Author Topic: POIS treatment: theory & supplement stack  (Read 345711 times)

quiteQuiet

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Re: POIS treatment: theory & supplement stack
« Reply #580 on: February 14, 2024, 05:22:11 PM »
I believe that for me pois is caused by inflammation too.
I have some shoulder and elbow issues that have always been on and off from over 10 years ago, seemingly randomly appearing out of nowhere and also disappearing. Only a year or two ago I came to understand that it happens when I am not feeling well in general (a pois episode for example) and have high inflammation in my body in general.

Physi

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Re: POIS treatment: theory & supplement stack
« Reply #581 on: October 21, 2024, 11:36:07 AM »
Does someone know if both Nanna?s stack can be combined ?

Meaning taking the cascade stack for long term and the other one as a pre pack.

Also, there are very few testimonies on his prepack.

Warrior

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Re: POIS treatment: theory & supplement stack
« Reply #582 on: October 21, 2024, 04:45:58 PM »
Does someone know if both Nanna?s stack can be combined ?

Meaning taking the cascade stack for long term and the other one as a pre pack.

Also, there are very few testimonies on his prepack.
If I remember correctly:

The POIS Cascade Stack and the Betaherpesvirinae Stack are not intended to be taken together.

The POIS Cascacde Stack works to inhibit POIS inflammatory pathways via D3/methylation/zero AA, requiring a vegan diet (zero arachidonic acid [AA] consumption) and/or high Omega-3 to replace AA, but apparently only effective with vegan diet (zero AA). The Betaherpesvirinae stack works to inhibit those same inflammatory pathways (which he hypothesised the Herpes virus as a possible cause for POIS) but was created for those who can't go on a vegan diet (a diet devoid of AA which triggers one of the POIS inflammatory pathways according to him). He hypothesised you can stop AA inflammatory pathway (temporarily) through Betaherpesvirinae stack, even if consuming AA.

The Betaherpesvirinae stack has more pharmaceuticals so I would be more cautious taking long-term and make sure you take his drug detox recommendations along with it.

You could try both and just see what works. His intention with these stacks was to improve/fix POIS symptoms, not cure. His immune competence therapy (broad-spectrum pathogen load reduction) was intended as a potential cure.
« Last Edit: October 21, 2024, 06:37:55 PM by Warrior »
Nothing I say is medical advice. Always do your own research. Follow anything I say at your own discretion.
My POIS Protocol | My YouTube Channel

Physi

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Re: POIS treatment: theory & supplement stack
« Reply #583 on: October 22, 2024, 03:36:15 AM »
Does someone know if both Nanna?s stack can be combined ?

Meaning taking the cascade stack for long term and the other one as a pre pack.

Also, there are very few testimonies on his prepack.
If I remember correctly:

The POIS Cascade Stack and the Betaherpesvirinae Stack are not intended to be taken together.

The POIS Cascacde Stack works to inhibit POIS inflammatory pathways via D3/methylation/zero AA, requiring a vegan diet (zero arachidonic acid [AA] consumption) and/or high Omega-3 to replace AA, but apparently only effective with vegan diet (zero AA). The Betaherpesvirinae stack works to inhibit those same inflammatory pathways (which he hypothesised the Herpes virus as a possible cause for POIS) but was created for those who can't go on a vegan diet (a diet devoid of AA which triggers one of the POIS inflammatory pathways according to him). He hypothesised you can stop AA inflammatory pathway (temporarily) through Betaherpesvirinae stack, even if consuming AA.

The Betaherpesvirinae stack has more pharmaceuticals so I would be more cautious taking long-term and make sure you take his drug detox recommendations along with it.

You could try both and just see what works. His intention with these stacks was to improve/fix POIS symptoms, not cure. His immune competence therapy (broad-spectrum pathogen load reduction) was intended as a potential cure.

Thanks Warrior.

I will begin Cascade Stack and take Betaherpesvirinae Stack before orgasm for now, as Cascade Stack is meant to be taken for a month before being efficient. I'll update.

Physi

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Re: POIS treatment: theory & supplement stack
« Reply #584 on: October 22, 2024, 04:18:56 AM »
Does someone know if both Nanna?s stack can be combined ?

Meaning taking the cascade stack for long term and the other one as a pre pack.

Also, there are very few testimonies on his prepack.
If I remember correctly:

The POIS Cascade Stack and the Betaherpesvirinae Stack are not intended to be taken together.

The POIS Cascacde Stack works to inhibit POIS inflammatory pathways via D3/methylation/zero AA, requiring a vegan diet (zero arachidonic acid [AA] consumption) and/or high Omega-3 to replace AA, but apparently only effective with vegan diet (zero AA). The Betaherpesvirinae stack works to inhibit those same inflammatory pathways (which he hypothesised the Herpes virus as a possible cause for POIS) but was created for those who can't go on a vegan diet (a diet devoid of AA which triggers one of the POIS inflammatory pathways according to him). He hypothesised you can stop AA inflammatory pathway (temporarily) through Betaherpesvirinae stack, even if consuming AA.

