I noted a very strange thing with my POIS that made me think, months ago I was so frustrated with my POIS that I have tried to increase the number of daily orgasms to see what would happened, very strangely I noted that after the second orgasm in a couple of hours I tend to be better than after the first, but the symptoms tend to return after some hours, some months ago I managed to have 5 orgasms in one night and after each orgasm after the first I felt better but also in this case was a brief thing and the symptoms of anxiety and depression POIS induced returned after a while.
Very strange, don't you think?
Brain fog tend to be worse with more than one orgasm but I tend to compensate it with nicotine or caffeine.