Author Topic: Why niacin lead me to sleep  (Read 4801 times)

sameer7777

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Why niacin lead me to sleep
« on: September 09, 2017, 11:44:42 AM »
Hi it was not happening before I was taking niacin for energy and flush but now niacin is making me sleepy and I sleep and there is no flush  is happening why it's like this pls guide any one
pls don't expose me.
AFTER SEX/MASTERBATION (FLU LIKE SYMPTOMS)
1)BACK NECK PAIN GOES TO DOWN SPINE
2)NERVES LIKE SQUEEZED OUT
3)MORNING FEET NERVES PAIN
4)NASAL INFLAMMATION
5)BRAIN FOG
6)DEPRESSION
7)HIGH SUGAR LEVELS (TRIED INSULIN FOR 1 YEAR MAKE ME MORE SICK

nanna1

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Re: Why niacin lead me to sleep
« Reply #1 on: September 09, 2017, 04:41:16 PM »
Hi sameer7777,

Niacin (nicotinic acid) has three effects that may produce drowsiness:
  • it binds to the benzodiazepine receptor (on the GABAA receptor) [1]
  • it pushes tryptophan metabolism away from niacin production and towards serotonin/melatonin production [1]
  • it causes Prostaglandin D2 release (PD2 induced flush) [2], and PD2 is the most potent sleep inducer naturally found in the body [3]

  The ability of PD2 to induce flush can wear off over time (tolerance, cAMP depletion), but I think the ability to induce sleep is more resilient. People who back off taking nicotinic acid for a week, can generally see the flush effect come back. Taking Picamilon (GABA-niacin) can greatly enhance the sleep effect. I do not take flush niacin.

  As a side note, niacinamide (no-flush niacin) inhibits antigen-induced mast cell degranulation [4] and crosses the blood-brain barrier better than nicotinic acid (flush niacin)[5]. Moreover, niacinamide does not increase PD2.

1. Niacinamides Potent role in Alleviating Anxiety with its Benzodiazepine-like Properties: A Case Report (2004)
2. The mechanism and mitigation of niacin-induced flushing (2009)
3. Prostaglandin D2 and sleep/wake regulation.
4. The Role of Vitamins B3 and C in the Treatment of Histadelia
5. Niacinamide transport through the blood-brain barrier.
« Last Edit: September 09, 2017, 05:15:44 PM by nanna1 »
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sameer7777

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Re: Why niacin lead me to sleep
« Reply #2 on: September 10, 2017, 02:52:48 AM »
Thankyou for your reply
I am also taking 0.5 clonozepam
And 0.5 of resperidone everyday this might intereact with niacin my niacin is flush type..... Use to be great
Any way thanks
pls don't expose me.
AFTER SEX/MASTERBATION (FLU LIKE SYMPTOMS)
1)BACK NECK PAIN GOES TO DOWN SPINE
2)NERVES LIKE SQUEEZED OUT
3)MORNING FEET NERVES PAIN
4)NASAL INFLAMMATION
5)BRAIN FOG
6)DEPRESSION
7)HIGH SUGAR LEVELS (TRIED INSULIN FOR 1 YEAR MAKE ME MORE SICK

fathom

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Re: Why niacin lead me to sleep
« Reply #3 on: September 26, 2017, 12:50:17 PM »
On a related note, could someone help me, I have tried Niacin non-flush "after" an o on 2 occasions, and felt very crappy after taking it.  Its a bad feeling where you feel as if your eyes and mouth is burning (and maybe itching from inside) which makes you very uncomfortable - it spoils your day.  Since then I am not using it before or after an o, because I hate to get that feeling "before" an o, I mean whats the point of having an o, its to feel good (at least at that very moment) and if Niacin takes that away, then whats the point?  Am I missing something here (or maybe its just me that gets this effect?)

sameer7777

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Re: Why niacin lead me to sleep
« Reply #4 on: September 26, 2017, 01:07:00 PM »
Hi this flush will give you relief from symptoms or take it when you feel like to not before o or after try it
pls don't expose me.
AFTER SEX/MASTERBATION (FLU LIKE SYMPTOMS)
1)BACK NECK PAIN GOES TO DOWN SPINE
2)NERVES LIKE SQUEEZED OUT
3)MORNING FEET NERVES PAIN
4)NASAL INFLAMMATION
5)BRAIN FOG
6)DEPRESSION
7)HIGH SUGAR LEVELS (TRIED INSULIN FOR 1 YEAR MAKE ME MORE SICK