Post Orgasmic Illness Syndrome (P.O.I.S.)
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: adamw
+  Post Orgasmic Illness Syndrome (P.O.I.S.)
|-+  POIS Cause/Treatment Discussions
| |-+  Hormonal Causes and Treatments
| | |-+  High or low ENDORPHINS ?
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: High or low ENDORPHINS ?  ( 2359 )
: 39

« : July 31, 2017, 03:14:04 PM »


i'm investigating about endorphins,i thinks i have high  endorphins  " i have most of the symptoms below" and endorphins are released  after orgasm,and after too much exercice :

The SYMPTOMS of Very HIGH β-Endorphin and / or DYNORPHIN levels (includes naturally or genetically) are...

Social Isolation, and low social motivation
Impulsivity (due to excess Kappa/k-opioid activation, dynorphin mediated)
Depression or Anhedonia (Emotional Numbness)
Low/Absent Sex Drive
Low Testosterone / Universal Hypogonadism in either Sex
Infertility : in both Men and Women ; Low Sperm Count, Lack of ovulation
COGNITIVE INFLEXIBILITY (unable to switch Tasks easily and unable to understand or unwillingness to Internalize what one is not used to; unable to pick up new 'concepts' and generally resorts to what one knows)
Indifference, lack of competitive behavior, doesn't care about 'Winning' or 'Losing'
Lack of the Ability to ''Cry''.

To correct most of those issues you must.
Resolve the underlying hormonal imbalance (too much Progesterone or Estrogen etc)
Use Naltrexone in the short-term if no anxiety disorder is present. (25-50 mg once per day)
Use Cialis to counter-act the sexual deficits in the short-term. (5-20 mg once per day)

 source "where you can find olso symptoms of low endorphins" :
« : July 31, 2017, 03:15:38 PM youcefrouiba »
Jr. Member
: 80

« #1 : August 02, 2017, 11:30:05 AM »

Thanks for the information!

Did you have success with this?
: 39

« #2 : August 02, 2017, 05:19:03 PM »

Naltrexone is not available in my country
Hero Member
: 781

« #3 : October 16, 2017, 01:05:00 PM »

I would say "high" just after orgasm an "low" some hours and days later.

Taurine = Anti-Pois
Jr. Member
: 74

« #4 : October 19, 2017, 08:35:18 AM »

This is a very interesting topic which I think we should continue to investigate. From my research I have come across that this low dose of Naltrexone (LDN) is effective for a lot of conditions including CFS, Fibromyalgia, auto-immune issues and multiple sclerosis.

Dr David Gluck is working on trialing LDN for auto-immune diseases. This is his website which gives more details about LDN:

I have taken some excerpts from the website and posted here:

"The major mechanism of action of LDN involves blocking the body?s opioid/narcotic receptors for just a very few hours (rather than the all-day blockade caused by the 50mg dosage). Those are the same receptors used by the body?s endorphins. The body responds to this by greatly increasing its endorphin production, and those higher levels last all day -- far after the blockade by LDN has ended. Endorphins turn out to be the major normalizer/upregulator of one?s immune system.

This is of critical importance to anyone who has an autoimmune disease. Published studies have demonstrated that all autoimmune disorders thus far tested are marked by weak, dysfunctional immune systems (in contrast to the common belief that they are probably too strong). This makes good sense, because the first commandment of the immune system is ?Thou shalt not attack self!? Only a dysfunctional immune system attacks self. When the LDN normalizes one?s immune system, it halts the further progression of any autoimmune disease. When one takes LDN, one is regaining a normalized immune system ? and it is the immune system that has such a positive effect on such a wide variety of conditions."

The below link has reviews of patients who have used it for their conditions, and I am seeing overwhelming positive reports from patients who have used it for fibromyalgia:

I did the above post in another thread a few months before regarding Low Dose Naltrexone

30 years old, POIS for around 9 years with increasing severity.
Major symptoms - Severe fatigue, back pain, unrefreshed even after 9+ hours sleep, pain behind eyes, very dry face, bald head with inflamed scalp, digestion issues and constipation. Very low testosterone and high glucose in blood tests.
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