https://www.perplexity.ai/search/what-are-the-top-5-mast-cell-m-1uoEyUTZRGCHXeGc1.32MgBased on the search results, here are the top 5 mast cell mediators in terms of quantities a mast cell can produce:
1. Tryptase: Tryptases are the most abundant proteases in human mast cells, comprising up to 20% of the total cell protein[3]. Some human mast cells can contain up to 35 micrograms of tryptase per 10^6 cells[3].
2. Histamine: While exact quantities are not specified, histamine is one of the key preformed mediators stored in mast cell granules and rapidly released upon activation[1][3].
3. Carboxypeptidase A (CPA3): Human foreskin mast cells are estimated to contain about 16 micrograms of CPA per 10^6 cells[3].
4. Chymase: Found in the MCTC and rare MCC subpopulations of human mast cells[3]. While exact quantities are not provided, it is mentioned as one of the important mast cell proteases.
5. Heparin: Although specific quantities are not given, heparin is listed as one of the preformed mediators stored in large amounts in mast cell granules[5].
It's worth noting that mast cells contain 50-200 large granules storing these and other inflammatory mediators[5]. The exact quantities can vary depending on the mast cell subtype, location, and activation state. Additionally, mast cells can produce and release hundreds of different mediators (
390 identified in humans)[2][4], but the search results don't provide specific quantities for most of them.
Citations:
[1]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231949/[2]
https://link.springer.com/article/10.1007/s00210-023-02545-y[3]
https://medilib.ir/uptodate/show/3972[4]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567897/[5]
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00620/full[6]
https://www.sciencedirect.com/science/article/pii/S221321982400271X[7]
https://www.mdpi.com/1422-0067/23/22/14004[8]
https://onlinelibrary.wiley.com/doi/10.1111/imj.80_16230Paper 4, table 1 is quite handy:
Check the supplementary information ESM 1 for all the mediators, this is some sick stuff. This knowledge is far above the level at which clinical doctors operate.