The Betaherpesvirinae stack has more pharmaceuticals so I would be more cautious taking long-term and make sure you take his drug detox recommendations along with it.

You could try both and just see what works. His intention with these stacks was to improve/fix POIS symptoms, not cure. His immune competence therapy (broad-spectrum pathogen load reduction) was intended as a potential cure.

Also, after the Cascade stack stopped being effective for you, could you fix it again ? Could you verify your theory on Omega 6 ?

Warrior

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Re: POIS treatment: theory & supplement stack
« Reply #585 on: October 22, 2024, 05:02:10 AM »
Does someone know if both Nanna?s stack can be combined ?

Meaning taking the cascade stack for long term and the other one as a pre pack.

Also, there are very few testimonies on his prepack.
If I remember correctly:

The POIS Cascade Stack and the Betaherpesvirinae Stack are not intended to be taken together.

The POIS Cascacde Stack works to inhibit POIS inflammatory pathways via D3/methylation/zero AA, requiring a vegan diet (zero arachidonic acid [AA] consumption) and/or high Omega-3 to replace AA, but apparently only effective with vegan diet (zero AA). The Betaherpesvirinae stack works to inhibit those same inflammatory pathways (which he hypothesised the Herpes virus as a possible cause for POIS) but was created for those who can't go on a vegan diet (a diet devoid of AA which triggers one of the POIS inflammatory pathways according to him). He hypothesised you can stop AA inflammatory pathway (temporarily) through Betaherpesvirinae stack, even if consuming AA.

The Betaherpesvirinae stack has more pharmaceuticals so I would be more cautious taking long-term and make sure you take his drug detox recommendations along with it.

You could try both and just see what works. His intention with these stacks was to improve/fix POIS symptoms, not cure. His immune competence therapy (broad-spectrum pathogen load reduction) was intended as a potential cure.

Also, after the Cascade stack stopped being effective for you, could you fix it again ? Could you verify your theory on Omega 6 ?

Yes that's correct to some degree. When I first begun taking SAMe, it felt like a miracle. It was like an off switch for my entire condition, including my food sensitivities. This lasted around 3-4 weeks until symptoms began emerging again. For whatever reason, it stopped working at 100%. I tried lots of different methylation nutrients, supporting minerals, buffer nutrients like folate etc but nothing worked 100% long-term. But I do think it did "permanently" top up my methylation such that I no longer need to constantly take B vitamins, eggs (choline), etc. Before SAMe, I always felt an enormous difference before and after re my B complex, eggs, etc. Like I needed to take the B complex daily to feel good. These days I don't really feel the need as much for methylatio nutrients, apart from eggs and red meat for POIS.

For what it's worth tho, my sensitivties and POIS definitely seemed to permanently improve since the SAMe, but it's hard to put a number on exactly how much.

I also don't know about SAMe's long-term safety so I am personally hesitant to continue taking it long-term as well, even tho I do think it benefited me.

Nanna1's stack also taught me how important D3 serum is. D3 serum is king.

Re the Omega-6, I honestly have no idea. It's too difficult to test. These days I stick to a low seed oil diet given that I eat so much saturated and animal fat. Vegetable oils oxidise cholesterol apparently. The science is a bit controversial, but I definitely don't want to eat both concurrently. I'm also seeing a low-carb Dr here in Aus who advises to keep Omega-6/seed oils virtually to zero. I also personally haven't responded at all to Omega-3, hasn't made any impact on my POIS whatsoever but for others it's been a gamechanger.
« Last Edit: October 22, 2024, 05:19:08 AM by Warrior »
Nothing I say is medical advice. Always do your own research. Follow anything I say at your own discretion.
My POIS Protocol | My YouTube Channel

Physi

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Re: POIS treatment: theory & supplement stack
« Reply #586 on: October 23, 2024, 02:12:04 AM »
Does someone know if both Nanna?s stack can be combined ?

Meaning taking the cascade stack for long term and the other one as a pre pack.

Also, there are very few testimonies on his prepack.
If I remember correctly:

The POIS Cascade Stack and the Betaherpesvirinae Stack are not intended to be taken together.

The POIS Cascacde Stack works to inhibit POIS inflammatory pathways via D3/methylation/zero AA, requiring a vegan diet (zero arachidonic acid [AA] consumption) and/or high Omega-3 to replace AA, but apparently only effective with vegan diet (zero AA). The Betaherpesvirinae stack works to inhibit those same inflammatory pathways (which he hypothesised the Herpes virus as a possible cause for POIS) but was created for those who can't go on a vegan diet (a diet devoid of AA which triggers one of the POIS inflammatory pathways according to him). He hypothesised you can stop AA inflammatory pathway (temporarily) through Betaherpesvirinae stack, even if consuming AA.

