Author Topic: POIS cure: theory & supplement stack  (Read 46535 times)

Vandemolen

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Re: POIS cure: theory & supplement stack
« Reply #375 on: October 07, 2018, 06:54:51 PM »
Mel, I understand very good why you turned to 23andme. Because of your positive result with Nana’s stack I will start with it about two days. I had almost all the supplements for a few months. But I was lazy to start taking so many pills. Because I already take some pills. But now it’s sure that helped you and Nanna it’s worth to try it. I will let you the know the result about two weeks. I will ask my PoIS doctor about that MTHFR test.
« Last Edit: October 07, 2018, 08:21:10 PM by Vandemolen »
POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 70% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.

itsmel

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Re: POIS cure: theory & supplement stack
« Reply #376 on: October 08, 2018, 03:43:07 PM »
Mel, I understand very good why you turned to 23andme. Because of your positive result with Nana’s stack I will start with it about two days. I had almost all the supplements for a few months. But I was lazy to start taking so many pills. Because I already take some pills. But now it’s sure that helped you and Nanna it’s worth to try it. I will let you the know the result about two weeks. I will ask my PoIS doctor about that MTHFR test.

Good luck  :)

itsmel

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Re: POIS cure: theory & supplement stack
« Reply #377 on: October 08, 2018, 03:46:03 PM »
Just want to report back that I came across my first side effect with the supplement. I would wake up after several hours after going to sleep. Read that B12 can cause insomnia which haven't happen to me yet but instead interruptions. But after some googling, it mentions that intake of potassium might help.

https://forums.phoenixrising.me/index.php?threads/methyl-folate-insomnia.50342/

Vandemolen

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Re: POIS cure: theory & supplement stack
« Reply #378 on: October 09, 2018, 08:08:49 AM »
I started yesterday with Nanna’s stack. Today I woke up with lower back pain. I already have UTI/prostitis. But after going trough this topic I read that Alpha GPC causes lower back pain. So I will start with 1 pill a day for a week. And then go to 2.
POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 70% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.

Bombardier

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Re: POIS cure: theory & supplement stack
« Reply #379 on: October 09, 2018, 10:57:57 AM »
So I've started using this stack once again, this time making sure I was following a vegan diet. Cutting out animal proteins has indeed helped immensely with my cognitive performance outside of POIS. I've been wondering, however: Is there any indication outside of climaxing that the stack is working for me?

I haven't gotten any additional cognitive benefit since I started the stack, but knowing the answer might give me a great deal of confidence. I'd test this out myself, but I've been very busy at work. Thanks in advance, Nanna.

Vandemolen

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Re: POIS cure: theory & supplement stack
« Reply #380 on: October 09, 2018, 06:07:14 PM »
The lowest vitamin B6 I could find is 50mg. So I bought pyridoxal-5-phosphate pills with 20mg of vitamin B6.
POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 70% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.

Bombardier

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Re: POIS cure: theory & supplement stack
« Reply #381 on: October 10, 2018, 06:29:45 PM »
We're looking forward to your results, Vandemolen!

nanna1

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Re: POIS cure: theory & supplement stack
« Reply #382 on: October 11, 2018, 11:17:34 PM »
Hi All,

  I know I'm behind on the conversation, but I just wanted to contribute anything I can. If you are trying the POIS Cascade stack, I would give it about 1 month to assess if it is working for you.
Note: Many of these supplements have slow diffusion across the blood/brain barrier and/or slow incorporation into the phospholipid bilayer. So it may take 3 to 4 weeks of consistent supplementation before you are able to assess the full benefit. I continue daily maintenance of supplementation with the POIS Cascade Stack even after seeing my symptoms disappear.
  Both D3 and EPA are fat soluble, so it may take a month of consistent supplementation to see their full effects. B6 is water soluble and should kick-in within a couple of days. Many of the supplements in the POIS Cascade Stack have slow diffusion across the blood/brain barrier and/or slow incorporation into the phospholipid bilayer. So it could take 3 to 4 weeks of consistent supplementation before the effects can be assessed.

