Gather and Post Here Your Medical Tests Results - Discussion Thread

[Nas]

Neuropeptides can cause flushing and itching.

Source?

[fernab]

I know It is POIS related because 7 months ago with my last ejaculation, all the symptoms I had, got worse during the following days. In addition to the usual bad symptoms I have since POIS began:
1.- Strong fatigue
2.- Strong palpitations
3.- Runny nose.
4.- Red eyes.
5.- itchy skin.
6.- lung pain when breathing, as if the air entering were blades.
7.- Muscles pain.
8.- Abdominal discomfort
9.- Inability to sleep well, I always woke up after a few hours. variable times. 3-4 hours in the worst case not to arrive at 2 hours.
10.- Now, some weeks ago. I only got a little excited, and just because of that, I got some precum. and as soon as it came out I noticed that it burned and hurted everything it touched. urethra and skin of the glans mucosa.

Nas, some months after I began with problems just by sitting (pressure on testicles and perineal area) I did an MRI. And results noticed some post prostatitis (some areas around prostate showed some inflammation....

[Nas]

Nas, some months after I began with problems just by sitting (pressure on testicles and perineal area) I did an MRI. And results noticed some post prostatitis (some areas around prostate showed some inflammation....

What about the other glands? Were they also normal? Also if you can find the data of this test can you please post them here?

[fernab]

Yes, I had posted it on the other thread (for results post #20 here: https://poiscenter.com/forums/index.php?topic=2684.15 )

I copy it here below. Other glands were normal. But this situation was produced just because of pressure when sitting down. Not after an ejaculation. The problem for me right now is that I cannot ejaculate again while I continue being so sick. Because if I'm already like that I do not want to think about the consequences of getting even worse ...

Here the result of pelvic MRI (pelvic area, testicles were not included):

Pelvic Magnetic Resonance Imaging (March 2018):
prostate of conserved size showing some slight hyperintense areas in the peripheral region predominantly in third that could be suggestive of slight post-prostatitis changes. There are no suspicious lesions of malignancy in the prostate. Seminal vesicle without alterations. Perineal region without significant alterations.

[Vandemolen]

Fernab, that does not look like my symptoms. I only have sleeping problems too and I get tired. Maybe because of the lack of sleep. Well, I also have muscle pain (maybe because of bad sleep) and itchy skin.

[fernab]

Vandemolen, remember we poisers don't have always exactly the same symptoms....

Have you tried any 5-ht receptor inhibitor? Or any positive allosteric modulator of GABAA receptors?
In my case I found with them some relief. In addition of disodium cromoglycate(Mast Cell stabilizer).

But still not found the necessary remedies to get out of this continue state of sickness...

[Nas]

Pelvic Magnetic Resonance Imaging (March 2018):
prostate of conserved size showing some slight hyperintense areas in the peripheral region predominantly in third that could be suggestive of slight post-prostatitis changes. There are no suspicious lesions of malignancy in the prostate. Seminal vesicle without alterations. Perineal region without significant alterations.

I think this test should be replicated by more members during arousal induced POIS. If tests all positive, this could be a proof of the auto-immune theory. 

[Vandemolen]

Vandemolen, remember we poisers don't have always exactly the same symptoms....

Have you tried any 5-ht receptor inhibitor? Or any positive allosteric modulator of GABAA receptors?
In my case I found with them some relief. In addition of disodium cromoglycate(Mast Cell stabilizer).

But still not found the necessary remedies to get out of this continue state of sickness...

No I did not try that. I want to wait my appointment with my immunologist first.

Have you seen this topic?

https://poiscenter.com/forums/index.php?topic=2839.msg25939#msg25939

[fernab]

Neuropeptides can cause flushing and itching.

I am seeing that some neuropeptides are also neurotransmiters, like acetilcholine, epinephrine, norepinefrine, dopamine, serotonine....etc.

[fernab]

No I did not try that. I want to wait my appointment with my immunologist first.

Have you seen this topic?

https://poiscenter.com/forums/index.php?topic=2839.msg25939#msg25939

Thank you Vandemolen. Sounds pretty much like the symptoms I feel on my back but I also did an MRI of all my backbone and only some hemangiomas were detected. Nothing else. No cysts. But I feel almost the same thing described on that post. This is why I think something regarding the nervous system is linked to POIS. Neurotransmiters are fully related with this I guess... And also... If you think about it... Any orgasm or arousal must be driven by the nervous system...to open bulbourethral glands (the ones containing the precum, just below the prostate)....

[Hopeoneday]

Vandemolen,

What are your symptoms?

I am sick since 12 months ago and in my case is POIS related...

Can't seat, can't stand up for too much time, and having lot of dificulties to lay down on bed. Can't flex the lumbar vertebrae. Pain on knees and back at the level of several vertebrae when standing up for some time.... Really difficult situation also. My work is at risk to be loosed. Hope to find any solution as soon as posible. Need it.

Wish you as much luck as posible!

Hi Fernab.
You and I have almost the same symptoms.
Perhaps the pain I feel over the prostate in pois days
indicates some sort of unknown infection on glands and prostate
leading to  neuro-autoimunity.
And the same out of pois in sick condition with these symptoms mentioned above.

