fatigue) is a psychopathological condition in which the patient experiences constant fatigue and apathy, difficulties with concentrating, decreased ability to work/learn, and rapid exhaustion of nervous processes"

Seems someone renamed CFS. I do think CFS stems from a pro-inflammatory cytokine going into systemic circulation.

[drop247]

Here is all my recent blood work. The red lines separate different days. Nothing really stands out to me other than one day had low neutrophils and another had high sodium. Hopefully the people here smarter than me can make use of this information.
https://i.imgur.com/mJ0gZyg.jpg

[Muon]

Seems fine. The only thing I noticed is borderline low neutrophils. I got no clue about cholesterol measurements and ratio's, perhaps others know more about those. Total testosterone should be measured together with free testosterone and SHBG.

[berlin1984]

The only thing I noticed is borderline low neutrophils.

==>

Thanks Hopeoneday for finding the neutropenia correlation!

[berlin1984]

She recommended a only-meat or a meat based diet (with some vegetables that are ok with SIBO),

See also this forum for the keyword "carnivore" or in general the internet for "carnivore diet"

[Muon]

Thanks Hopeoneday for finding the neutropenia correlation!

They could be used up during an infection. https://en.wikipedia.org/wiki/Neutrophil#Degranulation

Low neutrophil count + high lactoferrin. Check wiki link.
https://poiscenter.com/forums/index.php?topic=2684.msg24765#msg24765

Problems with sugar/refined carbs in POISers, https://en.wikipedia.org/wiki/Neutrophil#Structure:

"Neutrophils have a preference to engulf refined carbohydrates[16][17][18] (from ingested glucose, fructose, sucrose, honey and orange juice[16]) over bacteria.[16] In 1973 Sanchez et al. found that the neutrophil phagocytic capacity to engulf bacteria is affected when simple sugars are digested,[16] and that fasting strengthens the neutrophils' phagocytic capacity to engulf bacteria.[16] However, the digestion of normal starches has no effect. It was concluded that the function, and not the number, of phagocytes in engulfing bacteria was altered by the ingestion of sugars.[16] In 2007 researchers at the Whitehead Institute of Biomedical Research found that given a selection of sugars, neutrophils engulf some types of sugar preferentially."

They produce reactive oxygen species (ROS) and use oxygen in the process. This could be checked in blood.

Or something might be interfering with the signaling that is related to neutrophil differentiation/granulopoiesis. I've also seen a few POISers with high monocytes. Here is the lineage:



Current Understanding in Neutrophil Differentiation and Heterogeneity

Some molecules described in the article above might show abnormal levels.

https://poiscenter.com/forums/index.php?topic=2805.msg25451#msg25451
Alpha-1-Antitrypsin, Quant
67 mg/dL (Low)
Reference Range:100 - 190

https://en.wikipedia.org/wiki/Neutrophil#Clinical_significance
Can affect neutrophil function. I've already checked elastase by the way which was normal.