I've been wondering, however: Is there any indication outside of climaxing that the stack is working for me?
  One of the ways I could tell when the POIS Cascade stack is working for me (apart from having an orgasm) is that my exercise induced sickness goes away. I used to get flu-like symptoms (sneezing) with CFS, IBS, diarrhea from heavy exercise that would last for 5 to 7 days.
Exercise: Exercise caused sneezing and runny nose in my left nostril. I also had exercise induced IBS with diarrhea, unusually long DOMS/recovery and chronic fatigue (5-8 days). I still can get fasciculation shortly after resistance exercise.
Now I do not get sick from exercise anymore! Also, the DOMS from exercise have almost completely gone away and I recover faster.

Just want to report back that I came across my first side effect with the supplement. I would wake up after several hours after going to sleep.
  Methyl-donors can shorten your sleep cycle. To prevent problems with sleep, I would avoid taking SAMe before bedtime. SAMe does not cause sleep problems for everyone, but sleep disturbance is a known side-effect of SAMe for some due to increased neurotransmitter production.
Do not take SAM-e within 5 hours of your typical bedtime or you may experience trouble going to sleep.
It may be wise to also avoid choline/lecithin right before bed. TMG (betaine) is fine to take before bed.

  I would agree that those who are undermethylated can benefit from methyl-donors, but I do not think that I personally have a problem with methylation. My methylation levels are normal even when I am not taking the stack. So for me, this stack does not correct any methylation problems, but it maybe possible that those who are undermethylated can receive additional benefits from methyl-donors and certain B vitamins.
12. Methylation/homocysteine blood test:
  I stopped taking the majority of my supplement stack (choline/B-vitamins/omega-3/CLA) more than a week prior to getting the blood test. No creatine loading. No creatine more than 3 days prior to the blood test. Avoided other supplemental sources of B-vitamins like sport drinks. The only supplement I took the day of the test was vitamin D3. My homocysteine levels are normal (test).

   In terms of the Betaherpesvirinae stack, I am sorry if I confused anybody about Indomethacin. Ibuprofen is not the same drug as Indomethacin. Indomethacin is about 50 times more potent (effective) COX-2 inhibitor than Ibuprofen, and it is about 430 times more effective COX-1 inhibitor than Ibuprofen. Indomethacin is a prescription-only drug.
An explaination of what the potency measure IC50 means can be found here. Smaller IC50 values result in a stronger effect (stronger COX inhibition). For example, indomethacin is a stronger COX-1 and COX-2 inhibitor than aspirin.
----------------
Ibuprofen is not an anti-inflammatory drug because it has extremely low potency. According to the above chart, Ibuprofen is the least effective COX inhibitor there is, because it does not inhibit COX-1 or COX-2 efficiently. I explain this in more details here.
   One more thing to consider is the pharmacokinetics. Taking indomethacin 30 minutes before orgasm will likely not be as effective since it requires more than an 2 hours to reach peak blood levels (post).

Please forgive me if there were any question directed toward me that I missed.  :)
« Last Edit: October 12, 2018, 12:57:35 AM by nanna1 »

nanna1

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Re: POIS cure: theory & supplement stack
« Reply #383 on: October 15, 2018, 01:33:44 AM »
Now I do not get sick from exercise anymore! Also, the DOMS from exercise have almost completely gone away and I recover faster.
  I just wanted to add that I also no longer experience irritable bowel syndrome (IBS). I'm not sure exactly why it went away. I used to experience it all of the time (even without orgasm and POIS). I started experiencing relief from my stack-diet last year, but it wasn't until this year that I noticed my IBS slowly started to disappear. Even if I break my diet for a week or two, I still do not experience IBS. So this is still a mystery.

  But I can say that, I have experienced more improvements over this past year than I have over the previous decade. I do think that the lifestyle changes I made last year through my diet and supplements (and occasional fasting) has improved my overall health and reduced inflammation in general.

Vandemolen

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Re: POIS cure: theory & supplement stack
« Reply #384 on: October 16, 2018, 06:25:49 AM »
Since I take Nanna’s stack I have to urinate almost 10 times a day. Al that water with those pills...

