Author Topic: Ideas on Herpes Induced POIS  (Read 92401 times)

Muon

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Re: Ideas on Herpes Induced POIS
« Reply #200 on: October 23, 2020, 07:22:42 AM »
Postural orthostatic tachycardia syndrome

"Prognosis depends on aetiology. Patients may have continuous symptoms. They may be unable to cope with their employment or normal daily activities. After post-viral episodes around 50% of patients recover in 2–5 years. Prognosis is good in adolescent patients. In the majority >90% respond to a combination of physical methods as well as pharmacotherapy. In the hyperadrenergic state patients will require life long treatment. In the secondary form the causative disorder has to be treated in order for patients to become symptom?free.

Pyridostigmine, an acetylcholine esterase inhibitor, has shown promising results in the management of POTS caused by post-viral infection and autoimmune disorders.29 Low dose combination therapy is better than high dose monotherapy.
"

swell

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Re: Ideas on Herpes Induced POIS
« Reply #201 on: November 02, 2020, 09:58:26 PM »
Thanks nanna1, I got HPV vaccinated by Gardasil9 a few days back.  I was fearing nasal congestion, but so far the vaccine has been ok, besides the fact, I have lost my strength - but that maybe somatic or hopefully NK cells getting created rapidly :) 

a) Would you have any ideas on healing gut lining?  I am considering L-Glutamine, though wondering if there is something better, since Glutamine is taken up by viruses as fuel.  I was trying to find some minimum glutamine dosage formula/info that if you take less than x mg, it will preferentially go to gut lining first foremost and not be sufficient enough to go towards pathogens.

b) when you get minute, if you are able to review my test results posted - 1st ever blood test done on me.  I feel forced to taking Iron 8mg daily, it is very therapeutic, prevents any Adderall induced headaches in me.  I thought I MUST have Iron deficiency anemia, but I dont see signs of anemia in my results.  Do you notice any other insights?  For one I see my innate immunity to be most active, but as a whole my immune system is low normal.  Link: https://poiscenter.com/forums/index.php?topic=3517.msg37283#msg37283


HPV vaccine: Most vaccines only work before infection. But there is some evidence that quadrivalent and 9-valent
 human papillomavirus (HPV) vaccines (9vHPV, Gardasil 9) are effective even after infection because it boost NK cell cytotoxicity and antiviral humoral immunity. T
POIS Free, 2+ yrs (occasional/predictive lapses)
Pois symptoms: Peripheral (Skin: Urticaria, dryness, pale blotchy skin), Exasperation of: [Nerve weakness, Muscle weakness + Mental (CNS: Brain Fog, Irritation, Isolation, Speech lethargy, Anxiety)].
Other conditions: ASD, ADD, GA

nanna1

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Re: Ideas on Herpes Induced POIS
« Reply #202 on: November 26, 2020, 01:43:15 AM »
a) Would you have any ideas on healing gut lining?

b) when you get minute, if you are able to review my test results posted - 1st ever blood test done on me...
https://poiscenter.com/forums/index.php?topic=3517.msg37283#msg37283
Hi swell,
  Vitamin B9 (folate) and resistance starch help to heal the gut lining. Please do not overdose folate.
Resistance starch is a prebiotic (like fiber) that gut bacteria convert to butyric acid (butyrate). Butyrate is a growth factor for epithelial cells in the digestive tract and helps to reduce inflammation.

  I don't see any ranges or units in your blood test results. So I'm not sure what the numbers stand for. If you have some time, please include the "normal" range and the titer units for each test result. I hope then I could be of more help. :)
POIS clusters: 1,3,4,5,7
POIS criteria: 1,2,3,4,5
2 stacks that give me complete relief of POIS symptoms are listed here: POIS cure: theory & supplement stack
Find medical test: https://www.findlabtest.com/

swell

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Re: Ideas on Herpes Induced POIS
« Reply #203 on: November 29, 2020, 11:58:59 PM »
Thanks Nanna1, I do eat a lot of fiber (resistant starch and take butyrate too) and take Methyl Folate 50% RDA every other day.   Surprisingly when I take Folinic (that I think gets to brain easily), even a small dosage, my muscles start to ache.   Ooops, I did just update the test results with units.
a) Would you have any ideas on healing gut lining?

