Author Topic: Medical and supplemental methods in treating POIS.  (Read 3903 times)

Nas

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Medical and supplemental methods in treating POIS.
« on: April 25, 2018, 03:23:16 PM »
Hello everybody

So today I wish to discus brain inflammation that occurs in POIS and how can we try to remedy the symptoms.

Most people who suffer from cognitive and psychological symptoms, are suffering because of the brain inflammation that occurs during ejaculation, and sometimes other triggers ( such as in my case smoking ).
We can theorize countless times about the mechanics of POIS and what causes it, but we all know for certain that inflammation is the main reason for our cognitive and psychological symptoms ( in theory of course, unless we have lab proof of the brain inflammation ).
Thus treating inflammation is the most important step into regaining control of who we are.
And thus we need to ask the question of how can we treat brain inflammation medically, and if not medically, perhaps supplementarily. 

Romies sent me  a message, a week ago, where he described that he uses an NSAID medication called Celebrex which worked as a COX-2 inhibitor. He also argued that the reason that Celebrex worked and other NSAID medication like Ibuprofen - that can also inhibit COX-2 - did not work, is because Celebrex can pass through the Blood Brain Barrier while the others don't. Thus he makes a good point about anti-inflammatory medications and supplements can have a hard time having access to the brain because of the BBB.
Consequently, we need to take into consideration the effectiveness of the anti-inflammatory treatment on the brain specifically in order for the treatment to succeed.
Finally, I would like to ask the question, based on this criteria, what can we use as an effective anti-inflammatory remedy? What would a doctor prescribe for the brain inflammation we suffer from?

If we can answer this question perhaps we can at least be able to deal with the symptoms we suffer from, for there are many POISers still, like me, who even though tried many methods to treat POIS, are still failing to at least lessen the symptoms to a manageable state.   

Thank you !

Scrub

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Re: Medical and supplemental methods in treating POIS.
« Reply #1 on: April 25, 2018, 04:04:39 PM »
I'm affected by POIS and all of my symptoms are cognitive, psychological, i managed to deal with the feeling of being extremely tired and fatigued by supplementing B-complex. i'm taking right now B-complex, Zinc, Magnessium, Taurine, vit-D and vit-E. Brain fog and all of the cognitive symptoms have been drastically reduced, but i'm not cured, i'm still being affected by it.

Did celebrex work during POIS reducing inflammation? Or are you taking it before release? FYI, unfortunately, alcohol fix POIS for me, if I get drunk, the next day i'm 100% POIS free. Dunno why, maybe alcohol reduces brain inflammation or something like that.

Nas

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Re: Medical and supplemental methods in treating POIS.
« Reply #2 on: April 25, 2018, 04:42:21 PM »

Did celebrex work during POIS reducing inflammation? Or are you taking it before release? FYI, unfortunately, alcohol fix POIS for me, if I get drunk, the next day i'm 100% POIS free. Dunno why, maybe alcohol reduces brain inflammation or something like that.

You did not read my post correctly scrub, I don't use Celebrex; rommies does and he says that it works for him.
Also many people note that alchol fixes POIS for them. I don't know about the effect of alchol on inflammation personally but I know that alchol works in other psychological cases such anxiety and ADHD, which means that alchol maybe effective in the case of balancing the the brain's chemical balance that is affected by inflammation.

certainlypois2

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Re: Medical and supplemental methods in treating POIS.
« Reply #3 on: April 26, 2018, 04:11:10 PM »
check out this guys website;http://www.lostfalco.com/the-brain-fog-two-step/, i think somebody posted about him here. He fights his brainfog by using galatamine for the acetylcholine inflammatory pathway and ,what i find interesting, IBUDILAST for inflammation the brain. I think one of the ways ibudilast fights inflammation in the brain is by working directly on microglia cells.
I tried this combination once while already in the pois and it was the best i felt cognitively in pois. I am going to be trying it again to be sure.
« Last Edit: April 26, 2018, 04:33:00 PM by certainlypois2 »

Nas

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Re: Medical and supplemental methods in treating POIS.
« Reply #4 on: April 27, 2018, 02:44:53 PM »
check out this guys website;http://www.lostfalco.com/the-brain-fog-two-step/, i think somebody posted about him here. He fights his brainfog by using galatamine for the acetylcholine inflammatory pathway and ,what i find interesting, IBUDILAST for inflammation the brain. I think one of the ways ibudilast fights inflammation in the brain is by working directly on microglia cells.
I tried this combination once while already in the pois and it was the best i felt cognitively in pois. I am going to be trying it again to be sure.