The Betaherpesvirinae stack has more pharmaceuticals so I would be more cautious taking long-term and make sure you take his drug detox recommendations along with it.

You could try both and just see what works. His intention with these stacks was to improve/fix POIS symptoms, not cure. His immune competence therapy (broad-spectrum pathogen load reduction) was intended as a potential cure.

Also, after the Cascade stack stopped being effective for you, could you fix it again ? Could you verify your theory on Omega 6 ?

Yes that's correct to some degree. When I first begun taking SAMe, it felt like a miracle. It was like an off switch for my entire condition, including my food sensitivities. This lasted around 3-4 weeks until symptoms began emerging again. For whatever reason, it stopped working at 100%. I tried lots of different methylation nutrients, supporting minerals, buffer nutrients like folate etc but nothing worked 100% long-term. But I do think it did "permanently" top up my methylation such that I no longer need to constantly take B vitamins, eggs (choline), etc. Before SAMe, I always felt an enormous difference before and after re my B complex, eggs, etc. Like I needed to take the B complex daily to feel good. These days I don't really feel the need as much for methylatio nutrients, apart from eggs and red meat for POIS.

For what it's worth tho, my sensitivties and POIS definitely seemed to permanently improve since the SAMe, but it's hard to put a number on exactly how much.

I also don't know about SAMe's long-term safety so I am personally hesitant to continue taking it long-term as well, even tho I do think it benefited me.

Nanna1's stack also taught me how important D3 serum is. D3 serum is king.

Re the Omega-6, I honestly have no idea. It's too difficult to test. These days I stick to a low seed oil diet given that I eat so much saturated and animal fat. Vegetable oils oxidise cholesterol apparently. The science is a bit controversial, but I definitely don't want to eat both concurrently. I'm also seeing a low-carb Dr here in Aus who advises to keep Omega-6/seed oils virtually to zero. I also personally haven't responded at all to Omega-3, hasn't made any impact on my POIS whatsoever but for others it's been a gamechanger.

Thanks for the info. I don?t get why you don?t take the Betaherpesvirinae Stack as you reponded to the Cascade stack ?

I understand that Cascade Stack does not work well with meat as meat contains AA.

But Betaherpes should work fine for you ?

Warrior

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Re: POIS treatment: theory & supplement stack
« Reply #587 on: October 23, 2024, 05:05:26 AM »

Thanks for the info. I don?t get why you don?t take the Betaherpesvirinae Stack as you reponded to the Cascade stack ?

I understand that Cascade Stack does not work well with meat as meat contains AA.

But Betaherpes should work fine for you ?

Tbh I should try the pharmeceuticals purely from an experimentive/insight POV. The relief I get from my own method is already significant for POIS. I can pretty much release whenever I want without problem, but I do still experience a distinct shift in my state for a good 12-24hrs. Back then I was mostly trying to fix my food sensitivities which coincide with my POIS as I was desperate to get off the animal-based diet I was on back then. These days I have seemingly hit a new level of satisfaction with diet being on ketogenic and am happily tolerating lots of standard keto foods inc. veggies, dark choc, etc with the help of Monolaurin. My energy, hormones, and overall diet satisfaction has improved dramatically since going keto. Something I really struggled with while I was on animal-based, despite it being a huge breakthrough for my POIS.
« Last Edit: October 23, 2024, 05:08:23 AM by Warrior »
Nothing I say is medical advice. Always do your own research. Follow anything I say at your own discretion.
My POIS Protocol | My YouTube Channel

Physi

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Re: POIS treatment: theory & supplement stack
« Reply #588 on: October 26, 2024, 05:24:52 AM »

Thanks for the info. I don?t get why you don?t take the Betaherpesvirinae Stack as you reponded to the Cascade stack ?

I understand that Cascade Stack does not work well with meat as meat contains AA.

But Betaherpes should work fine for you ?

Tbh I should try the pharmeceuticals purely from an experimentive/insight POV. The relief I get from my own method is already significant for POIS. I can pretty much release whenever I want without problem, but I do still experience a distinct shift in my state for a good 12-24hrs. Back then I was mostly trying to fix my food sensitivities which coincide with my POIS as I was desperate to get off the animal-based diet I was on back then. These days I have seemingly hit a new level of satisfaction with diet being on ketogenic and am happily tolerating lots of standard keto foods inc. veggies, dark choc, etc with the help of Monolaurin. My energy, hormones, and overall diet satisfaction has improved dramatically since going keto. Something I really struggled with while I was on animal-based, despite it being a huge breakthrough for my POIS.

Hi Warrior,

Thanks for sharing.

