Ideas on Herpes Induced POIS

[sartre02]

Thanks alot Nanna in your effort.
Although I have my doubts about Herpes; since I tried aciclovir myself and nothing changed. But most importantly the herpes infection needs to be tested in laboratory to confirm that what we have is a dormant hepres virus.
I'm 100% for an anti-inflammational treatment to the brain, but the problem is that celebrex is not that common of a medication. And not so many medication can cross the BBB. So this needs to be our focus point, which is finding an anti-inflammatory that can cross the BBB and is accessable to some degree for the public.
In a seance, I would like to know what would a doctor perscribe for us if we explained to him what we have ib detail.

nas which anti inflammatories do you think effectively cross BBB ?

[sartre02]

Long-term herpes relief and permanent virus removal strategies

"High dose IV vitamin C is in unexpectedly wide use by Complementary and Alternative Medicine practitioners. Other than the known complications of IV vitamin C in those with renal impairment or glucose 6 phosphate dehydrogenase deficiency, high dose intravenous vitamin C appears to be remarkably safe."
-Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects (2010)

In vivo human trials treating herpes complications:
The effects of intravenous vitamin C (ascrobate) against herpes have been shown in promising human trials.

  Case 1: "Five days after taking the pregabalin and vitamin C IV, she reported a complete resolution of the pain and stopped taking the medication. At 3 months follow-up, she continued to have no pain without any complications." -Administration of Vitamin C in a Patient with Herpes Zoster - A case report (2011)

  Case 2: 7.5g vitamin C, 2-4 times/week "...the study presented here demonstrates that concomitant intravenous administration of ascorbic acid has positive effects on herpes zoster-associated pain and zoster-associated dermatologic findings. Furthermore, common clinical symptoms in patients with shingles, such as general fatigue and impaired concentration, were significantly improved and the risk of developing postherpetic neuralgia was reduced."
-Intravenous Vitamin C in the treatment of shingles: Results of a multicenter prospective cohort study (2012) (NIH ClinicalTrials.gov Identifier: NCT00921934)

  Case 3: Vitamin C IV infusions cure post-herpetic neuralgia in two patients, shown by reduced VAS pain score.

  "Sudden and total remission of the neuropathic pain (measured on the basis of the visual analogous-scale, VAS) could be observed. Remission of the cutaneous lesions was noted within 10 days." -Intravenous administration of vitamin C in the treatment of herpetic neuralgia: two case reports (2010) (click figure to show full resolution)

  Case 4: Ascorbate IV reduces Epstein-Barr virus early antigen IgG antibody levels as well as improving symptoms of virus related disease (measured by percent of decrease in EBV EA IgG from the 0 baseline). After 10 IV injections all patients showed at least a 17% reduction in viral IgG. With increasing number of vitamin C IV infusions, some patients showed IgG reductions approaching 100%.

  "We found an inverse correlation between EBV VCA IgM and vitamin C in plasma in patients with mononucleosis and chronic fatigue syndrome (CFS) meaning that patients with high levels of vitamin C tended to have lower levels of antigens in the acute state of disease...In addition, a relation was found between vitamin D levels and EBV EA IgG with lower levels of EBV early antigen IgG for higher levels of vitamin D....The clinical study of ascorbic acid and EBV infection showed the reduction in EBV EA IgG and EBV VCA IgM antibody levels over time during IVC therapy" -Effect of high dose vitamin C on Epstein-Barr viral infection (2014) (click figure to show full resolution)

Case: 5 "We treated this patient with IV 2.5 g ascorbate... on days 1, 3, and 5. His intermittent, spontaneous, shooting pain completely resolved within 1 wk, and his baseline pain decreased to a level of 3 (his plasma vitamin C level reached 14.9 mg/L). We advised him to increase his intake of fruits and vegetables. On follow-up examination 3 mo later he has had no recurrence of the extreme intermittent pain, and his plasma vitamin C level was 11.6 mg/L."
-Treatment of Postherpetic Neuralgia with Intravenous Administration of Vitamin C (2006)

Case 6: "In the patient who received the intravenous administration of vitamin C and cantharidin patches beside standard analgesis and virostatic treatment, a swift regression and clinical improvement of the herpes zoster-induced efflorescences was obtained, rapid pain reduction was illustrated by the NAS-scores and possibly of prevention of a later ongoing PHN were presented. The rapid therapy benefits were impressive." -Cantharidin patches and intravenous administration of vitamin C in the concomitant treatment of herpes zoster: A case report (2011)