b) when you get minute, if you are able to review my test results posted - 1st ever blood test done on me...
https://poiscenter.com/forums/index.php?topic=3517.msg37283#msg37283
Hi swell,
  Vitamin B9 (folate) and resistance starch help to heal the gut lining. Please do not overdose folate.
Resistance starch is a prebiotic (like fiber) that gut bacteria convert to butyric acid (butyrate). Butyrate is a growth factor for epithelial cells in the digestive tract and helps to reduce inflammation.

  I don't see any ranges or units in your blood test results. So I'm not sure what the numbers stand for. If you have some time, please include the "normal" range and the titer units for each test result. I hope then I could be of more help. :)
POIS Free, 2+ yrs (occasional/predictive lapses)
Pois symptoms: Peripheral (Skin: Urticaria, dryness, pale blotchy skin), Exasperation of: [Nerve weakness, Muscle weakness + Mental (CNS: Brain Fog, Irritation, Isolation, Speech lethargy, Anxiety)].
Other conditions: ASD, ADD, GA

Muon

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Re: Ideas on Herpes Induced POIS
« Reply #204 on: January 10, 2021, 01:30:02 PM »
If infection plays a part in POIS wouldn't you see more positive tests for autoantibodies? Not enough POISers have done autoantibody panels. And in addition to that, I haven't seen a single POISers who has done tests for adrenergic receptor autoantibodies. Autoantibodies against opioid receptors?
« Last Edit: January 10, 2021, 01:56:50 PM by Muon »

swell

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Re: Ideas on Herpes Induced POIS
« Reply #205 on: February 02, 2021, 04:31:09 PM »
I have had my general ANA panel Muon and my total count is too low.  While I tested negative, however, I could be wrong in my hypothesis that Auto-anti-bodies may be appearing (relatively) at a later stage in life, when body repair mechanisms are increasingly getting compromised, which is to say that in early mid life, despite having an issue (for e.g. with opoid receptors), your body would resist creating ANA's, till as long as it can. 

If infection plays a part in POIS wouldn't you see more positive tests for autoantibodies? Not enough POISers have done autoantibody panels. And in addition to that, I haven't seen a single POISers who has done tests for adrenergic receptor autoantibodies. Autoantibodies against opioid receptors?
POIS Free, 2+ yrs (occasional/predictive lapses)
Pois symptoms: Peripheral (Skin: Urticaria, dryness, pale blotchy skin), Exasperation of: [Nerve weakness, Muscle weakness + Mental (CNS: Brain Fog, Irritation, Isolation, Speech lethargy, Anxiety)].
Other conditions: ASD, ADD, GA

Muon

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Re: Ideas on Herpes Induced POIS
« Reply #206 on: February 24, 2021, 05:21:21 PM »
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

Furthermore, it was demonstrated that EBV dUTPase is secreted in exosomes from chemically induced Raji cells at sufficient levels to induce NF-?B activation and cytokine secretion in hDCs and PBMCs through a TLR 2-dependent mechanism [72]. Exosomes are produced by numerous cell types, have been implicated in numerous diseases, including ME/CFS [84], and are capable of trafficking to various organs within the body, including the brain, where they function as intercellular messengers.

A virus that is changing exosome content?

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses


Muon

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Mr Raba

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Re: Ideas on Herpes Induced POIS
« Reply #208 on: April 30, 2021, 10:23:45 PM »
Found this blog comment by coincidence. It sounds intriguing..


Explaining ME/CFS? Prusty / Naviaux Study Ties Infections to Energy Breakdowns
Quote
Ric on April 27, 2020 at 10:28 pm
Cort,
I have both CFS and POIS. Both simultaneously onset same day

In 1993.
Post Orgasmic Syndrome is a NORD validated rare disease. Where men crash with severe CFS like symptoms for 2 to 5 days after every ejaculation takes place (does not matter how (sex, nocturnal emissions etc.)).