That was very interesting certainlypois2
Problem is that Ibudilast is only availabe in Japan and not souch in other countries, so I don't see how a doctor would perscribe that.


certainlypois2

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Re: Medical and supplemental methods in treating POIS.
« Reply #5 on: April 27, 2018, 03:24:26 PM »
check out this guys website;http://www.lostfalco.com/the-brain-fog-two-step/, i think somebody posted about him here. He fights his brainfog by using galatamine for the acetylcholine inflammatory pathway and ,what i find interesting, IBUDILAST for inflammation the brain. I think one of the ways ibudilast fights inflammation in the brain is by working directly on microglia cells.
I tried this combination once while already in the pois and it was the best i felt cognitively in pois. I am going to be trying it again to be sure.

That was very interesting certainlypois2
Problem is that Ibudilast is only availabe in Japan and not souch in other countries, so I don't see how a doctor would perscribe that.
I am in the US. I got the pills it from https://www.mimaki-family-japan.com/ without prescription for 100 after shipping. Took about a week to get to me.  https://irc.bio/product/ibudilast-powder/ in the US sells the powder and solution for much cheaper.  The powder was a pain to deal with.

Nas

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Re: Medical and supplemental methods in treating POIS.
« Reply #6 on: April 27, 2018, 04:09:58 PM »
Well I'm in Iraq soooo :/

PoisMan

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Re: Medical and supplemental methods in treating POIS.
« Reply #7 on: January 05, 2022, 11:29:57 AM »
Hi everybody.
Does anyone else have experience with ibudilast?

Progecitor

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Re: Medical and supplemental methods in treating POIS.
« Reply #8 on: January 08, 2022, 12:08:54 PM »
Hi everybody.
Does anyone else have experience with ibudilast?

Hi PoisMan and welcome to the forum!

Have you checked other threads for Ibudilast?
It should be quite clear that the pharmacological mechanism of Ibudilast is PDE inhibition.

Ibudilast is an orally bioavailable inhibitor of cyclic nucleotide phosphodiesterase (PDE), mainly PDE-3, -4, -10, and -11, with anti-(neuro)inflammatory, vasorelaxant, bronchodilator, analgesic, neuroprotective and potential anti-tumor activities. Ibudilast (IBD) is able to cross the blood-brain barrier (BBB). Upon administration, IBD exerts its potential anti-tumor activity against glioblastoma multiforme (GBM) cells by inhibiting PDE-4 and the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF), which results in a decrease in MIF, its receptor CD74, and AKT expression, and attenuates the immunosuppressive properties of monocytic myeloid-derived suppressor cells (MDSCs) and reduces T-regulatory cells (Tregs). This causes GBM cell apoptosis and inhibits GBM cell proliferation. In addition, IBD reduces, through its inhibitory effect on various PDEs, the production of certain pro-inflammatory cytokines, such as interleukin-6 (IL-6), IL- 1beta, leukotriene B4, and tumor necrosis factor-alpha (TNF-a). IBD also upregulates the anti-inflammatory cytokine (IL-10), and promotes the production of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin-4 (NT-4). It also blocks toll-like receptor-4 (TLR-4), inhibits nitric oxide (NO) synthesis and reduces the level of reactive oxygen species (ROS). It also prevents platelet aggregation, causes cerebral vasodilation, bronchial smooth muscle relaxation, and improves cerebral blood flow. In addition, IBD attenuates the PDE-mediated activation of glial cells and abrogates PDE-mediated neuroinflammation and neurodegeneration.
Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume shrinkage in patients with relapsing-remitting (RR) and/or secondary progressive (SP) multiple sclerosis (MS). Ibudilast is currently in development in the U.S., but is approved for use as an antiinflammatory in Japan.

https://pubchem.ncbi.nlm.nih.gov/compound/Ibudilast

As you can see due to its limited availability I don't think many of us could test its effectiveness.
Nevertheless many of us had success with other PDE inhibitors, especially PDE4. Some examples for PDE4 inhibitors are drotaverine (No-Spa), luteolin, Diazepam and Mesembrenone (Kanna).
https://en.wikipedia.org/wiki/Phosphodiesterase-4_inhibitor

Maybe you could check these on the forum for a reference.
Of course it would be best if you could also share your own experience with Ibudilast as someone who actually managed to try it.
The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.