[fernab]

Yes HOD,

We two are really similar on symptoms.

I found some relief with Diazepam, trazodone and disodium cromoglycate right now. Have you tried these?

Before using trazodone I was using etoricoxib (a Cox 2 inhibitor). with whom I also felt relief. but I discovered that it is not compatible with trazodone. Another thing that I think helped me was Tramadol. but this one alone. or with the complement of a laxative because you can suffer fecal compaction as a side effect. but I only used it 8 days and then I went back to etoricoxib. and after about two or three weeks I noticed a good improvement. I have been searching and thinking for some time that it could be an infection. but I was in many infectologists and never found anything. How do you know it's an infection if you can not find anything? Have you ever found any infection result as being active?.... because this is the only way to conclude It is an infection. And also.... If It was due to an infection... Why my wife feels perfect?....someone else could get also this 'unkown' infection. But it is not the case. For that reason I decided long time ago to forget this posibility....

 Another question.... have you ever used a drug called finasteride or some other (5-alpha-reductase inhibitor)?

[Nas]

I have been searching and thinking for some time that it could be an infection. but I was in many infectologists and never found anything.

This is another indicator of auto-immunity.
I think this could be valuable for the current investigation team. I wish that I tested my prostate last time I did an testicular MRI. I highly advise people to do prostate MRI when aroused.

[Hopeoneday]

Nas i agree.

Fernab, i tought on inflamation, not direct to possible infection strictly, but i tought on autoimune reaction neuroimune etc...
I teke benzos as i mentioned before, only in cases of " my life is in question"
, because it is adictive and need a lot time to detox....
I work now on different stuff to improwe me self on naturall way.
I will post this later.
I found coffee is the most helpfull for me when pois hit me. (i learned
how to dosing cofee without side effect).
What else helped me a lot, magnesium, oxide form is the worst,
discowered citrate and that hepled me a lot on manage heart palpilations and overall health.
About finasteride, i didnt never used that drug. But in my age of 15-16 to 22 i had wery severere acne (from 3 moonth antibiotic use i suspect),
and who knows what i didnt use in that time for my acne(my face was devastated) suffered a lot.
About cox2 who been helped to you,
that indicate prostagladins involved.

[Muon]

When I'm exposed to precum for a while it can give me a burning sensation in my penile urethra. This burning sensation can lead to an urgency of urination. I don't need to go to the toliet (empty bladder) but it keeps signaling me, this will only happen when the burning happens prior to it.

Another weird thing is that a part of my lower spine will get affected by POIS. You will feel pressure in the lower spinal area and as the pressure increases my legs become weaker. When I'm exposed to precum while standing, I can literally tremble on my legs. When the arousal stops and the erection diminishes the trembling will vanish.

There are other examples but this make me think neurological systems are involved or affected.

[Nas]

Another weird thing is that a part of my lower spine will get affected by POIS. You will feel pressure in the lower spinal area and as the pressure increases my legs become weaker. When I'm exposed to precum while standing, I can literally tremble on my legs. When the arousal stops and the erection diminishes the trembling will vanish.

There are other examples but this make me think neurological systems are involved or affected.

It's more likely that it's affected, if only we knew how though? the fact the inflammation is present in the prostate yet, there are neurological symptoms? And many other physical side effects, or the fact that I only get cognitive symptoms? Weird. Waldinger suspects that it's because of resultant cytokines from this reaction. Can different symptoms depend on specific cytokines in the body?

[Nas]

I think the reason why dexamethasone works for me, is because corticosteriods decrease pro-inflammatory cytokines synthesis, thus reducing their population in the body, making the recovery time for me quicker.
NSAID's won't work because they only block prostaglandins, which is irrelevant if you don't have inflammation.
What we need, is to increase our anti-inflammatory cytokines or block the pro-inflammatory cytokines somehow.

[Nas]

Finally, a really good test for POIS could be, to abstain from exposure to any sort of arousal for 7 days, then do an MRI to the prostate. Then take a half an hour watching porn or arousing yourself any other way. Then make another MRI and see if inflammation is now observed.
What do you think guys think? Can that be a valid test for POIS? Technically you can replicate that with urine test for urethritis (if you have POIS urethritis) pre and pro ejaculation.

[Muon]

I think the reason why dexamethasone works for me, is because corticosteriods decrease pro-inflammatory cytokines synthesis, thus reducing their population in the body, making the recovery time for me quicker.
NSAID's won't work because they only block prostaglandins, which is irrelevant if you don't have inflammation.
What we need, is to increase our anti-inflammatory cytokines or block the pro-inflammatory cytokines somehow.

This is another one suppressing the release of inflammatory cytokines by T-lymphocytes: https://en.wikipedia.org/wiki/Ciclosporin 

[Nas]

This is another one suppressing the release of inflammatory cytokines by T-lymphocytes: https://en.wikipedia.org/wiki/Ciclosporin

I tried ciclosporin, but the pill I took was literally the last sheet in the pharmacy with only one month left on its expiration date. It didn't do anything when I took it. There are however ciclosporin shots, which I don't think I can inject myself, however it would be an excellent experiment.