What I had in mind is that the Betaherpes from my understanding is compatible with other methods to achieve 100% relief and the acid arachidonic blockers seemed to be efficient on you.

I?m currently trying to figure out if the acid arachidonic blocker methods (the 2 nanna?s stack) are efficient for me as well so that I can combine them with my current treatments to try and maximize relief.



Physi

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Re: POIS treatment: theory & supplement stack
« Reply #589 on: October 26, 2024, 05:32:52 AM »
I also produced a simplified explanation of Nanna s theory using Chatgpt, I am posting it below as it could help some people getting the principles:

This theory on Post-Orgasmic Illness Syndrome (POIS) suggests that POIS symptoms result from a complex chain of biological events referred to here as the ?POIS Cascade starting with overstimulation of α1-adrenergic (α1A) and histaminergic (H1) receptors. This cascade triggers a rapid release of arachidonic acid (AA), leading to the production of inflammatory molecules, which then cause the flu-like symptoms associated with POIS.

Key Points of the Theory

   1.   Role of Norepinephrine and the α1-Adrenergic (α1A) Receptor:
   -   During orgasm, norepinephrine levels temporarily rise. In people with POIS, this norepinephrine surge overactivates the α1A receptor.
   -   Stimulation of α1A activates enzymes Phospholipase A2 and C, which release arachidonic acid (AA) from the cell membrane.

   2.   Release of Arachidonic Acid (AA):
   -   The release of AA, a pro-inflammatory omega-6 fatty acid, activates enzymes 5-LOX and COX-2, which convert AA into inflammatory prostaglandins (such as prostaglandin E2), causing POIS symptoms.

   3.   Similar Mechanisms with Histamine and Glutamate:
   -   External triggers (e.g., allergens, food) may produce POIS-like symptoms through different receptors (H1 for histamine, NMDA for glutamate), similarly leading to AA release and inflammation.

Intervention: Blocking the POIS Cascade

The theory proposes blocking three main steps in the cascade to prevent POIS:

   1.   Reduce α1A and H1 Receptor Expression:
   -   SAM-e (S-adenosyl-methionine) is suggested to regulate α1A expression through methylation processes, which help stabilize the cell membrane and reduce AA release.
   -   Activated Vitamin B1 (Benfotiamine) can help downregulate H1 receptor expression, reducing histamine-triggered inflammation.

   2.   Inhibit NF-kB and Inflammatory Cytokines:
   -   Vitamin D3 inhibits NF-kB and COX-2, reducing the production of inflammatory cytokines (like TNF-α, IL-1B), which contribute to POIS symptoms.

   3.   Decrease Arachidonic Acid Release and Inhibit Pro-Inflammatory Enzymes:
   -   Omega-3s (EPA and DHA): EPA and DHA can reduce AA production by limiting its integration into cell membranes, thereby preventing the formation of inflammatory prostaglandins.
   -   The author also reduces dietary AA (avoiding omega-6-rich meats), lowering the amount of AA available for release.

Supplement Strategies

The author suggests two supplement protocols to manage POIS, each tailored to different situations:

   1.   The POIS Cascade Stack:
   -   This includes daily supplements (SAM-e, EPA, DHA, Vitamin D3, and various B vitamins) to inhibit the inflammatory cascade and maintain a biochemical environment less prone to triggering POIS symptoms.

   2.   The Betaherpesvirinae Stack:
   -   This protocol addresses a potential link between POIS and viral reactivation (such as CMV or HHV-6). It involves immune regulators and antioxidants (Vitamin D3, N-acetylcysteine, and selenomethionine) to prevent virus-related inflammation, used before sexual activity.

Conclusion and Insights

This theory suggests that POIS may result from an exaggerated inflammatory response, with arachidonic acid release playing a central role. By targeting each step in this cascade with supplements that act on receptors, inflammation pathways, and AA availability, the author reports relief from POIS symptoms.
« Last Edit: October 26, 2024, 05:35:52 AM by Physi »

Sisyphus

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Re: POIS treatment: theory & supplement stack
« Reply #590 on: November 03, 2024, 05:12:55 PM »
Thanks for this. I found this simplified explanation by Physi / Chatgpt useful. I've tried to read Nanna's original post quite a few times but I found a lot of it difficult to follow.

I wonder what made Nanna think that the rapid release of arachidonic acid is associated with pois? (I'm not saying he's wrong, I just find it interesting).

One thing I've never tried is SAMe. I've never taken it because it's had a few negative reports in the media and it's expensive. Anyone got experience with SAMe? It seems to be an essential component of Nanna's pois treatment?


Physi

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Re: POIS treatment: theory & supplement stack
« Reply #591 on: November 09, 2024, 06:13:09 AM »
Hi Sisyphus,

You?re welcome.

I think I have read on one of Nanna?s post that Sam e was an important component.