Case 7: "Clinical and subjective response to three consecutive daily 50 g IV vitamin C was excellent. Symptoms remitted in five days following beginning of therapy... The therapy was well tolerated and no adverse side effects were noted. The quickness of the patient response to high-dose IV vitamin C was dramatic... Our case provides evidence that high dose (50g) intravenous vitamin C therapy has a positive effect by reducing illness symptoms, disease duration and viral antibody levels."
-Intravenous Vitamin C and Infectious Mononucleosis: A Case Report (2018)

Other pathogens treated with IV ascorbate (vitamin C):

• HIV
• influenza virus (RefGO2018)
• Chikungunya virus (RefGC2014)
• Zika virus (RefGA2016)

  The Riordan Clinic are the leading specialist in IV Vitamin C administration. They describe their protocol in detail here: RiordanIVCprotocol

Vitamin C pharmacokinetics:

Fig. from: "Vitamin C pharmacokinetics: implications for oral and intravenous use", Ann Intern Med. 2004 (Ref) (click figure to show full resolution)

  Liposomal vitamin C is more than 60 times less bioavailable than intravenous ascorbate. See liposomal VC bioavailability graph (Fig 3) from: "Pharmacokinetics of Vitamin C: insights into the oral and intravenous administration of ascorbate", PRHSJ (2008) (Ref). Therefore, oral vitamin C supplementation cannot replace intravenous vitamin C.

  Many high-dose intravenous ascorbate studies are done in cancer patients. So cancer-ascorbate studies may provide useful information for experience with bioavaibility, tolerability and side-effects.

Fig. from: "Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients", Journal of Translational Medicine 2013 (click figure to show full resolution)

In vitro virucidal mechanism for copper + intravenous vitamin C:
  The inactivation of viruses by vitamin C (ascorbate) requires copper ions (Inactivation of Vaccinia Virus by Ascorbic Acid). Copper II ions (CuII) binds to the guanine (G base) of latent herpes RNA. Then vitamin C (ascorbate, AscH^-) reduces the copper ion in a Fenton reaction producing reactive oxygen species (free radicals: O_2*, H₂O₂, HO*) (Ref, Ref1987).

From Scheme 1

  The free radical HO* cuts and separates the virus RNA at the G base location of the bound copper ion (Ref1983, Ref1997, Ref1983). This removes the latent virus by destroying herpes genetic material and virus in the cytoplasm. CuII-ascorbate also disables viruses in the capsid (Ref1986).

  Intravenous vitamin C (ascorbate) is safe in humans (Ref2010) and has been used in clinical practice as both adjunct and primary therapy to treat various symptoms related to viral infections (Ref, Ref, Ref). The maximum tolerable daily dose is 18g (Ref2015).

Vitamin C (ascorbate) + copper (CuII) toxicity:
  Sodium Ascorbate can be taken intravenously up to 30g per day in healthy humans without complications. Cu(II) is natural found in the blood at a concentration of  1mg/L or 16uM (RefSL1997). However, if copper is also supplemented to superphysiological levels, then the dose of vitamin C will have to be monitored more closely.

Fig. from: "Inactivation of HSV-2 by ascorbate-Cu(II) and its protecting evaluation in CF-1 mice against encephalitis", Journal of Virological Methods 120 (2004) 161-165 (click figure to show full resolution)

Vitamin C: optimal dosages, supplementation and use in disease prevention (2105)
Vitamin C IV infusion is safe: Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects
DNA- and Protein-Scission Activities of Ascorbate in the Presence of Copper Ion and a Copper-Peptide Complex (1983)
Mechanism of copper-mediated inactivation of herpes simplex virus. (1997)
Virucidal agents in the eve of manorapid synergy (2007)
A Clinical Pilot Study of Lignin-Ascorbic Acid Combination Treatment of Herpes Simplex Virus (2009)
Inactivation of Vaccinia Virus by Ascorbic Acid (1964)
Inactivation of Vaccinia Virus by Ascorbic Acid and Glutathione (1937)
The antiviral properties of vitamin C (2019)

Back to: Table of Contents

nanna what would be the closest thing to IV , in the case of ascorbic acid in powder form , how would you do the protocol and dose?