I also had IBS because of POIS. The last years I don’t have IBS. Maybe because I use a lot of antibiotics for my UTI/prostatatitis.
POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 70% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.

fernab

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Re: POIS cure: theory & supplement stack
« Reply #385 on: October 18, 2018, 06:17:53 AM »
hi nanna1, first of all, I want to thank your contributions to the forum. I believe that your profession (if I remember correctly, biomedical engineer) and your dedication are of great help. I am in a very difficult situation since the end of February. Despite that, I decided to try your set of supplements and vitamins. but unfortunately, on the second day I had to leave them. I started to feel worse. people close to me just told me that I may also suffer from pudendal nerve neuralgia. I have been tested for the pudendal nerve. and the result is that apparently it is completely normal. yes it is true that the symptoms that I suffer especially since I rode a sleigh at the end of February last suggests that it could be a pudendal nerve neuralgia. but there are certain symptoms that I can not explain with the pudendal nerve neuralgia. since I have clearly worsened since the last release. and other symptoms are more associable to POIS. In fact they are the same as I had before that time I rode in a sleigh. Do you think POIS could have a neurological component?

Vandemolen

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Re: POIS cure: theory & supplement stack
« Reply #386 on: October 20, 2018, 10:00:17 AM »
I want to report that Nanna’s stack didn’t work for me. But I only use it for 10 days. Nanna said that you have to use it for 3 or 4 weeks. So I will try about 2 or 3 weeks again. I was also already a bit sick because of my allergy of Cefuroxim. I finished the cure on Thursday. So why did I try yesterday? That’s because Wednesday I have an appointment with my POIS doctor. I thought if it worked I could try it Monday again to be sure it works for me. And then I could tell my POIS doctor. When it’s sure that it worked for me he would take it more serious.

I will report when I tried it again. Now my fingers, feet and skull are very dry. My troath, mouth, tongue and nose are dry. Niacin didn’t work for me but at least it helped a bit against a dry mouth and nose. There is also another thing. I also over masturbated. For more than 4 hours. Maybe it doesn’t work that long? Doing it for this period is also unhealthy for a man without POIS.
« Last Edit: October 20, 2018, 10:02:11 AM by Vandemolen »
POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 70% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.

fernab

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Re: POIS cure: theory & supplement stack
« Reply #387 on: October 20, 2018, 02:10:42 PM »
I want to report that Nanna’s stack didn’t work for me. But I only use it for 10 days. Nanna said that you have to use it for 3 or 4 weeks. So I will try about 2 or 3 weeks again. I was also already a bit sick because of my allergy of Cefuroxim.

Yes, you are right. I remember I read It. But I am on a very delicate situation. I can get out of this difficult situation. and I find myself in a more stable situation I could try again 3 or 4 weeks. but now I can not risk getting worse. I need to be more stable first.... Thanks Vandemolen.

swell

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Re: POIS cure: theory & supplement stack
« Reply #388 on: October 20, 2018, 04:06:18 PM »
Yes.  For some, its a very big component.  I think as nanna1 postulates that POIS is an inflammatory response, so if your nerves are in the slightest compromised state (though still normal) however after POIS, with that increased inflammation, they will now will get significantly (clinically) pinched, disrupting nerve transmission and causing the symptoms - pain / paresis etc. 

Do you think POIS could have a neurological component?

Bombardier

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Re: POIS cure: theory & supplement stack
« Reply #389 on: October 21, 2018, 02:52:08 AM »
Alrighty, so I just tried climaxing after about a week and a half of taking Nanna's POIS Cascade Stack, while following a strict vegan diet, while also having taken 250mg flushing Niacin two hours ago. Let's see how this goes.

Bear in mind, I'm also taking a low dose of Adderall due to my recently-diagnosed ADHD. However, I'm confident that these writings reflect the "default" state of my mind.

Five minutes after: Nothing too-too interesting. I have a strange, almost tension-like feeling in the front of my cranium (forehead to just before the parietal lobe), but I can still talk and type rather eloquently.

Ten minutes: Ugh. Tension headache is getting worse. Still, my symptoms usually don't start till about half an hour later.

Fifteen minutes: Yeah, I get the feeling I'm in the midst of a pretty typical POIS episode now. Constant headache, mild cognitive impairment, mostly whilst trying to talk to people. Hopefully the niacin helps.

Thirty to fifty minutes: Ughh, this blows. Now my eyes are starting to defocus, my headache stretches all around my head above the ears. Cognitive impairment comes and goes, with stretches of mild symptoms interspersed with short bursts of extreme difficulty.

Overall I'm currently having a very typical POIS episode. On the bright side, climaxes seem to take away my neuropathic pain, to the point where orgasms could substitute medication if it weren't for these cognitive issues. I will keep supplementing regardless.