The symptoms are amazingly similar as as a bad CFS crash. But most men go back to higher plateau of functioning than people with CFS (unless they have both) in 2 to 5 days. For me 3.

Imagine the study gem this entails. The whole cycle ALWAYS happens. So it could show volumes if tracked daily monitoring multiple biomarkers.

Dr Maria Vera who works in Dr. Klimas office said to me ?EBV has an affinity for sexual organs like the testis?.

Light went on. These thousands of men could be the missing men in CFS! Testosterone goes down after ejaculation and it takes a few days to come back. The things that help them are exactly the same as what helps people with CFS. The similarities are perplexing. To the extreme that I have given them lots of good material from CFS that they use now to alleviate symptoms. Many are just waiting for the CFS cure with the hope it will somehow benefit them.

I have long suspected that herpes type virus are involved in POIS
. I came down with EBV then POIS + CFS simultaneously. So the link is there for me. I am not the only man who has both. Note that hormonal changes activate herpes viruses as well.

Studying this cohort could shed so much light into both CFS and POIS.

The problem I have is that few people with one label bother to look at the other. That is different they conjecture.

I have both and I believe they are one and the same. Except POIS. Is what these men call their short term CFS episodes.

More on POIS at

https://poiscenter.com/forums/index.php

Can you please consider taking a look bringing the group to researches attention? It could be the missing link in these diseases spectrum.

I don't know who this Ric is, but after reading nanna1's post about the NK cells, I had the same thoughts.

I am Ric.  Mr Raba in this forum. 
Simultaneous onset of CFS and POIS since Feb 1993. Married since 1989.

Helped by Immunocal (I explained how to take in previous posts).  Some relief on day one and day two.  It affects neurotransmitters.

nanna1

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Re: Ideas on Herpes Induced POIS
« Reply #209 on: May 01, 2021, 05:29:51 PM »
"When peripheral nerve fibers are hypersensitive from nerve injury due to viral infection, in addition to the drug therapy for infection, use of Vitamin B1, 25 mg., 2 times a day for an average adult often accelerates recovery time. As an anti-viral agent for the herpes virus family, the author found that EPA (Omega 3 fish oil, Eicosa Pentaenoic Acid, C20:5 omega 3), at doses between 180 mg. and 350 mg (depending upon body weight) 4 times a day for 2 to 6 weeks, without prescribing the common anti-viral agent Acyclovir, often eliminated the symptoms due to viral infection including all well-known types of the herpes virus, such as herpes simplex virus, Epstein-Barr virus, and cytomegalovirus."
Treatment of acute or chronic severe, intractable pain and other intractable medical problems associated with unrecognized viral or bacterial infection: Part I (1990)
POIS clusters: 1,3,4,5,7
POIS criteria: 1,2,3,4,5
2 stacks that give me complete relief of POIS symptoms are listed here: POIS cure: theory & supplement stack
Find medical test: https://www.findlabtest.com/

nanna1

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Re: Ideas on Herpes Induced POIS
« Reply #210 on: June 15, 2021, 06:16:11 PM »
Post-viral fatigue is associated with various infectious diseases (SARS coronavirus, Epstein-Barr virus, Ross River virus, enteroviruses, human herpesvirus-6, Ebola virus, West Nile virus, Dengue virus, and parvovirus; bacteria such as Borrelia burgdorferi, Coxiella burnetii, and Mycoplasma pneumoniae; and even parasites, such as Giardia lamblia), which often show very different symptoms during the acute stage [1]. Post-viral fatigue syndrome is rather similar to chronic fatigue syndrome (CFS). In this context, it is interesting to note that CFS often begins with an infection during a period of increased physical activity or stress.
-Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue (2021)
« Last Edit: June 15, 2021, 06:23:51 PM by nanna1 »
POIS clusters: 1,3,4,5,7
POIS criteria: 1,2,3,4,5
2 stacks that give me complete relief of POIS symptoms are listed here: POIS cure: theory & supplement stack
Find medical test: https://www.findlabtest.com/